Daniel T Monaghan, PhD

Professor

  • 10444 Citations
  • 46 h-Index
1981 …2019
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  • 9 Similar Profiles
N-Methyl-D-Aspartate Receptors Medicine & Life Sciences
Glutamic Acid Medicine & Life Sciences
Glutamate Receptors Medicine & Life Sciences
Binding Sites Medicine & Life Sciences
Hippocampus Medicine & Life Sciences
N-Methylaspartate Medicine & Life Sciences
Brain Medicine & Life Sciences
Pharmacology Medicine & Life Sciences

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Projects 1982 2018

N-Methyl-D-Aspartate Receptors
Glutamic Acid
Pharmacology
Binding Sites
Molecular Models
N-Methyl-D-Aspartate Receptors
Synaptic Transmission
Signal Transduction
Intercellular Signaling Peptides and Proteins
Insulin
N-Methyl-D-Aspartate Receptors
Brain
N-Methylaspartate
Toxicology
Binding Sites

BIO-ORGANIC BIOMEDICAL MASS SPECTROMETRY RESOURCE

Monaghan, D. T., Leffler, H., Griffiss, M., Tijian, R., Bass, N., Trimble, R., Shackleton, C. H., Ondarza, R., Johnson, W., Fainzilber, M., Dzgnes, N., Taylor, R., Wandless, T., Mendelson, R., Mayeri, E., Miller, W., Verkman, A., Medzihradszky, K., Benet, L., Bertozzi, C., Schultz, P., Mitchison, T., Bunnett, N., Ross, R., Griffiss, J. M., Duzgunes, N., Shin, Y., Ockner, R., Anders, M., Sadee, W., Schmitz, U. L. I., Wang, T., Santi, D. V., Stimson, E., Pongracz, K., Forte, J., Mobley, W., Weisgraber, K., Paphadjopoulos, D., Langseth, G., Fainzilber, M., Basus, V., Morales, M., Baldwin, M., Levitsky, A., Kane, J., Lowenstein, J., Mostov, K. E., Craig, J., Cleveland, D., Roberts, J., Gershwin, M., McDonagh, A., Prieto, M., Shetlar, M., Schultz, P., Takemoto, L., Agard, D., Mitchison, T., Bunnett, N., Ross, R., Taylor, R., Wandless, T., Griffiss, J. M., Oppenheimer, N., Mendelson, R., Mayeri, E., Duzgunes, N., Ondarza, R., Stroud, R., Shin, Y., Ockner, R., Anders, M., Baldwin, R., Sadee, W., Meares, C. F., McDevitt, H., Oppenheimer, N., Winyard, P., Apicella, M. A., Pallavicini, M. G., Coffino, P., Cohen, F., Bradshaw, R., Stokoe, D., Agard, D., Largman, C., Youngren, J., Pitas, R., Cowan, M., Vale, R., Frydman, J., Brunger, A. T., Stroud, R., Unwin, R., Gibson, B. W., Craig, J., Friesen, J., Collman, J., Mc Fall-Ngai, M., Bernstein, H., Weisgraber, K., Cooper, E., Rakhely, G., Bogyo, M., Von Zastrow, M. E., Miller, W., Rexach, M., Bikle, D. D., Baldwin, M., Stack, T. D., Smith-Beckerman, D., Griffiss, J. M., Bredt, D., Goldfarb, D., Mostov, K. E., Marks, J. D., Taunton, J., Scanlan, T. S., Benz, C., Trost, B., Brown, E. J., Allis, C. D., Levy, J., Wender, P. A., Matthay, M. A., Shetlar, M., Prusiner, S., Craik, C. S., Correia, M. A., McKerrow, J. H., Shokat, K. M., McCormick, F. P., Oldak, J. M., Fainzilber, M., Miller, S. M., Kane, J., Singh, S., Kahl, S., Wang, Z., Ortiz De Montellano, P., Szoka, F., Forte, J., Maher, J. J., Drummond, D., Shafer, R., Blackburn, E., Walbot, V., Fried, M. G., Abbott, C. H., Edwards, R., R Kiplin, G., Ondarza, R., Medzihradszky, K., Oppenheimer, N., Panning, B., Ma, A., Sonner, J. M., Moreno, S., Lavail, J. H., Jarvis, G., Wells, J., Pearce, D., Chua, K., Shoichet, B. K., Jurica, M., Casida, J., Von Zastrow, M. E., Rexach, M., Bull, L., Stack, T. D., Rhoads, R. E., Bunnett, N., Storr, C., Taunton, J., Agard, N. J., Verdin, E. M., Tauscher, G. H., Bernstein, H., Rubenstein, J. L. R., Cavalli, V., Schoepfer, A., Rakhely, G., Ruggero, D., Bunnett, N., Shannon, K. M., Gross, J., Andino, R., Weissman, J. S., Hart, S., Kenyon, C. J., Mullins, D., Stroud, R., Santi, D. V., Hirsch, J., derisi, J., Chalkley, G. R., Sullivan, W. T., Julius, D., Twiss, J., Rasband, M., Wysocka, J., Fujimori, D. G., Guo, Y. I., Krogan, N., Mucke, L., Marks, J. D., Narlikar, G., Minor, D., Jones, E. F., Lim, W., Stokoe, D., Youngren, J., Lavail, J. H., Jarvis, G., Quail, P. H., Shah, N. P., Braun, B., Sheppard, D., Portale, A., Bikle, D. D., Haas-Stapleton, E., Rhoads, R. E., derynck, R. M., Medzihradszky, K., Vonzastrow, M., Bertozzi, C., Roose, J., Barber, D., Kuntz, I., Boss, G., Goodis, H., Hearst, J., Maltby, D., Koshland, D., Falick, A., Herschlag, D., Michael, F., Latter, J., Hecht, M., Kyte, J., Fahey, R., Klinman, J., Hofmann, A., Roise, D., Basus, V., Ritter, G., Spiro, T., Stephens, R., Craig, J., Borch, R., Elias, P., Drueckhammer, D., Bodell, W., Shetlar, M., Takemoto, L., Agard, D., Oppenheimer, N., Stroud, R., Baldwin, R., Meares, C. F., McDevitt, H., McConnell, H., Wang, C., Craik, C., Correia, M. A., Townsend, R. R., Rosen, S., Smith, K., Cooke, R., Griffin, J., Stack, T., Miller, S., Scanlan, T. S., Meehan, T., Wender, P., Fincham, A., Trost, B., Singh, S., Kahl, S., Gibson, B. W., Ketcham, R., Apicella, M. A., Horwitz, M. A., Kenyon, G., Ortiz De Montellano, P., Collman, J., Prusiner, S., Szoka, F., Fisher, S., Brasch, R. & Burlingame, A.

