• 3554 Citations
  • 26 h-Index
1970 …2019
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Research Output 1970 2019

2019
osteoblasts
Osteoblasts
apoptosis
Cell death
Ion beam assisted deposition

Effects of novel pyrrolomycin MP1 in MYCN amplified chemoresistant neuroblastoma cell lines alone and combined with temsirolimus

McGuire, T. R., Coulter, D. W., Bai, D., Sughroue, J. A., Li, J., Yang, Z., Qiao, Z., Liu, Y., Murry, D. J., Chhonker, Y. S., McIntyre, E. M., Alexander, G., Sharp, J. G. & Li, R., Aug 27 2019, In : BMC cancer. 19, 1, 837.

Research output: Contribution to journalArticle

Open Access
Neuroblastoma
Cell Line
Toxicology
Inhibitory Concentration 50
Neoplasms

Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma

Chaturvedi, N. K., Mahapatra, S., Kesherwani, V., Kling, M. J., Shukla, M., Ray, S., Kanchan, R., Perumal, N., McGuire, T. R., Graham Sharp, J., Joshi, S. S. & Coulter, D. W., Nov 6 2019, In : BMC cancer. 19, 1, 1056.

Research output: Contribution to journalArticle

Open Access
Protein-Arginine N-Methyltransferases
Medulloblastoma
Proteins
Tumor Cell Line
Brain Neoplasms
2018
9 Citations (Scopus)

Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology

Khadge, S., Sharp, J. G., Thiele, G. M., McGuire, T. R., Klassen, L. W., Duryee, M. J., Britton, H. C., Dafferner, A. J., Beck, J., Black, P. N., DiRusso, C. C. & Talmadge, J. E., Feb 2018, In : Journal of Nutritional Biochemistry. 52, p. 92-102 11 p.

Research output: Contribution to journalArticle

Omega-6 Fatty Acids
Pathology
Nutrition
Unsaturated Fatty Acids
Diet
4 Citations (Scopus)
Lipids
Neoplasms
Obesity
Unsaturated Fatty Acids
Inflammation
5 Citations (Scopus)

Improved therapy for medulloblastoma: Targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy

Chaturvedi, N. K., Kling, M. J., Coulter, D. W., McGuire, T. R., Ray, S., Kesherwani, V., Joshi, S. S. & Sharp, J. G., Mar 30 2018, In : Oncotarget. 9, 24, p. 16619-16633 15 p.

Research output: Contribution to journalArticle

Medulloblastoma
Hedgehogs
Combination Drug Therapy
Phosphatidylinositol 3-Kinases
HhAntag691
7 Citations (Scopus)
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Breast Neoplasms
Neoplasm Metastasis
Survival
2 Citations (Scopus)
Omega-3 Fatty Acids
Human Mammary Glands
Unsaturated Fatty Acids
Diet
Inflammation
1 Citation (Scopus)

Suppression of STAT3 NH2-terminal domain chemosensitizes medulloblastoma cells by activation of protein inhibitor of activated STAT3 via de-repression by microRNA-21

Ray, S., Coulter, D. W., Gray, S. D., Sughroue, J. A., Roychoudhury, S., Mcintyre, E. M., Chaturvedi, N. K., Bhakat, K. K., Joshi, S. S., McGuire, T. R. & Sharp, J. G., Apr 2018, In : Molecular Carcinogenesis. 57, 4, p. 536-548 13 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Medulloblastoma
MicroRNAs
Proteins
Down-Regulation
2017
16 Citations (Scopus)

Challenges and Recent Advances in Medulloblastoma Therapy

Kumar, V., Kumar, V., McGuire, T. R., Coulter, D. W., Sharp, J. G. & Mahato, R. I., Dec 2017, In : Trends in Pharmacological Sciences. 38, 12, p. 1061-1084 24 p.

Research output: Contribution to journalReview article

Medulloblastoma
MicroRNAs
Tumors
Stem cells
Brain
2 Citations (Scopus)

Lipid inflammatory mediators in cancer progression and therapy

Khadge, S., Sharp, J. G., McGuire, T. R., Thiele, G. M. & Talmadge, J. E., Jan 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 145-156 12 p. (Advances in Experimental Medicine and Biology; vol. 1036).

