Aaron M Mohs, PhD

Assistant Professor

  • 2104 Citations
  • 16 h-Index
20042019
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Research Output 2004 2019

  • 2104 Citations
  • 16 h-Index
  • 32 Article
  • 6 Review article
  • 1 Chapter
  • 1 Conference contribution
2019

Organic Fluorescent Dye-based Nanomaterials: Advances in the Rational Design for Imaging and Sensing Applications

Svechkarev, D. & Mohs, A. M., Jan 1 2019, In : Current medicinal chemistry. 26, 21, p. 4042-4064 23 p.

Research output: Contribution to journalReview article

Nanostructures
Fluorescent Dyes
Nanostructured materials
Imaging techniques
Biocompatibility
1 Citation (Scopus)

Targeted drug delivery and image-guided therapy of heterogeneous ovarian cancer using HER2-targeted theranostic nanoparticles

Satpathy, M., Wang, L., Zielinski, R. J., Qian, W., Wang, Y. A., Mohs, A. M., Kairdolf, B. A., Ji, X., Capala, J., Lipowska, M., Nie, S., Mao, H. & Yang, L., Jan 1 2019, In : Theranostics. 9, 3, p. 778-795 18 p.

Research output: Contribution to journalArticle

Open Access
Ovarian Neoplasms
Nanoparticles
Pharmaceutical Preparations
Neoplasms
Therapeutics

Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistance

Souchek, J. J., Muraskin, L., Houser, L., Vu, Q. & Mohs, A. M., Jan 1 2019, Visualizing and Quantifying Drug Distribution in Tissue III. Chan, K. F. & Evans, C. L. (eds.). SPIE, 1085909. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10859).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fatty Acid Synthases
fatty acids
Fatty acids
Tumors
tumors

ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors

Bhuiyan, N. H., Varney, M. L., Bhattacharya, D. S., Payne, W. M., Mohs, A. M., Holstein, S. A. & Wiemer, D. F., Oct 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 19, 126633.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Terpenes
Diphosphonates
Plasma Cells
Protein Prenylation
2018
2 Citations (Scopus)

Development of colloidally stable carbazole-based fluorescent nanoaggregates

Svechkarev, D., Kyrychenko, A., Payne, W. M. & Mohs, A. M., Feb 1 2018, In : Journal of Photochemistry and Photobiology A: Chemistry. 352, p. 55-64 10 p.

Research output: Contribution to journalArticle

carbazoles
Nanostructured materials
Coloring Agents
Dyes
dyes
3 Citations (Scopus)

Fluorescence Guidance in Surgical Oncology: Challenges, Opportunities, and Translation

Olson, M. T., Ly, Q. P. & Mohs, A. M., Jun 25 2018, (Accepted/In press) In : Molecular Imaging and Biology. p. 1-19 19 p.

Research output: Contribution to journalArticle

Fluorescence
Neoplasms
Computer-Assisted Surgery
Technology
Optical Imaging
6 Citations (Scopus)

Hyaluronic acid formulation of near infrared fluorophores optimizes surgical imaging in a prostate tumor xenograft

Souchek, J. J., Wojtynek, N. E., Payne, W. M., Holmes, M. B., Dutta, S., Qi, B., Datta, K., LaGrange, C. A. & Mohs, A. M., Jul 15 2018, In : Acta Biomaterialia. 75, p. 323-333 11 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Fluorophores
Hyaluronic Acid
Heterografts
Tumors
3 Citations (Scopus)

Hybrid Donor-Acceptor Polymer Particles with Amplified Energy Transfer for Detection and On-Demand Treatment of Breast Cancer

Graham-Gurysh, E., Kelkar, S., McCabe-Lankford, E., Kuthirummal, N., Brown, T., Kock, N. D., Mohs, A. M. & Levi-Polyachenko, N., Mar 7 2018, In : ACS Applied Materials and Interfaces. 10, 9, p. 7697-7703 7 p.

