• 2823 Citations
  • 30 h-Index
19992019
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Research Output 1999 2019

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Review article
2019
1 Citation (Scopus)

Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases

Sharma, S. & Hopkins, C. R., Sep 12 2019, In : Journal of Medicinal Chemistry. 62, 17, p. 7589-7602 14 p.

Research output: Contribution to journalReview article

Transient Receptor Potential Channels
Chronic Renal Insufficiency
Cations
Kidney
Brain
2017
14 Citations (Scopus)

Return of D4 Dopamine Receptor Antagonists in Drug Discovery

Lindsley, C. W. & Hopkins, C. R., Jan 1 2017, In : Journal of Medicinal Chemistry. 60, 17, p. 7233-7243 11 p.

Research output: Contribution to journalReview article

Dopamine Antagonists
Clozapine
Drug Discovery
Parkinson Disease
Dopamine D4 Receptors
2016
9 Citations (Scopus)

Inhibitors of the bone morphogenetic protein (BMP) signaling pathway: a patent review (2008-2015)

Hopkins, C. R., Oct 2 2016, In : Expert Opinion on Therapeutic Patents. 26, 10, p. 1115-1128 14 p.

Research output: Contribution to journalReview article

Bone Morphogenetic Proteins
Anemia
Atherosclerosis
Body Patterning
Myositis Ossificans
75 Citations (Scopus)

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

Lindsley, C. W., Emmitte, K. A., Hopkins, C. R., Bridges, T. M., Gregory, K. J., Niswender, C. M. & Conn, P. J., Jun 8 2016, In : Chemical Reviews. 116, 11, p. 6707-6741 35 p.

Research output: Contribution to journalReview article

Metabotropic Glutamate Receptors
Modulators
Ligands
Metabolism
Conformations
2015
74 Citations (Scopus)

Advancing biological understanding and therapeutics discovery with small-molecule probes

Schreiber, S. L., Kotz, J. D., Li, M., Aubé, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., Clemons, P. A., De Souza, A., Foley, M. A., Palmer, M., Shamji, A. F., Wawer, M. J., McManus, O., Wu, M. & 26 others, Zou, B., Yu, H., Golden, J. E., Schoenen, F. J., Simeonov, A., Jadhav, A., Jackson, M. R., Pinkerton, A. B., Chung, T. D. Y., Griffin, P. R., Cravatt, B. F., Hodder, P. S., Roush, W. R., Roberts, E., Chung, D. H., Jonsson, C. B., Noah, J. W., Severson, W. E., Ananthan, S., Edwards, B., Oprea, T. I., Conn, P. J., Hopkins, C. R., Wood, M. R., Stauffer, S. R. & Emmitte, K. A., Jan 1 2015, In : Cell. 161, 6, p. 1252-1265 14 p.

Research output: Contribution to journalReview article

Molecules
Biological Phenomena
Therapeutics
Biological systems
Medicine
2012
24 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on begacestat (GSI-953)

Hopkins, C. R., Jan 18 2012, In : ACS Chemical Neuroscience. 3, 1, p. 3-4 2 p.

Research output: Contribution to journalReview article

Neurosciences
Thiophenes
Amyloid Precursor Protein Secretases
Clinical Trials, Phase I
Molecules
4 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on BMS-708163

Hopkins, C. R., Mar 21 2012, In : ACS Chemical Neuroscience. 3, 3, p. 149-150 2 p.

Research output: Contribution to journalReview article

Amyloid Precursor Protein Secretases
Phase II Clinical Trials
Sulfonamides
Neurosciences
Alzheimer Disease
2 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on potiga (Ezogabine)

Hopkins, C. R., Aug 15 2012, In : ACS Chemical Neuroscience. 3, 8, 1 p.

Research output: Contribution to journalReview article

Neurosciences
Molecules
United States Food and Drug Administration
Seizures
Pharmaceutical Preparations
9 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on suvorexant

Hopkins, C. R., Sep 19 2012, In : ACS Chemical Neuroscience. 3, 9, p. 647-648 2 p.

Research output: Contribution to journalReview article

Phase III Clinical Trials
Neurosciences
Sleep
Placebos
Molecules
162 Citations (Scopus)

Allosteric modulation of seven transmembrane spanning receptors: Theory, practice, and opportunities for central nervous system drug discovery

Melancon, B. J., Hopkins, C. R., Wood, M. R., Emmitte, K. A., Niswender, C. M., Christopoulos, A., Conn, P. J. & Lindsley, C. W., Feb 23 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1445-1464 20 p.

Research output: Contribution to journalReview article

Allosteric Regulation
Central Nervous System Agents
Metabotropic Glutamate Receptors
Muscarinic Receptors
Drug Discovery
26 Citations (Scopus)
Patents
Parkinson Disease
Therapeutics
Pain
Glutamate Receptors
2011
31 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on ELND006: Another γ-secretase inhibitor fails in the clinic

Hopkins, C. R., Jun 15 2011, In : ACS Chemical Neuroscience. 2, 6, p. 279-280 2 p.

Research output: Contribution to journalReview article

Amyloid Precursor Protein Secretases
Neurosciences
N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide
Alzheimer Disease
Clinical Trials
2 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on STX209 (Arbaclofen)

Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, 1 p.

Research output: Contribution to journalReview article

GABA-B Receptor Agonists
Butyric Acid
Neurosciences
Molecules
Industry
2 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on telcagepant (MK-0974)

Hopkins, C. R., Jul 20 2011, In : ACS Chemical Neuroscience. 2, 7, p. 334-335 2 p.

Research output: Contribution to journalReview article

Neurosciences
Molecules
Calcitonin Gene-Related Peptide Receptors
Phase III Clinical Trials
Migraine Disorders
30 Citations (Scopus)

Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics

Robichaud, A. J., Engers, D. W., Lindsley, C. W. & Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, p. 433-449 17 p.

Research output: Contribution to journalReview article

Neurology
Central Nervous System
Ligands
Pharmacokinetics
Solubility
2010
46 Citations (Scopus)

The antipsychotic potential of muscarinic allosteric modulation

Bridges, T. M., LeBois, E. P., Hopkins, C. R., Wood, M. R., Jones, C. K., Conn, P. J. & Lindsley, C. W., May 1 2010, In : Drug News and Perspectives. 23, 4, p. 229-240 12 p.

Research output: Contribution to journalReview article

xanomeline
Cholinergic Agents
Antipsychotic Agents
Muscarinic Receptors
Ligands
2009
51 Citations (Scopus)

MGluR4-positive allosteric modulation as potential treatment for Parkinson's disease

Hopkins, C. R., Lindsley, C. W. & Niswender, C. M., Jun 1 2009, In : Future Medicinal Chemistry. 1, 3, p. 501-513 13 p.

Research output: Contribution to journalReview article

Parkinson Disease
Therapeutics
Nerve Degeneration
Metabotropic Glutamate Receptors
Dopaminergic Neurons
35 Citations (Scopus)

Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease

Lindsley, C. W., Niswender, C. M., Engers, D. W. & Hopkins, C. R., Dec 1 2009, In : Current Topics in Medicinal Chemistry. 9, 10, p. 949-963 15 p.

Research output: Contribution to journalReview article

Parkinson Disease
Explosions
Basal Ganglia
metabotropic glutamate receptor 4
2008

Molecule of the month

Hopkins, C. R., Dec 1 2008, In : Current Topics in Medicinal Chemistry. 8, 18, p. 1710-1711 2 p.

Research output: Contribution to journalReview article