David W Mercer, MD &ndash; Research Output

2014

Anesthesia-related cardiac arrest

Ellis, S. J., Newland, M. C., Simonson, J. A., Peters, K. R., Romberger, D., Mercer, D. W., Tinker, J. H., Harter, R. L., Kindscher, J. D., Qiu, F. & Lisco, S. J., Jan 1 2014, In : Anesthesiology. 120, 4, p. 829-838 10 p.

Research output: Contribution to journal › Article

Heart Arrest

Anesthesia

Anesthetics

Incidence

Databases

2013

22 Citations (Scopus)

Farm Machinery Injuries: The 15-Year Experience at an Urban Joint Trauma Center System in a Rural State

Jawa, R. S., Young, D. H., Stothert Jr, J. C., Yetter, D., Dumond, R., Shostrom, V. K., Cemaj, S., Rautiainen, R. & Mercer, D. W., Apr 1 2013, In : Journal of Agromedicine. 18, 2, p. 98-106 9 p.

Research output: Contribution to journal › Article

Trauma Centers

Joints

Wounds and Injuries

Torso

Farms

11 Citations (Scopus)

Mesenteric ischemia-reperfusion injury up-regulates certain CC, CXC, and XC chemokines and results in multi-organ injury in a time-dependent manner

Jawa, R. S., Quist, E., Boyer, C. W., Shostrom, V. K. & Mercer, D. W., Jan 1 2013, In : European Cytokine Network. 24, 4, p. 148-156 9 p.

Research output: Contribution to journal › Article

CXC Chemokines

CC Chemokines

Reperfusion Injury

Chemokines

Up-Regulation

2012

2 Citations (Scopus)

A quick primer for setting up and maintaining surgical intensive care in an austere environment: practical tips from volunteers in a mass disaster.

Jawa, R. S., Heir, J. S., Cancelada, D., Young, D. H. & Mercer, D. W., Jan 1 2012, In : American journal of disaster medicine. 7, 3, p. 223-229 7 p.

Research output: Contribution to journal › Article

Disasters

Critical Care

Volunteers

Mobile Health Units

Haiti

16 Citations (Scopus)

Clostridium difficile-associated infection: A disease of varying severity

Jawa, R. S. & Mercer, D. W., Dec 1 2012, In : American journal of surgery. 204, 6, p. 836-842 7 p.

Research output: Contribution to journal › Article

Clostridium difficile

Virulence

Infection

Asymptomatic Infections

Pulsed Field Gel Electrophoresis

3 Citations (Scopus)

Data driven linear algebraic methods for analysis of molecular pathways: Application to disease progression in shock/trauma

McGuire, M. F., Sriram Iyengar, M. & Mercer, D. W., Apr 1 2012, In : Journal of Biomedical Informatics. 45, 2, p. 372-387 16 p.

Research output: Contribution to journal › Article

Semantics

Disease Progression

Shock

Multiple Organ Failure

Molecular interactions

Two hospitals with 1 trauma system: A joint approach to the care of the injured patient

Jawa, R. S., Young, D. H., Wagner, M., Yetter, D., Shostrom, V., Cemaj, S., Nelson, L., Ramey, R., Sorensen, M., Schwedhelm, M., Mercer, D. W. & Stothert Jr, J. C., Apr 1 2012, In : American journal of surgery. 203, 4, p. 454-460 7 p.

Research output: Contribution to journal › Article

Patient Care

Joints

Wounds and Injuries

Trauma Centers

Costs and Cost Analysis

2011

28 Citations (Scopus)

Effects of ketamine on endotoxin and traumatic brain injury induced cytokine production in the rat

Ward, J. L., Harting, M. T., Cox, C. S. & Mercer, D. W., Jun 1 2011, In : Journal of Trauma - Injury, Infection and Critical Care. 70, 6, p. 1471-1479 9 p.

Research output: Contribution to journal › Article

Ketamine

Endotoxins

Cytokines

Lipopolysaccharides

Interleukin-1

21 Citations (Scopus)

National trends in minimally invasive and open operative experience of graduating general surgery residents: Implications for surgical skills curricula development?

