Barbara J Morley, PhD

Director

  • 1720 Citations
  • 25 h-Index
1974 …2019
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Research Output 1974 2019

  • 1720 Citations
  • 25 h-Index
  • 69 Article
  • 2 Letter
  • 2 Review article
  • 1 Comment/debate
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Article
2019

Nicotinic acetylcholine receptor subunit α7-knockout mice exhibit degraded auditory temporal processing

Felix, R. A., Chavez, V. A., Novicio, D. M., Morley, B. J. & Portfors, C. V., Aug 2019, In : Journal of Neurophysiology. 122, 2, p. 451-465 15 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Knockout Mice
Mesencephalon
Brain Stem Auditory Evoked Potentials
Auditory Perceptual Disorders
2017
1 Citation (Scopus)

A time to listen: perinatal smoking affects the development of temporal sound processing

Morley, B. J. & Felix, R. A., Jun 1 2017, In : Journal of Physiology. 595, 11, p. 3241-3242 2 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
Autoimmune Experimental Encephalomyelitis
Nicotinic Receptors
Autoimmunity
Nicotine
Multiple Sclerosis
3 Citations (Scopus)

Dopamine D1A directly interacts with otoferlin synaptic pathway proteins: Ca2+ and phosphorylation underlie an NSF-to-AP2mu1 molecular switch

Selvakumar, D., Drescher, M. J., Deckard, N. A., Ramakrishnan, N. A., Morley, B. J. & Drescher, D. G., Jan 1 2017, In : Biochemical Journal. 474, 1, p. 79-104 26 p.

Research output: Contribution to journalArticle

Adaptor Protein Complex 2
N-Ethylmaleimide-Sensitive Proteins
Phosphorylation
Dopamine
SNARE Proteins
4 Citations (Scopus)

Generation and characterization of α9 and α10 nicotinic acetylcholine receptor subunit knockout mice on a C57BL/6J background

Morley, B. J., Dolan, D. F., Ohlemiller, K. K. & Simmons, D. D., Sep 21 2017, In : Frontiers in Neuroscience. 11, SEP, 516.

Research output: Contribution to journalArticle

Nicotinic Receptors
Knockout Mice
Exons
Auditory Hair Cells
Brain Stem Auditory Evoked Potentials
12 Citations (Scopus)

Nicotinic acetylcholine receptors regulate vestibular afferent gain and activation timing

Morley, B. J., Lysakowski, A., Vijayakumar, S., Menapace, D. & Jones, T. A., Apr 1 2017, In : Journal of Comparative Neurology. 525, 5, p. 1216-1233 18 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Knockout Mice
Vestibular Hair Cells
Evoked Potentials
Cholinergic Agents
2016
28 Citations (Scopus)

Infiltration of CCR2+Ly6Chigh proinflammatory monocytes and neutrophils into the central nervous system is modulated by nicotinic acetylcholine receptors in a model of multiple sclerosis

Jiang, W., St-Pierre, S., Roy, P., Morley, B. J., Hao, J. & Simard, A. R., Mar 1 2016, In : Journal of Immunology. 196, 5, p. 2095-2108 14 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Nicotine
Multiple Sclerosis
Monocytes
Neutrophils
23 Citations (Scopus)

Nicotinic acetylcholine receptors modulate bone marrow-derived pro-inflammatory monocyte production and survival

St-Pierre, S., Jiang, W., Roy, P., Champigny, C., LeBlanc, É., Morley, B. J., Hao, J. & Simard, A. R., Feb 2016, In : PloS one. 11, 2, e0150230.

Research output: Contribution to journalArticle

cholinergic receptors
Nicotinic Receptors
Nicotine
monocytes
bone marrow
2015
17 Citations (Scopus)

Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity

Gupta, S. C., Yadav, R., Pavuluri, R., Morley, B. J., Stairs, D. J. & Dravid, S. M., Jun 2015, In : Neuropharmacology. 93, p. 274-284 11 p.

