Dahn L Clemens, PhD

Associate Professor

  • 1833 Citations
  • 22 h-Index
1989 …2019
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Research Output 1989 2019

  • 1833 Citations
  • 22 h-Index
  • 57 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2 Citations (Scopus)

A combination of dietary N-3 fatty acids and a cyclooxygenase-1 inhibitor attenuates nonalcoholic fatty liver disease in mice

Viswanathan, S., Perriotte-Olson, C., Ganesan, M., Desouza, C. V., Alnouti, Y., Duryee, M. J., Thiele, G. M., Nordgren, T. M. & Clemens, D. L., Apr 1 2017, In : Journal of Nutritional Biochemistry. 42, p. 149-159 11 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Cyclooxygenase Inhibitors
Omega-3 Fatty Acids
Liver
Lipids
268 Citations (Scopus)

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

Roy, H. K., Olusola, B. F., Clemens, D. L., Karolski, W. J., Ratashak, A., Lynch, H. T. & Smyrk, T. C., Mar 21 2002, In : Carcinogenesis. 23, 1, p. 201-205 5 p.

Research output: Contribution to journalArticle

Proto-Oncogenes
Colon
Carcinogenesis
Azoxymethane
Neoplasms
19 Citations (Scopus)

Alcoholic pancreatitis: Lessons from the liver

Clemens, D. L. & Mahan, K. J., Mar 21 2010, In : World Journal of Gastroenterology. 16, 11, p. 1314-1320 7 p.

Research output: Contribution to journalArticle

Alcoholic Pancreatitis
Alcoholism
Liver
Pancreatitis
Pancreas
198 Citations (Scopus)

Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression

Harrison-Findik, D. D., Schafer, D. F., Klein, E., Timchenko, N. A., Kulaksiz, H., Clemens, D. L., Fein, E., Andriopoulos, B., Pantopoulos, K. & Gollan, J., Aug 11 2006, In : Journal of Biological Chemistry. 281, 32, p. 22974-22982 9 p.

Research output: Contribution to journalArticle

Hepcidins
Oxidative stress
Transcription
Metabolism
Oxidative Stress
31 Citations (Scopus)

Animal Model of Alcoholic Pancreatitis: Role of Viral Infections

Jerrells, T. R., Chapman, N. & Clemens, D. L., Nov 1 2003, In : Pancreas. 27, 4, p. 301-304 4 p.

Research output: Contribution to journalArticle

Alcoholic Pancreatitis
Virus Diseases
Pancreatitis
Animal Models
Enterovirus
4 Citations (Scopus)

A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells

Kim, T. H., Venugopal, S. K., Zhu, M., Wang, S. S., Lau, D., Lam, K. S., Clemens, D. L. & Zern, M. A., Feb 20 2009, In : Biochemical and Biophysical Research Communications. 379, 4, p. 876-881 6 p.

Research output: Contribution to journalArticle

Oxidative stress
Ethanol
Green Fluorescent Proteins
Alcohols
Apoptosis
289 Citations (Scopus)

Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice

Ding, W., Li, M., Chen, X., Ni, H., Lin, C., Gao, W., Lu, B., Stolz, D. B., Clemens, D. L. & Yin, X., Nov 2010, In : Gastroenterology. 139, 5, p. 1740-1752 13 p.

Research output: Contribution to journalArticle

Autophagy
Ethanol
Liver
Hepatocytes
Alcoholic Liver Diseases
27 Citations (Scopus)

Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3′,5-triiodothyronine as the substrate

Li, X., Clemens, D. L., Cole, J. R. & Anderson, R. J., Dec 1 2001, In : Journal of Endocrinology. 171, 3, p. 525-532 8 p.

Research output: Contribution to journalArticle

Arylsulfotransferase
Sulfotransferases
Triiodothyronine
Isoenzymes
Liver

Characterization of recombinant human liver dehydroepiandrosterone sulfotransferase (DHEA ST) with minoxidil as the substrate

Kudlacek, P., Clemens, D., Halgard, C. & Anderson, R., Dec 1 1996, In : FASEB Journal. 10, 3, p. A456

Research output: Contribution to journalArticle

Minoxidil
sulfotransferases
prasterone
Liver
liver
11 Citations (Scopus)

Characterization of recombinant human liver dehydroepiandrosterone sulfotransferase with minoxidil as the substrate

Kudlacek, P. E., Clemens, D. L., Halgard, C. M. & Anderson, R. J., Jan 24 1997, In : Biochemical Pharmacology. 53, 2, p. 215-221 7 p.