Carson, J. S., Smith, L. M., Are, M., Edney, J., Azarow, K., Mercer, D. W., Thompson, J. S. & Are, C., Dec 1 2011, In : American journal of surgery. 202, 6, p. 720-726 7 p.

Research output: Contribution to journal › Article

Curriculum

Graduate Medical Education

Accreditation

Internship and Residency

Thoracic Surgery

2010

5 Citations (Scopus)

Ketamine suppresses LPS-induced bile reflux and gastric bleeding in the rat

Ward, J. L., Adams, S. D., Delano, B. A., Clarke, C., Radhakrishnan, R. S., Weisbrodt, N. W. & Mercer, D. W., Jan 1 2010, In : Journal of Trauma - Injury, Infection and Critical Care. 68, 1, p. 69-75 7 p.

Research output: Contribution to journal › Article

Bile Reflux

Ketamine

Lipopolysaccharides

Stomach

Hemorrhage

1 Citation (Scopus)

Laparotomy attenuates lipopolysaccharide-induced gastric bleeding in the rat

Ward, J. L., Delano, B. A., Adams, S. D., Mercer, E. E. & Mercer, D. W., Apr 1 2010, In : Digestive Diseases and Sciences. 55, 4, p. 902-910 9 p.

Research output: Contribution to journal › Article

Laparotomy

Lipopolysaccharides

Stomach

Hemorrhage

Bile Reflux

2009

74 Citations (Scopus)

Early Cytokine Production Risk Stratifies Trauma Patients for Multiple Organ Failure

Jastrow, K. M., Gonzalez, E. A., McGuire, M. F., Suliburk, J. W., Kozar, R. A., Iyengar, S., Motschall, D. A., McKinley, B. A., Moore, F. A. & Mercer, D. W., Sep 1 2009, In : Journal of the American College of Surgeons. 209, 3, p. 320-331 12 p.

Research output: Contribution to journal › Article

Multiple Organ Failure

Cytokines

Wounds and Injuries

Shock

Injury Severity Score

6 Citations (Scopus)

Fasting exacerbates and feeding diminishes LPS-induced liver injury in the rat

Adams, S. D., Delano, B. A., Helmer, K. S. & Mercer, D. W., Apr 1 2009, In : Digestive Diseases and Sciences. 54, 4, p. 767-773 7 p.

Research output: Contribution to journal › Article

Fasting

Liver

Wounds and Injuries

Cytokines

Transaminases

11 Citations (Scopus)

Ketamine-induced hepatoprotection: The role of heme oxygenase-1

Suliburk, J. W., Ward, J. L., Helmer, K. S., Adams, S. D., Zuckerbraun, B. S. & Mercer, D. W., Jun 1 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 6, p. G1360-G1369

Research output: Contribution to journal › Article

Heme Oxygenase-1

Ketamine

Carbon Monoxide

Nitric Oxide Synthase Type II

Lipopolysaccharides

6 Citations (Scopus)

α-Melanocyte stimulating hormone in critically injured trauma patients

Todd, S. R., Kao, L. S., Catania, A., Mercer, D. W., Adams, S. D. & Moore, F. A., Feb 1 2009, In : Journal of Trauma - Injury, Infection and Critical Care. 66, 2, p. 465-469 5 p.

Research output: Contribution to journal › Article

Melanocyte-Stimulating Hormones

Wounds and Injuries

Multiple Organ Failure

Traumatic Brain Hemorrhage

Traumatic Subarachnoid Hemorrhage

2008

85 Citations (Scopus)

Acute, regional inflammatory response after traumatic brain injury: Implications for cellular therapy

Harting, M. T., Jimenez, F., Adams, S. D., Mercer, D. W. & Cox, C. S., Nov 1 2008, In : Surgery. 144, 5, p. 803-813 11 p.

Research output: Contribution to journal › Article

Wounds and Injuries

Respiratory Burst

Cytokines

Secondary Prevention

Interleukin-1

3 Citations (Scopus)

A report on associations among gastric pH, bleeding, duodenogastric reflux, and outcomes after trauma

Dial, E., Lopez-Storey, M., Adams, S., Lichtenberger, L., Gonzalez, E., McKinley, B., Moore, F. & Mercer, D., Jan 1 2008, In : Journal of Trauma - Injury, Infection and Critical Care. 64, 1, p. 105-110 6 p.

