Eppley Institute for Cancer Research

Research Output 1967 2020

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Review article
2020

Elevating pancreatic cystic lesion stratification: Current and future pancreatic cancer biomarker(s)

Carmicheal, J., Patel, A., Dalal, V., Atri, P., Dhaliwal, A. S., Wittel, U. A., Malafa, M. P., Talmon, G., Swanson, B. J., Singh, S., Jain, M., Kaur, S. & Batra, S. K., Jan 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1873, 1, 188318.

Research output: Contribution to journalReview article

Tumor Biomarkers
Pancreatic Neoplasms
Biomarkers
Pancreatic Juice
Neoplasms
2019
5 Citations (Scopus)

Aberrations in DNA repair pathways in cancer and therapeutic significances

Motegi, A., Masutani, M., Yoshioka, K. I. & Bessho, T., Oct 2019, In : Seminars in Cancer Biology. 58, p. 29-46 18 p.

Research output: Contribution to journalReview article

DNA Repair
Genomic Instability
Neoplasms
Physiological Phenomena
Therapeutics

A review of the molecular design and biological activities of RXR agonists

de Almeida, N. R. & Conda-Sheridan, M., Jul 2019, In : Medicinal Research Reviews. 39, 4, p. 1372-1397 26 p.

Research output: Contribution to journalReview article

Retinoid X Receptors
Cytoplasmic and Nuclear Receptors
Molecular Structure
Parkinson Disease
Alzheimer Disease
4 Citations (Scopus)

Cancer-associated fibroblasts’ functional heterogeneity in pancreatic ductal adenocarcinoma

Awaji, M. & Singh, R. K., Mar 2019, In : Cancers. 11, 3, 290.

Research output: Contribution to journalReview article

Open Access
Adenocarcinoma
Extracellular Matrix
Inflammation
Neoplasms
Myofibroblasts
7 Citations (Scopus)

Cancer-associated mucins: role in immune modulation and metastasis

Bhatia, R., Gautam, S. K., Cannon, A., Thompson, C., Hall, B. R., Aithal, A., Banerjee, K., Jain, M., Solheim, J. C., Kumar, S. & Batra, S. K., Jun 15 2019, In : Cancer and Metastasis Reviews. 38, 1-2, p. 223-236 14 p.

Research output: Contribution to journalReview article

Mucins
Neoplasm Metastasis
Neoplasms
Dendritic Cells
Glycosylation

Combination therapies and drug delivery platforms in combating pancreatic cancer

Lei, F., Xi, X., Batra, S. K. & Bronich, T. K., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 682-694 13 p.

Research output: Contribution to journalReview article

Open Access
Combination Drug Therapy
Pancreatic Neoplasms
Adenocarcinoma
Therapeutics
Neoplasms
1 Citation (Scopus)

Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.

Kozmin, S. G., Rogozin, I. B., Moore, E. A., Abney, M., Schaaper, R. M. & Pavlov, Y. I., Sep 11 2019, In : Science Advances. 5, 9, eaaw3915.

Research output: Contribution to journalReview article

Open Access
staphylococcus
deoxyribonucleic acid
yeast
nucleotides
synthesis
2 Citations (Scopus)

Design of Hedgehog pathway inhibitors for cancer treatment

Bariwal, J., Kumar, V., Dong, Y. & Mahato, R. I., May 2019, In : Medicinal Research Reviews. 39, 3, p. 1137-1204 68 p.

Research output: Contribution to journalReview article

Nanomedicine
Structure-Activity Relationship
Biological Products
Embryonic Development
Neoplasms

Emergency response to radiological and nuclear accidents and incidents

Gale, R. P., Armitage, J. O. & Hashmi, S. K., Jan 1 2019, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalReview article

Radioactive Hazard Release
Emergencies
Radiobiology
Continuing Medical Education
Whole-Body Irradiation
1 Citation (Scopus)

Immunometabolic alterations by HPV infection: New dimensions to head and neck cancer disparity

Chaudhary, S., Ganguly, K., Muniyan, S., Pothuraju, R., Sayed, Z., Jones, D. T., Batra, S. K. & Macha, M. A., Jan 1 2019, In : Journal of the National Cancer Institute. 111, 3, p. 233-244 12 p.

