David W Mercer, MD

Chairperson

  • 2604 Citations
  • 28 h-Index
1988 …2018
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Research Output 1990 2014

  • 2604 Citations
  • 28 h-Index
  • 95 Article
  • 7 Review article
  • 5 Chapter
2014
33 Citations (Scopus)

Anesthesia-related cardiac arrest

Ellis, S. J., Newland, M. C., Simonson, J. A., Peters, K. R., Romberger, D., Mercer, D. W., Tinker, J. H., Harter, R. L., Kindscher, J. D., Qiu, F. & Lisco, S. J., Jan 1 2014, In : Anesthesiology. 120, 4, p. 829-838 10 p.

Research output: Contribution to journalArticle

Heart Arrest
Anesthesia
Anesthetics
Incidence
Databases
2013
22 Citations (Scopus)

Farm Machinery Injuries: The 15-Year Experience at an Urban Joint Trauma Center System in a Rural State

Jawa, R. S., Young, D. H., Stothert Jr, J. C., Yetter, D., Dumond, R., Shostrom, V. K., Cemaj, S., Rautiainen, R. & Mercer, D. W., Apr 1 2013, In : Journal of Agromedicine. 18, 2, p. 98-106 9 p.

Research output: Contribution to journalArticle

Trauma Centers
Joints
Wounds and Injuries
Torso
Farms

Gastric outlet obstruction

Jawa, R. S. & Mercer, D. W., Jul 1 2013, Common Problems in Acute Care Surgery. Springer New York, p. 227-248 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gastric Outlet Obstruction
Duodenum
Neoplasms
Duodenal Obstruction
Pylorus
11 Citations (Scopus)

Mesenteric ischemia-reperfusion injury up-regulates certain CC, CXC, and XC chemokines and results in multi-organ injury in a time-dependent manner

Jawa, R. S., Quist, E., Boyer, C. W., Shostrom, V. K. & Mercer, D. W., Jan 1 2013, In : European Cytokine Network. 24, 4, p. 148-156 9 p.

Research output: Contribution to journalArticle

CXC Chemokines
CC Chemokines
Reperfusion Injury
Chemokines
Up-Regulation
2012
2 Citations (Scopus)

A quick primer for setting up and maintaining surgical intensive care in an austere environment: practical tips from volunteers in a mass disaster.

Jawa, R. S., Heir, J. S., Cancelada, D., Young, D. H. & Mercer, D. W., Jan 1 2012, In : American journal of disaster medicine. 7, 3, p. 223-229 7 p.

Research output: Contribution to journalArticle

Disasters
Critical Care
Volunteers
Mobile Health Units
Haiti
16 Citations (Scopus)

Clostridium difficile-associated infection: A disease of varying severity

Jawa, R. S. & Mercer, D. W., Dec 1 2012, In : American journal of surgery. 204, 6, p. 836-842 7 p.

Research output: Contribution to journalArticle

Clostridium difficile
Virulence
Infection
Asymptomatic Infections
Pulsed Field Gel Electrophoresis
3 Citations (Scopus)

Data driven linear algebraic methods for analysis of molecular pathways: Application to disease progression in shock/trauma

McGuire, M. F., Sriram Iyengar, M. & Mercer, D. W., Apr 1 2012, In : Journal of Biomedical Informatics. 45, 2, p. 372-387 16 p.

Research output: Contribution to journalArticle

Semantics
Disease Progression
Shock
Multiple Organ Failure
Molecular interactions

Postgastrectomy and postvagotomy syndromes

Mercer, D. W. & Goede, M. R., Feb 20 2012, Fischer's Mastery of Surgery: Sixth Edition. Wolters Kluwer Health Adis (ESP), Vol. 1.

Research output: Chapter in Book/Report/Conference proceedingChapter

Postgastrectomy Syndromes

Two hospitals with 1 trauma system: A joint approach to the care of the injured patient

Jawa, R. S., Young, D. H., Wagner, M., Yetter, D., Shostrom, V., Cemaj, S., Nelson, L., Ramey, R., Sorensen, M., Schwedhelm, M., Mercer, D. W. & Stothert Jr, J. C., Apr 1 2012, In : American journal of surgery. 203, 4, p. 454-460 7 p.

Research output: Contribution to journalArticle

Patient Care
Joints
Wounds and Injuries
Trauma Centers
Costs and Cost Analysis
2011
5 Citations (Scopus)

Computational approaches for translational clinical research in disease progression

McGuire, M. F., Iyengar, M. S. & Mercer, D. W., Aug 2011, In : Journal of Investigative Medicine. 59, 6, p. 893-903 11 p.

