Channabasavaiah B Gurumurthy, DVM, PhD, MBA

Assistant Professor

  • 938 Citations
  • 18 h-Index
20002019
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Research Output 2000 2019

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Article
2019
1 Citation (Scopus)

Ca2+ sensor synaptotagmin-1 mediates exocytosis in mammalian photoreceptors

Grassmeyer, J. J., Cahill, A. L., Hays, C. L., Barta, C., Quadros, R. M., Gurumurthy, C. B. & Thoreson, W. B., Jun 2019, In : eLife. 8, e45946.

Research output: Contribution to journalArticle

Open Access
Synaptotagmin I
Exocytosis
Sensors
Vertebrate Photoreceptor Cells
Cones
1 Citation (Scopus)

Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of zygotes by i-GONAD

Gurumurthy, C. B., Sato, M., Nakamura, A., Inui, M., Kawano, N., Islam, M. A., Ogiwara, S., Takabayashi, S., Matsuyama, M., Nakagawa, S., Miura, H. & Ohtsuka, M., Aug 1 2019, In : Nature protocols. 14, 8, p. 2452-2482 31 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Zygote
Genes
Nucleic Acids
Genome
5 Citations (Scopus)

Generating mouse models for biomedical research: Technological advances

Gurumurthy, C. B. & Lloyd, K. C. K., Jan 2019, In : DMM Disease Models and Mechanisms. 12, 1, dmm.029462.

Research output: Contribution to journalArticle

Biomedical Research
Genes
Genome
Endonucleases
Stem cells

Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I

Gomez-Ospina, N., Scharenberg, S. G., Mostrel, N., Bak, R. O., Mantri, S., Quadros, R. M., Gurumurthy, C. B., Lee, C., Bao, G., Suarez, C. J., Khan, S., Sawamoto, K., Tomatsu, S., Raj, N., Attardi, L. D., Aurelian, L. & Porteus, M. H., Dec 1 2019, In : Nature communications. 10, 1, 4045.

Research output: Contribution to journalArticle

Open Access
Mucopolysaccharidosis I
stem cells
genome
Human Genome
Hematopoietic Stem Cells

Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection 11 Medical and Health Sciences 1107 Immunology

Dagur, R. S., Branch-Woods, A., Mathews, S., Joshi, P. S., Quadros, R. M., Harms, D. W., Cheng, Y., Miles, S. M., Pirruccello, S. J., Gurumurthy, C. B., Gorantla, S. & Poluektova, L. Y., Jan 7 2019, In : BMC Immunology. 20, 1, 2.

Research output: Contribution to journalArticle

Allergy and Immunology
HIV Infections
HIV-1
Glycoproteins
Lymphocytes

Looking Forward: Cutting-Edge Technologies and Skills for Pathologists in the Future

Janardhan, K. S., Kohnken, R., Turner, O. C., Gurumurthy, C. B. & Kovi, R. C., Dec 1 2019, In : Toxicologic Pathology. 47, 8, p. 1082-1087 6 p.

Research output: Contribution to journalArticle

Pathology
Technology
Clustered Regularly Interspaced Short Palindromic Repeats
Education
Artificial Intelligence
2 Citations (Scopus)

Neuron-Type Specific Loss of CDKL5 Leads to Alterations in mTOR Signaling and Synaptic Markers

Schroeder, E., Yuan, L., Seong, E., Ligon, C., DeKorver, N., Gurumurthy, C. B. & Arikkath, J., Jun 1 2019, In : Molecular Neurobiology. 56, 6, p. 4151-4162 12 p.

Research output: Contribution to journalArticle

Sirolimus
Neurons
Hippocampus
GABAergic Neurons
Calcium-Calmodulin-Dependent Protein Kinase Type 2

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation

Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M. C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., Demambro, V., D'Hont, J., Dibb, K. M., Eudy, J. D. & 93 others, Gan, L., Gao, J., Gonzales, A., Guntur, A. R., Guo, H., Harms, D. W., Harrington, A., Hentges, K. E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N. C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C. B., Li, L., Lindner, V., Liu, X. D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L. A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y. I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M. P., Ray, D., Redder, R. J., Rosen, C. J., Ross, N., Ruhe, M. T., Ryzhova, L., Salvador, A. M., Alam, S. S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A. W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B. J., Wright, C. S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D. J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A. D., Yoshiki, A., Schmouth, J. F., Golovko, A., Thompson, W. R., Lloyd, K. C. K., Wood, J. A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J. M. & Burgio, G., Aug 26 2019, In : Genome biology. 20, 1, 171.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
reproducibility
allele
Alleles
alleles

