Eppley Institute for Cancer Research

Research Output 1967 2019

2019

Aberrations in DNA repair pathways in cancer and therapeutic significances

Motegi, A., Masutani, M., Yoshioka, K. I. & Bessho, T., Jan 1 2019, In : Seminars in Cancer Biology.

Research output: Contribution to journalReview article

DNA Repair
Genomic Instability
Neoplasms
Physiological Phenomena
Therapeutics
Open Access
temozolomide
Glioblastoma
Carcinogenesis
Neoplastic Stem Cells
Epidermal Growth Factor Receptor
1 Citation (Scopus)

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

He, C., Lv, X., Huang, C., Angeletti, P. C., Hua, G., Dong, J., Zhou, J., Wang, Z., Ma, B., Chen, X., Lambert, P. F., Rueda, B. R., Davis, J. S. & Wang, C., Mar 5 2019, In : Cell Reports. 26, 10, p. 2636-2650.e5

Research output: Contribution to journalArticle

Open Access
Uterine Cervical Neoplasms
Carcinogenesis
Animals
Animal Models
Infection

Alendronate-Modified Polymeric Micelles for the Treatment of Breast Cancer Bone Metastasis

Liu, T., Romanova, S., Wang, S., Hyun, M. A., Zhang, C., Cohen, S. M., Singh, R. K. & Bronich, T. K., Jan 1 2019, In : Molecular Pharmaceutics.

Research output: Contribution to journalArticle

docetaxel
Alendronate
Bone Neoplasms
Micelles
Breast Neoplasms

Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells

Banerjee, K., Gautam, S. K., Kshirsagar, P., Ross, K. A., Spagnol, G., Sorgen, P. L., Wannemuehler, M. J., Narasimhan, B., Solheim, J. C., Kumar, S., Batra, S. K. & Jain, M., Jan 1 2019, In : Genes and Cancer. 10, 3-4, p. 52-62 11 p.

Research output: Contribution to journalArticle

Open Access
Mucin-4
Polyanhydrides
Dendritic Cells
Nanoparticles
Pancreatic Neoplasms

Anti-Claudin-1 Conjugated to a Near-Infrared Fluorophore Targets Colon Cancer in PDOX Mouse Models

Hollandsworth, H. M., Lwin, T. M., Amirfakhri, S., Filemoni, F., Batra, S. K., Hoffman, R. M., Dhawan, P. & Bouvet, M., Oct 1 2019, In : Journal of Surgical Research. 242, p. 145-150 6 p.

Research output: Contribution to journalArticle

Claudin-1
Colonic Neoplasms
Optical Imaging
Antibodies
Coloring Agents
1 Citation (Scopus)

Aperiodic order coming of age: From inorganic materials to dynamic protein superstructures

Borgstahl, G. E., Goldman, A. I. & Thiel, P. A., Jan 1 2019, In : Acta Crystallographica Section A: Foundations and Advances. 75, p. 212-213 2 p.

Research output: Contribution to journalEditorial

Open Access
Quasicrystals
inorganic materials
proteins
Proteins
2 Citations (Scopus)

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Xing, X., Kane, D. P., Bulock, C. R., Moore, E. A., Sharma, S., Chabes, A. & Shcherbakova, P. V., Dec 1 2019, In : Nature Communications. 10, 1, 374.

Research output: Contribution to journalArticle

Exonucleases
DNA-Directed DNA Polymerase
enzymes
Substitution reactions
deoxyribonucleic acid

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors

Al-Mugotir, M., Kolar, C., Vance, K., Kelly, D. L., Natarajan, A. & Borgstahl, G. E., Mar 15 2019, In : Analytical Biochemistry. 569, p. 46-52 7 p.

Research output: Contribution to journalArticle

Assays
Proteins
Fluorescence
Replication Protein A
Protein Transport

Assembly of α-synuclein aggregates on phospholipid bilayers

Lv, Z., Hashemi, M., Banerjee, S., Zagorski, K., Rochet, J. C. & Lyubchenko, Y. L., Sep 1 2019, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1867, 9, p. 802-812 11 p.

Research output: Contribution to journalArticle

Synucleins
Phospholipids
Membranes
Agglomeration
Atomic Force Microscopy

Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells

Sliker, B. H., Goetz, B. T., Peters, H. L., Poelaert, B. J., Borgstahl, G. E. & Solheim, J. C., Jan 1 2019, In : Cancer Biology and Therapy.