Research output: Contribution to journalReview article

Translational Medical Research
Computational methods
Disease Progression
Systems Biology
Wounds and Injuries
28 Citations (Scopus)

Effects of ketamine on endotoxin and traumatic brain injury induced cytokine production in the rat

Ward, J. L., Harting, M. T., Cox, C. S. & Mercer, D. W., Jun 1 2011, In : Journal of Trauma - Injury, Infection and Critical Care. 70, 6, p. 1471-1479 9 p.

Research output: Contribution to journalArticle

Ketamine
Endotoxins
Cytokines
Lipopolysaccharides
Interleukin-1
21 Citations (Scopus)
Curriculum
Graduate Medical Education
Accreditation
Internship and Residency
Thoracic Surgery
2010
5 Citations (Scopus)

Ketamine suppresses LPS-induced bile reflux and gastric bleeding in the rat

Ward, J. L., Adams, S. D., Delano, B. A., Clarke, C., Radhakrishnan, R. S., Weisbrodt, N. W. & Mercer, D. W., Jan 1 2010, In : Journal of Trauma - Injury, Infection and Critical Care. 68, 1, p. 69-75 7 p.

Research output: Contribution to journalArticle

Bile Reflux
Ketamine
Lipopolysaccharides
Stomach
Hemorrhage
1 Citation (Scopus)

Laparotomy attenuates lipopolysaccharide-induced gastric bleeding in the rat

Ward, J. L., Delano, B. A., Adams, S. D., Mercer, E. E. & Mercer, D. W., Apr 1 2010, In : Digestive Diseases and Sciences. 55, 4, p. 902-910 9 p.

Research output: Contribution to journalArticle

Laparotomy
Lipopolysaccharides
Stomach
Hemorrhage
Bile Reflux
2009
74 Citations (Scopus)

Early Cytokine Production Risk Stratifies Trauma Patients for Multiple Organ Failure

Jastrow, K. M., Gonzalez, E. A., McGuire, M. F., Suliburk, J. W., Kozar, R. A., Iyengar, S., Motschall, D. A., McKinley, B. A., Moore, F. A. & Mercer, D. W., Sep 1 2009, In : Journal of the American College of Surgeons. 209, 3, p. 320-331 12 p.

Research output: Contribution to journalArticle

Multiple Organ Failure
Cytokines
Wounds and Injuries
Shock
Injury Severity Score
6 Citations (Scopus)

Fasting exacerbates and feeding diminishes LPS-induced liver injury in the rat

Adams, S. D., Delano, B. A., Helmer, K. S. & Mercer, D. W., Apr 1 2009, In : Digestive Diseases and Sciences. 54, 4, p. 767-773 7 p.

Research output: Contribution to journalArticle

Fasting
Liver
Wounds and Injuries
Cytokines
Transaminases
11 Citations (Scopus)

Ketamine-induced hepatoprotection: The role of heme oxygenase-1

Suliburk, J. W., Ward, J. L., Helmer, K. S., Adams, S. D., Zuckerbraun, B. S. & Mercer, D. W., Jun 1 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 6, p. G1360-G1369

Research output: Contribution to journalArticle

Heme Oxygenase-1
Ketamine
Carbon Monoxide
Nitric Oxide Synthase Type II
Lipopolysaccharides
6 Citations (Scopus)

α-Melanocyte stimulating hormone in critically injured trauma patients

Todd, S. R., Kao, L. S., Catania, A., Mercer, D. W., Adams, S. D. & Moore, F. A., Feb 1 2009, In : Journal of Trauma - Injury, Infection and Critical Care. 66, 2, p. 465-469 5 p.

Research output: Contribution to journalArticle

Melanocyte-Stimulating Hormones
Wounds and Injuries
Multiple Organ Failure
Traumatic Brain Hemorrhage
Traumatic Subarachnoid Hemorrhage
2008
85 Citations (Scopus)

Acute, regional inflammatory response after traumatic brain injury: Implications for cellular therapy

Harting, M. T., Jimenez, F., Adams, S. D., Mercer, D. W. & Cox, C. S., Nov 1 2008, In : Surgery. 144, 5, p. 803-813 11 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Respiratory Burst
Cytokines
Secondary Prevention
Interleukin-1
3 Citations (Scopus)

A report on associations among gastric pH, bleeding, duodenogastric reflux, and outcomes after trauma

