Eppley Institute for Cancer Research

Research Output 1967 2019

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Review article
2019

Aberrations in DNA repair pathways in cancer and therapeutic significances

Motegi, A., Masutani, M., Yoshioka, K. I. & Bessho, T., Jan 1 2019, In : Seminars in Cancer Biology.

Research output: Contribution to journalReview article

DNA Repair
Genomic Instability
Neoplasms
Physiological Phenomena
Therapeutics
2 Citations (Scopus)

Cancer-associated fibroblasts’ functional heterogeneity in pancreatic ductal adenocarcinoma

Awaji, M. & Singh, R. K., Mar 1 2019, In : Cancers. 11, 3, 290.

Research output: Contribution to journalReview article

Open Access
Adenocarcinoma
Extracellular Matrix
Inflammation
Neoplasms
Myofibroblasts
4 Citations (Scopus)

Cancer-associated mucins: role in immune modulation and metastasis

Bhatia, R., Gautam, S. K., Cannon, A., Thompson, C., Hall, B. R., Aithal, A., Banerjee, K., Jain, M., Solheim, J. C., Kumar, S. & Batra, S. K., Jun 15 2019, In : Cancer and Metastasis Reviews. 38, 1-2, p. 223-236 14 p.

Research output: Contribution to journalReview article

Mucins
Neoplasm Metastasis
Neoplasms
Dendritic Cells
Glycosylation
Neoplastic Stem Cells
Glioblastoma
Blood-Brain Barrier
temozolomide
Radiotherapy

Relevance of Prognostic Factors in the Era of Targeted Therapies in CLL

Kittai, A. S., Lunning, M. A. & Danilov, A. V., Aug 15 2019, In : Current Hematologic Malignancy Reports. 14, 4, p. 302-309 8 p.

Research output: Contribution to journalReview article

Biomarkers
Therapeutics
Phase III Clinical Trials
Chromosome Aberrations
Research

Sox2 dosage: A critical determinant in the functions of Sox2 in both normal and tumor cells

Metz, E. P. & Rizzino, A. A., Nov 1 2019, In : Journal of Cellular Physiology. 234, 11, p. 19298-19306 9 p.

Research output: Contribution to journalReview article

Tumors
Cells
Neoplasms
Cell proliferation
Stem cells
5 Citations (Scopus)

Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis

Thomas, D. & Radhakrishnan, P., Jan 21 2019, In : Molecular cancer. 18, 1, 14.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Fibrosis
Drug Resistance
Neoplasms
Adenocarcinoma
4 Citations (Scopus)

Unraveling the journey of cancer stem cells from origin to metastasis

Nimmakayala, R. K., Batra, S. K. & Palanimuthu Ponnusamy, M., Jan 1 2019, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1871, 1, p. 50-63 14 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Neoplasm Metastasis
Neoplasms
Population
Horizontal Gene Transfer
2018
11 Citations (Scopus)

A review of the catalytic mechanism of human manganese superoxide dismutase

Azadmanesh, J. & Borgstahl, G. E., Feb 1 2018, In : Antioxidants. 7, 2, 25.

Research output: Contribution to journalReview article

Superoxide Dismutase
Reactive Oxygen Species
Neurodegenerative diseases
Lymphatic System
Mutation
3 Citations (Scopus)

Current and emerging treatment options for a patient with a second relapse of Hodgkin’s lymphoma

Kallam, A. & Armitage, J. O., Apr 3 2018, In : Expert Review of Hematology. 11, 4, p. 293-300 8 p.

Research output: Contribution to journalReview article

Hodgkin Disease
Recurrence
Stem Cell Transplantation
Therapeutics
Standard of Care
1 Citation (Scopus)

Direct AFM visualization of the nanoscale dynamics of biomolecular complexes

Lyubchenko, Y. L., Aug 20 2018, In : Journal of Physics D: Applied Physics. 51, 40, 403001.

Research output: Contribution to journalReview article

Atomic force microscopy
Visualization
atomic force microscopy
high speed
Biophysics
8 Citations (Scopus)

Emerging therapeutic potential of graviola and its constituents in cancers

Qazi, A. K., Siddiqui, J. A., Jahan, R., Chaudhary, S., Walker, L. A., Sayed, Z., Jones, D. T., Batra, S. K. & Macha, M. A., Apr 5 2018, In : Carcinogenesis. 39, 4, p. 522-533 12 p.

