Dahn L Clemens, PhD

Associate Professor

  • 1821 Citations
  • 22 h-Index
1989 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1989 2019

  • 1821 Citations
  • 22 h-Index
  • 57 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/debate
2019

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis

Liu, X., Clemens, D. L., Grunkemeyer, J. A., Price, J. D., O’Connell, K., Chapman, N. M., Storz, P., Wen, H., Cox, J. L., Reid, W. L., Hollingsworth, M. A. & Thayer, S., Dec 1 2019, In : Scientific reports. 9, 1, 10656.

Research output: Contribution to journalArticle

Open Access
Mucin-1
Enterovirus
Pancreatitis
Macrophages
Inflammation
2018
2 Citations (Scopus)

Novel antioxidant properties of doxycycline

Clemens, D. L., Duryee, M. J., Sarmiento, C., Chiou, A., McGowan, J. D., Hunter, C. D., Schlichte, S. L., Tian, J., Klassen, L. W., O'Dell, J. R., Thiele, G. M., Mikuls, T. R., Zimmerman, M. C. & Anderson, D. R., Jan 1 2018, In : International journal of molecular sciences. 19, 12, 4078.

Research output: Contribution to journalArticle

Acetaldehyde
Doxycycline
acetaldehyde
antioxidants
Antioxidants
2017
1 Citation (Scopus)

A combination of dietary N-3 fatty acids and a cyclooxygenase-1 inhibitor attenuates nonalcoholic fatty liver disease in mice

Viswanathan, S., Perriotte-Olson, C., Ganesan, M., Desouza, C. V., Alnouti, Y., Duryee, M. J., Thiele, G. M., Nordgren, T. M. & Clemens, D. L., Apr 1 2017, In : Journal of Nutritional Biochemistry. 42, p. 149-159 11 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Cyclooxygenase Inhibitors
Omega-3 Fatty Acids
Liver
Lipids
8 Citations (Scopus)

Direct antioxidant properties of methotrexate: Inhibition of malondialdehyde-acetaldehyde-protein adduct formation and superoxide scavenging

Zimmerman, M. C., Clemens, D. L., Duryee, M. J., Sarmiento, C., Chiou, A., Hunter, C. D., Tian, J., Klassen, L. W., O'Dell, J. R., Thiele, G. M., Mikuls, T. R. & Anderson, D. R., Oct 2017, In : Redox Biology. 13, p. 588-593 6 p.

Research output: Contribution to journalArticle

Acetaldehyde
Scavenging
Malondialdehyde
Methotrexate
Superoxides
2 Citations (Scopus)

The effects of changes in glutathione levels through exogenous agents on intracellular cysteine content and protein adduct formation in chronic alcohol-treated VL17A cells

Kumar, S. M., Haridoss, M., Swaminathan, K., Gopal, R. K., Clemens, D. L. & Dey, A., Feb 12 2017, In : Toxicology Mechanisms and Methods. 27, 2, p. 128-135 8 p.

Research output: Contribution to journalArticle

Glutathione
Cysteine
Alcohols
Liver
Proteins
2016
8 Citations (Scopus)

Retinoid regulation of antiviral innate immunity in hepatocytes

Cho, N. E., Bang, B. R., Gurung, P., Li, M., Clemens, D. L., Underhill, T. M., James, L. P., Chase, J. R. & Saito, T., Jan 1 2016, In : Hepatology. 63, 6, p. 1783-1795 13 p.

Research output: Contribution to journalArticle

Retinoids
Tretinoin
Aldehyde Dehydrogenase
Innate Immunity
Alcohol Dehydrogenase
3 Citations (Scopus)

The involvement of acetaldehyde in ethanol-induced cell cycle impairment

Scheer, M. A., Schneider, K. J., Finnigan, R. L., Maloney, E. P., Wells, M. A. & Clemens, D. L., Mar 31 2016, In : Biomolecules. 6, 2

Research output: Contribution to journalArticle

Acetaldehyde
Cell Cycle
Ethanol
Cells
G2 Phase Cell Cycle Checkpoints
2015
7 Citations (Scopus)
Asialoglycoprotein Receptor
Monomeric GTP-Binding Proteins
Hepatocytes
Ethanol
Down-Regulation
14 Citations (Scopus)

Free fatty acids enhance the oxidative damage induced by ethanol metabolism in an in vitro model

Hernández, I., Domínguez-Pérez, M., Bucio, L., Souza, V., Miranda, R. U., Clemens, D. L., Gomez-Quiroz, L. E. & Gutiérrez-Ruiz, M. C., Feb 1 2015, In : Food and Chemical Toxicology. 76, p. 109-115 7 p.