Subcellular localization of sterol biosynthesis enzymes

Koczok, K., Gurumurthy, C. B., Balogh, I., Korade, Z. & Mirnics, K., Feb 15 2019, In : Journal of Molecular Histology. 50, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

Sterols
Enzymes
Cholesterol
Transgenic Mice
Nuclear Envelope
2018
3 Citations (Scopus)

Antiretroviral drug metabolism in humanized PXR-CAR-CYP3A-NOG mice

McMillan, J. M., Cobb, D. A., Lin, Z., Banoub, M. G., Dagur, R. S., Branch Woods, A. A., Wang, W., Makarov, E., Kocher, T., Joshi, P. S., Quadros, R. M., Harms, D. W., Cohen, S. M., Gendelman, H. E., Gurumurthy, C. B., Gorantla, S. & Poluektova, L. Y., May 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 2, p. 272-280 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Ritonavir
Pharmaceutical Preparations
Liver
Virus Diseases
26 Citations (Scopus)

Easi-CRISPR for creating knock-in and conditional knockout mouse models using long ssDNA donors

Miura, H., Quadros, R. M., Gurumurthy, C. B. & Ohtsuka, M., Jan 1 2018, In : Nature protocols. 13, 1, p. 195-215 21 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Knockout Mice
Genes
Recombinases
Insertional Mutagenesis
18 Citations (Scopus)

I-GONAD: A robust method for in situ germline genome engineering using CRISPR nucleases

Ohtsuka, M., Sato, M., Miura, H., Takabayashi, S., Matsuyama, M., Koyano, T., Arifin, N., Nakamura, S., Wada, K. & Gurumurthy, C. B., Feb 26 2018, In : Genome biology. 19, 1, 25.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
nucleases
nucleic acid
Nucleic Acids
nucleic acids
6 Citations (Scopus)

Precise and efficient nucleotide substitution near genomic nick via noncanonical homology-directed repair

Nakajima, K., Zhou, Y., Tomita, A., Hirade, Y., Gurumurthy, C. B. & Nakada, S., Feb 2018, In : Genome Research. 28, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

Nucleotides
Plasmids
Clustered Regularly Interspaced Short Palindromic Repeats
Gene Editing
Genes
88 Citations (Scopus)

Reprogramming human T cell function and specificity with non-viral genome targeting

Roth, T. L., Puig-Saus, C., Yu, R., Shifrut, E., Carnevale, J., Li, P. J., Hiatt, J., Saco, J., Krystofinski, P., Li, H., Tobin, V., Nguyen, D. N., Lee, M. R., Putnam, A. L., Ferris, A. L., Chen, J. W., Schickel, J. N., Pellerin, L., Carmody, D., Alkorta-Aranburu, G. & 25 others, Del Gaudio, D., Matsumoto, H., Morell, M., Mao, Y., Cho, M., Quadros, R. M., Gurumurthy, C. B., Smith, B., Haugwitz, M., Hughes, S. H., Weissman, J. S., Schumann, K., Esensten, J. H., May, A. P., Ashworth, A., Kupfer, G. M., Greeley, S. A. W., Bacchetta, R., Meffre, E., Roncarolo, M. G., Romberg, N., Herold, K. C., Ribas, A., Leonetti, M. D. & Marson, A., Jul 19 2018, In : Nature. 559, 7714, p. 405-409 5 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor Specificity
T-Cell Antigen Receptor
Genome
T-Lymphocytes
Transgenes
2017
13 Citations (Scopus)

Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior

Jung, E. M., Moffat, J. J., Liu, J., Dravid, S. M., Gurumurthy, C. B. & Kim, W. Y., Dec 1 2017, In : Nature Neuroscience. 20, 12, p. 1694-1707 14 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Interneurons
Intellectual Disability
Social Behavior
GABA-A Receptors
83 Citations (Scopus)

Easi-CRISPR: A robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins

Quadros, R. M., Miura, H., Harms, D. W., Akatsuka, H., Sato, T., Aida, T., Redder, R., Richardson, G. P., Inagaki, Y., Sakai, D., Buckley-McKeown, S. M., Seshacharyulu, P., Batra, S. K., Behlke, M. A., Zeiner, S. A., Jacobi, A. M., Izu, Y., Thoreson, W. B., Urness, L. D., Mansour, S. L. & 2 others, Ohtsuka, M. & Gurumurthy, C. B., May 17 2017, In : Genome biology. 18, 1, 92.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
ribonucleoproteins
single-stranded DNA
Ribonucleoproteins
allele
1 Citation (Scopus)