Research output: Contribution to journalReview article

Annona
Biological Products
Neoplasms
Acetogenins
Annonaceae

ErbB-2 signaling in advanced prostate cancer progression and potential therapy

Miller, D. R., Ingersoll, M. A. & Lin, M-F., Jan 1 2018, In : Endocrine-Related Cancer. 26, 4, p. R195-R209

Research output: Contribution to journalReview article

Prostatic Neoplasms
Castration
Therapeutics
Phosphorylation
MicroRNAs
6 Citations (Scopus)

Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis

Barkeer, S., Chugh, S., Batra, S. K. & Palanimuthu Ponnusamy, M., Aug 1 2018, In : Neoplasia (United States). 20, 8, p. 813-825 13 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Glycosylation
Carcinogenesis
Neoplasm Metastasis
Neoplasms
1 Citation (Scopus)

Hunting for transcription factors: STAT3 decoy in non-small cell lung cancer

Carmicheal, J., Kaur, S., Batra, S. K. & Ganti, A. K. P., Sep 1 2018, In : Translational Lung Cancer Research. 7, p. S254-S257

Research output: Contribution to journalReview article

STAT3 Transcription Factor
Non-Small Cell Lung Carcinoma
6 Citations (Scopus)

Lipid-polymer hybrid nanocarriers for delivering cancer therapeutics

Date, T., Nimbalkar, V., Kamat, J., Mittal, A., Mahato, R. I. & Chitkara, D., Feb 10 2018, In : Journal of Controlled Release. 271, p. 60-73 14 p.

Research output: Contribution to journalReview article

Polymers
Lipids
Neoplasms
Therapeutics
Nanotechnology
1 Citation (Scopus)

Management of untreated advanced stage follicular lymphoma: Role of patient discernment

Umakanthan, J. M. & Lunning, M. A., Mar 1 2018, In : Best Practice and Research: Clinical Haematology. 31, 1, p. 23-30 8 p.

Research output: Contribution to journalReview article

Follicular Lymphoma
Patient Care Planning
Tumors
Tumor Burden
Non-Hodgkin's Lymphoma
2 Citations (Scopus)

MUC16 as a novel target for cancer therapy

Aithal, A., Rauth, S., Kshirsagar, P., Shah, A., Lakshmanan, I., Junker, W. M., Jain, M., Palanimuthu Ponnusamy, M. & Batra, S. K., Aug 3 2018, In : Expert Opinion on Therapeutic Targets. 22, 8, p. 675-686 12 p.

Research output: Contribution to journalReview article

Physiology
Epitopes
Neoplasms
Antibodies
Expert Testimony
10 Citations (Scopus)

Natural products: A hope for glioblastoma patients

Vengoji, R., Macha, M. A., Batra, S. K. & Shonka, N. A., Apr 24 2018, In : Oncotarget. 9, 31, p. 22199-22224 26 p.

Research output: Contribution to journalReview article

temozolomide
Glioblastoma
Biological Products
Neoplastic Stem Cells
Blood-Brain Barrier
4 Citations (Scopus)

Pancreatic cancer associated with obesity and diabetes: An alternative approach for its targeting

Pothuraju, R., Rachagani, S., Junker, W. M., Chaudhary, S., Viswanathan, S., Kaur, S. & Batra, S. K., Dec 19 2018, In : Journal of Experimental and Clinical Cancer Research. 37, 1, 319.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Obesity
Type 2 Diabetes Mellitus
Adipokines
Metabolic Diseases
2 Citations (Scopus)

PD2/PAF1 at the crossroads of the cancer network

Karmakar, S., Dey, P., Vaz, A. P., Bhaumik, S. R., Palanimuthu Ponnusamy, M. & Batra, S. K., Jan 15 2018, In : Cancer Research. 78, 2, p. 313-319 7 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Pancreatic Neoplasms
Histone Code
cdc Genes
RNA Polymerase II
2 Citations (Scopus)

Pharmacokinetics and biodistribution of polymeric micelles containing miRNA and small-molecule drug in orthotopic pancreatic tumor-bearing mice

Kumar, V., Mundra, V., Peng, Y., Wang, Y., Tan, C. & Mahato, R. I., Jan 1 2018, In : Theranostics. 8, 15, p. 4033-4049 17 p.