Research output: Contribution to journalReview article

Open Access
Papillomavirus Infections
Head and Neck Neoplasms
African Americans
Population
Neoplasms
7 Citations (Scopus)

MicroRNA regulation of K-Ras in pancreatic cancer and opportunities for therapeutic intervention

Karmakar, S., Kaushik, G., Nimmakayala, R., Rachagani, S., Palanimuthu Ponnusamy, M. & Batra, S. K., Feb 2019, In : Seminars in Cancer Biology. 54, p. 63-71 9 p.

Research output: Contribution to journalReview article

MicroRNAs
Pancreatic Neoplasms
Mutation
Neoplasms
Therapeutics

Nano-carriers for delivery and targeting of active ingredients of Chinese medicine for hepatocellular carcinoma therapy

Chen, M., Zhou, X., Chen, R., Wang, J., Ye, R. D., Wang, Y., Wu, C. & Mahato, R. I., May 2019, In : Materials Today. 25, p. 66-87 22 p.

Research output: Contribution to journalReview article

medicine
ingredients
Medicine
therapy
delivery

Novel therapies hijack the blood-brain barrier to eradicate glioblastoma cancer stem cells

Vengoji, R., Ponnusamy, M. P., Rachagani, S., Mahapatra, S., Batra, S. K., Shonka, N. & Macha, M. A., Mar 12 2019, In : Carcinogenesis. 40, 1, p. 2-14 13 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Glioblastoma
Blood-Brain Barrier
temozolomide
Radiotherapy

Relevance of Prognostic Factors in the Era of Targeted Therapies in CLL

Kittai, A. S., Lunning, M. & Danilov, A. V., Aug 15 2019, In : Current Hematologic Malignancy Reports. 14, 4, p. 302-309 8 p.

Research output: Contribution to journalReview article

Biomarkers
Therapeutics
Phase III Clinical Trials
Chromosome Aberrations
Research

Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases

Sharma, S. & Hopkins, C. R., Sep 12 2019, In : Journal of Medicinal Chemistry. 62, 17, p. 7589-7602 14 p.

Research output: Contribution to journalReview article

Transient Receptor Potential Channels
Chronic Renal Insufficiency
Cations
Kidney
Brain

Roles of microRNAs in T cell immunity: Implications for strategy development against infectious diseases

Giri, B. R., Mahato, R. I. & Cheng, G., Mar 2019, In : Medicinal Research Reviews. 39, 2, p. 706-732 27 p.

Research output: Contribution to journalReview article

MicroRNAs
Communicable Diseases
Immunity
T-Lymphocytes
Untranslated RNA
1 Citation (Scopus)

Sox2 dosage: A critical determinant in the functions of Sox2 in both normal and tumor cells

Metz, E. P. & Rizzino, A., Nov 2019, In : Journal of Cellular Physiology. 234, 11, p. 19298-19306 9 p.

Research output: Contribution to journalReview article

Tumors
Cells
Neoplasms
Cell proliferation
Stem cells

The evolving role of maintenance therapy following autologous stem cell transplantation in multiple myeloma

Merz, A. M. A., Merz, M., Hillengass, J., Holstein, S. A. & McCarthy, P., Oct 3 2019, In : Expert review of anticancer therapy. 19, 10, p. 889-898 10 p.

Research output: Contribution to journalReview article

Stem Cell Transplantation
Multiple Myeloma
Maintenance
Autologous Transplantation
Cytogenetics
7 Citations (Scopus)

Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis

Thomas, D. & Radhakrishnan, P., Jan 21 2019, In : Molecular cancer. 18, 1, 14.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Fibrosis
Drug Resistance
Neoplasms
Adenocarcinoma
9 Citations (Scopus)

Unraveling the journey of cancer stem cells from origin to metastasis

Nimmakayala, R. K., Batra, S. K. & Palanimuthu Ponnusamy, M., Jan 2019, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1871, 1, p. 50-63 14 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Neoplasm Metastasis
Neoplasms
Population
Horizontal Gene Transfer
2018
5 Citations (Scopus)

An update on minding the gap in cancer

Mesnil, M., Aasen, T., Boucher, J., Chépied, A., Cronier, L., Defamie, N., Kameritsch, P., Laird, D. W., Lampe, P. D., Lathia, J. D., Leithe, E., Mehta, P. P., Monvoisin, A., Pogoda, K., Sin, W. C., Tabernero, A., Yamasaki, H., Yeh, E. S., Dagli, M. L. Z. & Naus, C. C., Jan 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 1, p. 237-243 7 p.