Mammalian ECD protein is a novel negative regulator of the PERK arm of the unfolded protein response

Olou, A. A., Sarkar, A., Bele, A., Gurumurthy, C. B., Mir, R. A., Ammons, S. A., Mirza, S., Saleem, I., Urano, F., Band, H. & Band, V., Sep 1 2017, In : Molecular and cellular biology. 37, 18, e00030-17.

Research output: Contribution to journalArticle

Unfolded Protein Response
Endoplasmic Reticulum Stress
Eukaryotic Initiation Factor-2
Eukaryotic Initiation Factors
Proteins
34 Citations (Scopus)

Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes

Jacobi, A. M., Rettig, G. R., Turk, R., Collingwood, M. A., Zeiner, S. A., Quadros, R. M., Harms, D. W., Bonthuis, P. J., Gregg, C., Ohtsuka, M., Gurumurthy, C. B. & Behlke, M. A., May 15 2017, In : Methods. 121-122, p. 16-28 13 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Guide RNA
Zygote
Genes
Cells
2016
11 Citations (Scopus)

A novel interaction of Ecdysoneless (ECD) protein with R2TP complex component RUVBL1 is required for the functional role of ECD in cell cycle progression

Mir, R. A., Bele, A., Mirza, S., Srivastava, S., Olou, A. A., Ammons, S. A., Kim, J. H., Gurumurthy, C. B., Qiu, F., Band, H. & Band, V., Jan 1 2016, In : Molecular and cellular biology. 36, 6, p. 886-899 14 p.

Research output: Contribution to journalArticle

Cell Cycle
Phosphorylation
Proteins
Cell Cycle Checkpoints
Post Translational Protein Processing
36 Citations (Scopus)

Cleavage by caspase 8 and mitochondrial membrane association activate the BH3-only protein bid during TRAIL-induced apoptosis

Huang, K., Zhang, J., O'Neill, K. L., Gurumurthy, C. B., Quadros, R. M., Tu, Y. & Luo, X., May 27 2016, In : Journal of Biological Chemistry. 291, 22, p. 11843-11851 9 p.

Research output: Contribution to journalArticle

BH3 Interacting Domain Death Agonist Protein
TNF-Related Apoptosis-Inducing Ligand
Caspase 8
Mitochondrial Membranes
Caspases
13 Citations (Scopus)

CRISPR: a versatile tool for both forward and reverse genetics research

Gurumurthy, C. B., Grati, M., Ohtsuka, M., Schilit, S. L. P., Quadros, R. M. & Liu, X. Z., Sep 1 2016, In : Human genetics. 135, 9, p. 971-976 6 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Reverse Genetics
Genetic Research
Medical Genetics
Mutation
9 Citations (Scopus)

GONAD: A novel CRISPR/Cas9 genome editing method that does not require ex vivo handling of embryos

Gurumurthy, C. B., Takahashi, G., Wada, K., Miura, H., Sato, M. & Ohtsuka, M., Jan 1 2016, In : Current Protocols in Human Genetics. 2016, p. 15.8.1-15.8.12

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Nucleic Acids
Embryonic Structures
Technology
Gene Transfer Techniques
19 Citations (Scopus)

Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer

Das, S., Rachagani, S., Sheinin, Y., Smith, L. M., Gurumurthy, C. B., Roy, H. K. & Batra, S. K., May 19 2016, In : Oncogene. 35, 20, p. 2645-2654 10 p.

Research output: Contribution to journalArticle

Colitis
Colorectal Neoplasms
Dextran Sulfate
Azoxymethane
Colon
4 Citations (Scopus)

Pronuclear injection-based targeted transgenesis

Schilit, S. L. P., Ohtsuka, M., Quadros, R. M. & Gurumurthy, C. B., Jan 1 2016, In : Current Protocols in Human Genetics. 2016, p. 15.10.1-15.10.28

Research output: Contribution to journalArticle

Gene Transfer Techniques
Injections
DNA
Genome
Transgenes
1 Citation (Scopus)

Simple and reliable genotyping protocol for mouse PrkdcSCID mutation

Quadros, R. M., Poluektova, L. Y. & Gurumurthy, C. B., Apr 1 2016, In : Journal of Immunological Methods. 431, p. 60-62 3 p.

