Bradley E Britigan, MD

Dean

  • 7173 Citations
  • 49 h-Index
1985 …2020
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Research Output 1985 2019

  • 7173 Citations
  • 49 h-Index
  • 140 Article
  • 10 Review article
  • 3 Comment/debate
  • 2 Letter
2019
gallium nitrate
Gallium
Porphyrins
Klebsiella pneumoniae
Pseudomonas aeruginosa
2 Citations (Scopus)
Acinetobacter baumannii
Gallium
Heme
Nanoparticles
Pseudomonas aeruginosa
1 Citation (Scopus)
Open Access
Gallium
Mycobacterium tuberculosis
Nanoparticles
HIV-1
Macrophages
2018
16 Citations (Scopus)

Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections

Goss, C. H., Kaneko, Y., Khuu, L., Anderson, G. D., Ravishankar, S., Aitken, M. L., Lechtzin, N., Zhou, G., Czyz, D. M., McLean, K., Olakanmi, O., Shuman, H. A., Teresi, M., Wilhelm, E., Caldwell, E., Salipante, S. J., Hornick, D. B., Siehnel, R. J., Becker, L., Britigan, B. E. & 1 others, Singh, P. K., Sep 26 2018, In : Science translational medicine. 10, 460, eaat7520.

Research output: Contribution to journalArticle

Gallium
Therapeutic Uses
Iron
Lung
Infection
3 Citations (Scopus)
Mycobacterium avium
Gallium
Mycobacterium
Nanoparticles
Growth
2017
9 Citations (Scopus)
Virus Release
Gallium
Interleukin-8
Mycobacterium tuberculosis
Nanoparticles
14 Citations (Scopus)

Gallium nanoparticles facilitate phagosome maturation and inhibit growth of virulent Mycobacterium tuberculosis in macrophages

Choi, S. R., Britigan, B. E., Moran, D. M. & Narayanasamy, P., May 2017, In : PloS one. 12, 5, e0177987.

Research output: Contribution to journalArticle

gallium
phagosomes
Phagosomes
Gallium
Macrophages

Passive transfer of interferon-γ over-expressing macrophages enhances resistance of SCID mice to Mycobacterium tuberculosis infection

Pasula, R., Martin, W. J., Kesavalu, B. R., Abdalla, M. Y. & Britigan, B. E., Jul 1 2017, In : Cytokine. 95, p. 70-79 10 p.

Research output: Contribution to journalArticle

Mycobacterium Infections
SCID Mice
Macrophages
Mycobacterium tuberculosis
Interferons
6 Citations (Scopus)

Pseudomonas quinolone signal induces oxidative stress and inhibits heme oxygenase-1 expression in lung epithelial cells

Abdalla, M. Y., Hoke, T., Seravalli, J., Switzer, B. L., Bavitz, M., Fliege, J. D., Murphy, P. J. & Britigan, B. E., Sep 1 2017, In : Infection and immunity. 85, 9, e00176-17.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Oxidative Stress
Epithelial Cells
Lung
Pseudomonas aeruginosa
2016
2 Citations (Scopus)

Airway delivery of interferon-γ overexpressing macrophages confers resistance to Mycobacterium avium infection in SCID mice

Pasula, R., Britigan, B. E., Kesavalu, B., Abdalla, M. Y. & Martin, W. J., Nov 1 2016, In : Physiological Reports. 4, 21, e13008.

Research output: Contribution to journalArticle

Mycobacterium avium
Mycobacterium Infections
SCID Mice
Interferons
Interferon-gamma
2015
16 Citations (Scopus)

Gallium compounds exhibit potential as new therapeutic agents against Mycobacterium abscessus

Abdalla, M. Y., Switzer, B. L., Goss, C. H., Aitken, M. L., Singh, P. K. & Britigan, B. E., Aug 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 8, p. 4826-4834 9 p.

Research output: Contribution to journalArticle

Gallium
Mycobacterium
Anti-Bacterial Agents
Growth
Cystic Fibrosis
16 Citations (Scopus)
Heme Oxygenase-1
Macrophages
Mycobacterium
Survival
Biliverdine
24 Citations (Scopus)
Gallium
Mycobacterium
Nanoparticles
Macrophages
HIV
2013
18 Citations (Scopus)

Gallium nitrate is efficacious in murine models of tuberculosis and inhibits key bacterial fe-dependent enzymes

Olakanmi, O., Kesavalu, B., Pasula, R., Abdalla, M. Y., Schlesinger, L. S. & Britigan, B. E., Dec 2013, In : Antimicrobial Agents and Chemotherapy. 57, 12, p. 6074-6080 7 p.

