Carol B Toris, PhD

Professor

  • 3712 Citations
  • 32 h-Index
1984 …2019
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Research Output 1984 2019

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Article
2019
1 Citation (Scopus)

A Highly Effective and Ultra-Long-Acting Anti-Glaucoma Drug, with a Novel Periorbital Delivery Method

Woodward, D. F., Wang, J. W., Coleman, R. A., Woodrooffe, A. J., Clark, K. L., Stamer, W. D., Tao, G., Fan, S. & Toris, C. B., Jun 2019, In : Journal of Ocular Pharmacology and Therapeutics. 35, 5, p. 265-277 13 p.

Research output: Contribution to journalArticle

Open Access
Glaucoma
Intraocular Pressure
Esters
Pharmaceutical Preparations
Ophthalmic Solutions

Chinese and Caucasian adults

Fan, S., Guo, T., Chen, B., Xiong, J., Havens, S., Gulati, V. & Toris, C. B., Jan 1 2019, In : British Journal of Ophthalmology.

Research output: Contribution to journalArticle

Intraocular Pressure
Aqueous Humor
Anterior Chamber
Glaucoma
Cornea

Effect of Timolol on Aqueous Humor Outflow Facility in Healthy Human Eyes

Kazemi, A., McLaren, J. W., Trese, M. G. J., Toris, C. B., Gulati, V., Fan, S., Reed, D. M., Kristoff, T., Gilbert, J., Moroi, S. E. & Sit, A. J., Jun 2019, In : American journal of ophthalmology. 202, p. 126-132 7 p.

Research output: Contribution to journalArticle

Timolol
Aqueous Humor
Intraocular Pressure
Trabecular Meshwork
Supine Position
1 Citation (Scopus)

The affinity, intrinsic activity and selectivity of a structurally novel EP 2 receptor agonist at human prostanoid receptors

Coleman, R. A., Woodrooffe, A. J., Clark, K. L., Toris, C. B., Fan, S., Wang, J. W. & Woodward, D. F., Mar 2019, In : British Journal of Pharmacology. 176, 5, p. 687-698 12 p.

Research output: Contribution to journalArticle

Tocolytic Agents
Prostaglandins
Anti-Inflammatory Agents
Ocular Hypotension
Thromboxane Receptors

The future of canine glaucoma therapy

Komáromy, A. M., Bras, D., Esson, D. W., Fellman, R. L., Grozdanic, S. D., Kagemann, L., Miller, P. E., Moroi, S. E., Plummer, C. E., Sapienza, J. S., Storey, E. S., Teixeira, L. B., Toris, C. B. & Webb, T. R., Sep 1 2019, In : Veterinary Ophthalmology. 22, 5, p. 726-740 15 p.

Research output: Contribution to journalArticle

Open Access
glaucoma
Glaucoma
Canidae
therapeutics
dogs
2018
1 Citation (Scopus)

Consequences of puberty on efficacy of intraocular pressure-lowering drugs in male Dutch-belted rabbits

Hays, C. L., Okafor, K. C., Fan, S., High, R., Singh, D. P. & Toris, C. B., Jan 1 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 76-84 9 p.

Research output: Contribution to journalArticle

Puberty
Intraocular Pressure
Rabbits
latanoprost
Pharmaceutical Preparations
6 Citations (Scopus)

Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, on Aqueous Humor Dynamics in Laser-Induced Ocular Hypertensive Monkeys

Fuwa, M., Toris, C. B., Fan, S., Taniguchi, T., Ichikawa, M., Odani-Kawabata, N., Iwamura, R., Yoneda, K., Matsugi, T., Shams, N. K. & Zhang, J. Z., Sep 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 7, p. 531-537 7 p.

Research output: Contribution to journalArticle

Aqueous Humor
Intraocular Pressure
Haplorhini
Lasers
Fluorophotometry
2017
2 Citations (Scopus)

Aqueous humour dynamics and biometrics in the ageing Chinese eye

Guo, T., Sampathkumar, S., Fan, S., Morris, N., Wang, F. & Toris, C. B., Sep 2017, In : British Journal of Ophthalmology. 101, 9, p. 1290-1296 7 p.

