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Fingerprint Dive into the research topics where Amarnath Natarajan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Structure-Activity Relationship Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
Assays Chemical Compounds
Quinoxalines Medicine & Life Sciences
Proteins Medicine & Life Sciences
Fluorescence Polarization Medicine & Life Sciences
Peptides Medicine & Life Sciences

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Projects 2007 2021

Quinoxalines
Mutation
Adenocarcinoma
Adenosine Triphosphate
Neoplasms
Pancreatic Neoplasms
Phosphotransferases
Post Translational Protein Processing
Phospho-Specific Antibodies
Neoplasms
Neoplasm Genes
Binding Sites
Breast Neoplasms
Neoplasms
Mutation
Proteins
Fluorescence Polarization
Mutation
DNA Damage
BRCA1 Protein

Research Output 2000 2019

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Zheng, X. F., Acharya, S. S., Choe, K. N., Nikhil, K., Adelmant, G., Satapathy, S. R., Sharma, S., Viccaro, K., Rana, S., Natarajan, A., Sicinski, P., Marto, J. A., Shah, K. & Chowdhury, D., Dec 1 2019, In : Nature communications. 10, 1, 4252.

Research output: Contribution to journalArticle

Open Access
mitosis
phosphatases
Mitosis
DNA Repair
Chromatin

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors

Al-Mugotir, M., Kolar, C., Vance, K., Kelly, D. L., Natarajan, A. & Borgstahl, G. E. O., Mar 15 2019, In : Analytical Biochemistry. 569, p. 46-52 7 p.

Research output: Contribution to journalArticle

Assays
Proteins
Fluorescence
Replication Protein A
Protein Transport

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Nowialis, P., Lopusna, K., Opavska, J., Haney, S. L., Abraham, A., Sheng, P., Riva, A., Natarajan, A., Guryanova, O., Simpson, M., Hlady, R., Xie, M. & Opavsky, R., Dec 1 2019, In : Nature communications. 10, 1, 4374.

Research output: Contribution to journalArticle

Open Access
accessories
Methyltransferases
Accessories
Embryonic Development
mice

CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax

Kour, S., Rana, S., Contreras, J. I., King, H. M., Robb, C. M., Sonawane, Y. A., Bendjennat, M., Crawford, A. J., Barger, C. J., Kizhake, S., Luo, X., Hollingsworth, M. A. & Natarajan, A., Oct 1 2019, In : Molecular pharmacology. 96, 4, p. 419-429 11 p.

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Down-Regulation
Cell Line
Apoptosis
Clustered Regularly Interspaced Short Palindromic Repeats
2 Citations (Scopus)

Selective degradation of CDK6 by a palbociclib based PROTAC

Rana, S., Bendjennat, M., Kour, S., King, H. M., Kizhake, S., Zahid, M. & Natarajan, A., Jun 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 11, p. 1375-1379 5 p.

Research output: Contribution to journalArticle

Phosphotransferases
Degradation
Adenosine Triphosphate
Binding Sites
Cyclin-Dependent Kinases