Research output: Contribution to journalReview article

HhAntag691
Micelles
MicroRNAs
Pharmacokinetics
Pancreatic Neoplasms
5 Citations (Scopus)

Phosphoinositide 3-kinase signaling pathway in pancreatic ductal adenocarcinoma progression, pathogenesis, and therapeutics

Murthy, D., Attri, K. S. & Singh, P., Apr 4 2018, In : Frontiers in Physiology. 9, APR, 335.

Research output: Contribution to journalReview article

1-Phosphatidylinositol 4-Kinase
Adenocarcinoma
Therapeutics
Neoplasms
Mutation
11 Citations (Scopus)

Protein–protein interactions with connexin 43: Regulation and function

Sorgen, P. L., Trease, A. J., Spagnol, G., Delmar, M. & Nielsen, M. S., May 10 2018, In : International Journal of Molecular Sciences. 19, 5, 1428.

Research output: Contribution to journalReview article

Connexin 43
Connexins
Gap Junctions
Proteins
proteins
1 Citation (Scopus)

Ramifications of secreted mucin MUC5AC in malignant journey: A holistic view

Krishn, S. R., Ganguly, K., Kaur, S. & Batra, S. K., Jan 1 2018, In : Carcinogenesis. 39, 5, p. 633-651 19 p.

Research output: Contribution to journalReview article

Mucins
Glycosylation
Gels
Epithelial Cells
Pathology
6 Citations (Scopus)

T-Cell Lymphomas, Version 2.2018 Featured Updates to the NCCN Guidelines

Horwitz, S. M., Ansell, S. M., Ai, W. Z., Barnes, J., Barta, S. K., Choi, M., Clemens, M. W., Dogan, A., Greer, J. P., Halwani, A., Bradley, M. H., Hoppe, R. T., Jacobsen, E., Jagadeesh, D., Kim, Y. H., Lunning, M. A., Mehta, A., Mehta-Shah, N., Oki, Y., Olsen, E. A. & 11 others, Pro, B., Rajguru, S. A., Shanbhag, S., Shustov, A., Sokol, L., Torka, P., Wilcox, R., William, B., Zain, J., Dwyer, M. A. & Sundar, H., Feb 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 2, p. 123-135 13 p.

Research output: Contribution to journalReview article

T-Cell Lymphoma
Natural Killer T-Cells
Guidelines
Extranodal NK-T-Cell Lymphoma
Nose
8 Citations (Scopus)

The enigmatic endosome - Sorting the ins and outs of endocytic trafficking

Naslavsky, N. & Caplan, S. H., Jul 1 2018, In : Journal of Cell Science. 131, 13, jcs216499.

Research output: Contribution to journalReview article

Endosomes
Organelles
Cell Membrane
Recycling
Endocytosis
2017
15 Citations (Scopus)

Angioimmunoblastic T-cell lymphoma: The many-faced lymphoma

Lunning, M. A. & Vose, J. M., Mar 2 2017, In : Blood. 129, 9, p. 1095-1102 8 p.

Research output: Contribution to journalReview article

T-cells
T-Cell Lymphoma
Lymphoma
Peripheral T-Cell Lymphoma
Vincristine
10 Citations (Scopus)

Biological determinants of radioresistance and their remediation in pancreatic cancer

Seshacharyulu, P., Baine, M. J., Souchek, J. J., Menning, M., Kaur, S., Yan, Y., Ouellette, M. M., Jain, M., Lin, C. & Batra, S. K., Aug 1 2017, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1868, 1, p. 69-92 24 p.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Radiotherapy
Radiation
Tumor Microenvironment
Neoplastic Stem Cells
9 Citations (Scopus)

Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras

Lewis, R. E., Frodyma, D., Neilsen, B., Costanzo-Garvey, D. & Fisher, K., 2017, In : F1000Research. 6, 1621.

Research output: Contribution to journalReview article

Scaffolds
Mitogen-Activated Protein Kinase Kinases
Energy balance
MAP Kinase Kinase Kinases
Phosphotransferases
9 Citations (Scopus)
DNA Adducts
Parkinson Disease
Dopamine
Estrogens
Neoplasms
15 Citations (Scopus)

Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells

Rädler, P. D., Wehde, B. L. & Wagner, K. U., Aug 15 2017, In : Molecular and Cellular Endocrinology. 451, p. 31-39 9 p.

Research output: Contribution to journalReview article

Crosstalk
Transducers
Phosphatidylinositol 3-Kinases
Breast
Human Mammary Glands
10 Citations (Scopus)

Elaborated action of the human primosome

Baranovskiy, A. G. & Tahirov, T. H., Feb 8 2017, In : Genes. 8, 2, 62.

