Caroline L Ng, PhD

Assistant Professor

  • 364 Citations
  • 10 h-Index
20032019
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Fingerprint Dive into the research topics where Caroline L Ng is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Antimalarials Medicine & Life Sciences
Plasmodium falciparum Medicine & Life Sciences
Parasites Medicine & Life Sciences
Malaria Medicine & Life Sciences
Plasmodium Medicine & Life Sciences
Proteasome Inhibitors Medicine & Life Sciences
Proteasome Endopeptidase Complex Medicine & Life Sciences
Clustered Regularly Interspaced Short Palindromic Repeats Medicine & Life Sciences

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Research Output 2003 2019

  • 364 Citations
  • 10 h-Index
  • 15 Article
  • 1 Chapter
  • 1 Editorial
  • 1 Review article
2 Citations (Scopus)

Covalent plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

Stokes, B. H., Yoo, E., Murithi, J. M., Luth, M. R., Afanasyev, P., da Fonseca, P. C. A., Winzeler, E. A., Ng, C. L., Bogyo, M. & Fidock, D. A., Jun 2019, In : PLoS pathogens. 15, 6, e1007722.

Research output: Contribution to journalArticle

Open Access
Proteasome Inhibitors
Antimalarials
Proteasome Endopeptidase Complex
Plasmodium falciparum
Parasites
2 Citations (Scopus)

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265

White, J., Dhingra, S. K., Deng, X., El Mazouni, F., Lee, M. C. S., Afanador, G. A., Lawong, A., Tomchick, D. R., Ng, C. L., Bath, J., Rathod, P. K., Fidock, D. A. & Phillips, M. A., Nov 1 2019, In : ACS infectious diseases. 5, 1, p. 90-101 12 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Point Mutation
Parasites
Malaria
Mutation

Plasmodium falciparum in vitro drug resistance selections and gene editing

Ng, C. L. & Fidock, D. A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 123-140 18 p. (Methods in Molecular Biology; vol. 2013).

Research output: Chapter in Book/Report/Conference proceedingChapter

Plasmodium falciparum
Drug Resistance
Malaria
Parasites
Antimalarials
16 Citations (Scopus)

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

Llanos-Cuentas, A., Casapia, M., Chuquiyauri, R., Hinojosa, J. C., Kerr, N., Rosario, M., Toovey, S., Arch, R. H., Phillips, M. A., Rozenberg, F. D., Bath, J., Ng, C. L., Cowell, A. N., Winzeler, E. A., Fidock, D. A., Baker, M., Möhrle, J. J., Hooft van Huijsduijnen, R., Gobeau, N., Araeipour, N. & 3 others, Andenmatten, N., Rückle, T. & Duparc, S., Aug 2018, In : The Lancet Infectious Diseases. 18, 8, p. 874-883 10 p.

Research output: Contribution to journalArticle

Vivax Malaria
Plasmodium
Antimalarials
Plasmodium falciparum
Infection
10 Citations (Scopus)

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors

Yoo, E., Stokes, B. H., De Jong, H., Vanaerschot, M., Kumar, T. R. S., Lawrence, N., Njoroge, M., Garcia, A., Van Der Westhuyzen, R., Momper, J. D., Ng, C. L., Fidock, D. A. & Bogyo, M., Sep 12 2018, In : Journal of the American Chemical Society. 140, 36, p. 11424-11437 14 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Plasmodium
Parasites
Antimalarials
Proteasome Endopeptidase Complex