Research output: Contribution to journalArticle

Nonesterified Fatty Acids
Metabolism
free fatty acids
Ethanol
ethanol
9 Citations (Scopus)

GSH protects against oxidative stress and toxicity in VL-17A cells exposed to high glucose

Kumar, S. M., Swaminathan, K., Clemens, D. L. & Dey, A., Jan 1 2015, In : European Journal of Nutrition. 54, 2, p. 223-234 12 p.

Research output: Contribution to journalArticle

Oxidative Stress
diethyl maleate
Glucose
Lactoylglutathione Lyase
Ursodeoxycholic Acid
2014
2 Citations (Scopus)

Modulation of GSH with exogenous agents leads to changes in glyoxalase 1 enzyme activity in VL-17A cells exposed to chronic alcohol plus high glucose

Kumar, S. M., Swaminathan, K., Clemens, D. L. & Dey, A., Feb 1 2014, In : Food and Function. 5, 2, p. 345-358 14 p.

Research output: Contribution to journalArticle

diethyl maleate
ursodeoxycholic acid
Buthionine Sulfoximine
maleates
Ursodeoxycholic Acid
2013
1 Citation (Scopus)
Cytochrome P-450 CYP2E1
Oxidative stress
Hyperglycemia
Alcohol Drinking
Liver
6 Citations (Scopus)

Inhibition of CYP2E1 leads to decreased advanced glycated end product formation in high glucose treated ADH and CYP2E1 over-expressing VL-17A cells

Swaminathan, K., Kumar, S. M., Clemens, D. L. & Dey, A., Jul 3 2013, In : Biochimica et Biophysica Acta - General Subjects. 1830, 10, p. 4407-4416 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Oxidative stress
Oxidative Stress
Glucose
Liver
14 Citations (Scopus)

Inhibition of CYP2E1 leads to decreased malondialdehyde-acetaldehyde adduct formation in VL-17A cells under chronic alcohol exposure

Swaminathan, K., Clemens, D. L. & Dey, A., Mar 14 2013, In : Life Sciences. 92, 6-7, p. 325-336 12 p.

Research output: Contribution to journalArticle

Acetaldehyde
Cytochromes
Malondialdehyde
Alcohol Dehydrogenase
Alcohols
43 Citations (Scopus)

Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells

Thomes, P. G., Ehlers, R. A., Trambly, C. S., Clemens, D. L., Fox, H. S., Tuma, D. J. & Donohue, T., Jan 2013, In : Autophagy. 9, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Ethanol
Cytochrome P-450 CYP2E1
Alcohol Dehydrogenase
Acetaldehyde
2012
8 Citations (Scopus)

Ethanol administration impairs pancreatic repair after injury

Schneider, K. J. M., Scheer, M., Suhr, M. & Clemens, D. L., Nov 1 2012, In : Pancreas. 41, 8, p. 1272-1279 8 p.

Research output: Contribution to journalArticle

Ethanol
Alcoholic Pancreatitis
Alcoholism
Wounds and Injuries
Exocrine Pancreas
16 Citations (Scopus)

Hepatic mitochondrial dysfunction induced by fatty acids and ethanol

Gyamfi, D., Everitt, H. E., Tewfik, I., Clemens, D. L. & Patel, V. B., Dec 1 2012, In : Free Radical Biology and Medicine. 53, 11, p. 2131-2145 15 p.

Research output: Contribution to journalArticle

Liver
Ethanol
Fatty Acids
Arachidonic Acid
Palmitic Acid
11 Citations (Scopus)

Increased oxidative stress and toxicity in ADH and CYP2E1 overexpressing human hepatoma VL-17A cells exposed to high glucose

Chandrasekaran, K., Swaminathan, K., Kumar, S. M., Clemens, D. L. & Dey, A., May 1 2012, In : Integrative Biology. 4, 5, p. 550-563 14 p.

