Deborah M Brown

  • 2168 Citations
  • 24 h-Index
1989 …2018
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Research Output 1989 2018

  • 2168 Citations
  • 24 h-Index
  • 41 Article
  • 6 Review article
  • 1 Comment/debate
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Article
2018
4 Citations (Scopus)

A mechanistic computational model reveals that plasticity of CD4+ T cell differentiation is a function of cytokine composition and dosage

Puniya, B. L., Todd, R. G., Mohammed, A., Brown, D. M., Barberis, M. & Helikar, T., Aug 2 2018, In : Frontiers in Physiology. 9, AUG, 878.

Research output: Contribution to journalArticle

Cell Differentiation
Cytokines
T-Lymphocytes
Phenotype
Transcription Factors
2017
3 Citations (Scopus)
Interferons
Gene Expression
Growth
Neoplasms
Poly I-C
16 Citations (Scopus)
Zein
Chitosan
Transgenes
DNA
Transfection
2016
18 Citations (Scopus)

Micro- and nanoparticulates for DNA vaccine delivery

Farris, E., Brown, D. M., Ramer-Tait, A. E. & Pannier, A. K., Jan 1 2016, In : Experimental Biology and Medicine. 241, 9, p. 919-929 11 p.

Research output: Contribution to journalArticle

DNA Vaccines
Biocompatible Materials
Vaccines
DNA
Antigen-Presenting Cells
8 Citations (Scopus)

Significant role for IRF3 in both T cell and APC effector functions during T cell responses

Guinn, Z., Lampe, A. T., Brown, D. M. & Petro, T. M., Dec 1 2016, In : Cellular Immunology. 310, p. 141-149 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Innate Immunity
Dendritic Cells
Interferon Regulatory Factor-3
Granzymes
2015
6 Citations (Scopus)

IRF3 deficiency impacts granzyme B expression and maintenance of memory T cell function in response to viral infection

Moore, T. C., Vogel, A. J., Petro, T. M. & Brown, D. M., Jan 1 2015, In : Microbes and Infection. 17, 6, p. 426-439 14 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
Granzymes
Virus Diseases
Maintenance
T-Lymphocytes
7 Citations (Scopus)
Influenza A virus
Immunization
Vaccines
T-Lymphocytes
Antigens
2014
14 Citations (Scopus)

Early cytokine dysregulation and viral replication are associated with mortality during lethal influenza infection

Vogel, A. J., Harris, S., Marsteller, N., Condon, S. A. & Brown, D. M., Jun 1 2014, In : Viral Immunology. 27, 5, p. 214-224 11 p.

Research output: Contribution to journalArticle

Lethal Dose 50
Human Influenza
Cytokines
Influenza A virus
Mortality
21 Citations (Scopus)

Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells

Workman, A. M., Jacobs, A. K., Vogel, A. J., Condon, S. & Brown, D. M., Feb 20 2014, In : PloS one. 9, 2, e89010.

Research output: Contribution to journalArticle

T-cells
interleukin-2
Interleukin-2
T-lymphocytes
inflammation
12 Citations (Scopus)

Interferon response factor 3 is crucial to poly-I: C induced NK cell activity and control of B16 melanoma growth

Moore, T. C., Kumm, P. M., Brown, D. M. & Petro, T. M., Apr 28 2014, In : Cancer Letters. 346, 1, p. 122-128 7 p.

Research output: Contribution to journalArticle

Poly I-C
Experimental Melanomas
Natural Killer Cells
Interferons
Growth
2013
15 Citations (Scopus)

IRF3 helps control acute TMEV infection through IL-6 expression but contributes to acute hippocampus damage following TMEV infection

Moore, T. C., Cody, L., Kumm, P. M., Brown, D. M. & Petro, T. M., Dec 26 2013, In : Virus Research. 178, 2, p. 226-233 8 p.

Research output: Contribution to journalArticle

Theilovirus
Virus Diseases
Interleukin-6
Hippocampus
Macrophages
2012
20 Citations (Scopus)
Theilovirus
Virus Replication
virus replication
interleukin-6
nitric oxide
33 Citations (Scopus)

Coxsackievirus B3 infection leads to the generation of cardiac myosin heavy chain-α-reactive CD4 T cells in A/J mice

Gangaplara, A., Massilamany, C., Brown, D. M., Delhon, G., Pattnaik, A. K., Chapman, N., Rose, N., Steffen, D. J. & Reddy, N. R. J., Sep 1 2012, In : Clinical Immunology. 144, 3, p. 237-249 13 p.