Research output: Contribution to journalArticle

Mutation
Restriction Fragment Length Polymorphisms
Transplantation Immunology
Biomedical Research
Polymerase Chain Reaction
2015
3 Citations (Scopus)

Assessment of artificial miRNA architectures for higher knockdown efficiencies without the undesired effects in mice

Miura, H., Inoko, H., Tanaka, M., Nakaoka, H., Kimura, M., Gurumurthy, C. B., Sato, M. & Ohtsuka, M., Aug 18 2015, In : PloS one. 10, 8, e0135919.

Research output: Contribution to journalArticle

MicroRNAs
microRNA
mice
Gene Transfer Techniques
Genes
47 Citations (Scopus)

CRISPR/Cas9-based generation of knockdown mice by intronic insertion of artificial microRNA using longer single-stranded DNA

Miura, H., Gurumurthy, C. B., Sato, T., Sato, M. & Ohtsuka, M., Aug 5 2015, In : Scientific reports. 5, 12799.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Single-Stranded DNA
MicroRNAs
Embryonic Stem Cells
Peptide Elongation Factor 2
5 Citations (Scopus)

Generation of a retinoblastoma (Rb)1-inducible dominant-negative (DN) mouse model

Tarang, S., Doi, S. M. S. R., Gurumurthy, C. B., Harms, D., Quadros, R. & Rocha-Sanchez, S. M., Feb 23 2015, In : Frontiers in Cellular Neuroscience. 9, FEB

Research output: Contribution to journalArticle

Retinoblastoma
Inner Auditory Hair Cells
Inner Ear
Retinoblastoma Genes
Cell Proliferation
36 Citations (Scopus)

GONAD: Genome-editing via Oviductal Nucleic Acids Delivery system: A novel microinjection independent genome engineering method in mice

Takahashi, G., Gurumurthy, C. B., Wada, K., Miura, H., Sato, M. & Ohtsuka, M., Jun 22 2015, In : Scientific reports. 5, 11406.

Research output: Contribution to journalArticle

Microinjections
Nucleic Acids
Genome
Embryonic Structures
Clustered Regularly Interspaced Short Palindromic Repeats
17 Citations (Scopus)

Insertion of sequences at the original provirus integration site of mouse ROSA26 locus using the CRISPR/Cas9 system

Quadros, R. M., Harms, D. W., Ohtsuka, M. & Gurumurthy, C. B., Jan 1 2015, In : FEBS Open Bio. 5, p. 191-197 7 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Virus Integration
Proviruses
Gene Transfer Techniques
Insertional Mutagenesis
8 Citations (Scopus)

One-step generation of multiple transgenic mouse lines using an improved Pronuclear Injection-based Targeted Transgenesis (i-PITT)

Ohtsuka, M., Miura, H., Mochida, K., Hirose, M., Hasegawa, A., Ogura, A., Mizutani, R., Kimura, M., Isotani, A., Ikawa, M., Sato, M. & Gurumurthy, C. B., Apr 9 2015, In : BMC genomics. 16, 1, 274.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Transgenic Mice
Injections
Transgenes
Zygote
19 Citations (Scopus)

TGFβ3 Regulates Periderm Removal Through ΔNp63 in the Developing Palate

Hu, L., Liu, J., Li, Z., Ozturk, F., Gurumurthy, C. B., Romano, R. A., Sinha, S. & Nawshad, A., Jun 1 2015, In : Journal of Cellular Physiology. 230, 6, p. 1212-1225 14 p.

Research output: Contribution to journalArticle

Palate
Transforming Growth Factors
Epithelium
Cleft Palate
Interferon Regulatory Factor-3
5 Citations (Scopus)

The cell cycle regulator ecdysoneless cooperates with H-ras to promote oncogenic transformation of human mammary epithelial cells

Bele, A., Mirza, S., Zhang, Y., Mir, R. A., Lin, S., Kim, J. H., Gurumurthy, C. B., West, W., Qiu, F., Band, H. & Band, V., Apr 1 2015, In : Cell Cycle. 14, 7, p. 990-1000 11 p.

