Eppley Institute for Cancer Research

Research Output 1967 2020

2020

A phase I study of weekly doxorubicin and oral topotecan for patients with relapsed or refractory small cell lung cancer (SCLC): A Fred and Pamela Buffet Cancer Center Clinical Trials Network study

Ernani, V., Jahan, R., Smith, L. M., Marr, A. S., Kimbrough, S. E., Kos, M. E., Tijerina, J., Pivovar, S., Lakshmanan, I., Ketcham, M., Rauth, S., Mallya, K., Nasser, M. W., Jain, M., Kessinger, A., Batra, S. K. & Ganti, A. K., 2020, In : Cancer Treatment and Research Communications. 22, 100162.

Research output: Contribution to journalArticle

Open Access
Topotecan
Small Cell Lung Carcinoma
Doxorubicin
Clinical Trials
Neoplasms

Elevating pancreatic cystic lesion stratification: Current and future pancreatic cancer biomarker(s)

Carmicheal, J., Patel, A., Dalal, V., Atri, P., Dhaliwal, A. S., Wittel, U. A., Malafa, M. P., Talmon, G., Swanson, B. J., Singh, S., Jain, M., Kaur, S. & Batra, S. K., Jan 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1873, 1, 188318.

Research output: Contribution to journalReview article

Tumor Biomarkers
Pancreatic Neoplasms
Biomarkers
Pancreatic Juice
Neoplasms
2019
5 Citations (Scopus)

Aberrations in DNA repair pathways in cancer and therapeutic significances

Motegi, A., Masutani, M., Yoshioka, K. I. & Bessho, T., Oct 2019, In : Seminars in Cancer Biology. 58, p. 29-46 18 p.

Research output: Contribution to journalReview article

DNA Repair
Genomic Instability
Neoplasms
Physiological Phenomena
Therapeutics

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells

Vengoji, R., Macha, M. A., Nimmakayala, R. K., Rachagani, S., Siddiqui, J. A., Mallya, K., Gorantla, S., Jain, M., Ponnusamy, M. P., Batra, S. K. & Shonka, N., Jun 18 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 266.

Research output: Contribution to journalArticle

Open Access
temozolomide
Glioblastoma
Carcinogenesis
Neoplastic Stem Cells
Epidermal Growth Factor Receptor

A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery

McMillan, E. A., Kwon, G., Clemenceau, J. R., Fisher, K. W., Vaden, R. M., Shaikh, A. F., Neilsen, B. K., Kelly, D., Potts, M. B., Sung, Y. J., Mendiratta, S., Hight, S. K., Lee, Y., MacMillan, J. B., Lewis, R. E., Kim, H. S. & White, M. A., Oct 17 2019, In : Cell Chemical Biology. 26, 10, p. 1380-1392.e6

Research output: Contribution to journalArticle

Biological Products
Ontology
Genes
Genome
Pharmacologic Actions
3 Citations (Scopus)

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

He, C., Lv, X., Huang, C., Angeletti, P. C., Hua, G., Dong, J., Zhou, J., Wang, Z., Ma, B., Chen, X., Lambert, P. F., Rueda, B. R., Davis, J. S. & Wang, C., Mar 5 2019, In : Cell Reports. 26, 10, p. 2636-2650.e5

Research output: Contribution to journalArticle

Open Access
Uterine Cervical Neoplasms
Carcinogenesis
Animals
Animal Models
Infection

Alendronate-Modified Polymeric Micelles for the Treatment of Breast Cancer Bone Metastasis

Liu, T., Romanova, S., Wang, S., Hyun, M. A., Zhang, C., Cohen, S. M., Singh, R. K. & Bronich, T. K., Jan 1 2019, In : Molecular Pharmaceutics.

Research output: Contribution to journalArticle

docetaxel
Alendronate
Bone Neoplasms
Micelles
Breast Neoplasms

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Zheng, X. F., Acharya, S. S., Choe, K. N., Nikhil, K., Adelmant, G., Satapathy, S. R., Sharma, S., Viccaro, K., Rana, S., Natarajan, A., Sicinski, P., Marto, J. A., Shah, K. & Chowdhury, D., Dec 1 2019, In : Nature communications. 10, 1, 4252.

Research output: Contribution to journalArticle

Open Access
mitosis
phosphatases
Mitosis
DNA Repair
Chromatin

Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells

Banerjee, K., Gautam, S. K., Kshirsagar, P., Ross, K. A., Spagnol, G., Sorgen, P., Wannemuehler, M. J., Narasimhan, B., Solheim, J. C., Kumar, S., Batra, S. K. & Jain, M., Jan 1 2019, In : Genes and Cancer. 10, 3-4, p. 52-62 11 p.