Research output: Chapter in Book/Report/Conference proceedingChapter

Tumors
Lipids
Nutrition
Fats
Infiltration
2016

Comparing biocompatibility of titanium orthopaedic implants with and without an ultra-thin coating of TiO2 by Ion beam assisted deposition

Miralami, R., Namavar, F., Thiele, G. M., Sharp, J. G. & Garvin, K. L., Jan 1 2016, Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016. Laudon, M., Case, F., Case, F., Romanowicz, B. & Romanowicz, B. (eds.). TechConnect, p. 43-46 4 p. (Advanced Materials - TechConnect Briefs 2016; vol. 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ion beam assisted deposition
Orthopedics
Titanium
Biocompatibility
Ions
10 Citations (Scopus)

Improved therapy for neuroblastoma using a combination approach: Superior efficacy with vismodegib and topotecan

Chaturvedi, N. K., McGuire, T. R., Coulter, D. W., Shukla, A., McIntyre, E. M., Sharp, J. G. & Joshi, S. S., Mar 22 2016, In : Oncotarget. 7, 12, p. 15215-15229 15 p.

Research output: Contribution to journalArticle

HhAntag691
Topotecan
Neuroblastoma
Hedgehogs
NF-kappa B

Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513

Coulter, D. W., McGuire, T. R., Sharp, J. G., McIntyre, E. M., Dong, Y., Wang, X., Gray, S., Alexander, G. R., Chatuverdi, N. K., Joshi, S. S., Chen, X. & Vennerstrom, J. L., Nov 8 2016, In : BMC cancer. 16, 1, 867.

Research output: Contribution to journalArticle

Antimalarials
Neuroblastoma
Cell Cycle
Cell Line
Neoplasms
2015

Translational Animal Models for Regenerative Medicine Research

Sharp, J. G., Jan 1 2015, Translational Regenerative Medicine. Elsevier Inc., p. 243-256 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Regenerative Medicine
Animal Models
Pan troglodytes
Papio
Macaca mulatta
2014
5 Citations (Scopus)

Changes in the frequencies of human hematopoietic stem and progenitor cells with age and site

Farrell, T. L., McGuire, T. R., Bilek, L. D., Brusnahan, S. K., Jackson, J. D., Lane, J. T., Garvin, K. L., O'Kane, B. J., Berger, A. M., Tuljapurkar, S. R., Kessinger, M. A. & Sharp, J. G., Feb 1 2014, In : Experimental Hematology. 42, 2, p. 146-154 9 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Bone Marrow
Thigh
Stem Cells
Granulocyte-Macrophage Progenitor Cells
24 Citations (Scopus)

Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis

Peters, S. L., Hlady, R. A., Opavska, J., Klinkebiel, D. L., Pirruccello, S. J., Talmon, G. A., Sharp, J. G., Wu, L., Jaenisch, R., Simpson, M. A., Karpf, A. R. & Opavsky, R., May 2014, In : Leukemia. 28, 5, p. 1138-1142 5 p.

Research output: Contribution to journalLetter

DNA (Cytosine-5-)-Methyltransferase
Lymphopoiesis
Tumor Suppressor Genes
Lymphoma
Neoplasms
2013
2 Citations (Scopus)

Comparing biocompatibility of nanocrystalline titanium and titanium-oxide with microcrystalline titanium

Miralami, R., Koepsell, L., Premaraj, T., Kim, B., Thiele, G. M., Sharp, J. G., Garvin, K. L. & Namavar, F., 2013, Materials Research Society Symposium Proceedings. Materials Research Society, Vol. 1569.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Titanium oxides
biocompatibility
Titanium
Biocompatibility
titanium oxides
6 Citations (Scopus)

Heterogeneity of functional properties of clone 66 murine breast cancer cells expressing various stem cell phenotypes

Mukhopadhyay, P., Farrell, T., Sharma, G., McGuire, T. R., O'Kane, B. & Sharp, J. G., Nov 12 2013, In : PloS one. 8, 11, e78725.