Research output: Contribution to journalArticle

Aqueous Humor
Intraocular Pressure
Anterior Chamber
Cornea
Venous Pressure
5 Citations (Scopus)

Comparison of aqueous outflow facility measurement by pneumatonography and digital schiøtz tonography

Kazemi, A., McLaren, J. W., Lin, S. C., Toris, C. B., Gulati, V., Moroi, S. E. & Sit, A. J., Jan 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 1, p. 204-210 7 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Supine Position
Weights and Measures
Equipment and Supplies
Posture
6 Citations (Scopus)

Mechanism of action of selective laser trabeculoplasty and predictors of response

Gulati, V., Fan, S., Gardner, B. J., Havens, S. J., Schaaf, M. T., Neely, D. G. & Toris, C. B., Mar 2017, In : Investigative Ophthalmology and Visual Science. 58, 3, p. 1462-1468 7 p.

Research output: Contribution to journalArticle

Trabeculectomy
Aqueous Humor
Lasers
Fluorophotometry
Linear Models
2016
5 Citations (Scopus)

Aqueous flow measured by fluorophotometry in the mouse

Toris, C. B., Fan, S., Johnson, T. V., Camras, L. J., Hays, C. L., Liu, H. & Ishimoto, B. M., Jul 2016, In : Investigative Ophthalmology and Visual Science. 57, 8, p. 3844-3852 9 p.

Research output: Contribution to journalArticle

Fluorophotometry
Ketamine
Xylazine
Anesthesia
dorzolamide
11 Citations (Scopus)

Effects of rho kinase inhibitors on intraocular pressure and aqueous humor dynamics in nonhuman primates and rabbits

Toris, C. B., McLaughlin, M. A., Dworak, D. P., Fan, S., Havens, S. J., Zhan, G. L., Horan, N. & Prasanna, G., Jul 1 2016, In : Journal of Ocular Pharmacology and Therapeutics. 32, 6, p. 355-364 10 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Aqueous Humor
Intraocular Pressure
Primates
Rabbits
5 Citations (Scopus)

Prostanoid Receptor Antagonist Effects on Intraocular Pressure, Supported by Ocular Biodisposition Experiments

Woodward, D. F., Wenthur, S. L., Rudebush, T. L., Fan, S. & Toris, C. B., Nov 1 2016, In : Journal of Ocular Pharmacology and Therapeutics. 32, 9, p. 606-622 17 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Prostaglandins
Biological Availability
Rabbits
Haplorhini
7 Citations (Scopus)
Aqueous Humor
Extracellular Matrix
Drainage
Pharmacology
Trabecular Meshwork
2015
7 Citations (Scopus)

Continuous non-cell autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy

Parameswaran, S., Dravid, S. M., Teotia, P., Krishnamoorthy, R. R., Qiu, F., Toris, C. B., Morrison, J. & Ahmad, I., Jun 1 2015, In : STEM CELLS. 33, 6, p. 1743-1758 16 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Induced Pluripotent Stem Cells
Glaucoma
Ocular Hypertension
Acids
8 Citations (Scopus)

Intraocular pressure–lowering activity of NCX 470, a novel nitric oxide–donating bimatoprost in preclinical models

Impagnatiello, F., Toris, C. B., Batugo, M., Prasanna, G., Borghi, V., Bastia, E., Ongini, E. & Krauss, A. H. P., Jan 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 11, p. 6558-6564 7 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Ciliary Body
Aqueous Humor
Iris
Rabbits
2014
9 Citations (Scopus)

Daytime and nighttime effects of brimonidine on IOP and aqueous humor dynamics in participants with ocular hypertension

Fan, S., Agrawal, A., Gulati, V., Neely, D. G. & Toris, C. B., Jan 1 2014, In : Journal of Glaucoma. 23, 5, p. 276-281 6 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Aqueous Humor
Intraocular Pressure
Fluorophotometry
Placebos
16 Citations (Scopus)

Effects of a Schlemm canal scaffold on collector channel ostia in human anterior segments

Johnstone, M. A., Saheb, H., Ahmed, I. I. K., Samuelson, T. W., Schieber, A. T. & Toris, C. B., Feb 1 2014, In : Experimental Eye Research. 119, p. 70-76 7 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Electron Scanning Microscopy
Tissue Fixation
Fixatives
Ciliary Body
3 Citations (Scopus)

FR-190997, a nonpeptide bradykinin B2-receptor partial agonist, is a potent and efficacious intraocular pressure lowering agent in ocular hypertensive cynomolgus monkeys

Sharif, N. A., Katoli, P., Scott, D., Li, L., Kelly, C., Xu, S., Husain, S., Toris, C. B. & Crosson, C., Jun 2014, In : Drug Development Research. 75, 4, p. 211-223 13 p.