Research output: Contribution to journalArticle

Minoxidil
Liver
Substrates
Sulfonation
Arylsulfotransferase
13 Citations (Scopus)

Characterization of recombinant human liver thermolabile phenol sulfotransferase with minoxidil as the substrate

Kudlacek, P. E., Clemens, D. L. & Anderson, R. J., May 16 1995, In : Biochemical and Biophysical Research Communications. 210, 2, p. 363-369 7 p.

Research output: Contribution to journalArticle

Arylsulfotransferase
Minoxidil
Liver
Substrates
Enzymes
1 Citation (Scopus)
Cytochrome P-450 CYP2E1
Oxidative stress
Hyperglycemia
Alcohol Drinking
Liver
9 Citations (Scopus)

Direct antioxidant properties of methotrexate: Inhibition of malondialdehyde-acetaldehyde-protein adduct formation and superoxide scavenging

Zimmerman, M. C., Clemens, D. L., Duryee, M. J., Sarmiento, C., Chiou, A., Hunter, C. D., Tian, J., Klassen, L. W., O'Dell, J. R., Thiele, G. M., Mikuls, T. R. & Anderson, D. R., Oct 2017, In : Redox Biology. 13, p. 588-593 6 p.

Research output: Contribution to journalArticle

Acetaldehyde
Scavenging
Malondialdehyde
Methotrexate
Superoxides
7 Citations (Scopus)
Asialoglycoprotein Receptor
Monomeric GTP-Binding Proteins
Hepatocytes
Ethanol
Down-Regulation
5 Citations (Scopus)

Effects of Ethanol Feeding on the Interaction of Rat Hepatocytes with Laminin Peptides

Xu, D., Sorrell, M. F., Clemens, D. L., Casey, C. A. & Tuma, D. J., Oct 1994, In : Alcoholism: Clinical and Experimental Research. 18, 5, p. 1215-1219 5 p.

Research output: Contribution to journalArticle

Laminin
Rats
Hepatocytes
Ethanol
Peptides
7 Citations (Scopus)
Cytochrome P-450 CYP2E1
Alcohol Dehydrogenase
Glutathione
Oxidative stress
Hepatocellular Carcinoma
53 Citations (Scopus)

Establishment of a recombinant hepatic cell line stably expressing alcohol dehydrogenase

Clemens, D. L., Halgard, C. M., Miles, R. R., Sorrell, M. F. & Tuma, D. J., Aug 20 1995, In : Archives of Biochemistry and Biophysics. 321, 2, p. 311-318 8 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Hepatocytes
Ethanol
Cell Line
Acetaldehyde
8 Citations (Scopus)

Ethanol administration impairs pancreatic repair after injury

Schneider, K. J. M., Scheer, M., Suhr, M. & Clemens, D. L., Nov 1 2012, In : Pancreas. 41, 8, p. 1272-1279 8 p.

Research output: Contribution to journalArticle

Ethanol
Alcoholic Pancreatitis
Alcoholism
Wounds and Injuries
Exocrine Pancreas
30 Citations (Scopus)

Ethanol consumption potentiates viral pancreatitis and may inhibit pancreas regeneration: Preliminary findings

Clemens, D. L. & Jerrells, T. R., Jan 1 2004, In : Alcohol. 33, 3, p. 183-189 7 p.