Research output: Contribution to journalReview article

Gap Junctions
France
British Columbia
Communication
Anniversaries and Special Events
18 Citations (Scopus)

A review of the catalytic mechanism of human manganese superoxide dismutase

Azadmanesh, J. & Borgstahl, G. E., Feb 2018, In : Antioxidants. 7, 2, 25.

Research output: Contribution to journalReview article

Superoxide Dismutase
Reactive Oxygen Species
Neurodegenerative diseases
Lymphatic System
Mutation
8 Citations (Scopus)

Concise Review: Current Status of Three-Dimensional Organoids as Preclinical Models

Kaushik, G., Palanimuthu Ponnusamy, M. & Batra, S. K., Sep 2018, In : STEM CELLS. 36, 9, p. 1329-1340 12 p.

Research output: Contribution to journalReview article

Organoids
Stem Cells
Pathology
Growth Inhibitors
Systems Biology
4 Citations (Scopus)

Current and emerging treatment options for a patient with a second relapse of Hodgkin’s lymphoma

Kallam, A. & Armitage, J. O., Apr 3 2018, In : Expert Review of Hematology. 11, 4, p. 293-300 8 p.

Research output: Contribution to journalReview article

Hodgkin Disease
Recurrence
Stem Cell Transplantation
Therapeutics
Standard of Care
2 Citations (Scopus)

Direct AFM visualization of the nanoscale dynamics of biomolecular complexes

Lyubchenko, Y. L., Aug 20 2018, In : Journal of Physics D: Applied Physics. 51, 40, 403001.

Research output: Contribution to journalReview article

Atomic force microscopy
Visualization
atomic force microscopy
high speed
Biophysics
9 Citations (Scopus)

Emerging therapeutic potential of graviola and its constituents in cancers

Qazi, A. K., Siddiqui, J. A., Jahan, R., Chaudhary, S., Walker, L. A., Sayed, Z., Jones, D. T., Batra, S. K. & Macha, M. A., Apr 5 2018, In : Carcinogenesis. 39, 4, p. 522-533 12 p.

Research output: Contribution to journalReview article

Annona
Biological Products
Neoplasms
Acetogenins
Annonaceae

ErbB-2 signaling in advanced prostate cancer progression and potential therapy

Miller, D. R., Ingersoll, M. A. & Lin, M. F., Jan 1 2018, In : Endocrine-Related Cancer. 26, 4, p. R195-R209

Research output: Contribution to journalReview article

Prostatic Neoplasms
Castration
Therapeutics
Phosphorylation
MicroRNAs
8 Citations (Scopus)

Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis

Barkeer, S., Chugh, S., Batra, S. K. & Palanimuthu Ponnusamy, M., Aug 2018, In : Neoplasia (United States). 20, 8, p. 813-825 13 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Glycosylation
Carcinogenesis
Neoplasm Metastasis
Neoplasms
1 Citation (Scopus)

Hunting for transcription factors: STAT3 decoy in non-small cell lung cancer

Carmicheal, J., Kaur, S., Batra, S. K. & Ganti, A. K. P., Sep 1 2018, In : Translational Lung Cancer Research. 7, p. S254-S257

Research output: Contribution to journalReview article

STAT3 Transcription Factor
Non-Small Cell Lung Carcinoma
10 Citations (Scopus)

Lipid-polymer hybrid nanocarriers for delivering cancer therapeutics

Date, T., Nimbalkar, V., Kamat, J., Mittal, A., Mahato, R. I. & Chitkara, D., Feb 10 2018, In : Journal of Controlled Release. 271, p. 60-73 14 p.

Research output: Contribution to journalReview article

Polymers
Lipids
Neoplasms
Therapeutics
Nanotechnology
1 Citation (Scopus)

Management of untreated advanced stage follicular lymphoma: Role of patient discernment

Umakanthan, J. M. & Lunning, M. A., Mar 2018, In : Best Practice and Research: Clinical Haematology. 31, 1, p. 23-30 8 p.

Research output: Contribution to journalReview article

Follicular Lymphoma
Patient Care Planning
Tumors
Tumor Burden
Non-Hodgkin's Lymphoma
9 Citations (Scopus)

Mechanisms of erythrocyte development and regeneration: Implications for regenerative medicine and beyond

Bresnick, E. H., Hewitt, K. J., Mehta, C., Keles, S., Paulson, R. F. & Johnson, K. D., Jan 2018, In : Development (Cambridge). 145, 1, dev151423.