Research output: Contribution to journalReview article

Cytochrome P-450 CYP2E1
Oxidative stress
Alcohol Dehydrogenase
Toxicity
Hepatocellular Carcinoma
9 Citations (Scopus)

In Vitro Evidence for Chronic Alcohol and High Glucose Mediated Increased Oxidative Stress and Hepatotoxicity

Chandrasekaran, K., Swaminathan, K., Mathan Kumar, S., Clemens, D. L. & Dey, A., Jun 2012, In : Alcoholism: Clinical and Experimental Research. 36, 6, p. 487-495 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Oxidative stress
Oxidative Stress
Alcohols
Toxicity

In vitro evidence for chronic alcohol and high glucose mediated increased oxidative stress and hepatotoxicity.

Chandrasekaran, K., Swaminathan, K., Mathan Kumar, S., Clemens, D. L. & Dey, A., Jun 2012, In : Alcoholism, clinical and experimental research. 36, 6, p. 1004-1012 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Oxidative stress
Oxidative Stress
Alcohols
Toxicity
23 Citations (Scopus)

Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats

Das, S., Hajnóczky, N., Antony, A. N., Csordás, G., Gaspers, L. D., Clemens, D. L., Hoek, J. B. & Hajnóczky, G., Jul 1 2012, In : Pflugers Archiv European Journal of Physiology. 464, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Mitochondria
Rats
Hepatocytes
Ethanol
2011
7 Citations (Scopus)
Cytochrome P-450 CYP2E1
Alcohol Dehydrogenase
Glutathione
Oxidative stress
Hepatocellular Carcinoma
6 Citations (Scopus)

Ethanol metabolism activates cell cycle checkpoint kinase, Chk2

Clemens, D. L., Mahan Schneider, K. J. & Nuss, R. F., Dec 1 2011, In : Alcohol. 45, 8, p. 785-793 9 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Metabolism
Ataxia Telangiectasia
Ethanol
Phosphotransferases
17 Citations (Scopus)

Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells

Choudhury, M., Pandey, R. S., Clemens, D. L., Davis, J. W., Lim, R. W. & Shukla, S. D., Jun 1 2011, In : Alcohol. 45, 4, p. 311-324 14 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Acetylation
Histones
Small Interfering RNA
Hepatocellular Carcinoma
13 Citations (Scopus)

Zinc deprivation mediates alcohol-induced hepatocyte IL-8 analog expression in rodents via an epigenetic mechanism

Zhao, Y., Zhong, W., Sun, X., Song, Z., Clemens, D. L., Kang, Y. J., McClain, C. J. & Zhou, Z., Aug 1 2011, In : American Journal of Pathology. 179, 2, p. 693-702 10 p.

Research output: Contribution to journalArticle

Interleukin-8
Epigenomics
Zinc
Hepatocytes
Rodentia
2010
19 Citations (Scopus)

Alcoholic pancreatitis: Lessons from the liver

Clemens, D. L. & Mahan, K. J., Mar 21 2010, In : World Journal of Gastroenterology. 16, 11, p. 1314-1320 7 p.

Research output: Contribution to journalArticle

Alcoholic Pancreatitis
Alcoholism
Liver
Pancreatitis
Pancreas
286 Citations (Scopus)

Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice

Ding, W., Li, M., Chen, X., Ni, H., Lin, C., Gao, W., Lu, B., Stolz, D. B., Clemens, D. L. & Yin, X., Nov 2010, In : Gastroenterology. 139, 5, p. 1740-1752 13 p.

Research output: Contribution to journalArticle

Autophagy
Ethanol
Liver
Hepatocytes
Alcoholic Liver Diseases
2009
4 Citations (Scopus)

A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells

Kim, T. H., Venugopal, S. K., Zhu, M., Wang, S. S., Lau, D., Lam, K. S., Clemens, D. L. & Zern, M. A., Feb 20 2009, In : Biochemical and Biophysical Research Communications. 379, 4, p. 876-881 6 p.