Research output: Contribution to journalArticle

Coxsackievirus Infections
Cardiac Myosins
Myosin Heavy Chains
Enterovirus
Myocarditis
118 Citations (Scopus)

Memory CD4 + T cells protect against influenza through multiple synergizing mechanisms

McKinstry, K. K., Strutt, T. M., Kuang, Y., Brown, D. M., Sell, S., Dutton, R. W. & Swain, S. L., Aug 1 2012, In : Journal of Clinical Investigation. 122, 8, p. 2847-2856 10 p.

Research output: Contribution to journalArticle

Human Influenza
T-Lymphocytes
Influenza A virus
Perforin
T-Lymphocyte Epitopes
124 Citations (Scopus)

Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection

Brown, D. M., Lee, S., de la Luz Garcia-Hernandez, M. & Swain, S. L., Jul 1 2012, In : Journal of virology. 86, 12, p. 6792-6803 12 p.

Research output: Contribution to journalArticle

Perforin
Virus Diseases
Orthomyxoviridae
interferon-gamma
Interferon-gamma
2011
11 Citations (Scopus)

IRF3 polymorphisms induce different innate anti-Theiler's virus immune responses in RAW264.7 macrophages

Moore, T. C., Al-Salleeh, F. M., Brown, D. M. & Petro, T. M., Sep 15 2011, In : Virology. 418, 1, p. 40-48 9 p.

Research output: Contribution to journalArticle

Theilovirus
Macrophages
Virus Diseases
Caspases
Interleukin-6
2009
63 Citations (Scopus)

IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells

Brown, D. M., Kamperschroer, C., Dilzer, A. M., Roberts, D. M. & Swain, S. L., Mar 31 2009, In : Cellular Immunology. 257, 1-2, p. 69-79 11 p.

Research output: Contribution to journalArticle

Perforin
CD4 Antigens
Interleukin-2
T-Lymphocytes
Antigens
2007
51 Citations (Scopus)

Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response

Jelley-Gibbs, D. M., Dibble, J. P., Brown, D. M., Strutt, T. M., McKinstry, K. K. & Swain, S. L., Jun 15 2007, In : Journal of Immunology. 178, 12, p. 7563-7570 8 p.

Research output: Contribution to journalArticle

Open Access
Human Influenza
T-Lymphocytes
Antigens
Infection
Maintenance
28 Citations (Scopus)

Unique ability of activated CD4+ T cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation

Agrewala, J. N., Brown, D. M., Lepak, N. M., Duso, D., Huston, G. & Swain, S. L., Mar 2 2007, In : Journal of Biological Chemistry. 282, 9, p. 6106-6115 10 p.

Research output: Contribution to journalArticle

Aptitude
T-cells
Inflammation
T-Lymphocytes
Data storage equipment
2006
207 Citations (Scopus)

CD4 T cell-mediated protection from lethal influenza: Perform and antibody-mediated mechanisms give a one-two punch

Brown, D. M., Dilzer, A. M., Meents, D. L. & Swain, S. L., Sep 1 2006, In : Journal of Immunology. 177, 5, p. 2888-2898 11 p.

Research output: Contribution to journalArticle

Cytoprotection
Human Influenza
T-Lymphocytes
Antibodies
B-Lymphocytes
58 Citations (Scopus)

Uneven distribution of MHC class II epitopes within the influenza virus

Crowe, S. R., Miller, S. C., Brown, D. M., Adams, P. S., Dutton, R. W., Harmsen, A. G., Lund, F. E., Randall, T. D., Swain, S. L. & Woodland, D. L., Jan 23 2006, In : Vaccine. 24, 4, p. 457-467 11 p.

Research output: Contribution to journalArticle

Orthomyxoviridae
epitopes
Epitopes
T-lymphocytes
Viral Proteins
2005
184 Citations (Scopus)

Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation

Jelley-Gibbs, D. M., Brown, D. M., Dibble, J. P., Haynes, L., Eaton, S. M. & Swain, S. L., Sep 5 2005, In : Journal of Experimental Medicine. 202, 5, p. 697-706 10 p.