Research output: Contribution to journalArticle

Alcoholic Pancreatitis
alcoholism
Pancreatitis
Regeneration
Pancreas
38 Citations (Scopus)

Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells

Osna, N. A., White, R. L., Todero, S., McVicker, B. L., Thiele, G. M., Clemens, D. L., Tuma, D. J. & Donohue, T., Jan 1 2007, In : Hepatology. 45, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

Antigen Presentation
Hepatocellular Carcinoma
Oxidative Stress
Ethanol
Peptides
27 Citations (Scopus)
Janus Kinases
Hep G2 Cells
Transducers
Metabolism
Rats
6 Citations (Scopus)

Ethanol metabolism activates cell cycle checkpoint kinase, Chk2

Clemens, D. L., Mahan Schneider, K. J. & Nuss, R. F., Dec 1 2011, In : Alcohol. 45, 8, p. 785-793 9 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Metabolism
Ataxia Telangiectasia
Ethanol
Phosphotransferases
44 Citations (Scopus)

Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells

Osna, N. A., Clemens, D. L. & Donohue, T., Nov 1 2005, In : Hepatology. 42, 5, p. 1109-1117 9 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Interferon-gamma
Ethanol
Phosphorylation
Cytochrome P-450 CYP2E1
24 Citations (Scopus)

Ethanol metabolism results in a G2/M cell-cycle arrest in recombinant Hep G2 cells

Clemens, D. L., Calisto, L. E., Sorrell, M. F. & Tuma, D. J., Aug 1 2003, In : Hepatology. 38, 2, p. 385-393 9 p.

Research output: Contribution to journalArticle

G2 Phase Cell Cycle Checkpoints
Cyclin B1
Hep G2 Cells
Ethanol
Cell Cycle
11 Citations (Scopus)

Ethanol oxidation mediates impaired hepatic receptor-mediated enocytosis

Clemens, D. L., Casey, C. A., Sorrell, M. F. & Tuma, D. J., Jul 8 1998, In : Alcoholism: Clinical and Experimental Research. 22, 4, p. 778-779 2 p.

Research output: Contribution to journalArticle

Genetic Transduction
Asialoglycoprotein Receptor
Experimental Liver Neoplasms
Alcoholic Liver Diseases
Transformed Cell Line
23 Citations (Scopus)

Expression of Aleutian mink disease parvovirus capsid proteins by a recombinant vaccinia virus: Self-assembly of capsid proteins into particles

Clemens, D. L., Wolfinbarger, J. B., Mori, S., Berry, B. D., Hayes, S. F. & Bloom, M. E., Jan 1 1992, In : Journal of virology. 66, 5, p. 3077-3085 9 p.

Research output: Contribution to journalArticle

Aleutian Mink Disease Virus
Aleutian mink disease virus
Virus Assembly
Vaccinia virus
Capsid Proteins
14 Citations (Scopus)

Free fatty acids enhance the oxidative damage induced by ethanol metabolism in an in vitro model

Hernández, I., Domínguez-Pérez, M., Bucio, L., Souza, V., Miranda, R. U., Clemens, D. L., Gomez-Quiroz, L. E. & Gutiérrez-Ruiz, M. C., Feb 1 2015, In : Food and Chemical Toxicology. 76, p. 109-115 7 p.

Research output: Contribution to journalArticle

Nonesterified Fatty Acids
Metabolism
free fatty acids
Ethanol
ethanol
9 Citations (Scopus)

GSH protects against oxidative stress and toxicity in VL-17A cells exposed to high glucose

Kumar, S. M., Swaminathan, K., Clemens, D. L. & Dey, A., Jan 1 2015, In : European Journal of Nutrition. 54, 2, p. 223-234 12 p.

Research output: Contribution to journalArticle

Oxidative Stress
diethyl maleate
Glucose
Lactoylglutathione Lyase
Ursodeoxycholic Acid
16 Citations (Scopus)

Hepatic mitochondrial dysfunction induced by fatty acids and ethanol

Gyamfi, D., Everitt, H. E., Tewfik, I., Clemens, D. L. & Patel, V. B., Dec 1 2012, In : Free Radical Biology and Medicine. 53, 11, p. 2131-2145 15 p.

