David W Mercer, MD

Chairperson

  • 2620 Citations
  • 29 h-Index
1988 …2018
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Research Output 1990 2014

  • 2620 Citations
  • 29 h-Index
  • 95 Article
  • 7 Review article
  • 5 Chapter
85 Citations (Scopus)

Acute, regional inflammatory response after traumatic brain injury: Implications for cellular therapy

Harting, M. T., Jimenez, F., Adams, S. D., Mercer, D. W. & Cox, C. S., Nov 1 2008, In : Surgery. 144, 5, p. 803-813 11 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Respiratory Burst
Cytokines
Secondary Prevention
Interleukin-1
26 Citations (Scopus)

Acute pancreatitis in intensive care unit patients: Value of clinical and radiologic prognosticators at predicting clinical course and outcome

Liu, T. H., Kwong, K. L., Tamm, E. P., Gill, B. S., Brown, S. D. & Mercer, D. W., Apr 1 2003, In : Critical care medicine. 31, 4, p. 1026-1030 5 p.

Research output: Contribution to journalArticle

Pancreatitis
Intensive Care Units
Organ Dysfunction Scores
Health
Tomography
13 Citations (Scopus)

Adaptive cytoprotection of gastric surface epithelial cells against injury by physiologic concentrations of bile acid

Dempsey, D. T., Mercer, D. W., Deb, B., Sauter, A. & Ritchie, W. P., Jan 1 1990, In : Surgery. 108, 2, p. 348-355 8 p.

Research output: Contribution to journalArticle

Taurocholic Acid
Cytoprotection
Bile Acids and Salts
Stomach
Epithelial Cells
11 Citations (Scopus)

Anatomic Considerations in Penetrating Gluteal Wounds

Mercer, D. W., Buckman, R. F., Sood, R., Kerr, T. M. & Gelman, J., Apr 1992, In : Archives of Surgery. 127, 4, p. 407-410 4 p.

Research output: Contribution to journalArticle

Penetrating Wounds
Gunshot Wounds
Wounds and Injuries
Femur
Blood Vessels
34 Citations (Scopus)

Anesthesia-related cardiac arrest

Ellis, S. J., Newland, M. C., Simonson, J. A., Peters, K. R., Romberger, D., Mercer, D. W., Tinker, J. H., Harter, R. L., Kindscher, J. D., Qiu, F. & Lisco, S. J., Jan 1 2014, In : Anesthesiology. 120, 4, p. 829-838 10 p.

Research output: Contribution to journalArticle

Heart Arrest
Anesthesia
Anesthetics
Incidence
Databases
2 Citations (Scopus)

A quick primer for setting up and maintaining surgical intensive care in an austere environment: practical tips from volunteers in a mass disaster.

Jawa, R. S., Heir, J. S., Cancelada, D., Young, D. H. & Mercer, D. W., Jan 1 2012, In : American journal of disaster medicine. 7, 3, p. 223-229 7 p.

Research output: Contribution to journalArticle

Disasters
Critical Care
Volunteers
Mobile Health Units
Haiti
3 Citations (Scopus)

A report on associations among gastric pH, bleeding, duodenogastric reflux, and outcomes after trauma

Dial, E., Lopez-Storey, M., Adams, S., Lichtenberger, L., Gonzalez, E., McKinley, B., Moore, F. & Mercer, D., Jan 1 2008, In : Journal of Trauma - Injury, Infection and Critical Care. 64, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

Duodenogastric Reflux
Stomach
Hemorrhage
Wounds and Injuries
Multiple Organ Failure
14 Citations (Scopus)

Bombesin-induced gastroprotection

West, S. D. & Mercer, D. W., Feb 1 2005, In : Annals of surgery. 241, 2, p. 227-231 5 p.

Research output: Contribution to journalReview article

Bombesin
Stomach
Gastrins
Sensory Receptor Cells
Somatostatin
7 Citations (Scopus)

Bombesin maintains enterocyte phenotype in fasted rats

Hodin, R. A., Meng, S., Shei, A., Bass, B., Mercer, D. & Rudnicki, M., Jan 1 1994, In : Surgery. 116, 2, p. 426-431 6 p.

Research output: Contribution to journalArticle

Bombesin
Enterocytes
Lactase
Phenotype
Alkaline Phosphatase
20 Citations (Scopus)

Bombesin prevents gastric injury in the rat: Role of gastrin

Mercer, D. W., Cross, J. M., Chang, L. & Lichtenberger, L. M., Apr 29 1998, In : Digestive Diseases and Sciences. 43, 4, p. 826-833 8 p.