Research output: Contribution to journalArticle

Dendritic Spines
Aptitude
Glutamic Acid
Hippocampus
Actin Depolymerizing Factors
2014
11 Citations (Scopus)

Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse

Smith, M. L., Oliveira Souza, F. G., Bruce, K. S., Strang, C. E., Morley, B. J. & Keyser, K. T., Sep 20 2014, In : Molecular Vision. 20, p. 1328-1356 29 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Cholinergic Receptors
Knockout Mice
Retina
Muscarinic Receptors
18 Citations (Scopus)

Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis

Ramakrishnan, N. A., Drescher, M. J., Morley, B. J., Kelley, P. M. & Drescher, D. G., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 8750-8766 17 p.

Research output: Contribution to journalArticle

Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
SNARE Proteins
Molecular interactions
Exocytosis
Cells
2013
25 Citations (Scopus)

Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice

Morley, B. J. & Mervis, R. F., Mar 3 2013, In : Neuroscience. 233, p. 54-63 10 p.

Research output: Contribution to journalArticle

alpha7 Nicotinic Acetylcholine Receptor
Dendritic Spines
Parietal Lobe
Knockout Mice
Hippocampus
29 Citations (Scopus)

Differential modulation of EAE by α9*- and β2*- nicotinic acetylcholine receptors

Simard, A. R., Gan, Y., St-Pierre, S., Kousari, A., Patel, V., Whiteaker, P., Morley, B. J., Lukas, R. J. & Shi, F. D., Mar 1 2013, In : Immunology and Cell Biology. 91, 3, p. 195-200 6 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Nicotinic Receptors
Nicotine
Knockout Mice
Central Nervous System
2011
14 Citations (Scopus)
Auditory Hair Cells
Inner Ear
Acetylcholine
Vestibular Hair Cells
Messenger RNA
2005
15 Citations (Scopus)

Nicotinic cholinergic intercellular communication: Implications for the developing auditory system

Morley, B. J., Aug 2005, In : Hearing Research. 206, 1-2, p. 74-88 15 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Cholinergic Agents
Acetylcholine
Cholinergic Agonists
Glutamate Receptors
2004
15 Citations (Scopus)

A phenotype for the α7 nicotinic acetylcholine receptor null mutant

Morley, B. J. & Rodriguez-Sierra, J. F., Oct 8 2004, In : Brain Research. 1023, 1, p. 41-47 7 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Phenotype
Estrous Cycle
Periodicity
Real-Time Polymerase Chain Reaction
16 Citations (Scopus)

Distribution and postnatal development of α7 nicotinic acetylcholine receptors in the rodent lower auditory brainstem

Happe, H. K. & Morley, B. J., Oct 15 2004, In : Developmental Brain Research. 153, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Brain Stem
Rodentia
Inferior Colliculi
Acetylcholinesterase
8 Citations (Scopus)

Transient expression of acetylcholinesterase in the posterior ventral cochlear nucleus of rat brain

Morley, B. J., Warr, W. B. & Rodriguez-Sierra, J., Dec 1 2004, In : JARO - Journal of the Association for Research in Otolaryngology. 5, 4, p. 391-403 13 p.

Research output: Contribution to journalArticle

Cochlear Nucleus
Acetylcholinesterase
Brain
Octopodiformes
Axons
2002
34 Citations (Scopus)

Developmental mRNA expression of the α10 nicotinic acetylcholine receptor subunit in the rat cochlea

Morley, B. J. & Simmons, D. D., Nov 15 2002, In : Developmental Brain Research. 139, 1, p. 87-96 10 p.

Research output: Contribution to journalArticle

Cochlea
Nicotinic Receptors
Outer Auditory Hair Cells
Messenger RNA
Inner Auditory Hair Cells
2000
49 Citations (Scopus)

Cholinergic receptors: Dual roles in transduction and plasticity

Morley, B. J. & Happe, H. K., Sep 2000, In : Hearing Research. 147, 1-2, p. 104-112 9 p.