Research output: Contribution to journalArticle

Liver
Ethanol
Fatty Acids
Arachidonic Acid
Palmitic Acid
38 Citations (Scopus)

Hepatocyte growth factor protects hepatocytes against oxidative injury induced by ethanol metabolism

Valdés-Arzate, A., Luna, A., Bucio, L., Licona, C., Clemens, D. L., Souza, V., Hernandez, E., Kershenobich, D., Gutiérrez-Ruiz, M. C. & Gómez-Quiroz, L. E., Aug 15 2009, In : Free Radical Biology and Medicine. 47, 4, p. 424-430 7 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Metabolism
Hepatocytes
Ethanol
Wounds and Injuries
3 Citations (Scopus)

Human liver thermostable phenol sulfotransferase its PST: CDNA cloning, bacterial expression and characterization

Clemens, D. L., Cole, J., Kudlacek, P., Halgard, C. & Andersen, R., Dec 1 1996, In : FASEB Journal. 10, 3, p. A284

Research output: Contribution to journalArticle

Arylsulfotransferase
sulfotransferases
Cloning
Liver
phenol
12 Citations (Scopus)

Impairment of the asialoglycoprotein receptor by ethanol oxidation

Clemens, D. L., Halgard, C. M., Cole, J. R., Miles, R. M., Sorrell, M. F. & Tuma, D. J., Nov 22 1996, In : Biochemical Pharmacology. 52, 10, p. 1499-1505 7 p.

Research output: Contribution to journalArticle

Asialoglycoprotein Receptor
Ethanol
Oxidation
Ligands
Alcohol Dehydrogenase
6 Citations (Scopus)

Inhibition of CYP2E1 leads to decreased advanced glycated end product formation in high glucose treated ADH and CYP2E1 over-expressing VL-17A cells

Swaminathan, K., Kumar, S. M., Clemens, D. L. & Dey, A., Jul 3 2013, In : Biochimica et Biophysica Acta - General Subjects. 1830, 10, p. 4407-4416 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Oxidative stress
Oxidative Stress
Glucose
Liver
14 Citations (Scopus)

Inhibition of CYP2E1 leads to decreased malondialdehyde-acetaldehyde adduct formation in VL-17A cells under chronic alcohol exposure

Swaminathan, K., Clemens, D. L. & Dey, A., Mar 14 2013, In : Life Sciences. 92, 6-7, p. 325-336 12 p.

Research output: Contribution to journalArticle

Acetaldehyde
Cytochromes
Malondialdehyde
Alcohol Dehydrogenase
Alcohols
48 Citations (Scopus)
Hep G2 Cells
Proteasome Endopeptidase Complex
Cytochromes
Interferon-gamma
Ethanol
9 Citations (Scopus)

In Vitro Evidence for Chronic Alcohol and High Glucose Mediated Increased Oxidative Stress and Hepatotoxicity

Chandrasekaran, K., Swaminathan, K., Mathan Kumar, S., Clemens, D. L. & Dey, A., Jun 2012, In : Alcoholism: Clinical and Experimental Research. 36, 6, p. 487-495 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Oxidative stress
Oxidative Stress
Alcohols
Toxicity

In vitro evidence for chronic alcohol and high glucose mediated increased oxidative stress and hepatotoxicity.

Chandrasekaran, K., Swaminathan, K., Mathan Kumar, S., Clemens, D. L. & Dey, A., Jun 2012, In : Alcoholism, clinical and experimental research. 36, 6, p. 1004-1012 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Oxidative stress
Oxidative Stress
Alcohols
Toxicity
17 Citations (Scopus)

Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells

Choudhury, M., Pandey, R. S., Clemens, D. L., Davis, J. W., Lim, R. W. & Shukla, S. D., Jun 1 2011, In : Alcohol. 45, 4, p. 311-324 14 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Acetylation
Histones
Small Interfering RNA
Hepatocellular Carcinoma
9 Citations (Scopus)
Extracellular Matrix
Hepatocytes
Ethanol
Liver
Digitonin
39 Citations (Scopus)

Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: Role of nonoxidative metabolism

Wu, H., Cai, P., Clemens, D. L., Jerrells, T. R., Ansari, G. A. S. & Kaphalia, B. S., Oct 15 2006, In : Toxicology and Applied Pharmacology. 216, 2, p. 238-247 10 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Cytotoxicity
Metabolism
Ethanol
Alcohol Dehydrogenase
23 Citations (Scopus)

Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats

Das, S., Hajnóczky, N., Antony, A. N., Csordás, G., Gaspers, L. D., Clemens, D. L., Hoek, J. B. & Hajnóczky, G., Jul 1 2012, In : Pflugers Archiv European Journal of Physiology. 464, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Mitochondria
Rats
Hepatocytes
Ethanol
2 Citations (Scopus)

Modulation of GSH with exogenous agents leads to changes in glyoxalase 1 enzyme activity in VL-17A cells exposed to chronic alcohol plus high glucose

Kumar, S. M., Swaminathan, K., Clemens, D. L. & Dey, A., Feb 1 2014, In : Food and Function. 5, 2, p. 345-358 14 p.