Research output: Contribution to journalArticle

Energy transfer
Polymers
Tumors
Semiconducting polymers
Nanoparticles
9 Citations (Scopus)

Indocyanine green loaded hyaluronan-derived nanoparticles for fluorescence-enhanced surgical imaging of pancreatic cancer

Qi, B., Crawford, A. J., Wojtynek, N. E., Holmes, M. B., Souchek, J. J., Almeida-Porada, G., Ly, Q. P., Cohen, S. M., Hollingsworth, M. A. & Mohs, A. M., Apr 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 3, p. 769-780 12 p.

Research output: Contribution to journalArticle

Indocyanine Green
Hyaluronic Acid
Pancreatic Neoplasms
Nanoparticles
Pancreas
4 Citations (Scopus)

Probing the self-assembly dynamics and internal structure of amphiphilic hyaluronic acid conjugates by fluorescence spectroscopy and molecular dynamics simulations

Svechkarev, D., Kyrychenko, A., Payne, W. M. & Mohs, A. M., Jan 1 2018, In : Soft Matter. 14, 23, p. 4762-4771 10 p.

Research output: Contribution to journalArticle

Fluorescence spectroscopy
Hyaluronic Acid
Self assembly
Molecular dynamics
self assembly
10 Citations (Scopus)

Ratiometric Fluorescent Sensor Array as a Versatile Tool for Bacterial Pathogen Identification and Analysis

Svechkarev, D., Sadykov, M. R., Bayles, K. W. & Mohs, A. M., Mar 23 2018, In : ACS Sensors. 3, 3, p. 700-708 9 p.

Research output: Contribution to journalArticle

pathogens
Sensor arrays
Pathogens
sensors
Discriminant analysis
8 Citations (Scopus)

The role of hydrophobic modification on hyaluronic acid dynamics and self-assembly

Payne, W. M., Svechkarev, D., Kyrychenko, A. & Mohs, A. M., Feb 15 2018, In : Carbohydrate Polymers. 182, p. 132-141 10 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Hyaluronic Acid
Self assembly
Medical nanotechnology
Amphiphiles
2017

Characterization of a Murine Model of Bioequivalent Bladder Wound Healing and Repair Following Subtotal Cystectomy

Zarifpour, M., Andersson, K. E., Kelkar, S. S., Mohs, A. M., Mendelsohn, C., Schneider, K., Marini, F. & Christ, G. J., May 2017, In : BioResearch Open Access. 6, 1, p. 35-45 11 p.

Research output: Contribution to journalArticle

Cystectomy
Wound Healing
Urinary Bladder
Repair
Magnetic resonance
10 Citations (Scopus)

Combination treatment with orlistat-containing nanoparticles and taxanes is synergistic and enhances microtubule stability in taxane-resistant prostate cancer cells

Souchek, J. J., Davis, A. L., Hill, T. K., Holmes, M. B., Qi, B., Singh, P., Kridel, S. J. & Mohs, A. M., Sep 2017, In : Molecular cancer therapeutics. 16, 9, p. 1819-1830 12 p.

Research output: Contribution to journalArticle

Taxoids
Microtubules
Nanoparticles
Prostatic Neoplasms
docetaxel
9 Citations (Scopus)

Direct Observation of a Photochemical Alkyne-Allene Reaction and of a Twisted and Rehybridized Intramolecular Charge-Transfer State in a Donor-Acceptor Dyad

Dereka, B., Svechkarev, D., Rosspeintner, A., Tromayer, M., Liska, R., Mohs, A. M. & Vauthey, E., Nov 22 2017, In : Journal of the American Chemical Society. 139, 46, p. 16885-16893 9 p.