Research output: Contribution to journalArticle

Stem cells
breast neoplasms
functional properties
stem cells
Stem Cells
2 Citations (Scopus)

Nanostructurally designed ultra-hydrophilic hard ceramic oxide coatings for orthopaedic application

Namavar, F., Sabirianov, R. F., Zhang, J., Cheung, C. L. B., Blatchley, C., Miralami, R., Sharp, J. G. & Garvin, K. L., Jan 1 2013, Titanium Dioxide: Fundamentals and Applications. Materials Research Society, p. 23-28 6 p. (Materials Research Society Symposium Proceedings; vol. 1578).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

orthopedics
Orthopedics
Oxides
biocompatibility
Titanium
2012
6 Citations (Scopus)

Engineered nanostructured coatings for enhanced protein adsorption and cell growth

Namavar, F., Rubinstein, A., Sabirianov, R. F., Thiele, G. M., Sharp, J. G., Pokharel, U., Namavar, R. M. & Garvin, K. L., Aug 20 2012, Gels and Biomedical Materials. p. 119-125 7 p. (Materials Research Society Symposium Proceedings; vol. 1418).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cell growth
Fibronectins
zirconium oxides
Zirconia
adhesion
11 Citations (Scopus)

Novel therapy for therapy-resistant mantle cell lymphoma: Multipronged approach with targeting of hedgehog signaling

Hegde, G. V., Nordgren, T. M., Munger, C. M., Mittal, A. K., Bierman, P. J., Weisenburger, D. D., Vose, J. M., Sharp, J. G. & Joshi, S. S., Dec 15 2012, In : International Journal of Cancer. 131, 12, p. 2951-2960 10 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Hedgehogs
Therapeutics
Drug Therapy
Inbred NOD Mouse
8 Citations (Scopus)

Nucleic Acid and Non-Nucleic Acid-Based Reprogramming of Adult Limbal Progenitors to Pluripotency

Parameswaran, S., Balasubramanian, S., Babai, N., DelDebbio, C. B., Harms, D. W., Gurumurthy, C. B., Rao, M. S., Sharp, J. G. & Ahmad, I., Oct 8 2012, In : PloS one. 7, 10, e46734.

Research output: Contribution to journalArticle

Nucleic Acids
nucleic acids
Acids
acids
Gene expression
2011
50 Citations (Scopus)

Changes in human bone marrow fat content associated with changes in hematopoietic stem cell numbers and cytokine levels with aging

Tuljapurkar, S. R., McGuire, T. R., Brusnahan, S. K., Jackson, J. D., Garvin, K. L., Kessinger, M. A., Lane, J. T., O'Kane, B. J. & Sharp, J. G., Nov 1 2011, In : Journal of Anatomy. 219, 5, p. 574-581 8 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
bone marrow
fat
bone
cytokines
14 Citations (Scopus)

Differentiation of embryonic stem cells into fibroblast-like cells in three-dimensional type i collagen gel cultures

Togo, S., Sato, T., Sugiura, H., Wang, X., Basma, H. E., Nelson, A., Liu, X., Bargar, T. W., Sharp, J. G. & Rennard, S. I., Feb 1 2011, In : In Vitro Cellular and Developmental Biology - Animal. 47, 2, p. 114-124 11 p.

Research output: Contribution to journalArticle

Fibroblasts
Embryonic Stem Cells
Stem cells
Cell culture
Collagen
6 Citations (Scopus)

IL-4 induces differentiation of human embryonic stem cells into fibrogenic fibroblast-like cells

Sato, T., Liu, X., Basma, H. E., Togo, S., Sugiura, H., Nelson, A., Nakanishi, M., Kanaji, N., Wang, X., Kim, M., Li, Y., Michalski, J., Farid, M., Sharp, J. G. & Rennard, S. I., Jun 2011, In : Journal of Allergy and Clinical Immunology. 127, 6, p. 1595-1603.e9

Research output: Contribution to journalArticle

Interleukin-4
Fibroblasts
Phenotype
Stem Cells
Fibronectins
19 Citations (Scopus)

Inflammation associated with obesity: Relationship with blood and bone marrow endothelial cells

McGuire, T. R., Brusnahan, S. K., Bilek, L. D., Jackson, J. D., Kessinger, M. A., Berger, A. M., Garvin, K. L., O'Kane, B. J., Tuljapurkar, S. R. & Sharp, J. G., Nov 1 2011, In : Obesity. 19, 11, p. 2130-2136 7 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Endothelial Cells
Obesity
Inflammation
Bone Marrow
2010
34 Citations (Scopus)

Human blood and marrow side population stem cell and Stro-1 positive bone marrow stromal cell numbers decline with age, with an increase in quality of surviving stem cells: Correlation with cytokines

Brusnahan, S. K., McGuire, T. R., Jackson, J. D., Lane, J. T., Garvin, K. L., O'Kane, B. J., Berger, A. M., Tuljapurkar, S. R., Kessinger, M. A. & Sharp, J. G., Nov 1 2010, In : Mechanisms of Ageing and Development. 131, 11-12, p. 718-722 5 p.