National Institutes of Health

3/1/825/31/15

Project: Research project

N-Methyl-D-Aspartate Receptors
Brain
Cytology
Glycosylation
Mass spectrometry

Research Output 1981 2019

  • 10444 Citations
  • 46 h-Index
  • 93 Article
  • 7 Chapter
  • 5 Review article

Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid

Irvine, M. W., Fang, G., Sapkota, K., Burnell, E. S., Volianskis, A., Costa, B. M., Culley, G., Collingridge, G. L., Monaghan, D. T. & Jane, D. E., Feb 15 2019, In : European Journal of Medicinal Chemistry. 164, p. 471-498 28 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Modulators
Structure-Activity Relationship
Derivatives
Neurodegenerative Diseases
8 Citations (Scopus)

Positive and Negative Allosteric Modulators of N-Methyl- d -aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action

Burnell, E. S., Irvine, M., Fang, G., Sapkota, K., Jane, D. E. & Monaghan, D. T., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 3-23 21 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Neurotransmitter Receptor
Glutamate Receptors
aspartic acid receptor
Psychiatry

The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators

Sapkota, K., Dore, K., Tang, K., Irvine, M., Fang, G., Burnell, E. S., Malinow, R., Jane, D. E. & Monaghan, D. T., Jan 1 2019, In : Biochemical Pharmacology. 159, p. 140-153 14 p.

Research output: Contribution to journalArticle

Pulse amplitude modulation
N-Methyl-D-Aspartate Receptors
Modulators
Post Translational Protein Processing
Psychiatry
5 Citations (Scopus)

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors

Chopra, DI. A., Sapkota, K., Irvine, M. W., Fang, G., Jane, D. E., Monaghan, D. T. & Dravid, S. M., Dec 1 2017, In : Scientific reports. 7, 1, 6933.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Pharmacology
Ligands
Glutamic Acid
Disulfides
5 Citations (Scopus)

Mechanism and properties of positive allosteric modulation of N-methyl-D-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives

Sapkota, K., Irvine, M. W., Fang, G., Burnell, E. S., Bannister, N., Volianskis, A., Culley, G. R., Dravid, S. M., Collingridge, G. L., Jane, D. E. & Monaghan, D. T., Oct 1 2017, In : Neuropharmacology. 125, p. 64-79 16 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Ligands
Glycine
Glutamic Acid
Schizophrenia