David W Mercer, MD

Chairperson

  • 2620 Citations
  • 29 h-Index
1988 …2018
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Research Output 1990 2014

  • 2620 Citations
  • 29 h-Index
  • 95 Article
  • 7 Review article
  • 5 Chapter
1990
13 Citations (Scopus)

Adaptive cytoprotection of gastric surface epithelial cells against injury by physiologic concentrations of bile acid

Dempsey, D. T., Mercer, D. W., Deb, B., Sauter, A. & Ritchie, W. P., Jan 1 1990, In : Surgery. 108, 2, p. 348-355 8 p.

Research output: Contribution to journalArticle

Taurocholic Acid
Cytoprotection
Bile Acids and Salts
Stomach
Epithelial Cells

Topical leukotriene (LTC4) exacerbates bile acid injury to the superficial gastric mucosa in rats

Mercer, D. W., Milner, R. E., Kirshner, M. J., Ritchie, W. P. & Dempsey, D. T., Dec 1 1990, In : Surgical forum. 41, p. 138-139 2 p.

Research output: Contribution to journalArticle

Leukotriene C4
Leukotrienes
Gastric Mucosa
Bile Acids and Salts
Wounds and Injuries
1991
3 Citations (Scopus)

Leukotriene receptor blockade reduces bile acid-induced superficial gastric mucosal injury

Mercer, D. W., Milner, R., O'Neill, S., Ritchie, W. P. & Dempsey, D. T., Jun 1991, In : Journal of Surgical Research. 50, 6, p. 602-608 7 p.

Research output: Contribution to journalArticle

Leukotriene Receptors
Bile Acids and Salts
Leukotriene D4
Leukotriene C4
Stomach
19 Citations (Scopus)

Mediators of bile acid-induced alterations in gastric mucosal blood flow

Ritchie, W. P. & Mercer, D., Jan 1991, In : The American Journal of Surgery. 161, 1, p. 126-130 5 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Stomach
Epoprostenol
Indomethacin
Prostaglandins
1992
11 Citations (Scopus)

Anatomic Considerations in Penetrating Gluteal Wounds

Mercer, D. W., Buckman, R. F., Sood, R., Kerr, T. M. & Gelman, J., Apr 1992, In : Archives of Surgery. 127, 4, p. 407-410 4 p.

Research output: Contribution to journalArticle

Penetrating Wounds
Gunshot Wounds
Wounds and Injuries
Femur
Blood Vessels
1 Citation (Scopus)

Do leukotrienes mediate bile acid-induced gastric mucosal injury?

Mercer, D. W., Ritchie, W. P. & Dempsey, D. T., Sep 30 1992, In : American Surgeon. 58, 9, p. 567-572 6 p.

Research output: Contribution to journalArticle

Leukotrienes
Bile Acids and Salts
Stomach
Leukotriene D4
Leukotriene C4
15 Citations (Scopus)

Do sensory neurons mediate adaptive cytoprotection of gastric mucosa against bile acid injury?

Mercer, D. W., Ritchie, W. P. & Dempsey, D. T., Jan 1992, In : The American Journal of Surgery. 163, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

Taurocholic Acid
Cytoprotection
Sensory Receptor Cells
Gastric Mucosa
Bile Acids and Salts
2 Citations (Scopus)

Selective lipoxygenase inhibitor reduces bile acid-induced gastric mucosal injury

Sullivan, T. R., Cordero, J. A., Mercer, D. W., Ritchie, W. P. & Dempsey, D. T., Dec 1992, In : Journal of Surgical Research. 53, 6, p. 568-571 4 p.