Research output: Contribution to journalArticle

gallium nitrate
Gallium
Tuberculosis
Enzymes
Mycobacterium tuberculosis
12 Citations (Scopus)

Iron acquisition by Mycobacterium tuberculosis residing within myeloid dendritic cells

Olakanmi, O., Kesavalu, B., Abdalla, M. Y. & Britigan, B. E., Dec 1 2013, In : Microbial Pathogenesis. 65, p. 21-28 8 p.

Research output: Contribution to journalArticle

Myeloid Cells
Mycobacterium tuberculosis
Dendritic Cells
Iron
Macrophages
2012
12 Citations (Scopus)

Inactivation of the potent Pseudomonas aeruginosa cytotoxin pyocyanin by airway peroxidases and nitrite

Reszka, K. J., Xiong, Y., Sallans, L., Pasula, R., Olakanmi, O., Hassett, D. J. & Britigan, B. E., May 15 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 302, 10, p. L1044-L1056

Research output: Contribution to journalArticle

Pyocyanine
Pregnenolone Carbonitrile
Peroxidases
Nitrites
Pseudomonas aeruginosa
2011
412 Citations (Scopus)

Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria

Nguyen, D., Joshi-Datar, A., Lepine, F., Bauerle, E., Olakanmi, O., Beer, K., McKay, G., Siehnel, R., Schafhauser, J., Wang, Y., Britigan, B. E. & Singh, P. K., Nov 18 2011, In : Science. 334, 6058, p. 982-986 5 p.

Research output: Contribution to journalArticle

Biofilms
Starvation
Anti-Bacterial Agents
Bacteria
Food
7 Citations (Scopus)

Airway peroxidases catalyze nitration of the β2-agonist salbutamol and decrease its pharmacological activity

Reszka, K. J., Sallans, L., Macha, S., Brown, K., McGraw, D. W., Kovacic, M. B. & Britigan, B. E., Feb 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 336, 2, p. 440-449 10 p.

Research output: Contribution to journalArticle

Peroxidases
Albuterol
Pharmacology
Peroxidase
Lactoperoxidase
10 Citations (Scopus)
Pyocyanine
Pseudomonas
Sulfhydryl Compounds
Oxidation-Reduction
Epithelial Cells
2010
30 Citations (Scopus)

Gallium disrupts iron uptake by intracellular and extracellular Francisella strains and exhibits therapeutic efficacy in a murine pulmonary infection model

Olakanmi, O., Gunn, J. S., Su, S., Soni, S., Hassett, D. J. & Britigan, B. E., Jan 1 2010, In : Antimicrobial Agents and Chemotherapy. 54, 1, p. 244-253 10 p.

Research output: Contribution to journalArticle

Francisella
Gallium
Iron
Lung
Infection
8 Citations (Scopus)

Quenching of singlet oxygen by pyocyanin and related phenazines

Reszka, K. J., Bilski, P. J. & Britigan, B. E., Jul 1 2010, In : Photochemistry and Photobiology. 86, 4, p. 742-746 5 p.

Research output: Contribution to journalArticle

Pyocyanine
Phenazines
Singlet Oxygen
pathogens
bacteria
1 Citation (Scopus)

Salami science or editorial imperialism?

Britigan, B., Strauss, A. & Susman, J., Sep 1 2010, In : Journal of Pediatrics. 157, 3, p. 518-519 2 p.

Research output: Contribution to journalLetter

Editorial Policies
2009
14 Citations (Scopus)

Airway delivery of silica increases susceptibility to mycobacterial infection in mice: Potential role of repopulating macrophages

Pasula, R., Britigan, B. E., Turner, J. & Martin, W. J., Jun 1 2009, In : Journal of Immunology. 182, 11, p. 7102-7109 8 p.

Research output: Contribution to journalArticle

Silicon Dioxide
Macrophages
Infection
Mycobacterium
Alveolar Macrophages
13 Citations (Scopus)

Copper egress is induced by PMA in human THP-1 monocytic cell line

Afton, S. E., Caruso, J. A., Britigan, B. E. & Qin, Z., Jun 1 2009, In : BioMetals. 22, 3, p. 531-539 9 p.

Research output: Contribution to journalArticle

Copper
Acetates
copper
acetates
Cells
12 Citations (Scopus)

Peroxidative metabolism of β2-agonists salbutamol and fenoterol and their analogues

Reszka, K. J., McGraw, D. W. & Britigan, B. E., Jun 15 2009, In : Chemical Research in Toxicology. 22, 6, p. 1137-1150 14 p.