Research output: Contribution to journalArticle

Oxidative stress
Ethanol
Green Fluorescent Proteins
Alcohols
Apoptosis
37 Citations (Scopus)

Hepatocyte growth factor protects hepatocytes against oxidative injury induced by ethanol metabolism

Valdés-Arzate, A., Luna, A., Bucio, L., Licona, C., Clemens, D. L., Souza, V., Hernandez, E., Kershenobich, D., Gutiérrez-Ruiz, M. C. & Gómez-Quiroz, L. E., Aug 15 2009, In : Free Radical Biology and Medicine. 47, 4, p. 424-430 7 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Metabolism
Hepatocytes
Ethanol
Wounds and Injuries
2007
14 Citations (Scopus)

Effects of ethanol on hepatic cellular replication and cell cycle progression

Clemens, D. L., Oct 7 2007, In : World Journal of Gastroenterology. 13, 37, p. 4955-4959 5 p.

Research output: Contribution to journalReview article

Cell Cycle
Ethanol
Liver
NAD
Acetaldehyde

Erratum to "Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: Role of nonoxidative metabolism" [Toxicol. Appl. Pharmacol. 216 (2006) 238-247] (DOI:10.1016/j.taap.2006.05.003)

Wu, H., Cai, P., Clemens, D. L., Jerrells, T. R., Ansari, G. A. S. & Kaphalia, B. S., Apr 1 2007, In : Toxicology and Applied Pharmacology. 220, 1, p. 111-112 2 p.

Research output: Contribution to journalComment/debate

Hep G2 Cells
Ethanol
38 Citations (Scopus)

Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells

Osna, N. A., White, R. L., Todero, S., McVicker, B. L., Thiele, G. M., Clemens, D. L., Tuma, D. J. & Donohue, T., Jan 1 2007, In : Hepatology. 45, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

Antigen Presentation
Hepatocellular Carcinoma
Oxidative Stress
Ethanol
Peptides
48 Citations (Scopus)

Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells

Venugopal, S. K., Chen, J., Zhang, Y., Clemens, D. L., Follenzi, A. & Zern, M. A., Nov 2 2007, In : Journal of Biological Chemistry. 282, 44, p. 31900-31908 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Phosphatases
Dual Specificity Phosphatase 1
JNK Mitogen-Activated Protein Kinases
Hepatocytes
Ethanol
2006
197 Citations (Scopus)

Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression

Harrison-Findik, D. D., Schafer, D. F., Klein, E., Timchenko, N. A., Kulaksiz, H., Clemens, D. L., Fein, E., Andriopoulos, B., Pantopoulos, K. & Gollan, J., Aug 11 2006, In : Journal of Biological Chemistry. 281, 32, p. 22974-22982 9 p.

Research output: Contribution to journalArticle

Hepcidins
Oxidative stress
Transcription
Metabolism
Oxidative Stress
39 Citations (Scopus)

Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: Role of nonoxidative metabolism

Wu, H., Cai, P., Clemens, D. L., Jerrells, T. R., Ansari, G. A. S. & Kaphalia, B. S., Oct 15 2006, In : Toxicology and Applied Pharmacology. 216, 2, p. 238-247 10 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Cytotoxicity
Metabolism
Ethanol
Alcohol Dehydrogenase
87 Citations (Scopus)
Cytochrome P-450 CYP2E1
Alcohol Dehydrogenase
Hep G2 Cells
Cytotoxicity
Ethanol
10 Citations (Scopus)

Use of cultured cells to study alcohol metabolism

Clemens, D. L., Dec 1 2006, In : Alcohol Research and Health. 29, 4, p. 291-295 5 p.

Research output: Contribution to journalReview article

Cultured Cells
Alcohols
Alcoholic Liver Diseases
Confounding Factors (Epidemiology)
Metabolic Networks and Pathways
2005
43 Citations (Scopus)

Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells

Osna, N. A., Clemens, D. L. & Donohue, T., Nov 1 2005, In : Hepatology. 42, 5, p. 1109-1117 9 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Interferon-gamma
Ethanol
Phosphorylation
Cytochrome P-450 CYP2E1

Use of Isolated Cells in the Study of Ethanol-Induced Hepatotoxicity

Clemens, D. L., Jan 1 2005, Comprehensive Handbook of Alcohol Related Pathology. Elsevier Inc., Vol. 3-3. p. 1559-1572 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Liver
Ethanol
Alcoholic Liver Diseases
Hepatocytes
Metabolism
2004
30 Citations (Scopus)

Ethanol consumption potentiates viral pancreatitis and may inhibit pancreas regeneration: Preliminary findings

Clemens, D. L. & Jerrells, T. R., Jan 1 2004, In : Alcohol. 33, 3, p. 183-189 7 p.