Research output: Contribution to journalArticle

Lipoxygenase Inhibitors
Bile Acids and Salts
Stomach
Wounds and Injuries
Leukotrienes
1993

Effects of topical isoproterenol on bile acid-induced gastric mucosal injury

Mercer, D. W., Podolsky, R. S., Ritchie, W. P. & Dempsey, D. T., Jan 1 1993, In : American Surgeon. 59, 8, p. 479-483 5 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Isoproterenol
Stomach
Wounds and Injuries
Gastric Mucosa
1994
7 Citations (Scopus)

Bombesin maintains enterocyte phenotype in fasted rats

Hodin, R. A., Meng, S., Shei, A., Bass, B., Mercer, D. & Rudnicki, M., Jan 1 1994, In : Surgery. 116, 2, p. 426-431 6 p.

Research output: Contribution to journalArticle

Bombesin
Enterocytes
Lactase
Phenotype
Alkaline Phosphatase
20 Citations (Scopus)

Capsaicin-induced gastric mucosal hyperemia and protection: The role of calcitonin gene-related peptide

Merchant, N. B., Dempsey, D. T., Grabowski, M. W., Rizzo, M., Ritchie, W. P., Bass, B., Mercer, D., Kellum, J. M. & Carvajal, S., Jan 1 1994, In : Surgery. 116, 2, p. 419-425 7 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
Capsaicin
Hyperemia
Stomach
Dinoprostone
12 Citations (Scopus)

Sensory neuron-mediated gastric mucosal protection is blocked by cyclooxygenase inhibition

Mercer, D. W., Ritchie, W. P. & Dempsey, D. T., Jan 1 1994, In : Surgery. 115, 2, p. 156-163 8 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Prostaglandin-Endoperoxide Synthases
Capsaicin
Stomach
Wounds and Injuries
6 Citations (Scopus)

Topical prostaglandin e2 and isoproterenol reduce bile acid-induced gastric mucosal injury in shocked rats

Mercer, D. W., Kirshner, M. S., Ritchie, W. P. & Dempsey, D. T., Feb 1994, In : Journal of Surgical Research. 56, 2, p. 184-191 8 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Isoproterenol
Dinoprostone
Stomach
Wounds and Injuries
1995
24 Citations (Scopus)

Cholecystokinin is a potent protective agent against alcohol-induced gastric injury in the rat - Role of endogenous prostaglandins

Mercer, D. W., Cross, J. M., Barreto, J. C., Strobel, N. H. P., Russell, D. H. & Miller, T. A., Mar 1 1995, In : Digestive Diseases and Sciences. 40, 3, p. 651-660 10 p.

Research output: Contribution to journalArticle

Protective Agents
Cholecystokinin
Sincalide
Prostaglandins
Stomach
4 Citations (Scopus)

Isoproterenol-induced gastric mucosal protection from bile acid - Role of endogenous prostaglandins

Mercer, D. W., Merchant, N. B., Ritchie, W. P. & Dempsey, D. T., Oct 1 1995, In : Digestive Diseases and Sciences. 40, 10, p. 2227-2235 9 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Isoproterenol
Prostaglandins
Stomach
Dinoprostone
2 Citations (Scopus)

Protective effect of a 21-aminosteroid against hemorrhage-induced ischemia-reperfusion injury in the rat stomach: role of lipid peroxidation.

Cross, J. M., Smith, G. S., Russell, D. H., Nguyen, P. H., Mercer, D. W., Barreto, J. C. & Miller, T. A., May 1 1995, In : Shock (Augusta, Ga.). 3, 5, p. 385-390 6 p.

Research output: Contribution to journalArticle

Reperfusion Injury
Lipid Peroxidation
Stomach
Hemorrhage
Reperfusion
12 Citations (Scopus)

Stimulation of Na+-K+-ATPase by thyrotropin in cultured thyroid follicular cells

Pressley, T. A., Higham, S. C., Joson, L. A. & Mercer, D. W., Jan 1 1995, In : American Journal of Physiology - Cell Physiology. 268, 5 37-5, p. C1252-C1258

Research output: Contribution to journalArticle

thyrotropin
sodium-potassium-exchanging ATPase
Thyrotropin
Adenosine Triphosphatases
Cultured Cells
1996
28 Citations (Scopus)