Research output: Contribution to journalArticle

Fenoterol
Albuterol
Metabolism
Methimazole
Terbutaline
Fenoterol
Albuterol
Metabolism
2008
28 Citations (Scopus)

Hepatitis C core protein inhibits induction of heme oxygenase-1 and sensitizes hepatocytes to cytotoxicity

Wen, F., Brown, K. E., Britigan, B. E. & Schmidt, W. N., Apr 1 2008, In : Cell Biology and Toxicology. 24, 2, p. 175-188 14 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Cytotoxicity
Hepatitis C
Hepatocytes
Proteins
20 Citations (Scopus)

The peptidoglycan-associated lipoprotein OprL helps protect a Pseudomonas aeruginosa mutant devoid of the transactivator OxyR from hydrogen peroxide-mediated killing during planktonic and biofilm culture

Panmanee, W., Gomez, F., Witte, D., Pancholi, V., Britigan, B. E. & Hassett, D. J., May 1 2008, In : Journal of bacteriology. 190, 10, p. 3658-3669 12 p.

Research output: Contribution to journalArticle

Trans-Activators
Peptidoglycan
Biofilms
Pseudomonas aeruginosa
Hydrogen Peroxide
2007
16 Citations (Scopus)
Lactoperoxidase
Doxorubicin
Oxidation
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
Degradation
60 Citations (Scopus)

Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages

Olakanmi, O., Schlesinger, L. S. & Britigan, B. E., Jan 1 2007, In : Journal of Leukocyte Biology. 81, 1, p. 195-204 10 p.

Research output: Contribution to journalArticle

Hemochromatosis
Mycobacterium tuberculosis
Iron
Macrophages
Lactoferrin
9 Citations (Scopus)

Inactivation of anthracyclines by serum heme proteins

Wagner, B. A., Teesch, L. M., Buettner, G. R., Britigan, B. E., Burns, C. P. & Reszka, K. J., Jun 1 2007, In : Chemical Research in Toxicology. 20, 6, p. 920-926 7 p.

Research output: Contribution to journalArticle

Hemeproteins
Anthracyclines
Hydrogen Peroxide
Blood Proteins
Doxorubicin
344 Citations (Scopus)

The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity

Kaneko, Y., Thoendel, M., Olakanmi, O., Britigan, B. E. & Singh, P. K., Apr 2 2007, In : Journal of Clinical Investigation. 117, 4, p. 877-888 12 p.

Research output: Contribution to journalArticle

Gallium
Pseudomonas aeruginosa
Biofilms
Iron
Metals
2006
17 Citations (Scopus)

Nitric oxide decreases the stability of DMPO spin adducts

Reszka, K. J., McCormick, M. L., Buettner, G. R., Michael Hart, C. & Britigan, B. E., Sep 1 2006, In : Nitric Oxide - Biology and Chemistry. 15, 2, p. 133-141 9 p.

Research output: Contribution to journalArticle

Nitric Oxide
Oxides
5,5-dimethyl-1-pyrroline-1-oxide
Cell-Free System
Endothelial cells
15 Citations (Scopus)

Photosensitized oxidation and inactivation of pyocyanin, a virulence factor of Pseudomonas aeruginosa

Reszka, K. J., Denning, G. M. & Britigan, B. E., Mar 1 2006, In : Photochemistry and Photobiology. 82, 2, p. 466-473 8 p.

Research output: Contribution to journalArticle

Pyocyanine
virulence
pseudomonas
Virulence Factors
deactivation
2005
34 Citations (Scopus)

Effects of peroxidase substrates on the Amplex red/peroxidase assay: Antioxidant properties of anthracyclines

Reszka, K. J., Wagner, B. A., Burns, C. P. & Britigan, B. E., Jul 15 2005, In : Analytical Biochemistry. 342, 2, p. 327-337 11 p.

Research output: Contribution to journalArticle

Anthracyclines
Peroxidase
Assays
Antioxidants
Horseradish Peroxidase
7 Citations (Scopus)
Gallium
Cell membranes
Transferrin
Iron
Cell Membrane
10 Citations (Scopus)

Hemin induces active chloride secretion in Caco-2 cells

Uc, A., Husted, R. F., Giriyappa, R. L., Britigan, B. E. & Stokes, J. B., Aug 1 2005, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 289, 2 52-2, p. G202-G208

Research output: Contribution to journalArticle

Hemin
Caco-2 Cells
Chlorides
Carbon Monoxide
Electrolytes
91 Citations (Scopus)

Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses

Abdalla, M. Y., Ahmad, I. M., Spitz, D. R., Schmidt, W. N. & Britigan, B. E., Aug 1 2005, In : Journal of Medical Virology. 76, 4, p. 489-497 9 p.

Research output: Contribution to journalArticle

Hepacivirus
Antioxidants
Hepatocytes
Proteins
Oxidative Stress
13 Citations (Scopus)

Inactivation of anthracyclines by cellular peroxidase

Reszka, K. J., Wagner, B. A., Teesch, L. M., Britigan, B. E., Spitz, D. R. & Burns, C. P., Jul 15 2005, In : Cancer Research. 65, 14, p. 6346-6353 8 p.