Research output: Contribution to journalArticle

CD4 Antigens
Antigen Presentation
Human Influenza
T-Lymphocytes
Infection
2004
31 Citations (Scopus)

CD8 + T cells responding to influenza infection reach and persist at higher numbers than CD4 + T cells independently of precursor frequency

Powell, T. J., Brown, D. M., Hollenbaugh, J. A., Charbonneau, T., Kemp, R. A., Swain, S. L. & Dutton, R. W., Oct 1 2004, In : Clinical Immunology. 113, 1, p. 89-100 12 p.

Research output: Contribution to journalArticle

T-Lymphoid Precursor Cells
Human Influenza
T-Lymphocytes
Infection
CD8 Antigens
2002
5 Citations (Scopus)

Generation of monoclonal antibodies specific for human kallikrein 2 (hK2) using hK2-expressing tumors

Fisher, T. L., Nocera, M., Willis, R. A., Turner, M. J., Siddiq Abdul Alim, C., Brown, D. M., Bourne, P. A., Anthony Di Sant'Agnese, P., Messing, E. M., Lord, E. M. & Frelinger, J. G., May 15 2002, In : Prostate. 51, 3, p. 153-165 13 p.

Research output: Contribution to journalArticle

Tissue Kallikreins
Monoclonal Antibodies
Neoplasms
Prostate-Specific Antigen
Prostatic Neoplasms
24 Citations (Scopus)

Regulation of memory CD4 T cells: Generation, localization and persistence

Swain, S. L., Agrewala, J. N., Brown, D. M. & Román, E., Nov 26 2002, In : Advances in experimental medicine and biology. 512, p. 113-120 8 p.

Research output: Contribution to journalArticle

Immunologic Memory
CD4-Positive T-Lymphocytes
Lymphocyte Count
T-Cell Antigen Receptor
Transgenic Mice
2001
84 Citations (Scopus)

Human papillomavirus virus-like particles are efficient oral immunogens when coadministered with Escherichia coli heat-labile enterotoxin mutant R192G or CpG DNA

Gerber, S., Lane, C., Brown, D. M., Lord, E., Dilorenzo, M., Clements, J. D., Rybicki, E., Williamson, A. L. & Rose, R. C., May 9 2001, In : Journal of virology. 75, 10, p. 4752-4760 9 p.

Research output: Contribution to journalArticle

Papillomaviridae
virus-like particles
Enterotoxins
enterotoxins
Virion
63 Citations (Scopus)

Tumours can act as adjuvants for humoral immunity

Brown, D. M., Fisher, T. L., Wei, C., Frelinger, J. G. & Lord, E. M., Apr 30 2001, In : Immunology. 102, 4, p. 486-497 12 p.

Research output: Contribution to journalArticle

Humoral Immunity
Ovalbumin
Antigens
Immunoglobulin G
Neoplasms
1997
8 Citations (Scopus)

Antibody cross-linking of the thymocyte-specific cell surface molecule CTX causes abnormal mitosis and multinucleation of tumor cells

Robert, J., Brown, D. M., Pasquier, L. D. & Cohen, N., Aug 25 1997, In : Experimental Cell Research. 235, 1, p. 227-237 11 p.

Research output: Contribution to journalArticle

Thymocytes
Mitosis
Antibodies
Neoplasms
Thymus Neoplasms
4 Citations (Scopus)

Prostaglandin E2 mediated apoptosis in subsets of malignant B lymphoma cells

Brown, D. M. & Phipps, R. P., Dec 1 1997, In : Advances in experimental medicine and biology. 400, B, p. 565-570 6 p.

Research output: Contribution to journalArticle

Drug Dose Response Relationship
Cultured Tumor Cells
Dinoprost
B-Cell Lymphoma
Dinoprostone
1996
49 Citations (Scopus)

A molecular analysis of PGE receptor (EP) expression on normal and transformed B lymphocytes: Coexpression of EP1, EP2, EP and EP4

Fedyk, E. R., Ripper, J. M., Brown, D. M. & Phipps, R. P., Jan 1996, In : Molecular Immunology. 33, 1, p. 33-45 13 p.

Research output: Contribution to journalArticle

Prostaglandin E Receptors
B-Lymphocytes
Prostaglandins E
Cell Line
Dinoprostone
28 Citations (Scopus)

Bcl-2 Expression Inhibits Prostaglandin E2-Mediated Apoptosis in B Cell Lymphomas

Brown, D. M. & Phipps, R. P., Aug 15 1996, In : Journal of Immunology. 157, 4, p. 1359-1370 12 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Dinoprostone
Apoptosis
Growth
Cell Cycle
15 Citations (Scopus)

PGE2 regulation of B lymphocytes and T helper 1 and T helper 2 cells: Induction of inflammatory versus allergic responses

Fedyk, E. R., Brown, D. M. & Phipps, R. P., Dec 1 1996, In : Advances in experimental medicine and biology. 407, p. 237-242 6 p.