Research output: Contribution to journalArticle

beta 2-Microglobulin
Amyloid beta-Protein Precursor
Pancreatic Neoplasms
Cell Movement
Cell Line

Biphasic changes in airway epithelial cell EGF receptor binding and phosphorylation induced by components of hogbarn dust

Dodmane, P. R., Schulte, N. A., Heires, A. J., Band, H., Romberger, D. & Toews, M. L., Jan 1 2019, In : Experimental Lung Research.

Research output: Contribution to journalArticle

Phosphorylation
Dust
Epidermal Growth Factor Receptor
Epithelial Cells
Confocal microscopy
2 Citations (Scopus)

Cancer-associated fibroblasts’ functional heterogeneity in pancreatic ductal adenocarcinoma

Awaji, M. & Singh, R. K., Mar 1 2019, In : Cancers. 11, 3, 290.

Research output: Contribution to journalReview article

Open Access
Adenocarcinoma
Extracellular Matrix
Inflammation
Neoplasms
Myofibroblasts
4 Citations (Scopus)

Cancer-associated mucins: role in immune modulation and metastasis

Bhatia, R., Gautam, S. K., Cannon, A., Thompson, C., Hall, B. R., Aithal, A., Banerjee, K., Jain, M., Solheim, J. C., Kumar, S. & Batra, S. K., Jun 15 2019, In : Cancer and Metastasis Reviews. 38, 1-2, p. 223-236 14 p.

Research output: Contribution to journalReview article

Mucins
Neoplasm Metastasis
Neoplasms
Dendritic Cells
Glycosylation

Clinical impact of Internet-based tools to guide therapeutic decisions for mantle cell lymphoma

Gopalsamy, S. N., Rosenthal, K. M., Ayers, A. A., Goy, A., Leonard, J. P., Vose, J. M., Obholz, K. L., Armitage, J. O. & Flowers, C. R., Jan 1 2019, In : Leukemia and Lymphoma.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Internet
Therapeutics
Expert Testimony
Standard of Care
12 Citations (Scopus)

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., Tomar, G., Papke, B., Hobbs, G. A., Yan, L., Hayes, T. K., Diehl, J. N., Goode, G. D., Chaika, N. V., Wang, Y., Zhang, G. F. & 11 others, Witkiewicz, A. K., Knudsen, E. S., Petricoin, E. F., Singh, P., Macdonald, J. M., Tran, N. L., Lyssiotis, C. A., Ying, H., Kimmelman, A. C., Cox, A. D. & Der, C. J., Apr 1 2019, In : Nature Medicine. 25, 4, p. 628-640 13 p.

Research output: Contribution to journalArticle

Autophagy
Chloroquine
Pancreatic Neoplasms
Fluxes
Adenocarcinoma

Common genetic variants contribute to incomplete penetrance: evidence from cancer-free BRCA1 mutation carriers

Downs, B., Sherman, S., Cui, J., Kim, Y. C., Snyder, C., Christensen, M., Luo, J., Lynch, H. & Wang, S. M., Jan 1 2019, In : European Journal of Cancer. 107, p. 68-78 11 p.

Research output: Contribution to journalArticle

Penetrance
Mutation
Neoplasms
Breast
Breast Neoplasms

Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad

Grigorenko, B. L., Novichkova, D. A., Lushchekina, S. V., Zueva, I. V., Schopfer, L. M., Nemukhin, A. V., Varfolomeev, S. D., Lockridge, O. & Masson, P., Jun 1 2019, In : Chemico-Biological Interactions. 306, p. 138-146 9 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Organophosphates
Enzymes
Electrophoresis
Cell culture

CXCR2: A Novel Mediator of Mammary Tumor Bone Metastasis

Sharma, B., Nannuru, K. C., Saxena, S., Varney, M. L. & Singh, R. K., Mar 12 2019, In : International journal of molecular sciences. 20, 5

Research output: Contribution to journalArticle

Open Access
CXC Chemokines
Chemokine Receptors
metastasis
bones
Tumors

Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity

Yin, L., Zeng, Y., Xiao, Y., Chen, Y., Shen, H. & Dong, J., Jun 1 2019, In : Cell Death and Disease. 10, 6, 385.