Research output: Contribution to journalArticle

Bombesin
Gastrins
Stomach
Wounds and Injuries
Somatostatin
102 Citations (Scopus)

Butyrate-induced differentiation of Caco-2 cells is associated with apoptosis and early induction of p21(Waf1/Cip1) and p27(Kip1)

Litvak, D. A., Evers, B. M., Hwang, K. O., Hellmich, M. R., Ko, T. C., Townsend, J., Mercer, D. W., Hodin, R. A., Postier, R. G. & Soybel, D. I., Jan 1 1998, In : Surgery. 124, 2, p. 161-170 10 p.

Research output: Contribution to journalArticle

Caco-2 Cells
Butyrates
Apoptosis
Enterocytes
Sucrase
20 Citations (Scopus)

Capsaicin-induced gastric mucosal hyperemia and protection: The role of calcitonin gene-related peptide

Merchant, N. B., Dempsey, D. T., Grabowski, M. W., Rizzo, M., Ritchie, W. P., Bass, B., Mercer, D., Kellum, J. M. & Carvajal, S., Jan 1 1994, In : Surgery. 116, 2, p. 419-425 7 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
Capsaicin
Hyperemia
Stomach
Dinoprostone
12 Citations (Scopus)

Cholecystokinin-induced gastroprotection: A review of current protective mechanisms

West, S. D. & Mercer, D. W., Mar 1 2004, In : Digestive Diseases and Sciences. 49, 3, p. 361-369 9 p.

Research output: Contribution to journalReview article

Cholecystokinin
Stomach
Endocrine System
Aptitude
Irritants
28 Citations (Scopus)

Cholecystokinin-induced protection against gastric injury is independent of endogenous somatostatin

Mercer, D. W., Klemm, K., Cross, J. M., Smith, G. S., Cashman, M. & Miller, T. A., Oct 1 1996, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 271, 4 34-4, p. G692-G700

Research output: Contribution to journalArticle

Cholecystokinin
Somatostatin
Stomach
Wounds and Injuries
Ethanol
24 Citations (Scopus)

Cholecystokinin is a potent protective agent against alcohol-induced gastric injury in the rat - Role of endogenous prostaglandins

Mercer, D. W., Cross, J. M., Barreto, J. C., Strobel, N. H. P., Russell, D. H. & Miller, T. A., Mar 1 1995, In : Digestive Diseases and Sciences. 40, 3, p. 651-660 10 p.

Research output: Contribution to journalArticle

Protective Agents
Cholecystokinin
Sincalide
Prostaglandins
Stomach
29 Citations (Scopus)

Cholecystokinin secretagogue-induced gastroprotection: Role of nitric oxide and blood flow

West, S. D., Helmer, K. S., Chang, L. K., Cui, Y., Greeley, G. H. & Mercer, D. W., Mar 1 2003, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 284, 3 47-3, p. G399-G410

Research output: Contribution to journalArticle

Cholecystokinin
Stomach
Nitric Oxide
Nitric Oxide Synthase
Irritants
16 Citations (Scopus)

Clostridium difficile-associated infection: A disease of varying severity

Jawa, R. S. & Mercer, D. W., Dec 1 2012, In : American journal of surgery. 204, 6, p. 836-842 7 p.

Research output: Contribution to journalArticle

Clostridium difficile
Virulence
Infection
Asymptomatic Infections
Pulsed Field Gel Electrophoresis
5 Citations (Scopus)

Computational approaches for translational clinical research in disease progression

McGuire, M. F., Iyengar, M. S. & Mercer, D. W., Aug 2011, In : Journal of Investigative Medicine. 59, 6, p. 893-903 11 p.

Research output: Contribution to journalReview article

Translational Medical Research
Computational methods
Disease Progression
Systems Biology
Wounds and Injuries
29 Citations (Scopus)

Conventional dose hypertonic saline provides optimal gut protection and limits remote organ injury after gut ischemia reperfusion

Gonzalez, E. A., Kozar, R. A., Suliburk, J. W., Weisbrodt, N. W., Mercer, D. W. & Moore, F. A., Jul 1 2006, In : Journal of Trauma - Injury, Infection and Critical Care. 61, 1, p. 66-73 8 p.

Research output: Contribution to journalArticle

Superior Mesenteric Artery
Reperfusion
Ischemia
Resuscitation
Wounds and Injuries
6 Citations (Scopus)

Cyclooxygenase-1 suppresses lipopolysaccharide-induced changes in rat gastric inducible nitric oxide synthase

West, S. D., Suliburk, J. W., Helmer, K. S. & Mercer, D. W., Feb 2008, In : Critical care medicine. 36, 2, p. 572-579 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Nitric Oxide Synthase Type II
Lipopolysaccharides
Stomach
Prostaglandin-Endoperoxide Synthases
10 Citations (Scopus)

Cyclooxygenase inhibition attenuates cholecystokinin-induced gastroprotection

Mercer, D. W., Smith, G. S. & Miller, T. A., Apr 18 1998, In : Digestive Diseases and Sciences. 43, 3, p. 468-475 8 p.