Research output: Contribution to journalArticle

diethyl maleate
ursodeoxycholic acid
Buthionine Sulfoximine
maleates
Ursodeoxycholic Acid

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis

Liu, X., Clemens, D. L., Grunkemeyer, J. A., Price, J. D., O’Connell, K., Chapman, N. M., Storz, P., Wen, H., Cox, J. L., Reid, W. L., Hollingsworth, M. A. & Thayer, S., Dec 1 2019, In : Scientific reports. 9, 1, 10656.

Research output: Contribution to journalArticle

Open Access
Mucin-1
Enterovirus
Pancreatitis
Macrophages
Inflammation
44 Citations (Scopus)

Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells

Thomes, P. G., Ehlers, R. A., Trambly, C. S., Clemens, D. L., Fox, H. S., Tuma, D. J. & Donohue, T., Jan 2013, In : Autophagy. 9, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Ethanol
Cytochrome P-450 CYP2E1
Alcohol Dehydrogenase
Acetaldehyde
3 Citations (Scopus)

Novel antioxidant properties of doxycycline

Clemens, D. L., Duryee, M. J., Sarmiento, C., Chiou, A., McGowan, J. D., Hunter, C. D., Schlichte, S. L., Tian, J., Klassen, L. W., O'Dell, J. R., Thiele, G. M., Mikuls, T. R., Zimmerman, M. C. & Anderson, D. R., Jan 1 2018, In : International journal of molecular sciences. 19, 12, 4078.

Research output: Contribution to journalArticle

Acetaldehyde
Doxycycline
acetaldehyde
antioxidants
Antioxidants
88 Citations (Scopus)
Cytochrome P-450 CYP2E1
Alcohol Dehydrogenase
Hep G2 Cells
Cytotoxicity
Ethanol
13 Citations (Scopus)

Regulated expression of the feline panleukopenia virus P38 promoter on extrachromosomal FPV/EBV chimeric plasmids

Clemens, D. L. & Carlson, J. O., Jan 1 1989, In : Journal of virology. 63, 6, p. 2737-2745 9 p.

Research output: Contribution to journalArticle

Feline Panleukopenia Virus
Galactosidases
Human herpesvirus 4
Carnivore protoparvovirus 1
Human Herpesvirus 4
60 Citations (Scopus)

Relationship between acetaldehyde levels and cell survival in ethanol-metabolizing hepatoma cells

Clemens, D. L., Forman, A., Jerrells, T. R., Sorrell, M. F. & Tuma, D. J., Jan 1 2002, In : Hepatology. 35, 5, p. 1196-1204 9 p.

Research output: Contribution to journalArticle

Acetaldehyde
Hepatocellular Carcinoma
Cell Survival
Ethanol
2-Propanol
8 Citations (Scopus)

Retinoid regulation of antiviral innate immunity in hepatocytes

Cho, N. E., Bang, B. R., Gurung, P., Li, M., Clemens, D. L., Underhill, T. M., James, L. P., Chase, J. R. & Saito, T., Jan 1 2016, In : Hepatology. 63, 6, p. 1783-1795 13 p.

Research output: Contribution to journalArticle

Retinoids
Tretinoin
Aldehyde Dehydrogenase
Innate Immunity
Alcohol Dehydrogenase
48 Citations (Scopus)

Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells

Venugopal, S. K., Chen, J., Zhang, Y., Clemens, D. L., Follenzi, A. & Zern, M. A., Nov 2 2007, In : Journal of Biological Chemistry. 282, 44, p. 31900-31908 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Phosphatases
Dual Specificity Phosphatase 1
JNK Mitogen-Activated Protein Kinases
Hepatocytes
Ethanol