Ghribi Othman, PhD

Professor

  • 3388 Citations
  • 36 h-Index
1992 …2019

Research output per year

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Research Output

2019

A Diet Enriched in Palmitate and Deficient in Linoleate Exacerbates Oxidative Stress and Amyloid-β Burden in the Hippocampus of 3xTg-AD Mouse Model of Alzheimer's Disease

Marwarha, G., Claycombe-Larson, K., Lund, J., Schommer, J. & Ghribi, O., Jan 1 2019, In : Journal of Alzheimer's Disease. 68, 1, p. 219-237 19 p.

Research output: Contribution to journalArticle

1 Scopus citations

Palmitate-Induced SREBP1 Expression and Activation Underlies the Increased BACE 1 Activity and Amyloid Beta Genesis

Marwarha, G., Claycombe-Larson, K., Lund, J. & Ghribi, O., Jul 1 2019, In : Molecular Neurobiology. 56, 7, p. 5256-5269 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

27-hydroxycholesterol decreases cell proliferation in colon cancer cell lines

Warns, J., Marwarha, G., Freking, N. & Ghribi, O., Oct 2018, In : Biochimie. 153, p. 171-180 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons

Schommer, J., Marwarha, G., Schommer, T., Flick, T., Lund, J. & Ghribi, O., Apr 3 2018, In : BMC Neuroscience. 19, 1, 17.

Research output: Contribution to journalArticle

3 Scopus citations

Palmitate-induced C/EBP homologous protein activation leads to NF-κB-mediated increase in BACE1 activity and amyloid beta genesis

Marwarha, G., Schommer, J., Lund, J., Schommer, T. & Ghribi, O., Mar 2018, In : Journal of Neurochemistry. 144, 6, p. 761-779 19 p.

Research output: Contribution to journalArticle

4 Scopus citations

Palmitic acid-enriched diet increases α-synuclein and tyrosine hydroxylase expression levels in the mouse brain

Schommer, J., Marwarha, G., Nagamoto-Combs, K. & Ghribi, O., Aug 6 2018, In : Frontiers in Neuroscience. 12, AUG, 552.

Research output: Contribution to journalArticle

2 Scopus citations
2017

27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer

Marwarha, G., Raza, S., Hammer, K. & Ghribi, O., Oct 2017, In : Chemistry and Physics of Lipids. 207, p. 108-126 19 p.

Research output: Contribution to journalReview article

17 Scopus citations

Cellular hormetic response to 27-hydroxycholesterol promotes neuroprotection through AICD induction of MAST4 abundance and kinase activity

Gongol, B., Marin, T. L., Jeppson, J. D., Mayagoitia, K., Shin, S., Sanchez, N., Kirsch, W. M., Vinters, H. V., Wilson, C. G., Ghribi, O. & Soriano, S., Dec 1 2017, In : Scientific reports. 7, 1, 13898.

Research output: Contribution to journalArticle

3 Scopus citations

Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring

Marwarha, G., Claycombe-Larson, K., Schommer, J. & Ghribi, O., Jul 1 2017, In : Journal of Nutritional Biochemistry. 45, p. 54-66 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Meet our editorial board member

Othman, G., 2017, In : Current Alzheimer Research. 14, 6, p. 577 1 p.

Research output: Contribution to journalEditorial

Method for organotypic tissue culture in the aged animal

Schommer, J., Schrag, M., Nackenoff, A., Marwarha, G. & Ghribi, O., Jan 1 2017, In : MethodsX. 4, p. 166-171 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
4 Scopus citations

Palmitate Increases β-site AβPP-Cleavage Enzyme 1 Activity and Amyloid-β Genesis by Evoking Endoplasmic Reticulum Stress and Subsequent C/EBP Homologous Protein Activation

Marwarha, G., Rostad, S., Lilek, J., Kleinjan, M., Schommer, J. & Ghribi, O., Jan 1 2017, In : Journal of Alzheimer's Disease. 57, 3, p. 907-925 19 p.

Research output: Contribution to journalArticle

12 Scopus citations

The cholesterol metabolite 27-hydroxycholesterol stimulates cell proliferation via ERβ in prostate cancer cells

Raza, S., Meyer, M., Goodyear, C., Hammer, K. D. P., Guo, B. & Ghribi, O., May 11 2017, In : Cancer Cell International. 17, 1, 52.

Research output: Contribution to journalArticle

18 Scopus citations
2016

27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells

Raza, S., Meyer, M., Schommer, J., Hammer, K. D. P., Guo, B. & Ghribi, O., Feb 1 2016, In : Medical Oncology. 33, 2, p. 1-9 9 p., 12.