Research output: Contribution to journalArticle

Alkynes
Charge transfer
Excited states
Observation
Isomerization
13 Citations (Scopus)

Impact of structurally modifying hyaluronic acid on CD44 interaction

Bhattacharya, D. S., Svechkarev, D., Souchek, J. J., Hill, T. K., Taylor, M. A., Natarajan, A. & Mohs, A. M., Jan 1 2017, In : Journal of Materials Chemistry B. 5, 41, p. 8183-8192 10 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Hyaluronic Acid
Molecular modeling
Imaging techniques
Glycoproteins
6 Citations (Scopus)

Multimodal imaging nanoparticles derived from hyaluronic acid for integrated preoperative and intraoperative cancer imaging

Payne, W. M., Hill, T. K., Svechkarev, D., Holmes, M. B., Sajja, B. R. & Mohs, A. M., Sep 11 2017, In : Contrast Media and Molecular Imaging. 2017, 9616791.

Research output: Contribution to journalArticle

Multimodal Imaging
Hyaluronic Acid
Nanoparticles
Fluorescence
Computer-Assisted Surgery
2016
13 Citations (Scopus)

Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines

Hill, T. K., Davis, A. L., Wheeler, F. B., Kelkar, S. S., Freund, E. C., Lowther, W. T., Kridel, S. J. & Mohs, A. M., Mar 7 2016, In : Molecular Pharmaceutics. 13, 3, p. 720-728 9 p.

Research output: Contribution to journalArticle

Tumor Cell Line
Nanoparticles
Fatty Acid Synthases
orlistat
Cell Line
5 Citations (Scopus)

Fluorescent imaging of endothelial cells in bioengineered blood vessels: the impact of crosslinking of the scaffold

Niu, G., Sapoznik, E., Lu, P., Criswell, T., Mohs, A. M., Wang, G., Lee, S. J., Xu, Y. & Soker, S., Nov 1 2016, In : Journal of Tissue Engineering and Regenerative Medicine. 10, 11, p. 955-966 12 p.

Research output: Contribution to journalArticle

Endothelial cells
Blood vessels
Signal-To-Noise Ratio
Scaffolds
Crosslinking
17 Citations (Scopus)

Image-guided tumor surgery: will there be a role for fluorescent nanoparticles?

Hill, T. K. & Mohs, A. M., Jul 1 2016, In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 8, 4, p. 498-511 14 p.

Research output: Contribution to journalReview article

Computer-Assisted Surgery
Nanoparticles
Surgery
Tumors
Neoplasms
20 Citations (Scopus)

Near infrared fluorescent nanoparticles based on hyaluronic acid: Self-assembly, optical properties, and cell interaction

Kelkar, S. S., Hill, T. K., Marini, F. C. & Mohs, A. M., May 1 2016, In : Acta Biomaterialia. 36, p. 112-121 10 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Hyaluronic Acid
Cell Communication
Nanoparticles
Self assembly
22 Citations (Scopus)

Near infrared fluorescent nanoparticles derived from hyaluronic acid improve tumor contrast for image-guided surgery

Hill, T. K., Kelkar, S. S., Wojtynek, N. E., Souchek, J. J., Payne, W. M., Stumpf, K., Marini, F. C. & Mohs, A. M., Jan 1 2016, In : Theranostics. 6, 13, p. 2314-2328 15 p.

Research output: Contribution to journalArticle

Computer-Assisted Surgery
Hyaluronic Acid
Nanoparticles
Neoplasms
Indocyanine Green
2015
15 Citations (Scopus)

An integrated widefield imaging and spectroscopy system for contrast-enhanced, image-guided resection of tumors

Mohs, A. M., Mancini, M. C., Provenzale, J. M., Saba, C. F., Cornell, K. K., Howerth, E. W. & Nie, S., May 1 2015, In : IEEE Transactions on Biomedical Engineering. 62, 5, p. 1416-1424 9 p., 7005462.

Research output: Contribution to journalArticle

Tumors
Spectroscopy
Imaging techniques
Surgery
Tissue
20 Citations (Scopus)

Fabrication and characterization of medical grade polyurethane composite catheters for near-infrared imaging

Stevenson, A. T., Reese, L. M., Hill, T. K., McGuire, J., Mohs, A. M., Shekhar, R., Bickford, L. R. & Whittington, A. R., Jun 1 2015, In : Biomaterials. 54, p. 168-176 9 p.

