Ghribi Othman, PhD

Professor

  • 3303 Citations
  • 36 h-Index
1992 …2019
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Research Output 1992 2019

2019
1 Citation (Scopus)

A Diet Enriched in Palmitate and Deficient in Linoleate Exacerbates Oxidative Stress and Amyloid-β Burden in the Hippocampus of 3xTg-AD Mouse Model of Alzheimer's Disease

Marwarha, G., Claycombe-Larson, K., Lund, J., Schommer, J. & Ghribi, O., Jan 1 2019, In : Journal of Alzheimer's Disease. 68, 1, p. 219-237 19 p.

Research output: Contribution to journalArticle

Palmitates
Linoleic Acid
Amyloid
Hippocampus
Alzheimer Disease
1 Citation (Scopus)

Palmitate-Induced SREBP1 Expression and Activation Underlies the Increased BACE 1 Activity and Amyloid Beta Genesis

Marwarha, G., Claycombe-Larson, K., Lund, J. & Ghribi, O., Jul 1 2019, In : Molecular Neurobiology. 56, 7, p. 5256-5269 14 p.

Research output: Contribution to journalArticle

Palmitates
Response Elements
Sterols
Amyloid
Carrier Proteins
2018
6 Citations (Scopus)

27-hydroxycholesterol decreases cell proliferation in colon cancer cell lines

Warns, J., Marwarha, G., Freking, N. & Ghribi, O., Oct 2018, In : Biochimie. 153, p. 171-180 10 p.

Research output: Contribution to journalArticle

Cell proliferation
Colonic Neoplasms
Colorectal Neoplasms
Cholesterol
Cells
1 Citation (Scopus)

27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons

Schommer, J., Marwarha, G., Schommer, T., Flick, T., Lund, J. & Ghribi, O., Apr 3 2018, In : BMC Neuroscience. 19, 1, 17.

Research output: Contribution to journalArticle

Synucleins
Dopaminergic Neurons
HSP70 Heat-Shock Proteins
Proteins
Cholesterol
4 Citations (Scopus)

Palmitate-induced C/EBP homologous protein activation leads to NF-κB-mediated increase in BACE1 activity and amyloid beta genesis

Marwarha, G., Schommer, J., Lund, J., Schommer, T. & Ghribi, O., Mar 2018, In : Journal of Neurochemistry. 144, 6, p. 761-779 19 p.

Research output: Contribution to journalArticle

Transcription Factor CHOP
Palmitates
Amyloid
Chemical activation
Alzheimer Disease
1 Citation (Scopus)

Palmitic acid-enriched diet increases α-synuclein and tyrosine hydroxylase expression levels in the mouse brain

Schommer, J., Marwarha, G., Nagamoto-Combs, K. & Ghribi, O., Aug 6 2018, In : Frontiers in Neuroscience. 12, AUG, 552.

Research output: Contribution to journalArticle

Synucleins
Palmitic Acid
Tyrosine 3-Monooxygenase
Palmitates
Parkinson Disease
2017
14 Citations (Scopus)

27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer

Marwarha, G., Raza, S., Hammer, K. & Ghribi, O., Oct 2017, In : Chemistry and Physics of Lipids. 207, p. 108-126 19 p.

Research output: Contribution to journalReview article

Selective Estrogen Receptor Modulators
Tumors
Prostatic Neoplasms
Carcinogenesis
Breast Neoplasms
2 Citations (Scopus)

Cellular hormetic response to 27-hydroxycholesterol promotes neuroprotection through AICD induction of MAST4 abundance and kinase activity

Gongol, B., Marin, T. L., Jeppson, J. D., Mayagoitia, K., Shin, S., Sanchez, N., Kirsch, W. M., Vinters, H. V., Wilson, C. G., Ghribi, O. & Soriano, S., Dec 1 2017, In : Scientific reports. 7, 1, 13898.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Protein-Serine-Threonine Kinases
Microtubules
Phosphotransferases
Brain
8 Citations (Scopus)

Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring

Marwarha, G., Claycombe-Larson, K., Schommer, J. & Ghribi, O., Jul 1 2017, In : Journal of Nutritional Biochemistry. 45, p. 54-66 13 p.