Research output: Contribution to journalArticle

Alcoholic Pancreatitis
alcoholism
Pancreatitis
Regeneration
Pancreas
6 Citations (Scopus)

Suicide gene therapy: Conversion of ethanol to acetaldehyde mediated by human beta 2 alcohol dehydrogenase

Savage, P., Cowburn, P., Clemens, D. L., Hurley, T., Laguda, B., Martin-Duque, P., Vassaux, G. & Lemoine, N. R., Dec 1 2004, In : Cancer Gene Therapy. 11, 12, p. 774-781 8 p.

Research output: Contribution to journalArticle

Gene Conversion
Acetaldehyde
Genetic Therapy
Suicide
Ethanol
2003
31 Citations (Scopus)

Animal Model of Alcoholic Pancreatitis: Role of Viral Infections

Jerrells, T. R., Chapman, N. & Clemens, D. L., Nov 1 2003, In : Pancreas. 27, 4, p. 301-304 4 p.

Research output: Contribution to journalArticle

Alcoholic Pancreatitis
Virus Diseases
Pancreatitis
Animal Models
Enterovirus
24 Citations (Scopus)

Ethanol metabolism results in a G2/M cell-cycle arrest in recombinant Hep G2 cells

Clemens, D. L., Calisto, L. E., Sorrell, M. F. & Tuma, D. J., Aug 1 2003, In : Hepatology. 38, 2, p. 385-393 9 p.

Research output: Contribution to journalArticle

G2 Phase Cell Cycle Checkpoints
Cyclin B1
Hep G2 Cells
Ethanol
Cell Cycle
47 Citations (Scopus)
Hep G2 Cells
Proteasome Endopeptidase Complex
Cytochromes
Interferon-gamma
Ethanol
2002
268 Citations (Scopus)

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

Roy, H. K., Olusola, B. F., Clemens, D. L., Karolski, W. J., Ratashak, A., Lynch, H. T. & Smyrk, T. C., Mar 21 2002, In : Carcinogenesis. 23, 1, p. 201-205 5 p.

Research output: Contribution to journalArticle

Proto-Oncogenes
Colon
Carcinogenesis
Azoxymethane
Neoplasms
60 Citations (Scopus)

Relationship between acetaldehyde levels and cell survival in ethanol-metabolizing hepatoma cells

Clemens, D. L., Forman, A., Jerrells, T. R., Sorrell, M. F. & Tuma, D. J., Jan 1 2002, In : Hepatology. 35, 5, p. 1196-1204 9 p.

Research output: Contribution to journalArticle

Acetaldehyde
Hepatocellular Carcinoma
Cell Survival
Ethanol
2-Propanol
2001
27 Citations (Scopus)

Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3′,5-triiodothyronine as the substrate

Li, X., Clemens, D. L., Cole, J. R. & Anderson, R. J., Dec 1 2001, In : Journal of Endocrinology. 171, 3, p. 525-532 8 p.

Research output: Contribution to journalArticle

Arylsulfotransferase
Sulfotransferases
Triiodothyronine
Isoenzymes
Liver
27 Citations (Scopus)
Janus Kinases
Hep G2 Cells
Transducers
Metabolism
Rats
15 Citations (Scopus)

Use of cultured cells in assessing ethanol toxicity and ethanol-related metabolism

Donohue, J., Clemens, D. L., Galli, A., Crabb, D., Nieto, N., Kato, J. & Barve, S. S., Jun 27 2001, In : Alcoholism: Clinical and Experimental Research. 25, 5 SUPPL., p. 87S-93S

Research output: Contribution to journalArticle

Metabolism
Toxicity
Cultured Cells
Ethanol
Cells
2000
30 Citations (Scopus)

Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)

Li, X., Clemens, D. L. & Anderson, R. J., Dec 1 2000, In : Biochemical Pharmacology. 60, 11, p. 1713-1716 4 p.

Research output: Contribution to journalArticle

Sulfotransferases
Thyroid Hormones
Reverse Triiodothyronine
Thyroid Gland
Enzymes