Research output: Contribution to journalArticle

Anthracyclines
Peroxidase
HL-60 Cells
Cardiac Myoblasts
4-Aminobenzoic Acid
73 Citations (Scopus)

Modulation of lung epithelial functions by Pseudomonas aeruginosa

Lau, G. W., Hassett, D. J. & Britigan, B. E., Aug 1 2005, In : Trends in Microbiology. 13, 8, p. 389-397 9 p.

Research output: Contribution to journalReview article

Pseudomonas aeruginosa
Lung
Epithelium
Nasal Mucosa
Cystic Fibrosis
8 Citations (Scopus)

Oxidation of anthracyclines by peroxidase metabolites of salicylic acid

Reszka, K. J., Britigan, L. H. & Britigan, B. E., Oct 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 315, 1, p. 283-290 8 p.

Research output: Contribution to journalArticle

Salicylic Acid
Anthracyclines
Peroxidase
Lactoperoxidase
Peroxidases
55 Citations (Scopus)

Pseudomonas aeruginosa OxyR is required for full virulence in rodent and insect models of infection and for resistance to human neutrophils

Lau, G. W., Britigan, B. E. & Hassett, D. J., Apr 1 2005, In : Infection and immunity. 73, 4, p. 2550-2553 4 p.

Research output: Contribution to journalArticle

Blood Bactericidal Activity
Repressor Proteins
Bacterial Pneumonia
Pseudomonas Infections
DNA-Binding Proteins
47 Citations (Scopus)

Pyocyanin and its precursor phenazine-1-carboxylic acid increase IL-8 and intercellular adhesion molecule-1 expression in human airway epithelial cells by oxidant-dependent mechanisms

Look, D. C., Stoll, L. L., Romig, S. A., Humlicek, A., Britigan, B. E. & Denning, G. M., Sep 15 2005, In : Journal of Immunology. 175, 6, p. 4017-4023 7 p.

Research output: Contribution to journalArticle

Open Access
Pyocyanine
Intercellular Adhesion Molecule-1
Interleukin-8
Oxidants
Epithelial Cells
2004
12 Citations (Scopus)

Acetaminophen stimulates the peroxidative metabolism of anthracyclines

Reszka, K. J., Britigan, L. H., Rasmussen, G. T., Wagner, B. A., Burns, C. P. & Britigan, B. E., Jul 1 2004, In : Archives of Biochemistry and Biophysics. 427, 1, p. 16-29 14 p.

Research output: Contribution to journalArticle

Daunorubicin
Anthracyclines
Acetaminophen
Metabolism
Lactoperoxidase
21 Citations (Scopus)

Cleavage of human transferrin by Porphyromonas gingivalis gingipains promotes growth and formation of hydroxyl radicals

Goulet, V., Britigan, B., Nakayama, K. & Grenier, D., Aug 1 2004, In : Infection and immunity. 72, 8, p. 4351-4356 6 p.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Transferrin
Hydroxyl Radical
Iron
Growth
49 Citations (Scopus)
Pyocyanine
Oxidation-Reduction
Reactive Oxygen Species
ametantrone
Oxidation
64 Citations (Scopus)

Down-regulation of heme oxygenase-1 by hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C core protein

Abdalla, M. Y., Britigan, B. E., Wen, F., Icardi, M., McCormick, M. L., LaBrecque, D. R., Voigt, M., Brown, K. E. & Schmidt, W. N., Sep 15 2004, In : Journal of Infectious Diseases. 190, 6, p. 1109-1118 10 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Virus Diseases
Hepatitis C
Hepacivirus
Down-Regulation
41 Citations (Scopus)
Caco-2 Cells
Hemin
Heme
Membrane Proteins
Trypsin
39 Citations (Scopus)

Increased Prooxidant Production and Enhanced Susceptibility to Glutathione Depletion in HepG2 Cells Co-expressing HCV Core Protein and CYP2E1

Wen, F., Abdalla, M. Y., Aloman, C., Xiang, J., Ahmad, I. M., Walewski, J., McCormick, M. L., Brown, K. E., Branch, A. D., Spitz, D. R., Britigan, B. E. & Schmidt, W. N., Feb 1 2004, In : Journal of Medical Virology. 72, 2, p. 230-240 11 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Hep G2 Cells
Glutathione
Oxidative Stress
Buthionine Sulfoximine
60 Citations (Scopus)

Oxidation of pyocyanin, a cytotoxic product from Pseudomonas aeruginosa, by microperoxidase 11 and hydrogen peroxide

Reszka, K. J., O'Malley, Y., McCormick, M. L., Denning, G. M. & Britigan, B. E., Jun 1 2004, In : Free Radical Biology and Medicine. 36, 11, p. 1448-1459 12 p.

Research output: Contribution to journalArticle

Pyocyanine
Pseudomonas aeruginosa
Hydrogen Peroxide
Oxidation
Pigments