Research output: Contribution to journalArticle

12 Scopus citations

Maternal low protein diet leads to placental angiogenic compensation via dysregulated M1/M2 macrophages and TNFα expression in Sprague-Dawley rats

Vomhof-DeKrey, E., Darland, D., Ghribi, O., Bundy, A., Roemmich, J. & Claycombe, K., Nov 1 2016, In : Journal of Reproductive Immunology. 118, p. 9-17 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Molecular events linking cholesterol to alzheimer’s disease and inclusion body myositis in a rabbit model

Liu, Q. Y., Koukiekolo, R., Zhang, D. L., Smith, B., Ly, D., Lei, J. X. & Ghribi, O., Jan 1 2016, In : American Journal of Neurodegenerative Diseases. 5, 1, p. 74-84 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain

Marwarha, G., Claycombe, K., Schommer, J., Collins, D. & Ghribi, O., Nov 1 2016, In : Cellular Signalling. 28, 11, p. 1789-1805 17 p.

Research output: Contribution to journalArticle

23 Scopus citations
4 Scopus citations
2015

Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?

Marwarha, G. & Ghribi, O., Aug 1 2015, In : Experimental Gerontology. 68, p. 13-18 6 p.

Research output: Contribution to journalReview article

38 Scopus citations

Epigenetics of inflammation, maternal infection, and nutrition

Claycombe, K. J., Brissette, C. A. & Ghribi, O., Jan 1 2015, In : Journal of Nutrition. 145, 5, p. 1109S-1115S

Research output: Contribution to journalArticle

26 Scopus citations

Maternal low-protein diet causes body weight loss in male, neonate Sprague-Dawley rats involving UCP-1-mediated thermogenesis

Claycombe, K. J., Vomhof-DeKrey, E. E., Roemmich, J. N., Rhen, T. & Ghribi, O., Jan 1 2015, In : Journal of Nutritional Biochemistry. 26, 7, p. 729-735 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells

Raza, S., Ohm, J. E., Dhasarathy, A., Schommer, J., Roche, C., Hammer, K. D. P. & Ghribi, O., Sep 8 2015, In : Molecular and cellular biochemistry. 410, 1-2, p. 187-195 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Cholesterol-enriched diet disrupts the blood-testis barrier in rabbits

Morgan, D. H., Ghribi, O., Hui, L., Geiger, J. D. & Chen, X., Dec 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 12, p. E1125-E1130

Research output: Contribution to journalArticle

14 Scopus citations

Identification of microRNAs involved in Alzheimer’s progression using a rabbit model of the disease

Liu, Q. Y., Chang, M. N. V., Lei, J. X., Koukiekolo, R., Smith, B., Zhang, D. & Ghribi, O., Jan 1 2014, In : American Journal of Neurodegenerative Diseases. 3, 1, p. 33-44 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway

Marwarha, G., Raza, S., Meiers, C. & Ghribi, O., Sep 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 9, p. 1587-1595 9 p.

Research output: Contribution to journalArticle

60 Scopus citations
2013

Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells

Dasari, B., Prasanthi, J. R. P., Meiers, C., Singh, B. B. & Ghribi, O., Nov 1 2013, In : Current Eye Research. 38, 11, p. 1159-1171 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Gadd153 and NF-κB Crosstalk Regulates 27-Hydroxycholesterol-Induced Increase in BACE1 and β-Amyloid Production in Human Neuroblastoma SH-SY5Y Cells

Marwarha, G., Raza, S., Prasanthi, J. R. P. & Ghribi, O., Aug 9 2013, In : PloS one. 8, 8, e70773.

Research output: Contribution to journalArticle

49 Scopus citations

Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: A meta-analysis

Schrag, M., Mueller, C., Zabel, M., Crofton, A., Kirsch, W. M., Ghribi, O., Squitti, R. & Perry, G., Nov 1 2013, In : Neurobiology of Disease. 59, p. 100-110 11 p.

Research output: Contribution to journalArticle

163 Scopus citations
2012

Cellular model of Alzheimer's disease - Relevance to therapeutic testing

Marwarha, G. & Ghribi, O., Feb 1 2012, In : Experimental Neurology. 233, 2, p. 733-739 7 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

Deferiprone reduces amyloid-β and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet

Prasanthi, J. R. P., Schrag, M., Dasari, B., Marwarha, G., Dickson, A., Kirsch, W. M. & Ghribi, O., 2012, In : Journal of Alzheimer's Disease. 30, 1, p. 167-182 16 p.