Research output: Contribution to journalArticle

Polyurethanes
Catheters
Infrared imaging
Fabrication
Dyes
45 Citations (Scopus)

Indocyanine green-loaded nanoparticles for image-guided tumor surgery

Hill, T. K., Abdulahad, A., Kelkar, S. S., Marini, F. C., Long, T. E., Provenzale, J. M. & Mohs, A. M., Feb 18 2015, In : Bioconjugate Chemistry. 26, 2, p. 294-303 10 p.

Research output: Contribution to journalArticle

Computer-Assisted Surgery
Indocyanine Green
Nanoparticles
Surgery
Tumors

Translational Imaging for Regenerative Medicine

Kelkar, S. S. & Mohs, A. M., Jan 1 2015, Translational Regenerative Medicine. Elsevier Inc., p. 257-265 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Regenerative Medicine
Magnetic Resonance Imaging
Positron-Emission Tomography
Stem Cells
Tissue Engineering
2014
20 Citations (Scopus)

Hybrid spectral micro-CT: System design, implementation, and preliminary results

Bennett, J. R., Opie, A. M. T., Xu, Q., Yu, H., Walsh, M., Butler, A., Butler, P., Cao, G., Mohs, A. & Wang, G., Feb 2014, In : IEEE Transactions on Biomedical Engineering. 61, 2, p. 246-253 8 p., 6587073.

Research output: Contribution to journalArticle

Systems analysis
Imaging techniques
Dosimetry
Tomography
Costs
1 Citation (Scopus)

Study of scan protocol for exposure reduction in hybrid spectral micro-CT

Opie, A. M. T., Bennett, J. R., Walsh, M., Rajendran, K., Yu, H., Xu, Q., Butler, A., Butler, P., Cao, G., Mohs, A. M. & Wang, G., Jan 1 2014, In : Scanning. 36, 4, p. 444-455 12 p.

Research output: Contribution to journalArticle

Tomography
tomography
Imaging techniques
projection
radiation dosage
2010
12 Citations (Scopus)

Applications of nanotechnology to imaging and therapy of brain tumors

Mohs, A. M. & Provenzale, J. M., Aug 1 2010, In : Neuroimaging Clinics of North America. 20, 3, p. 283-292 10 p.

Research output: Contribution to journalReview article

Nanotechnology
Brain Neoplasms
Nanoparticles
Nanomedicine
Technology
131 Citations (Scopus)

Hand-held spectroscopic device for in vivo and intraoperative tumor detection: Contrast enhancement, detection sensitivity, and tissue penetration

Mohs, A. M., Mancini, M. C., Singhal, S., Provenzale, J. M., Leyland-Jones, B., Wang, M. D. & Nie, S., Nov 1 2010, In : Analytical chemistry. 82, 21, p. 9058-9065 8 p.

Research output: Contribution to journalArticle

Tumors
Tissue
Contrast Media
Light pens
Surgery
2009
513 Citations (Scopus)

Tuning the optical and electronic properties of colloidal nanocrystals by lattice strain

Smith, A. M., Mohs, A. M. & Nie, S., Jan 2009, In : Nature Nanotechnology. 4, 1, p. 56-63 8 p.

Research output: Contribution to journalArticle

Crystal lattices
Electronic properties
Nanocrystals
Semiconductor quantum dots
nanocrystals
2008
867 Citations (Scopus)

Bioconjugated quantum dots for in vivo molecular and cellular imaging

Smith, A. M., Duan, H., Mohs, A. M. & Nie, S., Aug 17 2008, In : Advanced Drug Delivery Reviews. 60, 11, p. 1226-1240 15 p.