Research output: Contribution to journal › Article

Duodenogastric Reflux

Stomach

Hemorrhage

Wounds and Injuries

Multiple Organ Failure

6 Citations (Scopus)

Cyclooxygenase-1 suppresses lipopolysaccharide-induced changes in rat gastric inducible nitric oxide synthase

West, S. D., Suliburk, J. W., Helmer, K. S. & Mercer, D. W., Feb 2008, In : Critical care medicine. 36, 2, p. 572-579 8 p.

Research output: Contribution to journal › Article

Cyclooxygenase 1

Nitric Oxide Synthase Type II

Lipopolysaccharides

Stomach

Prostaglandin-Endoperoxide Synthases

10 Citations (Scopus)

Differential effects of luminal arginine and glutamine on metalloproteinase production in the postischemic gut

Robinson, E. K., Kelly, D. P., Mercer, D. W. & Kozar, R. A., Jul 1 2008, In : Journal of Parenteral and Enteral Nutrition. 32, 4, p. 433-438 6 p.

Research output: Contribution to journal › Article

gelatinase A

Matrix Metalloproteinase 2

Metalloproteases

metalloproteinases

Nitric Oxide Synthase Type II

14 Citations (Scopus)

Effects of anesthesia on lipopolysaccharide-induced changes in serum cytokines

Adams, S. D., Radhakrishnan, R. S., Helmer, K. S. & Mercer, D. W., Jul 1 2008, In : Journal of Trauma - Injury, Infection and Critical Care. 65, 1, p. 170-174 5 p.

Research output: Contribution to journal › Article

Lipopolysaccharides

Ketamine

Isoflurane

Anesthesia

Cytokines

12 Citations (Scopus)

Effects of poloxamer 188 on human PMN cells

Harting, M. T., Jimenez, F., Kozar, R. A., Moore, F. A., Mercer, D. W., Hunter, R. L., Cox, C. S. & Gonzalez, E. A., Aug 1 2008, In : Surgery. 144, 2, p. 198-203 6 p.

Research output: Contribution to journal › Article

Poloxamer

Respiratory Burst

Superoxides

L-Selectin

Cellular Structures

4 Citations (Scopus)

Gastric alkalinization after major trauma

Cocanour, C. S., Dial, E. D., Lichtenberger, L. M., Gonzalez, E. A., Kozar, R. A., Moore, F. A. & Mercer, D. W., Mar 1 2008, In : Journal of Trauma - Injury, Infection and Critical Care. 64, 3, p. 681-687 7 p.

Research output: Contribution to journal › Article

Stomach

Wounds and Injuries

Bile Reflux

Bile Acids and Salts

Ventilator-Associated Pneumonia

2007

4 Citations (Scopus)

Ketamine attenuates early lipopolysaccharide-induced gastric dysfunction: Role of stress-inducible phosphoproteins

Suliburk, J. W. & Mercer, D. W., Feb 1 2007, In : Journal of Trauma - Injury, Infection and Critical Care. 62, 2, p. 316-319 4 p.

Research output: Contribution to journal › Article

Phosphoproteins

Ketamine

Lipopolysaccharides

Stomach

Phosphorylation

2006

28 Citations (Scopus)

Conventional dose hypertonic saline provides optimal gut protection and limits remote organ injury after gut ischemia reperfusion

Gonzalez, E. A., Kozar, R. A., Suliburk, J. W., Weisbrodt, N. W., Mercer, D. W. & Moore, F. A., Jul 1 2006, In : Journal of Trauma - Injury, Infection and Critical Care. 61, 1, p. 66-73 8 p.

Research output: Contribution to journal › Article

Superior Mesenteric Artery

Reperfusion

Ischemia

Resuscitation

Wounds and Injuries

9 Citations (Scopus)

Effect of NOS inhibition on rat gastric matrix metalloproteinase production during endotoxemia

Robinson, E. K., Seaworth, C. M., Suliburk, J. W., Adams, S. D., Kao, L. S. & Mercer, D. W., May 1 2006, In : Shock. 25, 5, p. 507-514 8 p.