Research output: Contribution to journalArticle

Protein-Restricted Diet
Brain-Derived Neurotrophic Factor
Nutrition
Rats
Brain

Meet our editorial board member

Othman, G., 2017, In : Current Alzheimer Research. 14, 6, p. 577 1 p.

Research output: Contribution to journalEditorial

5 Citations (Scopus)

Method for organotypic tissue culture in the aged animal

Schommer, J., Schrag, M., Nackenoff, A., Marwarha, G. & Ghribi, O., Jan 1 2017, In : MethodsX. 4, p. 166-171 6 p.

Research output: Contribution to journalArticle

Tissue culture
Cell culture
Brain
Animals
Tissue
4 Citations (Scopus)
Alzheimer Disease
B-Lymphocytes
Light
Neuronal Plasticity
Learning
11 Citations (Scopus)

Palmitate Increases β-site AβPP-Cleavage Enzyme 1 Activity and Amyloid-β Genesis by Evoking Endoplasmic Reticulum Stress and Subsequent C/EBP Homologous Protein Activation

Marwarha, G., Rostad, S., Lilek, J., Kleinjan, M., Schommer, J. & Ghribi, O., Jan 1 2017, In : Journal of Alzheimer's Disease. 57, 3, p. 907-925 19 p.

Research output: Contribution to journalArticle

Transcription Factor CHOP
Endoplasmic Reticulum Stress
Amyloid beta-Protein Precursor
Palmitates
Amyloid
17 Citations (Scopus)

The cholesterol metabolite 27-hydroxycholesterol stimulates cell proliferation via ERβ in prostate cancer cells

Raza, S., Meyer, M., Goodyear, C., Hammer, K. D. P., Guo, B. & Ghribi, O., May 11 2017, In : Cancer Cell International. 17, 1, 52.

Research output: Contribution to journalArticle

Estrogen Receptors
Prostatic Neoplasms
Cholesterol
Cell Proliferation
27-hydroxycholesterol
2016
12 Citations (Scopus)

27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells

Raza, S., Meyer, M., Schommer, J., Hammer, K. D. P., Guo, B. & Ghribi, O., Feb 1 2016, In : Medical Oncology. 33, 2, p. 1-9 9 p., 12.

Research output: Contribution to journalArticle

docetaxel
Prostatic Hyperplasia
Prostate
Androgen Receptors
Epithelial Cells
4 Citations (Scopus)

Maternal low protein diet leads to placental angiogenic compensation via dysregulated M1/M2 macrophages and TNFα expression in Sprague-Dawley rats

Vomhof-DeKrey, E., Darland, D., Ghribi, O., Bundy, A., Roemmich, J. & Claycombe, K., Nov 1 2016, In : Journal of Reproductive Immunology. 118, p. 9-17 9 p.

Research output: Contribution to journalArticle

Protein-Restricted Diet
Placenta
Sprague Dawley Rats
Angiogenesis Inducing Agents
Macrophages
6 Citations (Scopus)

Molecular events linking cholesterol to alzheimer’s disease and inclusion body myositis in a rabbit model

Liu, Q. Y., Koukiekolo, R., Zhang, D. L., Smith, B., Ly, D., Lei, J. X. & Ghribi, O., Jan 1 2016, In : American Journal of Neurodegenerative Diseases. 5, 1, p. 74-84 11 p.

Research output: Contribution to journalArticle

Inclusion Body Myositis
Alzheimer Disease
Cholesterol
Rabbits
Muscles
21 Citations (Scopus)

Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain

Marwarha, G., Claycombe, K., Schommer, J., Collins, D. & Ghribi, O., Nov 1 2016, In : Cellular Signalling. 28, 11, p. 1789-1805 17 p.