Research output: Contribution to journalArticle

32 Scopus citations
35 Scopus citations

Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease

Liu, R., Lei, J. X., Luo, C., Lan, X., Chi, L., Deng, P., Lei, S., Ghribi, O. & Liu, Q. Y., Mar 1 2012, In : Neurobiology of Disease. 45, 3, p. 902-912 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Leptin signaling and Alzheimer’s disease

Marwarha, G. & Ghribi, O., Nov 30 2012, In : American Journal of Neurodegenerative Diseases. 1, 3, p. 245-265 21 p.

Research output: Contribution to journalReview article

48 Scopus citations

Targeted glycomics by selected reaction monitoring for highly sensitive glycan compositional analysis

Zhang, H., Wang, Z., Stupak, J., Ghribi, O., Geiger, J. D., Liu, Q. Y. & Li, J., Aug 1 2012, In : Proteomics. 12, 15-16, p. 2510-2522 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

The neuroprotective effect of fisetin in the MPTP model of Parkinson's disease

Patel, M. Y., Panchal, H. V., Ghribi, O. & Benzeroual, K. E., Dec 1 2012, In : Journal of Parkinson's Disease. 2, 4, p. 287-302 16 p.

Research output: Contribution to journalArticle

27 Scopus citations
2011

Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina

Dasari, B., Prasanthi, J. R., Marwarha, G., Singh, B. B. & Ghribi, O., Aug 22 2011, In : BMC Ophthalmology. 11, 1, 22.

Research output: Contribution to journalArticle

37 Scopus citations

Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus

Marwarha, G., Prasanthi, J. R., Schommer, J., Dasari, B. & Ghribi, O., Jun 10 2011, In : Molecular neurodegeneration. 6, 1, 41.

Research output: Contribution to journalArticle

29 Scopus citations

Silencing gadd153/chop gene expression protects against alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus

Prasanthi, J. R. P., Larson, T., Schommer, J. & Ghribi, O., Oct 21 2011, In : PloS one. 6, 10, e26420.

Research output: Contribution to journalArticle

55 Scopus citations

The cholesterol-fed rabbit as a model system for cholesterol-Alzheimer's disease studies

Prasanthi, R. P. J., Marwarha, G. & Ghribi, O., Dec 1 2011, Handbook of Animal Models in Alzheimer's Disease. Casadesus, G. (ed.). p. 163-178 16 p. (Advances in Alzheimer's Disease; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingChapter

49 Scopus citations
2010
73 Scopus citations

Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet

Prasanthi, J. R. P., Dasari, B., Marwarha, G., Larson, T., Chen, X., Geiger, J. D. & Ghribi, O., Oct 1 2010, In : Free Radical Biology and Medicine. 49, 7, p. 1212-1220 9 p.

Research output: Contribution to journalArticle

97 Scopus citations

Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet

Chen, X., Wagener, J. F., Morgan, D. H., Hui, L., Ghribi, O. & Geiger, J. D., 2010, In : Journal of Alzheimer's Disease. 22, 4, p. 1289-1303 15 p.

Research output: Contribution to journalArticle

24 Scopus citations

Leptin reduces the accumulation of Aβ and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices

Marwarha, G., Dasari, B., Prasanthi, J. R. P., Schommer, J. & Ghribi, O., 2010, In : Journal of Alzheimer's Disease. 19, 3, p. 1007-1019 13 p.

Research output: Contribution to journalArticle

91 Scopus citations

The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells

Dasari, B., Prasanthi, J. R., Marwarha, G., Singh, B. B. & Ghribi, O., Sep 16 2010, In : BMC Ophthalmology. 10, 1, 22.

Research output: Contribution to journalArticle

51 Scopus citations

β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway

Marwarha, G., Dasari, B., Prabhakara, J. P. R., Schommer, J. & Ghribi, O., Oct 1 2010, In : Journal of Neurochemistry. 115, 2, p. 373-384 12 p.

Research output: Contribution to journalArticle

32 Scopus citations
2009

Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits

Wu, M., Audet, A., Cusic, J., Seeger, D., Cochran, R. & Ghribi, O., Nov 1 2009, In : Journal of Neurochemistry. 111, 4, p. 1011-1021 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells

Prasanthi, J. R. P., Huls, A., Thomasson, S., Thompson, A., Schommer, E. & Ghribi, O., Mar 18 2009, In : Molecular neurodegeneration. 4, 1, 1.

Research output: Contribution to journalArticle

88 Scopus citations

β-amyloid peptide, endoplasmic reticulum stress, and Alzheimer's disease

Ghribi, O., Dec 1 2009, Protein Misfolding Disorders: A Trip into the ER. Bentham Science Publishers Ltd., p. 114-126 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter