Corey R Hopkins, PhD

Associate Professor

  • 2520 Citations
  • 28 h-Index
19992019
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Modulators Chemical Compounds
Molecules Chemical Compounds
Neurosciences Medicine & Life Sciences
Structure-Activity Relationship Medicine & Life Sciences
Inwardly Rectifying Potassium Channel Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Scaffolds Chemical Compounds
Pharmacology Medicine & Life Sciences

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Research Output 1999 2019

Transient Receptor Potential Channels
Amines
Chronic Renal Insufficiency
Podocytes
Scaffolds

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

Sharma, S., Kozek, K. A., Abney, K. K., Kumar, S., Gautam, N., Alnouti, Y., David Weaver, C. & Hopkins, C. R., Mar 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 6, p. 791-796 6 p.

Research output: Contribution to journalArticle

G Protein-Coupled Inwardly-Rectifying Potassium Channels
Acetamides
Inwardly Rectifying Potassium Channel
Potassium Channels
GTP-Binding Proteins

The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate

Panarese, J. D., Engers, D. W., Wu, Y. J., Guernon, J. M., Chun, A., Gregro, A. R., Bender, A. M., Capstick, R. A., Wieting, J. M., Bronson, J. J., Macor, J. E., Westphal, R., Soars, M., Engers, J. E., Felts, A. S., Rodriguez, A. L., Emmitte, K. A., Jones, C. K., Blobaum, A. L., Jeffrey Conn, P. & 3 othersNiswender, C. M., Hopkins, C. R. & Lindsley, C. W., Jan 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 2, p. 342-346 5 p.

Research output: Contribution to journalArticle

Modulators
1 Citations (Scopus)

Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992

Kharade, S. V., Kurata, H., Bender, A. M., Blobaum, A. L., Figueroa, E. E., Duran, A., Kramer, M., Days, E., Vinson, P., Flores, D., Satlin, L. M., Meiler, J., Weaver, C. D., Lindsley, C. W., Hopkins, C. R. & Denton, J. S., Aug 1 2018, In : Molecular Pharmacology. 94, 2, p. 926-937 12 p.

Research output: Contribution to journalArticle

Potassium Channel Blockers
Electrolytes
Electrophysiology
Kidney
Inhibitory Concentration 50
2 Citations (Scopus)

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)

Bollinger, S. R., Engers, D. W., Panarese, J. D., West, M., Engers, J. L., Loch, M. T., Rodriguez, A. L., Blobaum, A. L., Jones, C. K., Thompson Gray, A., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Jan 1 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Cytochrome P-450 CYP1A2
Catalepsy
Haloperidol
Inhibitory Concentration 50