Research output: Contribution to journalArticle

Side-Population Cells
Mesenchymal Stromal Cells
Stem Cells
Cell Count
Bone Marrow
59 Citations (Scopus)

Long-term cigarette smoke exposure in a mouse model of ciliated epithelial cell function

Simet Chadwick, S. M., Sisson, J. H., Pavlik, J. A., DeVasure, J. M., Boyer, C., Liu, X., Kawasaki, S., Sharp, J. G., Rennard, S. I. & Wyatt, T. A., Dec 1 2010, In : American journal of respiratory cell and molecular biology. 43, 6, p. 635-640 6 p.

Research output: Contribution to journalArticle

Smoke
Tobacco Products
Epithelial Cells
Protein Kinase C
Cell Count
2009
36 Citations (Scopus)

Non cell-autonomous reprogramming of adult ocular progenitors: Generation of pluripotent stem cells without exogenous transcription factors

Balasubramanian, S., Babai, N., Chaudhuri, A., Qui, F., Bhattacharya, S., Dave, B. J., Parameswaran, S., Carson, S. D., Thoreson, W. B., Sharp, J. G., Rao, M. & Ahmad, I., Dec 1 2009, In : STEM CELLS. 27, 12, p. 3053-3062 10 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Induced Pluripotent Stem Cells
Transcription Factors
Stem Cells
Virus Integration
2008
1 Citation (Scopus)

A comparative evaluation of teaching methods in an introductory neuroscience course for physical therapy students.

Willett, G. M., Sharp, J. G. & Smith, L. M., Jan 1 2008, In : Journal of allied health. 37, 3, p. e177-198

Research output: Contribution to journalArticle

Neurosciences
Teaching
Students
Therapeutics
Costs and Cost Analysis
47 Citations (Scopus)

Effects of exercise on hematological parameters, circulating side population cells, and cytokines

Wardyn, G. G., Rennard, S. I., Brusnahan, S. K., McGuire, T. R., Carlson, M. L., Smith, L. M., McGranaghan, S. & Sharp, J. G., Feb 1 2008, In : Experimental Hematology. 36, 2, p. 216-223 8 p.

Research output: Contribution to journalArticle

Side-Population Cells
Cytokines
Interleukin-6
Hematocrit
Vascular Endothelial Growth Factor A

Mesenchymal Cells of the Lung

Rennard, S. I. & Sharp, J. G., Jan 11 2008, Chronic Obstructive Pulmonary Disease. Blackwell Publishing Ltd, p. 308-316 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pericytes
Chondrocytes
Fibroblasts
Lung
2007
28 Citations (Scopus)
Side-Population Cells
Bone Marrow Cells
Stem Cells
Bone Marrow
Tacrine
95 Citations (Scopus)

Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-γc-/- mice

Gorantla, S., Sneller, H., Walters, L., Sharp, J. G., Pirruccello, S. J., West, J. T., Wood, C., Dewhurst, S., Gendelman, H. E. & Poluektova, L. Y., Mar 1 2007, In : Journal of virology. 81, 6, p. 2700-2712 13 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
HIV-1
mice
Thymus Gland
busulfan
2006
1 Citation (Scopus)

Cytotoxic lymphocytes for the clinic

Barrett, A. J. & Sharp, J. G., May 1 2006, In : Cytotherapy. 8, 2, p. 93-94 2 p.

Research output: Contribution to journalComment/debate

Immunologic Cytotoxicity
Immunologic Cytotoxicity Tests
Cytotoxic T-Lymphocytes
Hematologic Neoplasms
Lymphocytes
2 Citations (Scopus)

Novel engineered nanocrystalline ultra-hydrophilic hard ceramic coatings for attachment and growth of bone marrow stromal cells

Namavar, F., Jackson, J. D., Sharp, J. G., Varma, S., Haider, H., Feschuk, C. & Garvin, K. L., Dec 1 2006, In : MCB Molecular and Cellular Biomechanics. 3, 4, p. 171-172 2 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Hardness
Ceramics
Titanium
Aluminum
2 Citations (Scopus)

Searching for smart durable coatings to promote bone marrow stromal cell growth while preventing biofilm formation