Research output: Contribution to journalReview article

Regenerative Medicine
Regeneration
Erythrocytes
Hematopoietic Stem Cells
Oxygen
12 Citations (Scopus)

MicroRNAs in the pathogenesis and treatment of progressive liver injury in NAFLD and liver fibrosis

Su, Q., Kumar, V., Sud, N. & Mahato, R. I., Apr 2018, In : Advanced Drug Delivery Reviews. 129, p. 54-63 10 p.

Research output: Contribution to journalReview article

MicroRNAs
Liver Cirrhosis
Liver
Wounds and Injuries
Hepatocytes
4 Citations (Scopus)

MUC16 as a novel target for cancer therapy

Aithal, A., Rauth, S., Kshirsagar, P., Shah, A., Lakshmanan, I., Junker, W. M., Jain, M., Palanimuthu Ponnusamy, M. & Batra, S. K., Aug 3 2018, In : Expert Opinion on Therapeutic Targets. 22, 8, p. 675-686 12 p.

Research output: Contribution to journalReview article

Physiology
Epitopes
Neoplasms
Antibodies
Expert Testimony
13 Citations (Scopus)

Natural products: A hope for glioblastoma patients

Vengoji, R., Macha, M. A., Batra, S. K. & Shonka, N. A., Apr 24 2018, In : Oncotarget. 9, 31, p. 22199-22224 26 p.

Research output: Contribution to journalReview article

temozolomide
Glioblastoma
Biological Products
Neoplastic Stem Cells
Blood-Brain Barrier
5 Citations (Scopus)

Pancreatic cancer associated with obesity and diabetes: An alternative approach for its targeting

Pothuraju, R., Rachagani, S., Junker, W. M., Chaudhary, S., Viswanathan, S., Kaur, S. & Batra, S. K., Dec 19 2018, In : Journal of Experimental and Clinical Cancer Research. 37, 1, 319.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Obesity
Type 2 Diabetes Mellitus
Adipokines
Metabolic Diseases
3 Citations (Scopus)

PD2/PAF1 at the crossroads of the cancer network

Karmakar, S., Dey, P., Vaz, A. P., Bhaumik, S. R., Palanimuthu Ponnusamy, M. & Batra, S. K., Jan 15 2018, In : Cancer Research. 78, 2, p. 313-319 7 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Pancreatic Neoplasms
Histone Code
cdc Genes
RNA Polymerase II
5 Citations (Scopus)

PD-L1, inflammation, non-coding RNAs, and neuroblastoma: Immuno-oncology perspective

Nallasamy, P., Chava, S., Verma, S. S., Mishra, S., Gorantla, S., Coulter, D. W., Byrareddy, S. N., Batra, S. K., Gupta, S. C. & Challagundla, K. B., Oct 2018, In : Seminars in Cancer Biology. 52, p. 53-65 13 p.

Research output: Contribution to journalReview article

Untranslated RNA
Neuroblastoma
Ligands
Inflammation
Long Noncoding RNA
8 Citations (Scopus)

Pharmacokinetics and biodistribution of polymeric micelles containing miRNA and small-molecule drug in orthotopic pancreatic tumor-bearing mice

Kumar, V., Mundra, V., Peng, Y., Wang, Y., Tan, C. & Mahato, R. I., Jan 1 2018, In : Theranostics. 8, 15, p. 4033-4049 17 p.

Research output: Contribution to journalReview article

HhAntag691
Micelles
MicroRNAs
Pharmacokinetics
Pancreatic Neoplasms
7 Citations (Scopus)

Phosphoinositide 3-kinase signaling pathway in pancreatic ductal adenocarcinoma progression, pathogenesis, and therapeutics

Murthy, D., Attri, K. S. & Singh, P., Apr 4 2018, In : Frontiers in Physiology. 9, APR, 335.

Research output: Contribution to journalReview article

1-Phosphatidylinositol 4-Kinase
Adenocarcinoma
Therapeutics
Neoplasms
Mutation
3 Citations (Scopus)

Precision Medicine for CRC Patients in the Veteran Population: State-of-the-Art, Challenges and Research Directions

Mohapatra, S. S., Batra, S. K., Bharadwaj, S., Bouvet, M., Cosman, B., Goel, A., Jogunoori, W., Kelley, M. J., Mishra, L., Mishra, B., Mohapatra, S., Patel, B., Pisegna, J. R., Raufman, J. P., Rao, S., Roy, H., Scheuner, M., Singh, S., Vidyarthi, G. & White, J., May 1 2018, In : Digestive Diseases and Sciences. 63, 5, p. 1123-1138 16 p.