Research output: Contribution to journal › Article

Endotoxemia

Matrix Metalloproteinases

Stomach

Matrix Metalloproteinase 2

Matrix Metalloproteinase 14

6 Citations (Scopus)

Effects of lipopolysaccharide on gastric stasis: Role of cyclooxygenase

West, S. D., Suliburk, J. W., Smith, G. S. & Mercer, D. W., Apr 1 2006, In : Digestive Diseases and Sciences. 51, 4, p. 754-765 12 p.

Research output: Contribution to journal › Article

Gastroparesis

Prostaglandin-Endoperoxide Synthases

Lipopolysaccharides

Cyclooxygenase 2

Stomach

30 Citations (Scopus)

Ketamine-induced gastroprotection during endotoxemia: Role of heme-oxygenase-1

Helmer, K. S., Suliburk, J. W. & Mercer, D. W., Sep 1 2006, In : Digestive Diseases and Sciences. 51, 9, p. 1571-1581 11 p.

Research output: Contribution to journal › Article

Heme Oxygenase-1

Endotoxemia

Ketamine

Stomach

Nitric Oxide Synthase Type II

92 Citations (Scopus)

Randomized, open-label, comparative study of piperacillin-tazobactam administered by continuous infusion versus intermittent infusion for treatment of hospitalized patients with complicated intra-abdominal infection

Lau, W. K., Mercer, D., Itani, K. M., Nicolau, D. P., Kuti, J. L., Mansfield, D. & Dana, A., Nov 1 2006, In : Antimicrobial Agents and Chemotherapy. 50, 11, p. 3556-3561 6 p.

Research output: Contribution to journal › Article

Intraabdominal Infections

Therapeutics

tazobactam drug combination piperacillin

APACHE

Drug-Related Side Effects and Adverse Reactions

2 Citations (Scopus)

Rat gastric gelatinase induction during endotoxemia

Robinson, E. K., West, S. D., Garay, A. & Mercer, D. W., Mar 1 2006, In : Digestive Diseases and Sciences. 51, 3, p. 548-559 12 p.

Research output: Contribution to journal › Article

Gelatinases

Endotoxemia

Matrix Metalloproteinases

Stomach

Lipopolysaccharides

2 Citations (Scopus)

Salicylate Enhances Rat Gastric Gelatinase Activity

Robinson, E. K., West, S. D. & Mercer, D. W., Jun 15 2006, In : Journal of Surgical Research. 133, 2, p. 69-75 7 p.

Research output: Contribution to journal › Article

Gelatinases

Salicylates

Stomach

Matrix Metalloproteinases

Wounds and Injuries

2005

27 Citations (Scopus)

Differential effects of anesthetics on endotoxin-induced liver injury

Suliburk, J. W., Gonzalez, E. A., Kennison, S. D., Helmer, K. S., Mercer, D. W., Meyer, A. A., Bulger, E. M. & Ogura, H., Apr 1 2005, In : Journal of Trauma - Injury, Infection and Critical Care. 58, 4, p. 711-717 7 p.

Research output: Contribution to journal › Article

Endotoxins

Heme Oxygenase-1

Anesthetics

Nitric Oxide Synthase Type II

Ketamine

10 Citations (Scopus)

Hypertonic saline resuscitation after mesenteric ischemia/reperfusion induces ileal apoptosis

Gonzalez, E. A., Kozar, R. A., Suliburk, J. W., Weisbrodt, N. W., Mercer, D. W. & Moore, F. A., Nov 1 2005, In : Journal of Trauma - Injury, Infection and Critical Care. 59, 5, p. 1092-1098 7 p.

Research output: Contribution to journal › Article

Resuscitation

Reperfusion

Superior Mesenteric Artery

Apoptosis

Wounds and Injuries

45 Citations (Scopus)

Ketamine attenuates liver injury attributed to endotoxemia: Role of cyclooxygenase-2

Suliburk, J. W., Helmer, K. S., Gonzalez, E. A., Robinson, E. K. & Mercer, D. W., Aug 1 2005, In : Surgery. 138, 2, p. 134-140 7 p.