Research output: Contribution to journalArticle

Cochlear Nucleus
Cholinergic Receptors
Octopodiformes
Brain Stem
Inferior Colliculi
1999
21 Citations (Scopus)

Olivocochlear neurons in the chinchilla: A retrograde fluorescent labelling study

Azeredo, W. J., Kliment, M. L., Morley, B. J., Relkin, E., Slepecky, N. B., Sterns, A., Warr, W. B., Weekly, J. M. & Woods, C. I., Aug 1 1999, In : Hearing Research. 134, 1-2, p. 57-70 14 p.

Research output: Contribution to journalArticle

Chinchilla
Neurons
Scala Tympani
Olivary Nucleus
Acoustic Stimulation
1998
16 Citations (Scopus)

ARIA is heavily expressed in rat peripheral auditory and vestibular ganglia

Morley, B. J., Feb 1 1998, In : Molecular Brain Research. 54, 1, p. 170-174 5 p.

Research output: Contribution to journalArticle

Spiral Ganglion
Cholinergic Receptors
Nicotinic Receptors
Ganglia
Messenger RNA
50 Citations (Scopus)

Differential expression of the α9 nicotinic acetylcholine receptor subunit in neonatal and adult cochlear hair cells

Simmons, D. D. & Morley, B. J., May 1 1998, In : Molecular Brain Research. 56, 1-2, p. 287-292 6 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Auditory Hair Cells
Nicotinic Receptors
Complementary RNA
Cochlea
64 Citations (Scopus)

Identification of the subunits of the nicotinic cholinergic receptors in the rat cochlea using RT-PCR and in situ hybridization

Morley, B. J., Li, H. S., Hiel, H., Drescher, D. G. & Elgoyhen, A. B., Jan 1 1998, In : Molecular Brain Research. 53, 1-2, p. 78-87 10 p.

Research output: Contribution to journalArticle

Spiral Ganglion
Cochlea
Nicotinic Receptors
Cholinergic Receptors
In Situ Hybridization
31 Citations (Scopus)
Cochlear Nucleus
Bungarotoxins
Nicotinic Receptors
Autoradiography
In Situ Hybridization
1997
10 Citations (Scopus)

The embryonic and post-natal expression of the nicotinic receptor α3-subunit in rat lower brainstem

Morley, B. J., Sep 1 1997, In : Molecular Brain Research. 48, 2, p. 407-412 6 p.

Research output: Contribution to journalArticle

Cochlear Nucleus
Nicotinic Receptors
Brain Stem
Messenger RNA
Embryonic Structures
1996
57 Citations (Scopus)

Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system

Hiel, H., Elgoyhen, A. B., Drescher, D. G. & Morley, B. J., Nov 4 1996, In : Brain Research. 738, 2, p. 347-352 6 p.

Research output: Contribution to journalArticle

Vestibular Nerve
Nicotinic Receptors
Messenger RNA
Neurons
Vestibular Hair Cells
11 Citations (Scopus)

Regional distribution of a creatine transporter in rat auditory brainstem: An in-situ hybridization study

Hiel, H., Happe, H. K., Warr, W. B. & Morley, B. J., Sep 1 1996, In : Hearing Research. 98, 1-2, p. 29-37 9 p.

Research output: Contribution to journalArticle

Creatine
Cochlear Nucleus
Brain Stem
In Situ Hybridization
Messenger RNA
1995
16 Citations (Scopus)

Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse

Drescher, D. G., Khan, K. M., Green, G. E., Morley, B. J., Beisel, K. W., Kaul, H., Gordon, D., Gupta, A. K., Drescher, M. J. & Barretto, R. L., Nov 1995, In : Comparative Biochemistry and Physiology. Part C: Comparative. 112, 3, p. 267-273 7 p.