Research output: Contribution to journalArticle

Transcription Factor CHOP
Endoplasmic Reticulum Stress
Palmitates
Somatomedins
Leptin
4 Citations (Scopus)
Alzheimer Disease
Skeletal Muscle
Cholesterol
Pathology
Rabbits
2015
37 Citations (Scopus)

Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?

Marwarha, G. & Ghribi, O., Aug 1 2015, In : Experimental Gerontology. 68, p. 13-18 6 p.

Research output: Contribution to journalReview article

Parkinson Disease
Alzheimer Disease
Synucleins
Cholesterol
27-hydroxycholesterol
26 Citations (Scopus)

Epigenetics of inflammation, maternal infection, and nutrition

Claycombe, K. J., Brissette, C. A. & Ghribi, O., Jan 1 2015, In : Journal of Nutrition. 145, 5, p. 1109S-1115S

Research output: Contribution to journalArticle

Epigenomics
Mothers
Inflammation
Food
Infection
13 Citations (Scopus)

Maternal low-protein diet causes body weight loss in male, neonate Sprague-Dawley rats involving UCP-1-mediated thermogenesis

Claycombe, K. J., Vomhof-DeKrey, E. E., Roemmich, J. N., Rhen, T. & Ghribi, O., Jan 1 2015, In : Journal of Nutritional Biochemistry. 26, 7, p. 729-735 7 p.

Research output: Contribution to journalArticle

Protein-Restricted Diet
Thermogenesis
Nutrition
Sprague Dawley Rats
Rats
14 Citations (Scopus)

The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells

Raza, S., Ohm, J. E., Dhasarathy, A., Schommer, J., Roche, C., Hammer, K. D. P. & Ghribi, O., Sep 8 2015, In : Molecular and cellular biochemistry. 410, 1-2, p. 187-195 9 p.

Research output: Contribution to journalArticle

Cell proliferation
Metabolites
Estrogen Receptors
Cholesterol
Cells
2014
13 Citations (Scopus)

Cholesterol-enriched diet disrupts the blood-testis barrier in rabbits

Morgan, D. H., Ghribi, O., Hui, L., Geiger, J. D. & Chen, X., Dec 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 12, p. E1125-E1130

Research output: Contribution to journalArticle

Blood-Testis Barrier
Dietary Cholesterol
Seminiferous Tubules
Tight Junctions
Male Infertility
21 Citations (Scopus)

Identification of microRNAs involved in Alzheimer’s progression using a rabbit model of the disease

Liu, Q. Y., Chang, M. N. V., Lei, J. X., Koukiekolo, R., Smith, B., Zhang, D. & Ghribi, O., Jan 1 2014, In : American Journal of Neurodegenerative Diseases. 3, 1, p. 33-44 12 p.

Research output: Contribution to journalArticle

MicroRNAs
Alzheimer Disease
Rabbits
Leptin
Cholesterol
59 Citations (Scopus)

Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway

Marwarha, G., Raza, S., Meiers, C. & Ghribi, O., Sep 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 9, p. 1587-1595 9 p.

Research output: Contribution to journalArticle

Leptin
Amyloid
NF-kappa B
Aspartic Acid Proteases
Adipokines
2013
7 Citations (Scopus)

Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells

Dasari, B., Prasanthi, J. R. P., Meiers, C., Singh, B. B. & Ghribi, O., Nov 1 2013, In : Current Eye Research. 38, 11, p. 1159-1171 13 p.

Research output: Contribution to journalArticle

Estradiol
Estrogens
Estrogen Receptors
Cholesterol
Cytokines
45 Citations (Scopus)

Gadd153 and NF-κB Crosstalk Regulates 27-Hydroxycholesterol-Induced Increase in BACE1 and β-Amyloid Production in Human Neuroblastoma SH-SY5Y Cells

Marwarha, G., Raza, S., Prasanthi, J. R. P. & Ghribi, O., Aug 9 2013, In : PloS one. 8, 8, e70773.