Research output: Contribution to journal › Article

Endotoxemia

Ketamine

Cyclooxygenase 2

Lipopolysaccharides

Nitric Oxide Synthase Type II

9 Citations (Scopus)

Ketamine inhibits lipopolysacharide (LPS) induced gastric luminal fluid accumulation

Suliburk, J. W., Gonzalez, E. A., Moore-Olufemi, S. D., Weisbrodt, N., Moore, F. A. & Mercer, D. W., Aug 1 2005, In : Journal of Surgical Research. 127, 2, p. 203-207 5 p.

Research output: Contribution to journal › Article

Ketamine

Gastric Emptying

Gastrointestinal Transit

Stomach

Ileus

3 Citations (Scopus)

Presidential address: Academic surgery: Can we adapt?

Mercer, D. W., Aug 1 2005, In : Surgery. 138, 2, p. 115-124 10 p.

Research output: Contribution to journal › Article

Organizational Objectives

Medical Societies

9 Citations (Scopus)

Rat gastric injury after lipopolysaccharide: Role of inducible nitric oxide synthase

Robinson, E. K., Kennison, S. D., Suliburk, J. W. & Mercer, D. W., Sep 1 2005, In : Surgery. 138, 3, p. 523-529 7 p.

Research output: Contribution to journal › Article

Nitric Oxide Synthase Type II

Lipopolysaccharides

Stomach

Wounds and Injuries

Irritants

9 Citations (Scopus)

Time-dependent aggravation or attenuation of lipopolysaccharide-induced gastric injury by nitric oxide synthase inhibition

Suliburk, J. W., Helmer, K. S., Kennison, S. D., Mercer, D. W. & Robinson, E. K., Dec 1 2005, In : Journal of Surgical Research. 129, 2, p. 265-271 7 p.

Research output: Contribution to journal › Article

Nitric Oxide Synthase

Lipopolysaccharides

Stomach

Wounds and Injuries

Bile

2004

119 Citations (Scopus)

Inflammatory mechanisms contributing to pancreatic cancer development

Farrow, B., Sugiyama, Y., Chen, A., Uffort, E., Nealon, W., Evers, B. M., Pitt, H. A., Cole, D. J., Mercer, D. W. & O'Leary, J. P., Jun 1 2004, In : Annals of surgery. 239, 6, p. 763-771 9 p.

Research output: Contribution to journal › Article

Chronic Pancreatitis

Pancreatic Neoplasms

Neoplasms

Laser Capture Microdissection

Genes

13 Citations (Scopus)

Lipopolysaccharide-Induced Changes in Rat Gastric H/K-ATPase Expression

Helmer, K. S., West, S. D., Vilela, R., Chang, L., Cui, Y., Kone, B. C. & Mercer, D. W., Apr 1 2004, In : Annals of surgery. 239, 4, p. 501-509 9 p.

Research output: Contribution to journal › Article

H(+)-K(+)-Exchanging ATPase

Proton-Translocating ATPases

Lipopolysaccharides

Gastric Acid

Acids

2003

26 Citations (Scopus)

Acute pancreatitis in intensive care unit patients: Value of clinical and radiologic prognosticators at predicting clinical course and outcome

Liu, T. H., Kwong, K. L., Tamm, E. P., Gill, B. S., Brown, S. D. & Mercer, D. W., Apr 1 2003, In : Critical care medicine. 31, 4, p. 1026-1030 5 p.

Research output: Contribution to journal › Article

Pancreatitis

Intensive Care Units

Organ Dysfunction Scores

Health

Tomography

28 Citations (Scopus)

Cholecystokinin secretagogue-induced gastroprotection: Role of nitric oxide and blood flow

West, S. D., Helmer, K. S., Chang, L. K., Cui, Y., Greeley, G. H. & Mercer, D. W., Mar 1 2003, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 284, 3 47-3, p. G399-G410

Research output: Contribution to journal › Article

Cholecystokinin

Stomach

Nitric Oxide

Nitric Oxide Synthase

Irritants

43 Citations (Scopus)

Diverticulitis in the younger patient

West, S. D., Robinson, E. K., Delu, A. N., Ligon, R. E., Kao, L. S. & Mercer, D. W., Dec 2003, In : American journal of surgery. 186, 6, p. 743-746 4 p.

