David B Berkowitz, PhD

Professor

  • 2268 Citations
  • 31 h-Index
1987 …2019
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Organophosphonates Chemical Compounds
Amino Acids Chemical Compounds
Bearings (structural) Chemical Compounds
Enzymes Chemical Compounds
Esters Chemical Compounds
Stereochemistry Chemical Compounds
Screening Chemical Compounds
Catalytic Domain Medicine & Life Sciences

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Projects 1995 2000

Carboxy-Lyases
Amino Acids
Adenosylmethionine Decarboxylase
Carbidopa
Enzyme inhibition

Research Output 1987 2019

  • 2268 Citations
  • 31 h-Index
  • 70 Article
  • 1 Conference contribution
  • 1 Review article

Human serine racemase: Key residues/active site motifs and their relation to enzyme function

Graham, D. L., Beio, M. L., Nelson, D. L. & Berkowitz, D. B., Jan 1 2019, In : Frontiers in Molecular Biosciences. 6, MAR, 8.

Research output: Contribution to journalReview article

Open Access
Catalytic Domain
Serine
Enzymes
Pyridoxal Phosphate
Modulation
1 Citation (Scopus)

Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time

Tu, Y., Kreinbring, C. A., Hill, M., Liu, C., Petsko, G. A., McCune, C. D., Berkowitz, D. B., Liu, D. & Ringe, D., Jun 5 2018, In : Biochemistry. 57, 22, p. 3134-3145 12 p.

Research output: Contribution to journalArticle

Cystathionine
Heme
Yeast
Saccharomyces cerevisiae
Catalytic Domain
6 Citations (Scopus)

A thiocyanopalladation/carbocyclization transformation identified through enzymatic screening: Stereocontrolled tandem C-SCN and C-C bond formation

Malik, G., Swyka, R. A., Tiwari, V. K., Fei, X., Applegate, G. A. & Berkowitz, D. B., Jan 1 2017, In : Chemical Science. 8, 12, p. 8050-8060 11 p.

Research output: Contribution to journalArticle

Screening
Bearings (structural)
Substrates
Cyclization
Scaffolds
2 Citations (Scopus)

General Linker Diversification Approach to Bivalent Ligand Assembly: Generation of an Array of Ligands for the Cation-Independent Mannose 6-Phosphate Receptor

Fei, X., Zavorka, M. E., Malik, G., Connelly, C. M., MacDonald, R. G. & Berkowitz, D. B., Aug 18 2017, In : Organic Letters. 19, 16, p. 4267-4270 4 p.

Research output: Contribution to journalArticle

IGF Type 2 Receptor
Triazoles
Cations
phosphates
assembly
5 Citations (Scopus)

Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function

Nelson, D. L., Applegate, G. A., Beio, M. L., Graham, D. L. & Berkowitz, D. B., Aug 25 2017, In : Journal of Biological Chemistry. 292, 34, p. 13986-14002 17 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Serine
Tacrine
Substrates
N-Methylaspartate