Research output: Contribution to journalArticle

amyloid
Alzheimer disease
Crosstalk
Neuroblastoma
Amyloid
153 Citations (Scopus)

Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: A meta-analysis

Schrag, M., Mueller, C., Zabel, M., Crofton, A., Kirsch, W. M., Ghribi, O., Squitti, R. & Perry, G., Nov 1 2013, In : Neurobiology of Disease. 59, p. 100-110 11 p.

Research output: Contribution to journalArticle

Meta-Analysis
Alzheimer Disease
Oxidative Stress
Antioxidants
Copper
2012
6 Citations (Scopus)

Cellular model of Alzheimer's disease - Relevance to therapeutic testing

Marwarha, G. & Ghribi, O., Feb 1 2012, In : Experimental Neurology. 233, 2, p. 733-739 7 p.

Research output: Contribution to journalComment/debate

Genetic Transduction
tau Proteins
Nerve Degeneration
Amyloid beta-Peptides
Adenoviridae
31 Citations (Scopus)

Deferiprone reduces amyloid-β and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet

Prasanthi, J. R. P., Schrag, M., Dasari, B., Marwarha, G., Dickson, A., Kirsch, W. M. & Ghribi, O., 2012, In : Journal of Alzheimer's Disease. 30, 1, p. 167-182 16 p.

Research output: Contribution to journalArticle

Amyloid
Reactive Oxygen Species
Hippocampus
Iron
Cholesterol
33 Citations (Scopus)
Transcription Factor CHOP
Endoplasmic Reticulum Stress
Leptin
Neuroblastoma
Down-Regulation
28 Citations (Scopus)

Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease

Liu, R., Lei, J. X., Luo, C., Lan, X., Chi, L., Deng, P., Lei, S., Ghribi, O. & Liu, Q. Y., Mar 1 2012, In : Neurobiology of Disease. 45, 3, p. 902-912 11 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Alzheimer Disease
Transgenic Mice
Brain
Neurons
47 Citations (Scopus)

Leptin signaling and Alzheimer’s disease

Marwarha, G. & Ghribi, O., Nov 30 2012, In : American Journal of Neurodegenerative Diseases. 1, 3, p. 245-265 21 p.

Research output: Contribution to journalReview article

Leptin
Alzheimer Disease
Leptin Receptors
Adipokines
Brain
14 Citations (Scopus)

Targeted glycomics by selected reaction monitoring for highly sensitive glycan compositional analysis

Zhang, H., Wang, Z., Stupak, J., Ghribi, O., Geiger, J. D., Liu, Q. Y. & Li, J., Aug 1 2012, In : Proteomics. 12, 15-16, p. 2510-2522 13 p.

Research output: Contribution to journalArticle

Glycomics
Polysaccharides
Monitoring
Cells
Nutrition
24 Citations (Scopus)

The neuroprotective effect of fisetin in the MPTP model of Parkinson's disease

Patel, M. Y., Panchal, H. V., Ghribi, O. & Benzeroual, K. E., Dec 1 2012, In : Journal of Parkinson's Disease. 2, 4, p. 287-302 16 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Neuroprotective Agents
Parkinson Disease
Synucleins
Polyphenols
2011
37 Citations (Scopus)

Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina

Dasari, B., Prasanthi, J. R., Marwarha, G., Singh, B. B. & Ghribi, O., Aug 22 2011, In : BMC Ophthalmology. 11, 1, 22.

Research output: Contribution to journalArticle

Macular Degeneration
Retina
Cholesterol
Pathology
Diet
29 Citations (Scopus)

Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus

Marwarha, G., Prasanthi, J. R., Schommer, J., Dasari, B. & Ghribi, O., Jun 10 2011, In : Molecular neurodegeneration. 6, 1, 41.

Research output: Contribution to journalArticle

Somatomedins
Leptin
Amyloid
Hippocampus
Rabbits
54 Citations (Scopus)

Silencing gadd153/chop gene expression protects against alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus

Prasanthi, J. R. P., Larson, T., Schommer, J. & Ghribi, O., Oct 21 2011, In : PloS one. 6, 10, e26420.