Research output: Contribution to journalReview article

Precision Medicine
Veterans
Colorectal Neoplasms
Research
Population
12 Citations (Scopus)

Protein–protein interactions with connexin 43: Regulation and function

Sorgen, P. L., Trease, A. J., Spagnol, G., Delmar, M. & Nielsen, M. S., May 10 2018, In : International journal of molecular sciences. 19, 5, 1428.

Research output: Contribution to journalReview article

Connexin 43
Connexins
Gap Junctions
Proteins
proteins
1 Citation (Scopus)

Ramifications of secreted mucin MUC5AC in malignant journey: A holistic view

Krishn, S. R., Ganguly, K., Kaur, S. & Batra, S. K., Jan 1 2018, In : Carcinogenesis. 39, 5, p. 633-651 19 p.

Research output: Contribution to journalReview article

Mucins
Glycosylation
Gels
Epithelial Cells
Pathology
10 Citations (Scopus)

T-Cell Lymphomas, Version 2.2018 Featured Updates to the NCCN Guidelines

Horwitz, S. M., Ansell, S. M., Ai, W. Z., Barnes, J., Barta, S. K., Choi, M., Clemens, M. W., Dogan, A., Greer, J. P., Halwani, A., Bradley, M. H., Hoppe, R. T., Jacobsen, E., Jagadeesh, D., Kim, Y. H., Lunning, M. A., Mehta, A., Mehta-Shah, N., Oki, Y., Olsen, E. A. & 11 others, Pro, B., Rajguru, S. A., Shanbhag, S., Shustov, A., Sokol, L., Torka, P., Wilcox, R., William, B., Zain, J., Dwyer, M. A. & Sundar, H., Feb 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 2, p. 123-135 13 p.

Research output: Contribution to journalReview article

T-Cell Lymphoma
Natural Killer T-Cells
Guidelines
Extranodal NK-T-Cell Lymphoma
Nose
11 Citations (Scopus)

The enigmatic endosome - Sorting the ins and outs of endocytic trafficking

Naslavsky, N. & Caplan, S. H., Jul 1 2018, In : Journal of cell science. 131, 13, jcs216499.

Research output: Contribution to journalReview article

Endosomes
Organelles
Cell Membrane
Recycling
Endocytosis
3 Citations (Scopus)
Dairying
Hormones
Milk
Steroids
Meat
9 Citations (Scopus)

Tying trafficking to fusion and fission at the mighty mitochondria

Farmer, T., Naslavsky, N. & Caplan, S. H., Aug 2018, In : Traffic. 19, 8, p. 569-577 9 p.

Research output: Contribution to journalReview article

Mitochondrial Dynamics
Mitochondria
Fusion reactions
GTP Phosphohydrolases
Homeostasis
2017
17 Citations (Scopus)

Angioimmunoblastic T-cell lymphoma: The many-faced lymphoma

Lunning, M. A. & Vose, J. M., Mar 2 2017, In : Blood. 129, 9, p. 1095-1102 8 p.

Research output: Contribution to journalReview article

T-cells
T-Cell Lymphoma
Lymphoma
Peripheral T-Cell Lymphoma
Vincristine
12 Citations (Scopus)

Biological determinants of radioresistance and their remediation in pancreatic cancer

Seshacharyulu, P., Baine, M. J., Souchek, J. J., Menning, M., Kaur, S., Yan, Y., Ouellette, M. M., Jain, M., Lin, C. & Batra, S. K., Aug 1 2017, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1868, 1, p. 69-92 24 p.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Radiotherapy
Radiation
Tumor Microenvironment
Neoplastic Stem Cells
14 Citations (Scopus)

Challenges and Recent Advances in Medulloblastoma Therapy

Kumar, V., Kumar, V., McGuire, T. R., Coulter, D. W., Sharp, J. G. & Mahato, R. I., Dec 2017, In : Trends in Pharmacological Sciences. 38, 12, p. 1061-1084 24 p.

Research output: Contribution to journalReview article

Medulloblastoma
MicroRNAs
Tumors
Stem cells
Brain