Cholecystokinin-induced protection against gastric injury is independent of endogenous somatostatin

Mercer, D. W., Klemm, K., Cross, J. M., Smith, G. S., Cashman, M. & Miller, T. A., Oct 1 1996, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 271, 4 34-4, p. G692-G700

Research output: Contribution to journalArticle

Cholecystokinin
Somatostatin
Stomach
Wounds and Injuries
Ethanol
60 Citations (Scopus)

Effects of lipopolysaccharide on intestinal injury: Potential role of nitric oxide and lipid peroxidation

Mercer, D. W., Smith, G. S., Cross, J. M., Russell, D. H., Chang, L. & Cacioppo, J., Jun 1996, In : Journal of Surgical Research. 63, 1, p. 185-192 8 p.

Research output: Contribution to journalArticle

Lipid Peroxidation
Lipopolysaccharides
Nitric Oxide
Wounds and Injuries
Peroxynitrous Acid
1 Citation (Scopus)

Effects of polyunsaturated fatty acids on bile acid-induced gastric mucosal injury

Mercer, D. W., Ritchie, W. P. & Dempsey, D. T., Feb 15 1996, In : Journal of Surgical Research. 61, 1, p. 44-50 7 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Unsaturated Fatty Acids
Arachidonic Acid
Stomach
Prostaglandins
55 Citations (Scopus)

Gastric injury induced by ethanol and Ischemia-Reperfusion in the rat: Differing roles for lipid peroxidation and oxygen radicals

Smith, G. S., Mercer, D. W., Cross, J. M., Barreto, J. C. & Miller, T. A., Jul 22 1996, In : Digestive Diseases and Sciences. 41, 6, p. 1157-1164 8 p.

Research output: Contribution to journalArticle

Lipid Peroxidation
Reperfusion
Reactive Oxygen Species
Stomach
Ethanol
1997
2 Citations (Scopus)

Effects of Dopamine and Alpha-2 Adrenoreceptor Blockade on L-Dopa and Cholecystokinin-Induced Gastroprotection

Cross, J. M., Mercer, D. W., Gunter, J. & Miller, T. A., Jan 1 1997, In : Journal of Gastrointestinal Surgery. 1, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

Cholecystokinin
Levodopa
Dopamine
Stomach
Dopamine Receptors
13 Citations (Scopus)

Hypotension during Septic Shock Does Not Correlate with Plasma Levels of Nitric Oxide Metabolites in the Conscious Rat

Klemm, K., Mercer, D. W., Mailman, D. & Moody, F. G., Jan 1 1997, In : Journal of Gastrointestinal Surgery. 1, 4, p. 347-356 10 p.

Research output: Contribution to journalArticle

Septic Shock
Hypotension
Lipopolysaccharides
Nitric Oxide
Controlled Hypotension

Octreotide acetate attenuates bombesin induced gastroprotection

Mercer, D. W., Chang, L. & Lichtenberger, L. M., Dec 1 1997, In : FASEB Journal. 11, 3, p. A219

Research output: Contribution to journalArticle

octreotide
bombesin
Bombesin
Octreotide
acetates
24 Citations (Scopus)

Open-chest cardiac massage without major thoracotomy: Metabolic indicators of coronary and cerebral perfusion

Buckman, R. F., Badellino, M. M., Eynon, C. A., Mauro, L. H., Aldridge, S. C., Milner, R. E., Merchant, N. B., Buckman, R. F., Mercer, D., Malaspina, P. J. & Warren, R., Jun 1 1997, In : Resuscitation. 34, 3, p. 247-253 7 p.