Research output: Contribution to journalArticle

Cell Cycle
Breast
Epithelial Cells
Intercellular Signaling Peptides and Proteins
Carcinogenesis
4 Citations (Scopus)

Validation of simple sequence length polymorphism regions of commonly used mouse strains for marker assisted speed congenics screening

Gurumurthy, C. B., Joshi, P. S., Kurz, S. G., Ohtsuka, M., Quadros, R. M., Harms, D. W. & Lloyd, K. C. K., Feb 28 2015, In : International Journal of Genomics. 2015, 735845.

Research output: Contribution to journalArticle

Polymorphism
Screening
Polymerase Chain Reaction
Inbreeding
Agar Gel Electrophoresis
2014
6 Citations (Scopus)

Generation of conditional knockout mice

Sakamoto, K., Gurumurthy, C. B. & Wagner, K. U., 2014, In : Methods in molecular biology (Clifton, N.J.). 1194, p. 21-35 15 p.

Research output: Contribution to journalArticle

Knockout Mice
Gene Targeting
Organism Cloning
Embryonic Stem Cells
Genes
46 Citations (Scopus)

Mouse genome editing using the CRISPR/Cas system

Harms, D. W., Quadros, R. M., Seruggia, D., Ohtsuka, M., Takahashi, G., Montoliu, L. & Gurumurthy, C. B., Jan 1 2014, In : Current Protocols in Human Genetics. 83, p. 15.7.1-15.7.27

Research output: Contribution to journalArticle

CRISPR-Cas Systems
Clustered Regularly Interspaced Short Palindromic Repeats
Mutation
Medical Genetics
Microinjections
2013
11 Citations (Scopus)

Cytoplasmic localization of alteration/deficiency in activation 3 (ADA3) predicts poor clinical outcome in breast cancer patients

Mirza, S., Rakha, E. A., Alshareeda, A., Mohibi, S., Zhao, X., Katafiasz, B. J., Wang, J., Gurumurthy, C. B., Bele, A., Ellis, I. O., Green, A. R., Band, H. & Band, V., Feb 1 2013, In : Breast Cancer Research and Treatment. 137, 3, p. 721-731 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Staining and Labeling
Survival
Transcriptional Activation
2012
14 Citations (Scopus)

Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability

Mirza, S., Katafiasz, B. J., Kumar, R., Wang, J., Mohibi, S., Jain, S., Gurumurthy, C. B., Pandita, T. K., Dave, B. J., Band, H. & Band, V., Nov 15 2012, In : Cell Cycle. 11, 22, p. 4266-4274 9 p.

Research output: Contribution to journalArticle

Genomic Instability
DNA Damage
DNA Repair
Cell Cycle
Ionizing Radiation
11 Citations (Scopus)

Fluorescent transgenic mice suitable for multi-color aggregation chimera studies

Ohtsuka, M., Miura, H., Gurumurthy, C. B., Kimura, M., Inoko, H., Yoshimura, S. & Sato, M., Nov 1 2012, In : Cell and Tissue Research. 350, 2, p. 251-260 10 p.

Research output: Contribution to journalArticle

Transgenic Mice
Color
Embryonic Structures
Blastocyst
Cell Lineage
18 Citations (Scopus)

Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression

Mohibi, S., Gurumurthy, C. B., Nag, A., Wang, J., Mirza, S., Mian, Y., Quinn, M., Katafiasz, B., Eudy, J. D., Pandey, S., Guda, C., Naramura, M., Band, H. & Band, V., Aug 24 2012, In : Journal of Biological Chemistry. 287, 35, p. 29442-29456 15 p.

Research output: Contribution to journalArticle

Histones
Embryonic Development
Cell Cycle
Chemical activation
Cells
8 Citations (Scopus)

Nucleic Acid and Non-Nucleic Acid-Based Reprogramming of Adult Limbal Progenitors to Pluripotency

Parameswaran, S., Balasubramanian, S., Babai, N., DelDebbio, C. B., Harms, D. W., Gurumurthy, C. B., Rao, M. S., Sharp, J. G. & Ahmad, I., Oct 8 2012, In : PloS one. 7, 10, e46734.

Research output: Contribution to journalArticle

Nucleic Acids
nucleic acids
Acids
acids
Gene expression
11 Citations (Scopus)

Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: A marker of poor prognosis in HER2/neu-overexpressing breast cancer patients

Zhao, X., Mirza, S., Alshareeda, A., Zhang, Y., Gurumurthy, C. B., Bele, A., Kim, J. H., Mohibi, S., Goswami, M., Lele, S. M., West, W., Qiu, F., Ellis, I. O., Rakha, E. A., Green, A. R., Band, H. & Band, V., Jul 1 2012, In : Breast Cancer Research and Treatment. 134, 1, p. 171-180 10 p.