Research output: Contribution to journalArticle

Th2 Cells
Th1 Cells
Lymphocytes
Antigen Presentation
Lymphocyte Activation
1995
21 Citations (Scopus)

Characterization and regulation of prostaglandin E2 receptors on normal and malignant murine B lymphocytes

Brown, D. M. & Phipps, R. P., Mar 1995, In : Cellular Immunology. 161, 1, p. 79-87 9 p.

Research output: Contribution to journalArticle

Prostaglandin Receptors
Dinoprostone
B-Lymphocytes
B-Cell Lymphoma
Cell Lineage
Prostaglandin E Receptors
Prostaglandin Receptors
B-Cell Lymphoma
Dinoprostone
Lipopolysaccharides
115 Citations (Scopus)

Prostaglandin E2 promotes B lymphocyte Ig isotype switching to IgE

Roper, R. L., Brown, D. M. & Phipps, R. P., Jan 1 1995, In : Journal of Immunology. 154, 1, p. 162-170 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Class Switching
Dinoprostone
Immunoglobulin E
B-Lymphocytes
Interleukin-4
1993
4 Citations (Scopus)

Strategies for Studying the Regulation of B Lymphocytes by Prostaglandin E2

Borrello, M. A., Fedyk, E. R., Brown, D. M. & Phipps, R. P., Jun 1 1993, In : ImmunoMethods. 2, 3, p. 261-272 12 p.

Research output: Contribution to journalArticle

Lymphocytes
Dinoprostone
B-Lymphocytes
Cells
Immunoglobulin Class Switching
1992
56 Citations (Scopus)

Differential collagen and fibronectin production by Thy 1+ and Thy 1- lung fibroblast subpopulations

Derdak, S., Penney, D. P., Keng, P., Felch, M. E., Brown, D. & Phipps, R. P., Jan 1 1992, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 263, 2 7-2, p. L283-L290

Research output: Contribution to journalArticle

Fibronectins
Collagen
Fibroblasts
Lung
Clone Cells
78 Citations (Scopus)

Prostaglandin E2 induces apoptosis in immature normal and malignant B lymphocytes

Brown, D. M., Warner, G. L., Alés-Martínez, J. E., Scott, D. W. & Phipps, R. P., Jun 1992, In : Clinical Immunology and Immunopathology. 63, 3, p. 221-229 9 p.

Research output: Contribution to journalArticle

Dinoprostone
B-Lymphocytes
Apoptosis
Dinoprost
B-Lymphoid Precursor Cells
1990
43 Citations (Scopus)

Differential expression of interleukin 1α by Thy‐1+ and Thy‐1 lung fibroblast subpopulations: Enhancement of interleukin 1α production by tumor necrosis factor‐α

Phipps, R. P., Baecher, C., Frelinger, J. G., Penney, D. P., Keng, P. & Brown, D., Aug 1990, In : European Journal of Immunology. 20, 8, p. 1723-1727 5 p.

Research output: Contribution to journalArticle

Interleukin-1
Tumor Necrosis Factor-alpha
Fibroblasts
Lung
Clone Cells
118 Citations (Scopus)

Prostaglandin E2 promotes IL-4-induced IgE and IgG1 synthesis

Roper, R. L., Conrad, D. H., Brown, D. M., Warner, G. L. & Phipps, R. P., Jan 1 1990, In : Journal of Immunology. 145, 8, p. 2644-2651 8 p.

Research output: Contribution to journalArticle

Prostaglandins E
Dinoprostone
Interleukin-4
Immunoglobulin E
Immunoglobulin G
1989
12 Citations (Scopus)

Synergistic activation of granulocyte-macrophage colony-stimulating factor production by IL-1 and IL-2 in murine Th1 cells

Quill, H., Gaur, A., Brown, D., Infante, A. J. & Phipps, R. P., Jan 1 1989, In : Journal of Immunology. 143, 7, p. 2242-2247 6 p.

Research output: Contribution to journalArticle

Th1 Cells
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-1
Interleukin-2
Macrophages