Research output: Contribution to journalArticle

Heart Massage
Coronary Sinus
Thoracotomy
Neck
Thorax
28 Citations (Scopus)

Protective action of gastrin-17 against alcohol-induced gastric injury in the rat: Role in mucosal defense

Mercer, D. W., Cross, J. M., Smith, G. S. & Miller, T. A., Oct 13 1997, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 273, 2 36-2, p. G365-G373

Research output: Contribution to journalArticle

Gastrins
Stomach
Ethanol
Cholecystokinin
Alcohols
1998
20 Citations (Scopus)

Bombesin prevents gastric injury in the rat: Role of gastrin

Mercer, D. W., Cross, J. M., Chang, L. & Lichtenberger, L. M., Apr 29 1998, In : Digestive Diseases and Sciences. 43, 4, p. 826-833 8 p.

Research output: Contribution to journalArticle

Bombesin
Gastrins
Stomach
Wounds and Injuries
Somatostatin
102 Citations (Scopus)

Butyrate-induced differentiation of Caco-2 cells is associated with apoptosis and early induction of p21(Waf1/Cip1) and p27(Kip1)

Litvak, D. A., Evers, B. M., Hwang, K. O., Hellmich, M. R., Ko, T. C., Townsend, J., Mercer, D. W., Hodin, R. A., Postier, R. G. & Soybel, D. I., Jan 1 1998, In : Surgery. 124, 2, p. 161-170 10 p.

Research output: Contribution to journalArticle

Caco-2 Cells
Butyrates
Apoptosis
Enterocytes
Sucrase
10 Citations (Scopus)

Cyclooxygenase inhibition attenuates cholecystokinin-induced gastroprotection

Mercer, D. W., Smith, G. S. & Miller, T. A., Apr 18 1998, In : Digestive Diseases and Sciences. 43, 3, p. 468-475 8 p.

Research output: Contribution to journalArticle

Cholecystokinin
Prostaglandin-Endoperoxide Synthases
Prostaglandins
Stomach
Indomethacin
3 Citations (Scopus)

Effects of Cholecystokinin on Gastric Injury and Gastric Mucosal Blood Flow

Cross, J. M., Chang, L. & Mercer, D. W., Jan 1 1998, In : Journal of Gastrointestinal Surgery. 2, 2, p. 198-206 9 p.

Research output: Contribution to journalArticle

Cholecystokinin
Stomach
Wounds and Injuries
Irritants
Ethanol
31 Citations (Scopus)

Effects of endotoxin on gastric injury from luminal irritants in rats: Potential roles of nitric oxide

Mercer, D. W., Castaneda, A. A., Denning, J. W., Chang, L. & Russell, D. H., Sep 1 1998, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 275, 3 38-3, p. G449-G459

Research output: Contribution to journalArticle

Irritants
Endotoxins
Stomach
Nitric Oxide
Wounds and Injuries
7 Citations (Scopus)

Gastroprotective actions of bombesin L-DOPA, and mild irritants: Roles of prostaglandins and sensory neurons

Mercer, D. W., Cross, J. M., Castaneda, A. A. & Gunter, J. A., Jan 1 1998, In : Surgery. 124, 5, p. 864-870 7 p.

Research output: Contribution to journalArticle

Bombesin
Irritants
Sensory Receptor Cells
Prostaglandins
Ethanol
6 Citations (Scopus)

Store-operated calcium influx in human gastric cells: Role of endogenous prostaglandins

Kokoska, E. R., Smith, G. S., Miller, T. A., Mercer, D. W., Soybel, D. I. & Matthews, J. B., Jan 1 1998, In : Surgery. 124, 2, p. 429-437 9 p.

Research output: Contribution to journalArticle

Prostaglandins
Stomach
Calcium
Non-Steroidal Anti-Inflammatory Agents
Dinoprostone
1999
25 Citations (Scopus)

Does upregulation of inducible nitric oxide synthase (iNOS) render the stomach more susceptible to damage?