Research output: Contribution to journalArticle

Cholecystokinin
Prostaglandin-Endoperoxide Synthases
Prostaglandins
Stomach
Indomethacin
3 Citations (Scopus)

Data driven linear algebraic methods for analysis of molecular pathways: Application to disease progression in shock/trauma

McGuire, M. F., Sriram Iyengar, M. & Mercer, D. W., Apr 1 2012, In : Journal of Biomedical Informatics. 45, 2, p. 372-387 16 p.

Research output: Contribution to journalArticle

Semantics
Disease Progression
Shock
Multiple Organ Failure
Molecular interactions
1 Citation (Scopus)

Derangements in gastrointestinal function secondary to previous surgery

Savas, J. F., Miller, T. A. & Mercer, D. W., Jan 1 2006, Modern Surgical Care: Physiologic Foundations and Clinical Applications, Third Edition. CRC Press, Vol. 1. p. 617-630 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stomach
Intestines
Vagus Nerve Injuries
Digestion
Pylorus
27 Citations (Scopus)

Differential effects of anesthetics on endotoxin-induced liver injury

Suliburk, J. W., Gonzalez, E. A., Kennison, S. D., Helmer, K. S., Mercer, D. W., Meyer, A. A., Bulger, E. M. & Ogura, H., Apr 1 2005, In : Journal of Trauma - Injury, Infection and Critical Care. 58, 4, p. 711-717 7 p.

Research output: Contribution to journalArticle

Endotoxins
Heme Oxygenase-1
Anesthetics
Nitric Oxide Synthase Type II
Ketamine
11 Citations (Scopus)

Differential effects of luminal arginine and glutamine on metalloproteinase production in the postischemic gut

Robinson, E. K., Kelly, D. P., Mercer, D. W. & Kozar, R. A., Jul 1 2008, In : Journal of Parenteral and Enteral Nutrition. 32, 4, p. 433-438 6 p.

Research output: Contribution to journalArticle

gelatinase A
Matrix Metalloproteinase 2
Metalloproteases
metalloproteinases
Nitric Oxide Synthase Type II
43 Citations (Scopus)

Diverticulitis in the younger patient

West, S. D., Robinson, E. K., Delu, A. N., Ligon, R. E., Kao, L. S. & Mercer, D. W., Dec 2003, In : American journal of surgery. 186, 6, p. 743-746 4 p.

Research output: Contribution to journalArticle

Diverticulitis
Population
County Hospitals
Urban Hospitals
Poverty
25 Citations (Scopus)

Does upregulation of inducible nitric oxide synthase (iNOS) render the stomach more susceptible to damage?

Castañeda, A. A., Denning, J. W., Chang, L. & Mercer, D. W., Jun 15 1999, In : Journal of Surgical Research. 84, 2, p. 174-179 6 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Stomach
Up-Regulation
Gastric Mucosa
Lipopolysaccharides
28 Citations (Scopus)

Does upregulation of inducible nitric oxide synthase play a role in hepatic injury?

Liu, T. H., Robinson, E. K., Helmer, K. S., West, S. D., Castaneda, A. A., Chang, L. & Mercer, D. W., Dec 2002, In : Shock. 18, 6, p. 549-554 6 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Up-Regulation
Lipopolysaccharides
Liver
Wounds and Injuries
1 Citation (Scopus)

Do leukotrienes mediate bile acid-induced gastric mucosal injury?

Mercer, D. W., Ritchie, W. P. & Dempsey, D. T., Sep 30 1992, In : American Surgeon. 58, 9, p. 567-572 6 p.

Research output: Contribution to journalArticle

Leukotrienes
Bile Acids and Salts
Stomach
Leukotriene D4
Leukotriene C4
15 Citations (Scopus)

Do sensory neurons mediate adaptive cytoprotection of gastric mucosa against bile acid injury?

Mercer, D. W., Ritchie, W. P. & Dempsey, D. T., Jan 1992, In : The American Journal of Surgery. 163, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

Taurocholic Acid
Cytoprotection
Sensory Receptor Cells
Gastric Mucosa
Bile Acids and Salts
74 Citations (Scopus)

Early Cytokine Production Risk Stratifies Trauma Patients for Multiple Organ Failure

Jastrow, K. M., Gonzalez, E. A., McGuire, M. F., Suliburk, J. W., Kozar, R. A., Iyengar, S., Motschall, D. A., McKinley, B. A., Moore, F. A. & Mercer, D. W., Sep 1 2009, In : Journal of the American College of Surgeons. 209, 3, p. 320-331 12 p.