Research output: Contribution to journalArticle

Open Access
CDC2 Protein Kinase
Serine
Protein Isoforms
Phosphorylation
Mitosis
1 Citation (Scopus)

Dual delivery nanoscale device for miR-345 and gemcitabine co-delivery to treat pancreatic cancer

Uz, M., Kalaga, M., Pothuraju, R., Ju, J., Junker, W. M., Batra, S. K., Mallapragada, S. & Rachagani, S., Jan 28 2019, In : Journal of Controlled Release. 294, p. 237-246 10 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Equipment and Supplies
Heterografts
Neoplasms
5 Citations (Scopus)

Dual responsive micelles capable of modulating miRNA-34a to combat taxane resistance in prostate cancer

Lin, F., Wen, D., Wang, X. & Mahato, R. I., Feb 1 2019, In : Biomaterials. 192, p. 95-108 14 p.

Research output: Contribution to journalArticle

docetaxel
Micelles
MicroRNAs
Tumors
Prostatic Neoplasms

Effects of center type and socioeconomic factors on early mortality and overall survival of diffuse large B-cell lymphoma

Dhakal, P., Chen, B., Giri, S., Vose, J. M., Armitage, J. O. & Bhatt, V. R., Jun 1 2019, In : Future Oncology. 15, 18, p. 2113-2124 12 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Survival
Mortality
Insurance
Comorbidity

Engineering hydrogel based cancer microenvironments for in vitro breast cancer cell culture and therapeutics screening

Shi, W., Kuss, M. A., Mohapatra, B., Mirza, S., Band, H., Band, V. & Duan, B., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tumor Microenvironment
Hydrogel
Cell culture
Collagen
Hydrogels

Epigenetic activation of POTE genes in ovarian cancer

Sharma, A., Albahrani, M., Zhang, W., Kufel, C. N., James, S. R., Odunsi, K., Klinkebiel, D. L. & Karpf, A. R., Feb 1 2019, In : Epigenetics. 14, 2, p. 185-197 13 p.

Research output: Contribution to journalArticle

decitabine
Epigenomics
Ovarian Neoplasms
Transcriptional Activation
Epigenetic Repression
1 Citation (Scopus)

ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

Neilsen, B. K., Frodyma, D. E., McCall, J. L., Fisher, K. W. & Lewis, R. E., Jan 1 2019, In : PloS one. 14, 1, e0209224.

Research output: Contribution to journalArticle

colorectal neoplasms
Colonic Neoplasms
Cell proliferation
Cells
cell proliferation
Open Access
Actins
Apoptosis
MCF-7 Cells
Labels
Literature

Erratum: O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 (Immunity (2019) 50(3) (576–590.e6), (S1074761319300305) (10.1016/j.immuni.2019.01.007))

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. & Wen, H., Jan 1 2019, In : Immunity.

Research output: Contribution to journalComment/debate

Receptor-Interacting Protein Serine-Threonine Kinases
Immunity
Sepsis
Inflammation
O-GlcNAc transferase

Estrogen Metabolism in African-American Women with and without Breast Cancer: A Pilot Study

Zahid, M., Mondal, B., LeVan, T. D. & Rogan, E. G., Jan 22 2019, In : Chemical Research in Toxicology. 32, 1, p. 190-194 5 p.

Research output: Contribution to journalArticle

Metabolism
African Americans
Estrogens
Breast Neoplasms
DNA Adducts

Evaluating the metabolic alterations in pancreatic cancer

Dasgupta, A., Shukla, S. K., Gunda, V., King, R. J. & Singh, P., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 221-228 8 p. (Methods in Molecular Biology; vol. 1882).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pancreatic Neoplasms
Neoplasms
Metabolic Networks and Pathways
Glutamine
Oxygen Consumption

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Seshacharyulu, P., Rachagani, S., Muniyan, S., Siddiqui, J. A., Cruz, E., Sharma, S., Krishnan, R., Killips, B. J., Sheinin, Y., Lele, S. M., Smith, L. M., Talmon, G. A., Palanimuthu Ponnusamy, M., Datta, K. & Batra, S. K., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Geranyltranstransferase
Monomeric GTP-Binding Proteins
Prostatic Neoplasms
Mevalonic Acid
zoledronic acid

Force clamp approach for characterization of nano-assembly in amyloid beta 42 dimer

Maity, S. & Lyubchenko, Y. L., Jul 7 2019, In : Nanoscale. 11, 25, p. 12259-12265 7 p.