Namavar, F., Jackson, J. D., Sharp, J. G., Mann, E. E., Bayles, K. W., Cheung, C. L. B., Feschuk, C. A., Varma, S., Haider, H. & Garvin, K. L., Dec 1 2006, Biofilm-Material Interactions: New Tools, Technologies and Opportunities. p. 1-7 7 p. (Materials Research Society Symposium Proceedings; vol. 954).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Biofilms
Cell growth
Bone
Coatings
Ceramic coatings
2005
1 Citation (Scopus)

An ex vivo model of hematopoietic stem cell mobilization

Kessinger, A., O'Kane, M. B., Jackson, J. D. & Sharp, J. G., Dec 1 2005, In : Cytotherapy. 7, 6, p. 463-469 7 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Mobilization
Stem Cells
Cytokines
Cell Count
Bone Marrow
25 Citations (Scopus)

Evidence for a qualitative hierarchy within the Hoechst-33342 'side population' (SP) of murine bone marrow cells

Robinson, S. N., Seina, S. M., Gohr, J. C., Kuszynski, C. A. & Sharp, J. G., Apr 1 2005, In : Bone marrow transplantation. 35, 8, p. 807-818 12 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Population
Coloring Agents
Bone Marrow
Side-Population Cells

Governmental, national, international agency and other initiatives to advance the application of cellular therapies

Sharp, J. G., Jan 1 2005, In : Cytotherapy. 7, 4, p. 315-316 2 p.

Research output: Contribution to journalEditorial

International Agencies
Therapeutics
9 Citations (Scopus)

Hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor and erythropoietin in the absence of matrix metalloproteinase-9

Robinson, S. N., Seina, S. M., Gohr, J. C. & Sharp, J. G., Jun 1 2005, In : Stem Cells and Development. 14, 3, p. 317-328 12 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Granulocyte Colony-Stimulating Factor
Erythropoietin
Hematopoietic Stem Cells
Matrix Metalloproteinases
9 Citations (Scopus)

Promises and pitfalls of stem cell therapy for promotion of bone healing

Sharp, J. G., Murphy, B. O. K., Jackson, J. D., Brusnahan, S. K., Kessinger, A. & Neff, J. R., Jun 2005, In : Clinical Orthopaedics and Related Research. 435, p. 52-61 10 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Stem Cells
Bone and Bones
Thigh
Kidney
2004
2 Citations (Scopus)

A pilot evaluation of micrometastases for the prediction of outcome in lung cancer

Thompson, A. B., Kessinger, A. & Sharp, J. G., May 2004, In : Chest. 125, 5 SUPPL., p. 156S-157S

Research output: Contribution to journalArticle

Bone Marrow Neoplasms
Circulating Neoplastic Cells
Neoplasm Micrometastasis
Small Cell Carcinoma
Non-Small Cell Lung Carcinoma
131 Citations (Scopus)

Cells derived from the circulation contribute to the repair of lung injury

Abe, S., Boyer, C., Liu, X., Fu, Q. W., Kobayashi, T., Fang, Q., Wang, X., Hashimoto, M., Sharp, J. G. & Rennard, S. I., Dec 1 2004, In : American Journal of Respiratory and Critical Care Medicine. 170, 11, p. 1158-1163 6 p.

Research output: Contribution to journalArticle

Lung Injury
Stem Cells
Pancreatic Elastase
Green Fluorescent Proteins
Radiation
1 Citation (Scopus)

Circulating Hematopoietic Stem Cell Transplantation

Kessinger, A. & Sharp, J. G., Sep 14 2004, Adult and Fetal. Elsevier Inc., Vol. 2. p. 685-693 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hematopoietic Stem Cell Transplantation
Stem cells
Bone Marrow
Blood
Stem Cells
17 Citations (Scopus)

Lung cells transplanted to irradiated recipients generate lymphohematopoietic progeny

Abe, S., Lauby, G., Boyer, C., Manouilova, L., Rennard, S. I. & Sharp, J. G., Apr 1 2004, In : American journal of respiratory cell and molecular biology. 30, 4, p. 491-499 9 p.

Research output: Contribution to journalArticle

Stem cells
Bone
Tissue
Gene therapy
Lung

The Alvarnas/Forman article reviewed

Sharp, J. G. & Bierman, P. J., Jun 1 2004, In : ONCOLOGY. 18, 7, p. 881-884 4 p.

Research output: Contribution to journalReview article

2003
3 Citations (Scopus)
Stem Cell Transplantation
Blood Cells
Stem Cells
Breast Neoplasms
Blood Component Removal