Research output: Contribution to journalArticle

Cochlea
Nicotinic Receptors
Muscles
Complementary DNA
Polymerase Chain Reaction
1994
52 Citations (Scopus)

Identification of a glutamate / aspartate transporter in the rat cochlea

Li, H. S., Niedzielski, A. S., Beisel, K. W., Hiel, H., Wenthold, R. J. & Morley, B. J., Aug 1994, In : Hearing Research. 78, 2, p. 235-242 8 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Cochlea
Synapses
Glutamic Acid
Spiral Ganglion
7 Citations (Scopus)

Solid‐phase peptide synthesis and biological activity of bovine thymopoietin II (bTP–11)

Smith, D. D., Conlon, J. M., Petzel, J., Chen, L., Murphy, R. F. & Morley, B. J., Aug 1994, In : International Journal of Peptide and Protein Research. 44, 2, p. 183-191 9 p.

Research output: Contribution to journalArticle

Thymopoietins
Bioactivity
Peptides
Nicotinic Receptors
Thy-1 Antigens
1993
35 Citations (Scopus)

Analysis of γ‐Aminobutyric AcidA Receptor Subunits in the Mouse Cochlea by Means of the Polymerase Chain Reaction

Drescher, D. G., Green, G. E., Khan, K. M., Hajela, K., Beisel, K. W., Morley, B. J. & Gupta, A. K., Sep 1993, In : Journal of Neurochemistry. 61, 3, p. 1167-1170 4 p.

Research output: Contribution to journalArticle

Polymerase chain reaction
Cochlea
GABA-A Receptors
Polymerase Chain Reaction
Transcription
4 Citations (Scopus)

Effects of neonatal thymectomy on the densities of nicotinic cholinergic receptors in skeletal muscle and brain

Morley, B. J. & Murphy, R., Apr 1993, In : Experimental Neurology. 120, 2, p. 277-282 6 p.

Research output: Contribution to journalArticle

Thymectomy
Nicotinic Receptors
Cholinergic Receptors
Skeletal Muscle
Brain
5 Citations (Scopus)

The chronic infusion of nicotine into the developing chick embryo does not alter tensity of (-)-[3H]nicotine-binding sites or vestibular function

Roll, R. L., Jones, T. A., Benowitz, N. L. & Morley, B. J., Feb 26 1993, In : Brain Research. 604, 1-2, p. 260-265 6 p.

Research output: Contribution to journalArticle

Chick Embryo
Nicotine
Binding Sites
Cotinine
Brain
1991
7 Citations (Scopus)

Selective degeneration of a putative cholinergic pathway in the chinchilla cochlea following infusion with ethylcholine aziridinium ion

Morley, B. J., Spangler, K. M., Schneider, B. L. & Javel, E., Mar 22 1991, In : Brain Research. 544, 1, p. 94-100 7 p.

Research output: Contribution to journalArticle

Chinchilla
Cochlea
Cholinergic Agents
Ions
Perilymph
1990
5 Citations (Scopus)
Bungarotoxins
Choline
Binding Sites
Hippocampus
Cholinergic Agents
20 Citations (Scopus)
Bungarotoxins
Nicotine
Light
Locomotion
Rats
1989
13 Citations (Scopus)
Nicotinic Receptors
Locomotion
Circadian Rhythm
Choline
Activity Cycles
6 Citations (Scopus)

α-Bungarotoxin receptors in the CNS

Morley, B. J., Jan 1 1989, In : Progress in Brain Research. 79, C, p. 101-108 8 p.

Research output: Contribution to journalArticle

Bungarotoxins
Nicotine
Central Nervous System
Hypothalamus
Binding Sites
1987
10 Citations (Scopus)

A time course and dose-response study of the regulation of brain nicotinic receptors by dietary choline

Morley, B. J. & Fleck, D. L., Sep 22 1987, In : Brain Research. 421, 1-2, p. 21-29 9 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Choline
Brain
Oral Administration
Choline Deficiency
25 Citations (Scopus)

Somatostatin‐like immunoreactivity in the midbrain of the cat

Spangler, K. M. & Morley, B. J., Jun 1 1987, In : Journal of Comparative Neurology. 260, 1, p. 87-97 11 p.