Research output: Contribution to journalArticle

Bradykinin B2 Receptors
Macaca fascicularis
Intraocular Pressure
Prostaglandins
Trabecular Meshwork
17 Citations (Scopus)

Improvement in outflow facility by two novel microinvasive glaucoma surgery implants

Hays, C. L., Gulati, V., Fan, S., Samuelson, T. W., Ahmed, I. I. K. & Toris, C. B., Jan 1 2014, In : Investigative Ophthalmology and Visual Science. 55, 3, p. 1893-1900 8 p.

Research output: Contribution to journalArticle

Glaucoma
Pressure
Perfusion
Eye Diseases
Dilatation
2013
2 Citations (Scopus)
Trabeculectomy
Solid-State Lasers
Lasers
Steroids
Anterior Chamber
24 Citations (Scopus)

A novel 8-mm Schlemm's canal scaffold reduces outflow resistance in a human anterior segment perfusion model

Gulati, V., Fan, S., Hays, C. L., Samuelson, T. W., Ahmed, I. I. K. & Toris, C. B., Apr 2 2013, In : Investigative Ophthalmology and Visual Science. 54, 3, p. 1698-1704 7 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Perfusion
Pressure
22 Citations (Scopus)

Molecular biomarkers in glaucoma

Seventh ARVO/Pfizer Ophthalmics Research Institute Conference Working Group, Jan 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 1, p. 121-131 11 p.

Research output: Contribution to journalArticle

Metabolome
Genomics
Genetic Markers
Glaucoma
Proteomics
2012
38 Citations (Scopus)

A novel schlemm's canal scaffold increases outflow facility in a human anterior segment perfusion model

Camras, L. J., Yuan, F., Fan, S., Samuelson, T. W., Ahmed, I. K., Schieber, A. T. & Toris, C. B., Sep 1 2012, In : Investigative Ophthalmology and Visual Science. 53, 10, p. 6115-6121 7 p.

Research output: Contribution to journalArticle

Perfusion
Pressure
Trabecular Meshwork
Eye Diseases
Intraocular Pressure
28 Citations (Scopus)

Diurnal and nocturnal variations in aqueous humor dynamics of patients with ocular hypertension undergoing medical therapy

Gulati, V., Fan, S., Zhao, M., Maslonka, M. A., Gangahar, C. & Toris, C. B., Jun 1 2012, In : Archives of Ophthalmology. 130, 6, p. 677-684 8 p.

Research output: Contribution to journalArticle

dorzolamide
latanoprost
Ocular Hypertension
Aqueous Humor
Intraocular Pressure
2011
27 Citations (Scopus)

Aqueous humor dynamics during the day and night in healthy mature volunteers

Liu, H., Fan, S., Gulati, V., Camras, L. J., Zhan, G., Ghate, D. A., Camras, C. B. & Toris, C. B., Mar 1 2011, In : Archives of Ophthalmology. 129, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

Aqueous Humor
Intraocular Pressure
Healthy Volunteers
Fluorophotometry
Cornea
9 Citations (Scopus)

Aqueous humor dynamics during the day and night in volunteers with ocular hypertension

Fan, S., Hejkal, J. J., Gulati, V., Galata, S., Camras, C. B. & Toris, C. B., Sep 1 2011, In : Archives of Ophthalmology. 129, 9, p. 1162-1166 5 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Aqueous Humor
Intraocular Pressure
Volunteers
Fluorophotometry
4 Citations (Scopus)
Aqueous Humor
Intraocular Pressure
Ocular Hypertension
Glaucoma
Cornea
29 Citations (Scopus)

Effect of PF-04217329 a prodrug of a selective prostaglandin EP 2 agonist on intraocular pressure in preclinical models of glaucoma

Prasanna, G., Carreiro, S., Anderson, S., Gukasyan, H., Sartnurak, S., Younis, H., Gale, D., Xiang, C., Wells, P., Dinh, D., Almaden, C., Fortner, J., Toris, C. B., Niesman, M., Lafontaine, J. & Krauss, A., Sep 1 2011, In : Experimental Eye Research. 93, 3, p. 256-264 9 p.