Research output: Contribution to journalArticle

Clamping devices
Amyloid
Dimers
Oligomers
Oligomerization

Genistein treatment duration effects biomarkers of cell motility in human prostate

Zhang, H., Gordon, R., Li, W., Yang, X., Pattanayak, A., Fowler, G., Zhang, L., Catalona, W. J., Ding, Y., Xu, L., Huang, X., Jovanovic, B., Kelly, D. L., Jiang, H. & Bergan, R., Mar 1 2019, In : PLoS ONE. 14, 3, e0214078.

Research output: Contribution to journalArticle

Open Access
Genistein
genistein
Biomarkers
cell movement
Cell Movement

Hepatosplenic γ-δ T-Cell Lymphoma: Who Is on Your Speed Dial?

Krishnan, M. & Lunning, M. A., Jun 1 2019, In : Journal of oncology practice. 15, 6, p. 307-312 6 p.

Research output: Contribution to journalArticle

T-Cell Lymphoma
Peripheral T-Cell Lymphoma
Expert Testimony
Stem Cell Transplantation
Therapeutics

Immunometabolic Alterations by HPV Infection: New Dimensions to Head and Neck Cancer Disparity

Chaudhary, S., Ganguly, K., Muniyan, S., Pothuraju, R., Sayed, Z., Jones, D. T., Batra, S. K. & Macha, M. A., Mar 1 2019, In : Journal of the National Cancer Institute. 111, 3, p. 233-244 12 p.

Research output: Contribution to journalArticle

Open Access
Papillomavirus Infections
Head and Neck Neoplasms
African Americans
Population
Neoplasms

Inactivation of XPF Sensitizes Cancer Cells to Gemcitabine

George, J. W., Bessho, M. & Bessho, T., Jan 1 2019, In : Journal of Nucleic Acids. 2019, 6357609.

Research output: Contribution to journalArticle

Open Access
gemcitabine
Cells
Repair
Neoplasms
DNA
1 Citation (Scopus)

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Haney, S. L., Varney, M. L., Chhonker, Y. S., Shin, S., Mehla, K., Crawford, A. J., Smith, H. J., Smith, L. M., Murry, D. J., Hollingsworth, M. A. & Holstein, S. A., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Adenocarcinoma
Mucins
Unfolded Protein Response
Terpenes

Inhibition of miR-328-3p impairs cancer stem cell function and prevents metastasis in ovarian cancer

Srivastava, A. K., Banerjee, A., Cui, T., Han, C., Cai, S., Liu, L., Wu, D., Cui, R., Li, Z., Zhang, X., Xie, G., Selvendiran, K., Patnaik, S., Karpf, A. R., Liu, J., Cohn, D. E. & Wang, Q. E., Jan 1 2019, In : Cancer Research. 79, 9, p. 2314-2326 13 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Ovarian Neoplasms
Neoplasm Metastasis
Neoplasms
Maintenance
2 Citations (Scopus)

Integrated generation of induced pluripotent stem cells in a low-cost device

Lin, H., Li, Q., Du, Q., Wang, O., Wang, Z., Akert, L., Carlson, M. A., Zhang, C., Subramanian, A., Zhang, C., Lunning, M. A., Li, M. & Lei, Y., Jan 1 2019, In : Biomaterials. 189, p. 23-36 14 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Stem cells
Costs and Cost Analysis
Equipment and Supplies
Costs

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

Connor, A. A., Denroche, R. E., Jang, G. H., Lemire, M., Zhang, A., Chan-Seng-Yue, M., Wilson, G., Grant, R. C., Merico, D., Lungu, I., Bartlett, J. M. S., Chadwick, D., Liang, S. B., Eagles, J., Mbabaali, F., Miller, J. K., Krzyzanowski, P., Armstrong, H., Luo, X., Jorgensen, L. G. T. & 25 others, Romero, J. M., Bavi, P., Fischer, S. E., Serra, S., Hafezi-Bakhtiari, S., Caglar, D., Roehrl, M. H. A., Cleary, S., Hollingsworth, M. A., Petersen, G. M., Thayer, S. P., Law, C. H. L., Nanji, S., Golan, T., Smith, A. L., Borgida, A., Dodd, A., Hedley, D., Wouters, B. G., O'Kane, G. M., Wilson, J. M., Zogopoulos, G., Notta, F., Knox, J. J. & Gallinger, S., Feb 11 2019, In : Cancer Cell. 35, 2, p. 267-282.e7

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Cell Cycle
Neoplasm Metastasis
Neoplasms
Cell Hypoxia

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Song, L., Tang, S., Han, X., Jiang, Z., Dong, L., Liu, C., Liang, X., Dong, J., Qiu, C., Wang, Y. & Du, Y., Dec 1 2019, In : Nature Communications. 10, 1, 1639.