Castañeda, A. A., Denning, J. W., Chang, L. & Mercer, D. W., Jun 15 1999, In : Journal of Surgical Research. 84, 2, p. 174-179 6 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Stomach
Up-Regulation
Gastric Mucosa
Lipopolysaccharides
39 Citations (Scopus)

Effects of endotoxin on regulation of intestinal smooth muscle nitric oxide synthase and intestinal transit

Cullen, J. J., Mercer, D., Hinkhouse, M., Ephgrave, K. S. & Conklin, J. L., Jan 1 1999, In : Surgery. 125, 3, p. 339-344 6 p.

Research output: Contribution to journalArticle

Oxyhemoglobins
Endotoxins
Nitric Oxide Synthase
Endotoxemia
Smooth Muscle
67 Citations (Scopus)

The efficacy of magnetic resonance cholangiography for the evaluation of patients with suspected choledocholithiasis before laparoscopic cholecystectomy

Liu, T. H., Consorti, E. T., Kawashima, A., Ernst, R. D., Black, C. T., Greger, P. H., Fischer, R. P. & Mercer, D. W., Dec 1 1999, In : American journal of surgery. 178, 6, p. 480-484 5 p.

Research output: Contribution to journalArticle

Choledocholithiasis
Cholangiography
Laparoscopic Cholecystectomy
Magnetic Resonance Spectroscopy
Common Bile Duct
2000
6 Citations (Scopus)

Effects of intestinal ischemia/reperfusion injury on gastric acid secretion

Castañeda, A., Vilela, R., Chang, L. & Mercer, D. W., May 1 2000, In : Journal of Surgical Research. 90, 1, p. 88-93 6 p.

Research output: Contribution to journalArticle

Gastric Acid
Reperfusion Injury
Stomach
Superior Mesenteric Artery
Gastrins
7 Citations (Scopus)

Nitric oxide synthase inhibition negates bombesin-induced gastroprotection

Castañeda, A. A., Kim, Y. S., Chang, L. K., Cui, Y. & Mercer, D. W., Jan 1 2000, In : Surgery. 128, 3, p. 422-428 7 p.

Research output: Contribution to journalArticle

Bombesin
Nitric Oxide Synthase
NG-Nitroarginine Methyl Ester
Stomach
Nitric Oxide Synthase Type III
2001
9 Citations (Scopus)

Image of the month

Liu, T. H., Mehall, J. R. & Mercer, D. W., Jan 1 2001, In : Archives of Surgery. 136, 12, p. 1437-1438 2 p.

Research output: Contribution to journalArticle

Gastric Dilatation
Stomach
Differential Diagnosis
Necrosis
76 Citations (Scopus)

Inducible nitric oxide synthase mediates gut ischemia/reperfusion-induced ileus only after severe insults

Hassoun, H. T., Weisbrodt, N. W., Mercer, D. W., Kozar, R. A., Moody, F. G. & Moore, F. A., Jan 1 2001, In : Journal of Surgical Research. 97, 2, p. 150-154 5 p.

Research output: Contribution to journalArticle

Superior Mesenteric Artery
Ileus
Nitric Oxide Synthase Type II
Reperfusion
Ischemia
2 Citations (Scopus)

Lipopolysaccharide-induced gastroprotection is independent of the vagus nerve

Kim, Y. S., Chang, L. K. & Mercer, D. W., Jan 1 2001, In : Digestive Diseases and Sciences. 46, 7, p. 1526-1532 7 p., 342660.

Research output: Contribution to journalArticle

Vagus Nerve
Lipopolysaccharides
Stomach
Gastrins
Endotoxemia
83 Citations (Scopus)

Patient evaluation and management with selective use of magnetic resonance cholangiography and endoscopic retrograde cholangiopancreatography before laparoscopic cholecystectomy

Liu, T. H., Consorti, E. T., Kawashima, A., Tamm, E. P., Kwong, K. L., Gill, B. S., Sellin, J. H., Peden, E. K. & Mercer, D. W., Jul 18 2001, In : Annals of surgery. 234, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

Cholangiography
Endoscopic Retrograde Cholangiopancreatography
Laparoscopic Cholecystectomy
Magnetic Resonance Spectroscopy
Choledocholithiasis
409 Citations (Scopus)

Post-injury multiple organ failure: The role of the gut

Hassoun, H. T., Kone, B. C., Mercer, D. W., Moody, F. G., Weisbrodt, N. W. & Moore, F. A., Jan 2001, In : Shock. 15, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Multiple Organ Failure
Wounds and Injuries
Trauma Centers
Medical Schools
Research
2002
28 Citations (Scopus)

Does upregulation of inducible nitric oxide synthase play a role in hepatic injury?