Dial, E., Lopez-Storey, M., Adams, S., Lichtenberger, L., Gonzalez, E., McKinley, B., Moore, F. & Mercer, D., Jan 1 2008, In : Journal of Trauma - Injury, Infection and Critical Care. 64, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

Duodenogastric Reflux
Stomach
Hemorrhage
Wounds and Injuries
Multiple Organ Failure
6 Citations (Scopus)

Cyclooxygenase-1 suppresses lipopolysaccharide-induced changes in rat gastric inducible nitric oxide synthase

West, S. D., Suliburk, J. W., Helmer, K. S. & Mercer, D. W., Feb 2008, In : Critical care medicine. 36, 2, p. 572-579 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Nitric Oxide Synthase Type II
Lipopolysaccharides
Stomach
Prostaglandin-Endoperoxide Synthases
10 Citations (Scopus)

Differential effects of luminal arginine and glutamine on metalloproteinase production in the postischemic gut

Robinson, E. K., Kelly, D. P., Mercer, D. W. & Kozar, R. A., Jul 1 2008, In : Journal of Parenteral and Enteral Nutrition. 32, 4, p. 433-438 6 p.

Research output: Contribution to journalArticle

gelatinase A
Matrix Metalloproteinase 2
Metalloproteases
metalloproteinases
Nitric Oxide Synthase Type II
14 Citations (Scopus)

Effects of anesthesia on lipopolysaccharide-induced changes in serum cytokines

Adams, S. D., Radhakrishnan, R. S., Helmer, K. S. & Mercer, D. W., Jul 1 2008, In : Journal of Trauma - Injury, Infection and Critical Care. 65, 1, p. 170-174 5 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Ketamine
Isoflurane
Anesthesia
Cytokines
12 Citations (Scopus)

Effects of poloxamer 188 on human PMN cells

Harting, M. T., Jimenez, F., Kozar, R. A., Moore, F. A., Mercer, D. W., Hunter, R. L., Cox, C. S. & Gonzalez, E. A., Aug 1 2008, In : Surgery. 144, 2, p. 198-203 6 p.

Research output: Contribution to journalArticle

Poloxamer
Respiratory Burst
Superoxides
L-Selectin
Cellular Structures
4 Citations (Scopus)

Gastric alkalinization after major trauma

Cocanour, C. S., Dial, E. D., Lichtenberger, L. M., Gonzalez, E. A., Kozar, R. A., Moore, F. A. & Mercer, D. W., Mar 1 2008, In : Journal of Trauma - Injury, Infection and Critical Care. 64, 3, p. 681-687 7 p.

Research output: Contribution to journalArticle

Stomach
Wounds and Injuries
Bile Reflux
Bile Acids and Salts
Ventilator-Associated Pneumonia
37 Citations (Scopus)

The gut in systemic inflammatory response syndrome and sepsis: Enzyme systems fighting multiple organ failure

Suliburk, J., Helmer, K., Moore, F. & Mercer, D., Feb 1 2008, In : European Surgical Research. 40, 2, p. 184-189 6 p.

Research output: Contribution to journalReview article

Systemic Inflammatory Response Syndrome
Multiple Organ Failure
Sepsis
Ketamine
Critical Illness
43 Citations (Scopus)

Training future surgical scientists: Realities and recommendations

Suliburk, J. W., Kao, L. S., Kozar, R. A. & Mercer, D. W., May 1 2008, In : Annals of surgery. 247, 5, p. 741-749 9 p.

Research output: Contribution to journalReview article

Research
National Institutes of Health (U.S.)
Curriculum
Students
Graduate Medical Education
2007
66 Citations (Scopus)

Fulminant Clostridium difficile colitis

Adams, S. D. & Mercer, D. W., Aug 1 2007, In : Current Opinion in Critical Care. 13, 4, p. 450-455 6 p.

Research output: Contribution to journalReview article

Clostridium difficile
Colitis
Leukocytosis
Clostridium Infections
Colectomy
4 Citations (Scopus)
Phosphoproteins
Ketamine
Lipopolysaccharides
Stomach
Phosphorylation
2006
28 Citations (Scopus)

Conventional dose hypertonic saline provides optimal gut protection and limits remote organ injury after gut ischemia reperfusion

Gonzalez, E. A., Kozar, R. A., Suliburk, J. W., Weisbrodt, N. W., Mercer, D. W. & Moore, F. A., Jul 1 2006, In : Journal of Trauma - Injury, Infection and Critical Care. 61, 1, p. 66-73 8 p.