Research output: Contribution to journalArticle

Multiple Organ Failure
Cytokines
Wounds and Injuries
Shock
Injury Severity Score
9 Citations (Scopus)

Effect of NOS inhibition on rat gastric matrix metalloproteinase production during endotoxemia

Robinson, E. K., Seaworth, C. M., Suliburk, J. W., Adams, S. D., Kao, L. S. & Mercer, D. W., May 1 2006, In : Shock. 25, 5, p. 507-514 8 p.

Research output: Contribution to journalArticle

Endotoxemia
Matrix Metalloproteinases
Stomach
Matrix Metalloproteinase 2
Matrix Metalloproteinase 14
14 Citations (Scopus)

Effects of anesthesia on lipopolysaccharide-induced changes in serum cytokines

Adams, S. D., Radhakrishnan, R. S., Helmer, K. S. & Mercer, D. W., Jul 1 2008, In : Journal of Trauma - Injury, Infection and Critical Care. 65, 1, p. 170-174 5 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Ketamine
Isoflurane
Anesthesia
Cytokines
3 Citations (Scopus)

Effects of Cholecystokinin on Gastric Injury and Gastric Mucosal Blood Flow

Cross, J. M., Chang, L. & Mercer, D. W., Jan 1 1998, In : Journal of Gastrointestinal Surgery. 2, 2, p. 198-206 9 p.

Research output: Contribution to journalArticle

Cholecystokinin
Stomach
Wounds and Injuries
Irritants
Ethanol
2 Citations (Scopus)

Effects of Dopamine and Alpha-2 Adrenoreceptor Blockade on L-Dopa and Cholecystokinin-Induced Gastroprotection

Cross, J. M., Mercer, D. W., Gunter, J. & Miller, T. A., Jan 1 1997, In : Journal of Gastrointestinal Surgery. 1, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

Cholecystokinin
Levodopa
Dopamine
Stomach
Dopamine Receptors
31 Citations (Scopus)

Effects of endotoxin on gastric injury from luminal irritants in rats: Potential roles of nitric oxide

Mercer, D. W., Castaneda, A. A., Denning, J. W., Chang, L. & Russell, D. H., Sep 1 1998, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 275, 3 38-3, p. G449-G459

Research output: Contribution to journalArticle

Irritants
Endotoxins
Stomach
Nitric Oxide
Wounds and Injuries
39 Citations (Scopus)

Effects of endotoxin on regulation of intestinal smooth muscle nitric oxide synthase and intestinal transit

Cullen, J. J., Mercer, D., Hinkhouse, M., Ephgrave, K. S. & Conklin, J. L., Jan 1 1999, In : Surgery. 125, 3, p. 339-344 6 p.

Research output: Contribution to journalArticle

Oxyhemoglobins
Endotoxins
Nitric Oxide Synthase
Endotoxemia
Smooth Muscle
6 Citations (Scopus)

Effects of intestinal ischemia/reperfusion injury on gastric acid secretion

Castañeda, A., Vilela, R., Chang, L. & Mercer, D. W., May 1 2000, In : Journal of Surgical Research. 90, 1, p. 88-93 6 p.

Research output: Contribution to journalArticle

Gastric Acid
Reperfusion Injury
Stomach
Superior Mesenteric Artery
Gastrins
38 Citations (Scopus)

Effects of ketamine/xylazine on expression of tumor necrosis factor-alpha, inducible nitric oxide synthase, and cyclo-oxygenase-2 in rat gastric mucosa during endotoxemia.

Helmer, K. S., Cui, Y., Chang, L., Dewan, A. & Mercer, D. W., Jul 2003, In : Shock (Augusta, Ga.). 20, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

Xylazine
Endotoxemia
Ketamine
Nitric Oxide Synthase Type II
Prostaglandin-Endoperoxide Synthases
29 Citations (Scopus)

Effects of ketamine on endotoxin and traumatic brain injury induced cytokine production in the rat

Ward, J. L., Harting, M. T., Cox, C. S. & Mercer, D. W., Jun 1 2011, In : Journal of Trauma - Injury, Infection and Critical Care. 70, 6, p. 1471-1479 9 p.