Research output: Contribution to journalReview article

DNA Primase
DNA-Directed DNA Polymerase
DNA
DNA Primers
DNA-Directed RNA Polymerases
22 Citations (Scopus)

Gut permeability and mucosal inflammation: Bad, good or context dependent

Ahmad, R., Sorrell, M. F., Batra, S. K., Dhawan, P. & Singh, A. B., Mar 1 2017, In : Mucosal Immunology. 10, 2, p. 307-317 11 p.

Research output: Contribution to journalReview article

Permeability
Inflammation
Colitis
Proteins
Homeostasis
1 Citation (Scopus)

Into the linker's DENN: A tyrosine's control of autophagy

Caplan, S. H., Apr 28 2017, In : Journal of Biological Chemistry. 292, 17, p. 7283-7284 2 p.

Research output: Contribution to journalReview article

Guanine Nucleotide Exchange Factors
Phosphorylation
Autophagy
GTP-Binding Proteins
Tyrosine
6 Citations (Scopus)

KSR as a therapeutic target for Ras-dependent cancers

Neilsen, B. K., Frodyma, D. E., Lewis, R. E. & Fisher, K. W., May 4 2017, In : Expert Opinion on Therapeutic Targets. 21, 5, p. 499-509 11 p.

Research output: Contribution to journalReview article

Neoplasms
Therapeutics
ras Proteins
Dimerization
Expert Testimony
9 Citations (Scopus)

MicroRNAs are important regulators of drug resistance in colorectal cancer

Zhang, Y. & Wang, J., Jul 26 2017, In : Biological Chemistry. 398, 8, p. 929-938 10 p.

Research output: Contribution to journalReview article

MicroRNAs
Drug Resistance
Colorectal Neoplasms
Oncology
Pharmaceutical Preparations
14 Citations (Scopus)

MUC4 mucin- a therapeutic target for pancreatic ductal adenocarcinoma

Gautam, S. K., Kumar, S., Cannon, A., Hall, B., Bhatia, R., Nasser, M. W., Mahapatra, S., Batra, S. K. & Jain, M., Jul 3 2017, In : Expert Opinion on Therapeutic Targets. 21, 7, p. 657-669 13 p.

Research output: Contribution to journalReview article

Mucins
Tumors
Adenocarcinoma
Immune system
Pancreatic Neoplasms
13 Citations (Scopus)

Multifaceted role of neuropilins in the immune system: Potential targets for immunotherapy

Roy, S., Bag, A. K., Singh, R. K., Talmadge, J. E., Batra, S. K. & Datta, K., Oct 10 2017, In : Frontiers in immunology. 8, OCT, 1228.

Research output: Contribution to journalReview article

Neuropilins
Neuropilin-2
Neuropilin-1
Immunotherapy
Immune System
20 Citations (Scopus)

Myeloid growth factors, version 2.2017

Crawford, J., Becker, P. S., Armitage, J. O., Blayney, D. W., Chavez, J., Curtin, P., Dinner, S., Fynan, T., Gojo, I., Griffiths, E. A., Hough, S., Kloth, D. D., Kuter, D. J., Lyman, G. H., Mably, M., Mukherjee, S., Patel, S., Perez, L. E., Poust, A., Rampal, R. & 12 others, Roy, V., Rugo, H. S., Saad, A. A., Schwartzberg, L. S., Shayani, S., Talbott, M., Vadhan-Raj, S., Vasu, S., Wadleigh, M., Westervelt, P., Burns, J. L. & Pluchino, L., Dec 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 12, p. 1520-1541 22 p.

Research output: Contribution to journalReview article

Intercellular Signaling Peptides and Proteins
Chemotherapy-Induced Febrile Neutropenia
Febrile Neutropenia
Neutropenia
Patient Care
49 Citations (Scopus)

Non-Hodgkin lymphoma

Armitage, J. O., Gascoyne, R. D., Lunning, M. A. & Cavalli, F., Jul 15 2017, In : The Lancet. 390, 10091, p. 298-310 13 p.

Research output: Contribution to journalReview article

Non-Hodgkin's Lymphoma
Lymphoma
Primary Care Physicians
Hodgkin Disease
Lymphocytes
2 Citations (Scopus)

Racial disparity in metabolic regulation of cancer

Attri, K. S., Murthy, D. & Singh, P., Mar 1 2017, In : Frontiers in bioscience (Landmark edition). 22, p. 1221-1246 26 p.