Research output: Contribution to journalArticle

Superior Mesenteric Artery
Reperfusion
Ischemia
Resuscitation
Wounds and Injuries
1 Citation (Scopus)

Derangements in gastrointestinal function secondary to previous surgery

Savas, J. F., Miller, T. A. & Mercer, D. W., Jan 1 2006, Modern Surgical Care: Physiologic Foundations and Clinical Applications, Third Edition. CRC Press, Vol. 1. p. 617-630 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stomach
Intestines
Vagus Nerve Injuries
Digestion
Pylorus
9 Citations (Scopus)

Effect of NOS inhibition on rat gastric matrix metalloproteinase production during endotoxemia

Robinson, E. K., Seaworth, C. M., Suliburk, J. W., Adams, S. D., Kao, L. S. & Mercer, D. W., May 1 2006, In : Shock. 25, 5, p. 507-514 8 p.

Research output: Contribution to journalArticle

Endotoxemia
Matrix Metalloproteinases
Stomach
Matrix Metalloproteinase 2
Matrix Metalloproteinase 14
6 Citations (Scopus)

Effects of lipopolysaccharide on gastric stasis: Role of cyclooxygenase

West, S. D., Suliburk, J. W., Smith, G. S. & Mercer, D. W., Apr 1 2006, In : Digestive Diseases and Sciences. 51, 4, p. 754-765 12 p.

Research output: Contribution to journalArticle

Gastroparesis
Prostaglandin-Endoperoxide Synthases
Lipopolysaccharides
Cyclooxygenase 2
Stomach
1 Citation (Scopus)

Gastric physiology and acid-peptic disorders

Helmer, K. S. & Mercer, D. W., Jan 1 2006, Modern Surgical Care: Physiologic Foundations and Clinical Applications, Third Edition. CRC Press, Vol. 1. p. 295-368 74 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gastric Acid
Digestion
Food
Stomach
Gastric Juice
30 Citations (Scopus)

Ketamine-induced gastroprotection during endotoxemia: Role of heme-oxygenase-1

Helmer, K. S., Suliburk, J. W. & Mercer, D. W., Sep 1 2006, In : Digestive Diseases and Sciences. 51, 9, p. 1571-1581 11 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Endotoxemia
Ketamine
Stomach
Nitric Oxide Synthase Type II
92 Citations (Scopus)

Randomized, open-label, comparative study of piperacillin-tazobactam administered by continuous infusion versus intermittent infusion for treatment of hospitalized patients with complicated intra-abdominal infection

Lau, W. K., Mercer, D., Itani, K. M., Nicolau, D. P., Kuti, J. L., Mansfield, D. & Dana, A., Nov 1 2006, In : Antimicrobial Agents and Chemotherapy. 50, 11, p. 3556-3561 6 p.

Research output: Contribution to journalArticle

Intraabdominal Infections
Therapeutics
tazobactam drug combination piperacillin
APACHE
Drug-Related Side Effects and Adverse Reactions
2 Citations (Scopus)

Rat gastric gelatinase induction during endotoxemia

Robinson, E. K., West, S. D., Garay, A. & Mercer, D. W., Mar 1 2006, In : Digestive Diseases and Sciences. 51, 3, p. 548-559 12 p.

Research output: Contribution to journalArticle

Gelatinases
Endotoxemia
Matrix Metalloproteinases
Stomach
Lipopolysaccharides
2 Citations (Scopus)

Salicylate Enhances Rat Gastric Gelatinase Activity

Robinson, E. K., West, S. D. & Mercer, D. W., Jun 15 2006, In : Journal of Surgical Research. 133, 2, p. 69-75 7 p.

Research output: Contribution to journalArticle

Gelatinases
Salicylates
Stomach
Matrix Metalloproteinases
Wounds and Injuries
2005
14 Citations (Scopus)

Bombesin-induced gastroprotection

West, S. D. & Mercer, D. W., Feb 1 2005, In : Annals of surgery. 241, 2, p. 227-231 5 p.

Research output: Contribution to journalReview article

Bombesin
Stomach
Gastrins
Sensory Receptor Cells
Somatostatin
27 Citations (Scopus)

Differential effects of anesthetics on endotoxin-induced liver injury

Suliburk, J. W., Gonzalez, E. A., Kennison, S. D., Helmer, K. S., Mercer, D. W., Meyer, A. A., Bulger, E. M. & Ogura, H., Apr 1 2005, In : Journal of Trauma - Injury, Infection and Critical Care. 58, 4, p. 711-717 7 p.