Research output: Contribution to journal › Article

Diverticulitis

Population

County Hospitals

Urban Hospitals

Poverty

38 Citations (Scopus)

Effects of ketamine/xylazine on expression of tumor necrosis factor-alpha, inducible nitric oxide synthase, and cyclo-oxygenase-2 in rat gastric mucosa during endotoxemia.

Helmer, K. S., Cui, Y., Chang, L., Dewan, A. & Mercer, D. W., Jul 2003, In : Shock (Augusta, Ga.). 20, 1, p. 63-69 7 p.

Research output: Contribution to journal › Article

Xylazine

Endotoxemia

Ketamine

Nitric Oxide Synthase Type II

Prostaglandin-Endoperoxide Synthases

30 Citations (Scopus)

Ketamine/Xylazine attenuates LPS-induced iNOS expression in various rat tissues

Helmer, K. S., Cui, Y., Dewan, A. & Mercer, D. W., Jun 1 2003, In : Journal of Surgical Research. 112, 1, p. 70-78 9 p.

Research output: Contribution to journal › Article

Xylazine

Ketamine

Nitric Oxide Synthase Type II

Lipopolysaccharides

Endotoxemia

Open truncal vagotomy

Mercer, D. W. & Liu, T. H., Jun 2003, In : Operative Techniques in General Surgery. 5, 2, p. 80-85 6 p.

Research output: Contribution to journal › Article

Truncal Vagotomy

2002

28 Citations (Scopus)

Does upregulation of inducible nitric oxide synthase play a role in hepatic injury?

Liu, T. H., Robinson, E. K., Helmer, K. S., West, S. D., Castaneda, A. A., Chang, L. & Mercer, D. W., Dec 2002, In : Shock. 18, 6, p. 549-554 6 p.

Research output: Contribution to journal › Article

Nitric Oxide Synthase Type II

Up-Regulation

Lipopolysaccharides

Liver

Wounds and Injuries

38 Citations (Scopus)

Gastric nitric oxide synthase expression during endotoxemia: Implications in mucosal defense in rats

Helmer, K. S., West, S. D., Shipley, G. L., Chang, L., Cui, Y., Mailman, D. & Mercer, D. W., Jan 1 2002, In : Gastroenterology. 123, 1, p. 173-186 14 p.

Research output: Contribution to journal › Article

Endotoxemia

Nitric Oxide Synthase

Stomach

Lipopolysaccharides

Nitric Oxide Synthase Type II

36 Citations (Scopus)

Increased expression of alpha-1-antitrypsin, glutathione S-transferase π and vascular endothelial growth factor in human pancreatic adenocarcinoma

Trachte, A. L., Suthers, S. E., Lerner, M. R., Hanas, J. S., Jupe, E. R., Sienko, A. E., Adesina, A. M., Lightfoot, S. A., Brackett, D. J., Postier, R. G., Mercer, D., Barnes, S., Lang, N. & Moore, E., Dec 1 2002, In : American journal of surgery. 184, 6, p. 642-647 6 p.

Research output: Contribution to journal › Article

alpha 1-Antitrypsin

Glutathione Transferase

Adenocarcinoma

Gene Expression

Oligonucleotide Array Sequence Analysis

11 Citations (Scopus)

Induction of NF-κB, IκB-α, and iNOS in rat gastric mucosa during endotoxemia

Helmer, K. S., Chang, L., Cui, Y. & Mercer, D. W., Jan 1 2002, In : Journal of Surgical Research. 104, 1, p. 46-52 7 p.

Research output: Contribution to journal › Article

Endotoxemia

NF-kappa B

Nitric Oxide Synthase Type II

Gastric Mucosa

Stomach

6 Citations (Scopus)

Laparoscopic cholecystectomy for acute cholecystitis: Technical considerations and outcome

Liu, T. H., Consorti, E. T. & Mercer, D. W., Jan 1 2002, In : Seminars in Laparoscopic Surgery. 9, 1, p. 24-31 8 p.

Research output: Contribution to journal › Article

Acute Cholecystitis

Laparoscopic Cholecystectomy

Gallbladder Diseases

Therapeutics

Costs and Cost Analysis