Research output: Contribution to journalReview article

Genes
Neoplasms
Tumors
Mutation
Cells
4 Citations (Scopus)

Recent advances in cancer drug development: Targeting induced myeloid cell leukemia-1 (mcl-1) differentiation protein

Abid, M., Sonawane, Y. A., Contreras, J. I., Rana, S. & Natarajan, A., Jan 1 2017, In : Current Medicinal Chemistry. 24, 40, p. 4488-4514 27 p.

Research output: Contribution to journalReview article

Myeloid Leukemia
Myeloid Cells
Drug Delivery Systems
Drug Discovery
Pharmaceutical Preparations
60 Citations (Scopus)

Recent advances in hepatocellular carcinoma therapy

Dutta, R. & Mahato, R. I., May 1 2017, In : Pharmacology and Therapeutics. 173, p. 106-117 12 p.

Research output: Contribution to journalReview article

Hepatocellular Carcinoma
Therapeutics
Monoclonal Antibodies
Peptide Nucleic Acids
Peptide Initiation Factors
16 Citations (Scopus)

Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy

Barbari, S. R. & Shcherbakova, P. V., Aug 1 2017, In : DNA Repair. 56, p. 16-25 10 p.

Research output: Contribution to journalReview article

DNA-Directed DNA Polymerase
Defects
DNA Mismatch Repair
Tumors
DNA
8 Citations (Scopus)

SSB and the RecG DNA helicase: an intimate association to rescue a stalled replication fork

Bianco, P. R. & Lyubchenko, Y. L., Apr 1 2017, In : Protein Science. 26, 4, p. 638-649 12 p.

Research output: Contribution to journalReview article

DNA Helicases
src Homology Domains
Eukaryotic Cells
Thermal energy
DNA Replication
12 Citations (Scopus)

Surface-enhanced raman scattering-based immunoassay technologies for detection of disease biomarkers

Smolsky, J., Kaur, S., Hayashi, C., Batra, S. K. & Krasnoslobodtsev, A. V., Jan 12 2017, In : Biosensors. 7, 1, 7.

Research output: Contribution to journalReview article

Raman Spectrum Analysis
Biomarkers
Immunoassay
Raman scattering
Technology
41 Citations (Scopus)

The dark side of SOX2: Cancer - A comprehensive overview

Wuebben, E. L. & Rizzino, A. A., Jan 1 2017, In : Oncotarget. 8, 27, p. 44917-44943 27 p.

Research output: Contribution to journalReview article

Neoplasms
SOXB1 Transcription Factors
Long Noncoding RNA
Post Translational Protein Processing
Growth
2016
48 Citations (Scopus)

Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

Sonawane, Y. A., Taylor, M. A., Napoleon, J. V., Rana, S., Contreras, J. I. & Natarajan, A., Oct 13 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 8667-8684 18 p.

Research output: Contribution to journalReview article

Cyclin-Dependent Kinase 9
Small Molecule Libraries
Cyclin-Dependent Kinases
Cell Survival
Research
35 Citations (Scopus)

Diffuse large b-cell lymphoma version 1.2016: Clinical practice guidelines in oncology

Zelenetz, A. D., Gordon, L. I., Wierda, W. G., Abramson, J. S., Advani, R. H., Andreadis, C. B., Bartlett, N., Byrd, J. C., Fayad, L. E., Fisher, R. I., Glenn, M. J., Habermann, T. M., Harris, N. L., Hernandez-Ilizaliturri, F., Hoppe, R. T., Horwitz, S. M., Kaminski, M. S., Kelsey, C. R., Kim, Y. H., Krivacic, S. & 17 others, LaCasce, A. S., Lunning, M. A., Nademanee, A., Porcu, P., Press, O., Rabinovitch, R., Reddy, N., Reid, E., Roberts, K., Saad, A. A., Sokol, L., Swinnen, L. J., Vose, J. M., Yahalom, J., Zafar, N., Dwyer, M. & Sundar, H., Feb 1 2016, In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 2, p. 196-231 36 p.

Research output: Contribution to journalReview article

Open Access
Lymphoma, Large B-Cell, Diffuse
Practice Guidelines
B-Cell Lymphoma
Proto-Oncogene Proteins c-bcl-2
B-Lymphocytes