Research output: Contribution to journalReview article

Quantum Dots
Molecular Imaging
Nanoparticles
Photobleaching
Light
29 Citations (Scopus)

Characterization of tumor angiogenesis with dynamic contrast-enhanced MRI and biodegradable macromolecular contrast agents in mice

Feng, Y., Jeong, E. K., Mohs, A. M., Emerson, L. & Lu, Z. R., Dec 1 2008, In : Magnetic Resonance in Medicine. 60, 6, p. 1347-1352 6 p.

Research output: Contribution to journalArticle

gadodiamide
Contrast Media
Plasma Volume
Tumor Burden
Neoplasms
2007
40 Citations (Scopus)

Gadolinium(III)-based blood-pool contrast agents for magnetic resonance imaging: Status and clinical potential

Mohs, A. M. & Lu, Z. R., Mar 1 2007, In : Expert Opinion on Drug Delivery. 4, 2, p. 149-164 16 p.

Research output: Contribution to journalReview article

Gadolinium
Contrast Media
Magnetic Resonance Imaging
Vascular Endothelium
Cardiovascular System
14 Citations (Scopus)

Modification of Gd-DTPA cystine copolymers with PEG-1000 optimizes pharmacokinetics and tissue retention for magnetic resonance angiography

Mohs, A. M., Nguyen, T., Jeong, E. K., Feng, Y., Emerson, L., Zong, Y., Parker, D. L. & Lu, Z. R., Jul 1 2007, In : Magnetic Resonance in Medicine. 58, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

Cystine
Magnetic Resonance Angiography
Pharmacokinetics
Contrast Media
Angiography
2006
32 Citations (Scopus)

Effect of size and charge on pharmacokinetics and in vivo MRI contrast enhancement of biodegradable polydisulfide Gd(III) complexes

Zong, Y., Guo, J., Ke, T., Mohs, A. M., Parker, D. L. & Lu, Z. R., May 30 2006, In : Journal of Controlled Release. 112, 3, p. 350-356 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Contrast Media
Molecular Weight
Blood Circulation
gadolinium-DTPA cystine copolymer
48 Citations (Scopus)

Polydisulfide Gd(III) chelates as biodegradable macromolecular magnetic resonance imaging contrast agents

Lu, Z. R., Mohs, A. M., Zong, Y. & Feng, Y., Dec 1 2006, In : International journal of nanomedicine. 1, 1, p. 31-40 10 p.

Research output: Contribution to journalReview article

Gadolinium
Magnetic resonance
Contrast Media
Magnetic Resonance Imaging
Imaging techniques
2005
47 Citations (Scopus)

Contrast-enhanced MRI with new biodegradable macromolecular Gd(III) complexes in tumor-bearing mice

Zong, Y., Wang, X., Goodrich, K. C., Mohs, A. M., Parker, D. L. & Lu, Z. R., Apr 1 2005, In : Magnetic Resonance in Medicine. 53, 4, p. 835-842 8 p.

Research output: Contribution to journalArticle

gadodiamide
Sulfhydryl Compounds
Disulfides
Cystamine
Gadolinium DTPA
41 Citations (Scopus)

PEG-g-poly(GdDTPA-co-L-cystine): Effect of PEG chain length on in vivo contrast enhancement in MRI

Mohs, A. M., Zong, Y., Guo, J., Parker, D. L. & Lu, Z. R., Jul 1 2005, In : Biomacromolecules. 6, 4, p. 2305-2311 7 p.

Research output: Contribution to journalArticle

Cystines
Cystine
Chain length
Magnetic resonance imaging
Polyethylene glycols
2004
68 Citations (Scopus)

PEG-g-poly(GdDTPA-co-L-cystine): A biodegradable macromolecular blood pool contrast agent for MR imaging

Mohs, A. M., Wang, X., Goodrich, K. C., Zong, Y., Parker, D. L. & Lu, Z. R., Nov 1 2004, In : Bioconjugate Chemistry. 15, 6, p. 1424-1430 7 p.

Research output: Contribution to journalArticle

Cystines
Cystine
Contrast Media
Polyethylene glycols
Blood