Research output: Contribution to journalArticle

Open Access
Exosomes
secretions
Cell membranes
Multivesicular Bodies
degradation
4 Citations (Scopus)

Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer

Carmicheal, J., Hayashi, C., Huang, X., Liu, L., Lu, Y., Krasnoslobodtsev, A. V., Lushnikov, A., Kshirsagar, P. G., Patel, A., Jain, M., Lyubchenko, Y. L., Lu, Y., Batra, S. K. & Kaur, S., Feb 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 16, p. 88-96 9 p.

Research output: Contribution to journalArticle

Exosomes
Raman Spectrum Analysis
Pancreatic Neoplasms
Early Detection of Cancer
Raman spectroscopy

LIMD1 phosphorylation in mitosis is required for mitotic progression and its tumor-suppressing activity

Zhou, J., Zhang, L., Zhou, W., Chen, Y., Cheng, Y. & Dong, J., Mar 1 2019, In : FEBS Journal. 286, 5, p. 963-974 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Mitosis
Tumors
bis(2,3,3,3-tetrachloropropyl) ether
Lung Neoplasms
2 Citations (Scopus)

Management of immunotherapy-related toxicities, version 1.2019

Thompson, J. A., Schneider, B. J., Brahmer, J., Andrews, S., Armand, P., Bhatia, S., Budde, L. E., Costa, L., Davies, M., Dunnington, D., Ernstoff, M. S., Frigault, M., Hoffner, B., Hoimes, C. J., Lacouture, M., Locke, F., Lunning, M. A., Mohindra, N. A., Naidoo, J., Olszanski, A. J. & 11 others, Oluwole, O., Patel, S. P., Reddy, S., Ryder, M., Santomasso, B., Shofer, S., Sosman, J. A., Wahidi, M., Wang, Y., Johnson-Chilla, A. & Scavone, J. L., Mar 1 2019, In : JNCCN Journal of the National Comprehensive Cancer Network. 17, 3, p. 255-289 35 p.

Research output: Contribution to journalArticle

Immunotherapy
Guidelines
Oncology Nursing
Patient Advocacy
Neoplasms
2 Citations (Scopus)
Lysine
Mass spectrometry
Mass Spectrometry
Tubulin
Proteins
2 Citations (Scopus)

Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4 + and CD8 + T-lymphocytes

Moshfegh, C. M., Collins, C. W., Gunda, V., Vasanthakumar, A., Cao, J. Z., Singh, P., Godley, L. A. & Case, A., Jan 1 2019, In : Redox Biology. 101141.

Research output: Contribution to journalArticle

Open Access
T-cells
Epigenomics
Superoxides
T-Lymphocytes
Superoxide Dismutase

Molecular and physiological evaluation of pancreatic cancer-induced cachexia

Shukla, S. K., Dasgupta, A., Mulder, S. E. & Singh, P., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 321-333 13 p. (Methods in Molecular Biology; vol. 1882).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cachexia
Pancreatic Neoplasms
Muscles
Fats
Rotarod Performance Test

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis

Liu, X., Clemens, D. L., Grunkemeyer, J. A., Price, J. D., O’Connell, K., Chapman, N. M., Storz, P., Wen, H., Cox, J. L., Reid, W. L., Hollingsworth, M. A. & Thayer, S. P., Dec 1 2019, In : Scientific Reports. 9, 1, 10656.

Research output: Contribution to journalArticle

Open Access
Mucin-1
Enterovirus
Pancreatitis
Macrophages
Inflammation

Nanoparticulate delivery of potent microtubule inhibitor for metastatic melanoma treatment

Bariwal, J., Kumar, V., Chen, H., Bhattarai, R. S., Peng, Y., Li, W. & Mahato, R. I., Sep 10 2019, In : Journal of Controlled Release. 309, p. 231-243 13 p.

Research output: Contribution to journalArticle

Microtubules
Melanoma
Tubulin
Nanoparticles
G2 Phase Cell Cycle Checkpoints
Neoplastic Stem Cells
Glioblastoma
Blood-Brain Barrier
temozolomide
Radiotherapy