Research output: Contribution to journalArticle

Prodrugs
Intraocular Pressure
Glaucoma
Prostaglandins
Prostaglandin Receptors
61 Citations (Scopus)

Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating Prostaglandin F2α agonist, in preclinical models

Krauss, A. H. P., Impagnatiello, F., Toris, C. B., Gale, D. C., Prasanna, G., Borghi, V., Chiroli, V., Chong, W. K. M., Carreiro, S. T. & Ongini, E., Sep 1 2011, In : Experimental Eye Research. 93, 3, p. 250-255 6 p.

Research output: Contribution to journalArticle

latanoprost
Dinoprost
Nitric Oxide
Intraocular Pressure
Ocular Hypertension
34 Citations (Scopus)

Regulation of ocular angiogenesis by notch signaling: Implications in neovascular age-related macular degeneration

Ahmad, I., Balasubramanian, S., del Debbio, C. B., Parameswaran, S., Katz, A. R., Toris, C. B. & Fariss, R. N., May 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Macular Degeneration
Vascular Endothelial Growth Factor A
Gene Expression
Retinal Vessels
2010
52 Citations (Scopus)

A novel nitric oxide releasing prostaglandin analog, NCX 125, reduces intraocular pressure in rabbit, dog, and primate models of glaucoma

Borghi, V., Bastia, E., Guzzetta, M., Chiroli, V., Toris, C. B., Batugo, M. R., Carreiro, S. T., Chong, W. K. M., Gale, D. C., Kucera, D. J., Jia, L., Prasanna, G., Ongini, E., Krauss, A. H. P. & Impagnatiello, F., Apr 1 2010, In : Journal of Ocular Pharmacology and Therapeutics. 26, 2, p. 125-131 7 p.

Research output: Contribution to journalArticle

latanoprost
Synthetic Prostaglandins
Intraocular Pressure
Glaucoma
Primates
15 Citations (Scopus)

Aqueous humor dynamics during the day and night in juvenile and adult rabbits

Zhao, M., Hejkal, J. J., Camras, C. B. & Toris, C. B., Jun 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3145-3151 7 p.

Research output: Contribution to journalArticle

Aqueous Humor
Intraocular Pressure
Rabbits
Fluorophotometry
Reading
4 Citations (Scopus)

Aqueous humor dynamics in inbred rhesus monkeys with naturally occurring ocular hypertension

Toris, C. B., Risma, J. M., Gonzales-Martinez, J., McLaughlin, M. A. & Dawson, W. W., Dec 1 2010, In : Experimental Eye Research. 91, 6, p. 860-865 6 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Aqueous Humor
Macaca mulatta
Intraocular Pressure
Fluorophotometry
5 Citations (Scopus)

Aqueous humor dynamics in pigment dispersion syndrome

Toris, C. B., Haecker, N. R., Teasley, L. A., Zhan, G., Gulati, V. & Camras, C. B., Sep 1 2010, In : Archives of Ophthalmology. 128, 9, p. 1115-1118 4 p.

Research output: Contribution to journalArticle

Aqueous Humor
Intraocular Pressure
Ocular Hypertension
Venous Pressure
Anterior Chamber
22 Citations (Scopus)

Duration of anesthesia affects intraocular pressure, but not outflow facility in mice

Camras, L. J., Sufficool, K. E., Camras, C. B., Fan, S., Liu, H. & Toris, C. B., Sep 1 2010, In : Current Eye Research. 35, 9, p. 819-827 9 p.

Research output: Contribution to journalArticle

Intraocular Pressure
latanoprost
Anesthesia
Aqueous Humor
Xylazine
12 Citations (Scopus)
latanoprost
Timolol
Ocular Hypertension
Intraocular Pressure
Fluorophotometry
2 Citations (Scopus)

Intraocular pressure and aqueous humor flow during a euglycemic- hyperinsulinemic clamp in patients with type 1 diabetes and microvascular complications

Lane, J. T., Larson, L., Fan, S., Stoner, J. A., Margalit, E. & Toris, C. B., Jun 25 2010, In : BMC Ophthalmology. 10, 1, 19.

Research output: Contribution to journalArticle

Glucose Clamp Technique
Aqueous Humor
Diabetes Complications
Intraocular Pressure
Type 1 Diabetes Mellitus
45 Citations (Scopus)

Pharmacotherapies for glaucoma

Toris, C. B., Dec 1 2010, In : Current Molecular Medicine. 10, 9, p. 824-840 17 p.