Research output: Contribution to journalArticle

Cell Cycle
Breast Neoplasms
Breast
Hyperplasia
E2F Transcription Factors
16 Citations (Scopus)

Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis

Dey, P., Rachagani, S., Chakraborty, S., Singh, P., Zhao, X., Gurumurthy, C. B., Anderson, J. M., Lele, S. M., Hollingsworth, M. A., Band, V. & Batra, S. K., Nov 15 2012, In : Clinical Cancer Research. 18, 22, p. 6188-6198 11 p.

Research output: Contribution to journalArticle

Glycolysis
Pancreatic Neoplasms
Carcinogenesis
Neoplasms
Glucose
2011
27 Citations (Scopus)

Renal thrombotic microangiopathy in mice with combined deletion of endocytic recycling regulators EHD3 and EHD4

George, M., Rainey, M. A., Naramura, M., Foster, K. W., Holzapfel, M. S., Willoughby, L. L., Ying, G., Goswami, R. M., Gurumurthy, C. B., Band, V., Satchell, S. C. & Band, H., Mar 14 2011, In : PloS one. 6, 3, e17838.

Research output: Contribution to journalArticle

microangiopathy
Thrombotic Microangiopathies
Electrohydrodynamics
Pathology
sequence homology
2010
7 Citations (Scopus)

Biochemical characterization of human ecdysoneless reveals a role in transcriptional regulation

Kim, J. H., Gurumurthy, C. B., Band, H. & Band, V., Jan 1 2010, In : Biological Chemistry. 391, 1, p. 9-19 11 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Yeasts
Yeast
Cytoplasm
Histone Acetyltransferases
2009
18 Citations (Scopus)

Role of mammalian ecdysonelessin cell cycle regulation

Kim, J. H., Gurumurthy, C. B., Naramura, M., Zhang, Y., Dudley, A. T., Doglio, L., Band, H. & Band, V., Sep 25 2009, In : Journal of Biological Chemistry. 284, 39, p. 26402-26410 9 p.

Research output: Contribution to journalArticle

Cell Cycle
Cells
Fibroblasts
Oogenesis
Drosophila
2008
21 Citations (Scopus)

Upregulation of the let-7 microRNA with precocious development in lin-12/Notch hypermorphic Caenorhabditis elegans mutants

Solomon, A., Mian, Y., Ortega-Cava, C., Liu, V. W. T., Gurumurthy, C. B., Naramura, M., Band, V. & Band, H., Apr 15 2008, In : Developmental Biology. 316, 2, p. 191-199 9 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
MicroRNAs
Up-Regulation
Transgenes
Phenotype
2007
38 Citations (Scopus)

An essential role of human Ada3 in p53 acetylation

Nag, A., Germaniuk-Kurowska, A., Dimri, M., Sassack, M. A., Gurumurthy, C. B., Gao, Q., Dimri, G., Band, H. & Band, V., Mar 23 2007, In : Journal of Biological Chemistry. 282, 12, p. 8812-8820 9 p.

Research output: Contribution to journalArticle

Acetylation
DNA Damage
Yeast
Yeasts
Chemical activation
56 Citations (Scopus)

The Notch regulator MAML1 interacts with p53 and functions as a coactivator

Zhao, Y., Katzman, R. B., Delmolino, L. M., Bhat, I., Zhang, Y., Gurumurthy, C. B., Germaniuk-Kurowska, A., Reddi, H. V., Solomon, A., Zeng, M. S., Kung, A., Hui, M., Gao, Q., Dimri, G., Stanculescu, A., Miele, L., Wu, L., Griffin, J. D., Wazer, D. E., Band, H. & 1 others, Band, V., Apr 20 2007, In : Journal of Biological Chemistry. 282, 16, p. 11969-11981 13 p.

Research output: Contribution to journalArticle

p53 Genes
Caenorhabditis elegans
DNA Damage
DNA
Genes
2006
17 Citations (Scopus)

The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its function

Zhang, Y., Gurumurthy, C. B., Kim, J. H., Bhat, I., Gao, Q., Dimri, G., Lee, S. W., Band, H. & Band, V., Jul 15 2006, In : Cancer Research. 66, 14, p. 7167-7175 9 p.

Research output: Contribution to journalArticle

Tumor Suppressor Proteins
Proteins
p53 Genes
Drosophila melanogaster
Carcinogenesis