Liu, T. H., Robinson, E. K., Helmer, K. S., West, S. D., Castaneda, A. A., Chang, L. & Mercer, D. W., Dec 2002, In : Shock. 18, 6, p. 549-554 6 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Up-Regulation
Lipopolysaccharides
Liver
Wounds and Injuries
38 Citations (Scopus)

Gastric nitric oxide synthase expression during endotoxemia: Implications in mucosal defense in rats

Helmer, K. S., West, S. D., Shipley, G. L., Chang, L., Cui, Y., Mailman, D. & Mercer, D. W., Jan 1 2002, In : Gastroenterology. 123, 1, p. 173-186 14 p.

Research output: Contribution to journalArticle

Endotoxemia
Nitric Oxide Synthase
Stomach
Lipopolysaccharides
Nitric Oxide Synthase Type II
36 Citations (Scopus)

Increased expression of alpha-1-antitrypsin, glutathione S-transferase π and vascular endothelial growth factor in human pancreatic adenocarcinoma

Trachte, A. L., Suthers, S. E., Lerner, M. R., Hanas, J. S., Jupe, E. R., Sienko, A. E., Adesina, A. M., Lightfoot, S. A., Brackett, D. J., Postier, R. G., Mercer, D., Barnes, S., Lang, N. & Moore, E., Dec 1 2002, In : American journal of surgery. 184, 6, p. 642-647 6 p.

Research output: Contribution to journalArticle

alpha 1-Antitrypsin
Glutathione Transferase
Adenocarcinoma
Gene Expression
Oligonucleotide Array Sequence Analysis
11 Citations (Scopus)

Induction of NF-κB, IκB-α, and iNOS in rat gastric mucosa during endotoxemia

Helmer, K. S., Chang, L., Cui, Y. & Mercer, D. W., Jan 1 2002, In : Journal of Surgical Research. 104, 1, p. 46-52 7 p.

Research output: Contribution to journalArticle

Endotoxemia
NF-kappa B
Nitric Oxide Synthase Type II
Gastric Mucosa
Stomach
6 Citations (Scopus)

Laparoscopic cholecystectomy for acute cholecystitis: Technical considerations and outcome

Liu, T. H., Consorti, E. T. & Mercer, D. W., Jan 1 2002, In : Seminars in Laparoscopic Surgery. 9, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

Acute Cholecystitis
Laparoscopic Cholecystectomy
Gallbladder Diseases
Therapeutics
Costs and Cost Analysis
30 Citations (Scopus)

Lipopolysaccharide-induced gastrointestinal injury in rats: Role of surface hydrophobicity and bile salts

Dial, E. J., Romero, J. J., Villa, X., Mercer, D. W. & Lichtenberger, L. M., Jan 2002, In : Shock. 17, 1, p. 77-80 4 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Hydrophobic and Hydrophilic Interactions
Lipopolysaccharides
Stomach
Ileum
38 Citations (Scopus)

Standardized patient care guidelines reduce infectious morbidity in appendectomy patients

Helmer, K. S., Robinson, E. K., Lally, K. P., Vasquez, J. C., Kwong, K. L., Liu, T. H. & Mercer, D. W., Jan 1 2002, In : American journal of surgery. 183, 6, p. 608-613 6 p.

Research output: Contribution to journalArticle

Appendectomy
Patient Care
Appendicitis
Guidelines
Abdominal Abscess