Research output: Contribution to journalArticle

Drug therapy
Aqueous Humor
Glaucoma
Drug Therapy
Pharmaceutical Preparations
2009
26 Citations (Scopus)

Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes

Sharif, N. A., McLaughlin, M. A., Kelly, C. R., Katoli, P., Drace, C., Husain, S., Crosson, C., Toris, C. B., Zhan, G. L. & Camras, C., Mar 1 2009, In : Experimental Eye Research. 88, 3, p. 386-397 12 p.

Research output: Contribution to journalArticle

Macaca fascicularis
Aqueous Humor
Pharmacology
Intraocular Pressure
Trabecular Meshwork
23 Citations (Scopus)

Morphological and hydrodynamic correlates in monkey eyes with laser induced glaucoma

Zhang, Y., Toris, C. B., Liu, Y., Ye, W. & Gong, H., Nov 1 2009, In : Experimental Eye Research. 89, 5, p. 748-756 9 p.

Research output: Contribution to journalArticle

Hydrodynamics
Glaucoma
Haplorhini
Lasers
Intraocular Pressure
35 Citations (Scopus)

PRDX6 attenuates oxidative stress-and TGF-induced abnormalities of human trabecular meshwork cells

Fatma, N., Kubo, E., Toris, C. B., Stamer, W. D., Camras, C. B. & Singh, D. P., Nov 30 2009, In : Free Radical Research. 43, 9, p. 783-795 13 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Oxidative stress
Oxidative Stress
Peroxiredoxin VI
Antioxidants
29 Citations (Scopus)

Prostanoid EP 4 receptor stimulation produces ocular hypotension by a mechanism that does not appear to involve uveoscleral outflow

Woodward, D. F., Nilsson, S. F. E., Toris, C. B., Kharlamb, A. B., Nieves, A. L. & Krauss, A. H. P., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 7, p. 3320-3328 9 p.

Research output: Contribution to journalArticle

Ocular Hypotension
Prostaglandins
Haplorhini
Intraocular Pressure
Prostaglandins E
2008
37 Citations (Scopus)

Aqueous humor dynamics in exfoliation syndrome

Johnson, T. V., Fan, S., Camras, C. B. & Toris, C. B., Jul 1 2008, In : Archives of Ophthalmology. 126, 7, p. 914-920 7 p.

Research output: Contribution to journalArticle

Exfoliation Syndrome
Aqueous Humor
Intraocular Pressure
Ocular Hypertension
Research Design
8 Citations (Scopus)

Chapter 7 Aqueous Humor Dynamics I. Measurement Methods and Animal Studies

Toris, C. B., 2008, In : Current Topics in Membranes. 62, p. 193-229 37 p.

Research output: Contribution to journalArticle

Aqueous Humor
Glaucoma
Animal Models
Venous Pressure
Eye Diseases
6 Citations (Scopus)

Chapter 8 Aqueous Humor Dynamics II. Clinical Studies

Toris, C. B. & Camras, C. B., 2008, In : Current Topics in Membranes. 62, p. 231-272 42 p.

Research output: Contribution to journalArticle

Aqueous Humor
Glaucoma
Ocular Hypertension
Hydrodynamics
Cardiovascular System
16 Citations (Scopus)

Effects of central corneal thickness on the efficacy of topical ocular hypotensive medications

Johnson, T. V., Toris, C. B., Fan, S. & Camras, C. B., Mar 1 2008, In : Journal of Glaucoma. 17, 2, p. 89-99 11 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Cornea
Intraocular Pressure
latanoprost
Volunteers
103 Citations (Scopus)

Mechanism of Action of Bimatoprost, Latanoprost, and Travoprost in Healthy Subjects. A Crossover Study

Lim, K. S., Nau, C. B., O'Byrne, M. M., Hodge, D. O., Toris, C. B., McLaren, J. W. & Johnson, D. H., May 2008, In : Ophthalmology. 115, 5, p. 790-795.e4

Research output: Contribution to journalArticle

latanoprost
Aqueous Humor
Cross-Over Studies
Fluorophotometry
Healthy Volunteers
31 Citations (Scopus)
Manometry
Intraocular Pressure
Anesthesia
Xylazine
Ketamine
170 Citations (Scopus)

Update on the Mechanism of Action of Topical Prostaglandins for Intraocular Pressure Reduction

Toris, C. B., Gabelt, BA. T. & Kaufman, P. L., Nov 1 2008, In : Survey of Ophthalmology. 53, 6 SUPPL., p. S107-S120

Research output: Contribution to journalArticle

Synthetic Prostaglandins
Intraocular Pressure
Prostaglandins
Aqueous Humor
latanoprost