Research output: Contribution to journalArticle

Ketamine
Endotoxins
Cytokines
Lipopolysaccharides
Interleukin-1
6 Citations (Scopus)

Effects of lipopolysaccharide on gastric stasis: Role of cyclooxygenase

West, S. D., Suliburk, J. W., Smith, G. S. & Mercer, D. W., Apr 1 2006, In : Digestive Diseases and Sciences. 51, 4, p. 754-765 12 p.

Research output: Contribution to journalArticle

Gastroparesis
Prostaglandin-Endoperoxide Synthases
Lipopolysaccharides
Cyclooxygenase 2
Stomach
60 Citations (Scopus)

Effects of lipopolysaccharide on intestinal injury: Potential role of nitric oxide and lipid peroxidation

Mercer, D. W., Smith, G. S., Cross, J. M., Russell, D. H., Chang, L. & Cacioppo, J., Jun 1996, In : Journal of Surgical Research. 63, 1, p. 185-192 8 p.

Research output: Contribution to journalArticle

Lipid Peroxidation
Lipopolysaccharides
Nitric Oxide
Wounds and Injuries
Peroxynitrous Acid
12 Citations (Scopus)

Effects of poloxamer 188 on human PMN cells

Harting, M. T., Jimenez, F., Kozar, R. A., Moore, F. A., Mercer, D. W., Hunter, R. L., Cox, C. S. & Gonzalez, E. A., Aug 1 2008, In : Surgery. 144, 2, p. 198-203 6 p.

Research output: Contribution to journalArticle

Poloxamer
Respiratory Burst
Superoxides
L-Selectin
Cellular Structures
1 Citation (Scopus)

Effects of polyunsaturated fatty acids on bile acid-induced gastric mucosal injury

Mercer, D. W., Ritchie, W. P. & Dempsey, D. T., Feb 15 1996, In : Journal of Surgical Research. 61, 1, p. 44-50 7 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Unsaturated Fatty Acids
Arachidonic Acid
Stomach
Prostaglandins

Effects of topical isoproterenol on bile acid-induced gastric mucosal injury

Mercer, D. W., Podolsky, R. S., Ritchie, W. P. & Dempsey, D. T., Jan 1 1993, In : American Surgeon. 59, 8, p. 479-483 5 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Isoproterenol
Stomach
Wounds and Injuries
Gastric Mucosa
22 Citations (Scopus)

Farm Machinery Injuries: The 15-Year Experience at an Urban Joint Trauma Center System in a Rural State

Jawa, R. S., Young, D. H., Stothert Jr, J. C., Yetter, D., Dumond, R., Shostrom, V. K., Cemaj, S., Rautiainen, R. & Mercer, D. W., Apr 1 2013, In : Journal of Agromedicine. 18, 2, p. 98-106 9 p.

Research output: Contribution to journalArticle

Trauma Centers
Joints
Wounds and Injuries
Torso
Farms
6 Citations (Scopus)

Fasting exacerbates and feeding diminishes LPS-induced liver injury in the rat

Adams, S. D., Delano, B. A., Helmer, K. S. & Mercer, D. W., Apr 1 2009, In : Digestive Diseases and Sciences. 54, 4, p. 767-773 7 p.

Research output: Contribution to journalArticle

Fasting
Liver
Wounds and Injuries
Cytokines
Transaminases
67 Citations (Scopus)

Fulminant Clostridium difficile colitis

Adams, S. D. & Mercer, D. W., Aug 1 2007, In : Current Opinion in Critical Care. 13, 4, p. 450-455 6 p.

Research output: Contribution to journalReview article

Clostridium difficile
Colitis
Leukocytosis
Clostridium Infections
Colectomy
4 Citations (Scopus)

Gastric alkalinization after major trauma

Cocanour, C. S., Dial, E. D., Lichtenberger, L. M., Gonzalez, E. A., Kozar, R. A., Moore, F. A. & Mercer, D. W., Mar 1 2008, In : Journal of Trauma - Injury, Infection and Critical Care. 64, 3, p. 681-687 7 p.

Research output: Contribution to journalArticle

Stomach
Wounds and Injuries
Bile Reflux
Bile Acids and Salts
Ventilator-Associated Pneumonia
55 Citations (Scopus)

Gastric injury induced by ethanol and Ischemia-Reperfusion in the rat: Differing roles for lipid peroxidation and oxygen radicals

Smith, G. S., Mercer, D. W., Cross, J. M., Barreto, J. C. & Miller, T. A., Jul 22 1996, In : Digestive Diseases and Sciences. 41, 6, p. 1157-1164 8 p.

Research output: Contribution to journalArticle

Lipid Peroxidation
Reperfusion
Reactive Oxygen Species
Stomach
Ethanol