Research output: Contribution to journalArticle

Mesencephalon
Somatostatin
Cats
Periaqueductal Gray
Superior Colliculi
107 Citations (Scopus)

Structurally different neuronal nicotinic acetylcholine receptor subtypes purified and characterized using monoclonal antibodies

Whiting, P. J., Liu, R., Morley, B. J. & Lindstrom, J. M., Dec 1 1987, In : Journal of Neuroscience. 7, 12, p. 4005-4016 12 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Chickens
Monoclonal Antibodies
Brain
Cholinergic Receptors
1986
20 Citations (Scopus)

Ganglionic nAChRs and high-affinity nicotinic binding sites are not equivalent

Kemp, G. & Morley, B. J., Sep 15 1986, In : FEBS Letters. 205, 2, p. 265-268 4 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Acetylcholine
Binding Sites
Nicotine
PC12 Cells
14 Citations (Scopus)

Increases in the concentration of brain α-bungarotoxin binding sites induced by dietary choline are age-dependent

Morley, B. J. & Garner, L. L., Jul 23 1986, In : Brain Research. 378, 2, p. 315-319 5 p.

Research output: Contribution to journalArticle

Bungarotoxins
Choline
Binding Sites
Brain
Nicotinic Receptors
54 Citations (Scopus)

The interpeduncular nucleus

Morley, B. J., Jan 1986, In : International Review of Neurobiology. 28, C, p. 157-182 26 p.

Research output: Contribution to journalArticle

Acetylcholine
Habenula
Limbic System
Choline O-Acetyltransferase
Interpeduncular Nucleus
1985
5 Citations (Scopus)

Evidence that cell bodies in the arcuate nucleus of the hypothalamus are not cholinergic1

Rodriguez-Sierra, J. F. & Morley, B. J., Jan 1 1985, In : Neuroendocrinology. 41, 5, p. 427-431 5 p.

Research output: Contribution to journalArticle

Arcuate Nucleus of Hypothalamus
Acetylcholinesterase
Cholinergic Neurons
Choline O-Acetyltransferase
Neurons
32 Citations (Scopus)

Purification and characterization of the α-bungarotoxin binding protein from rat brain

Kemp, G., Bentley, L., McNamee, M. G. & Morley, B. J., Nov 18 1985, In : Brain Research. 347, 2, p. 274-283 10 p.

Research output: Contribution to journalArticle

Bungarotoxins
Neuromuscular Junction
Carrier Proteins
Cholinergic Receptors
Brain
11 Citations (Scopus)

The development of somatostatin immunoreactivity in the interpeduncular nucleus of the cat

Morley, B. J., Spangler, K. M. & Javel, E., Jun 1985, In : Developmental Brain Research. 20, 2, p. 241-248 8 p.

Research output: Contribution to journalArticle

Somatostatin
Cats
Neurons
Population
Interpeduncular Nucleus

The development of somatostatin immunoreactivity in the interpeduncular nucleus of the cat.

Morley, B. J., Spangler, K. M. & Javel, E., Jun 1985, In : Brain Research. 352, 2, p. 241-248 8 p.

Research output: Contribution to journalArticle

Somatostatin
Cats
Neurons
Population
Interpeduncular Nucleus
9 Citations (Scopus)

The localization and origin of somatostatin-containing fibers in an auditory brainstem nucleus

Morley, B. J., 1985, In : Peptides. 6, SUPPL. 1, p. 165-172 8 p.

Research output: Contribution to journalArticle

Somatostatin
Labeling
Peroxidase
Brain Stem
Rats