Research output: Contribution to journalArticle

chops
Pathology
Alzheimer disease
hippocampus
Gene expression

The cholesterol-fed rabbit as a model system for cholesterol-Alzheimer's disease studies

Prasanthi, R. P. J., Marwarha, G. & Ghribi, O., Dec 1 2011, Handbook of Animal Models in Alzheimer's Disease. Casadesus, G. (ed.). p. 163-178 16 p. (Advances in Alzheimer's Disease; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingChapter

Alzheimer Disease
Cholesterol
Rabbits
Hypercholesterolemia
Pathology
48 Citations (Scopus)
Synucleins
Tyrosine 3-Monooxygenase
Neuroblastoma
Estrogen Receptors
Liver
2010
68 Citations (Scopus)
Caffeine
Blood-Brain Barrier
Parkinson Disease
Alzheimer Disease
Animal Models
95 Citations (Scopus)

Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet

Prasanthi, J. R. P., Dasari, B., Marwarha, G., Larson, T., Chen, X., Geiger, J. D. & Ghribi, O., Oct 1 2010, In : Free Radical Biology and Medicine. 49, 7, p. 1212-1220 9 p.

Research output: Contribution to journalArticle

Oxidative stress
Pathology
Nutrition
Caffeine
Hippocampus
23 Citations (Scopus)

Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet

Chen, X., Wagener, J. F., Morgan, D. H., Hui, L., Ghribi, O. & Geiger, J. D., 2010, In : Journal of Alzheimer's Disease. 22, 4, p. 1289-1303 15 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Cholesterol
Pathology
Diet
Rabbits
89 Citations (Scopus)

Leptin reduces the accumulation of Aβ and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices

Marwarha, G., Dasari, B., Prasanthi, J. R. P., Schommer, J. & Ghribi, O., 2010, In : Journal of Alzheimer's Disease. 19, 3, p. 1007-1019 13 p.

Research output: Contribution to journalArticle

Leptin
Cholesterol
Rabbits
Alzheimer Disease
Diet
51 Citations (Scopus)

The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells

Dasari, B., Prasanthi, J. R., Marwarha, G., Singh, B. B. & Ghribi, O., Sep 16 2010, In : BMC Ophthalmology. 10, 1, 22.

Research output: Contribution to journalArticle

Retinal Pigments
Macular Degeneration
Amyloid
Oxidative Stress
Epithelial Cells
32 Citations (Scopus)

β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway

Marwarha, G., Dasari, B., Prabhakara, J. P. R., Schommer, J. & Ghribi, O., Oct 1 2010, In : Journal of Neurochemistry. 115, 2, p. 373-384 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Leptin
Amyloid
Glycogen Synthase Kinase 3
Alzheimer Disease
2009
20 Citations (Scopus)

Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits

Wu, M., Audet, A., Cusic, J., Seeger, D., Cochran, R. & Ghribi, O., Nov 1 2009, In : Journal of Neurochemistry. 111, 4, p. 1011-1021 11 p.

Research output: Contribution to journalArticle

DNA Repair
Interleukin-6
Repair
Chemical activation
Cholesterol
86 Citations (Scopus)

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells

Prasanthi, J. R. P., Huls, A., Thomasson, S., Thompson, A., Schommer, E. & Ghribi, O., Mar 18 2009, In : Molecular neurodegeneration. 4, 1, 1.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Neuroblastoma
Amyloid
Cholesterol
Alzheimer Disease

β-amyloid peptide, endoplasmic reticulum stress, and Alzheimer's disease

Ghribi, O., Dec 1 2009, Protein Misfolding Disorders: A Trip into the ER. Bentham Science Publishers Ltd., p. 114-126 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Endoplasmic Reticulum Stress
Amyloid
Alzheimer Disease
Peptides
Brain