Research output: Contribution to journalArticle

Endotoxins
Heme Oxygenase-1
Anesthetics
Nitric Oxide Synthase Type II
Ketamine
10 Citations (Scopus)

Hypertonic saline resuscitation after mesenteric ischemia/reperfusion induces ileal apoptosis

Gonzalez, E. A., Kozar, R. A., Suliburk, J. W., Weisbrodt, N. W., Mercer, D. W. & Moore, F. A., Nov 1 2005, In : Journal of Trauma - Injury, Infection and Critical Care. 59, 5, p. 1092-1098 7 p.

Research output: Contribution to journalArticle

Resuscitation
Reperfusion
Superior Mesenteric Artery
Apoptosis
Wounds and Injuries
45 Citations (Scopus)

Ketamine attenuates liver injury attributed to endotoxemia: Role of cyclooxygenase-2

Suliburk, J. W., Helmer, K. S., Gonzalez, E. A., Robinson, E. K. & Mercer, D. W., Aug 1 2005, In : Surgery. 138, 2, p. 134-140 7 p.

Research output: Contribution to journalArticle

Endotoxemia
Ketamine
Cyclooxygenase 2
Lipopolysaccharides
Nitric Oxide Synthase Type II
9 Citations (Scopus)

Ketamine inhibits lipopolysacharide (LPS) induced gastric luminal fluid accumulation

Suliburk, J. W., Gonzalez, E. A., Moore-Olufemi, S. D., Weisbrodt, N., Moore, F. A. & Mercer, D. W., Aug 1 2005, In : Journal of Surgical Research. 127, 2, p. 203-207 5 p.

Research output: Contribution to journalArticle

Ketamine
Gastric Emptying
Gastrointestinal Transit
Stomach
Ileus
3 Citations (Scopus)

Presidential address: Academic surgery: Can we adapt?

Mercer, D. W., Aug 1 2005, In : Surgery. 138, 2, p. 115-124 10 p.

Research output: Contribution to journalArticle

Organizational Objectives
Medical Societies
9 Citations (Scopus)

Rat gastric injury after lipopolysaccharide: Role of inducible nitric oxide synthase

Robinson, E. K., Kennison, S. D., Suliburk, J. W. & Mercer, D. W., Sep 1 2005, In : Surgery. 138, 3, p. 523-529 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Lipopolysaccharides
Stomach
Wounds and Injuries
Irritants
22 Citations (Scopus)

The impact of diabetes in patients with necrotizing soft tissue infections

Kao, L. S., Knight, M. T., Lally, K. P. & Mercer, D. W., Dec 1 2005, In : Surgical Infections. 6, 4, p. 427-438 12 p.

Research output: Contribution to journalReview article

Soft Tissue Infections
Hyperglycemia
Length of Stay
Mortality
Patient Admission
9 Citations (Scopus)

Time-dependent aggravation or attenuation of lipopolysaccharide-induced gastric injury by nitric oxide synthase inhibition

Suliburk, J. W., Helmer, K. S., Kennison, S. D., Mercer, D. W. & Robinson, E. K., Dec 1 2005, In : Journal of Surgical Research. 129, 2, p. 265-271 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Lipopolysaccharides
Stomach
Wounds and Injuries
Bile
2004
12 Citations (Scopus)

Cholecystokinin-induced gastroprotection: A review of current protective mechanisms

West, S. D. & Mercer, D. W., Mar 1 2004, In : Digestive Diseases and Sciences. 49, 3, p. 361-369 9 p.

Research output: Contribution to journalReview article

Cholecystokinin
Stomach
Endocrine System
Aptitude
Irritants

Gastric Ulcer

Mercer, D. W. & Robinson, E. K., Oct 2004, Surgical Decision Making: Fifth Edition. Elsevier Inc., p. 138-141 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stomach Ulcer
119 Citations (Scopus)

Inflammatory mechanisms contributing to pancreatic cancer development

Farrow, B., Sugiyama, Y., Chen, A., Uffort, E., Nealon, W., Evers, B. M., Pitt, H. A., Cole, D. J., Mercer, D. W. & O'Leary, J. P., Jun 1 2004, In : Annals of surgery. 239, 6, p. 763-771 9 p.

Research output: Contribution to journalArticle

Chronic Pancreatitis
Pancreatic Neoplasms
Neoplasms
Laser Capture Microdissection
Genes