Research output: Contribution to journalArticle

Open Access
Mucin-4
Polyanhydrides
Dendritic Cells
Nanoparticles
Pancreatic Neoplasms
1 Citation (Scopus)

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Linsdley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., Mar 20 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1294-1299 6 p.

Research output: Contribution to journalArticle

Acute Pain
Opioid Receptors
Morphine
Analgesics
G Protein-Coupled Inwardly-Rectifying Potassium Channels

Anti-Claudin-1 Conjugated to a Near-Infrared Fluorophore Targets Colon Cancer in PDOX Mouse Models

Hollandsworth, H. M., Lwin, T. M., Amirfakhri, S., Filemoni, F., Batra, S. K., Hoffman, R. M., Dhawan, P. & Bouvet, M., Oct 2019, In : Journal of Surgical Research. 242, p. 145-150 6 p.

Research output: Contribution to journalArticle

Claudin-1
Colonic Neoplasms
Optical Imaging
Antibodies
Coloring Agents

A patent review of bisphosphonates in treating bone disease

Holstein, S. A., May 4 2019, In : Expert Opinion on Therapeutic Patents. 29, 5, p. 315-325 11 p.

Research output: Contribution to journalArticle

Bone Diseases
Diphosphonates
Protein Prenylation
Farnesyltranstransferase
Bone and Bones
1 Citation (Scopus)

Aperiodic order coming of age: From inorganic materials to dynamic protein superstructures

Borgstahl, G., Goldman, A. I. & Thiel, P. A., Jan 1 2019, In : Acta Crystallographica Section A: Foundations and Advances. 75, p. 212-213 2 p.

Research output: Contribution to journalEditorial

Open Access
Quasicrystals
inorganic materials
proteins
Proteins

A polymeric nanogel-based treatment regimen for enhanced efficacy and sequential administration of synergistic drug combination in pancreatic cancer

Soni, K. S., Thomas, D., Caffrey, T., Mehla, K., Lei, F., O'Connell, K. A., Sagar, S., Lele, S. M., Hollingsworth, M. A., Radhakrishnan, P. & Bronich, T. K., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 894-901 8 p.

Research output: Contribution to journalArticle

Open Access
gemcitabine
Drug Combinations
Pancreatic Neoplasms
Adenocarcinoma
Nanomedicine
3 Citations (Scopus)

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Xing, X., Kane, D. P., Bulock, C. R., Moore, E. A., Sharma, S., Chabes, A. & Shcherbakova, P. V., Dec 1 2019, In : Nature communications. 10, 1, 374.

Research output: Contribution to journalArticle

Exonucleases
DNA-Directed DNA Polymerase
enzymes
Substitution reactions
deoxyribonucleic acid

A review of the molecular design and biological activities of RXR agonists

de Almeida, N. R. & Conda-Sheridan, M., Jul 2019, In : Medicinal Research Reviews. 39, 4, p. 1372-1397 26 p.

Research output: Contribution to journalReview article

Retinoid X Receptors
Cytoplasmic and Nuclear Receptors
Molecular Structure
Parkinson Disease
Alzheimer Disease

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors

Al-Mugotir, M., Kolar, C., Vance, K., Kelly, D. L., Natarajan, A. & Borgstahl, G. E. O., Mar 15 2019, In : Analytical Biochemistry. 569, p. 46-52 7 p.

Research output: Contribution to journalArticle

Assays
Proteins
Fluorescence
Replication Protein A
Protein Transport

Assembly of α-synuclein aggregates on phospholipid bilayers

Lv, Z., Hashemi, M., Banerjee, S., Zagorski, K., Rochet, J. C. & Lyubchenko, Y. L., Sep 2019, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1867, 9, p. 802-812 11 p.

Research output: Contribution to journalArticle

Synucleins
Phospholipids
Membranes
Agglomeration
Atomic Force Microscopy

Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells

Sliker, B. H., Goetz, B. T., Peters, H. L., Poelaert, B. J., Borgstahl, G. E. O. & Solheim, J. C., Jun 3 2019, In : Cancer Biology and Therapy. 20, 6, p. 931-940 10 p.

Research output: Contribution to journalArticle

beta 2-Microglobulin
Amyloid beta-Protein Precursor
Pancreatic Neoplasms
Cell Movement
Cell Line
4 Citations (Scopus)

BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL

Greaves, G., Milani, M., Butterworth, M., Carter, R. J., Byrne, D. P., Eyers, P. A., Luo, X., Cohen, G. M. & Varadarajan, S., Jun 1 2019, In : Cell Death and Differentiation. 26, 6, p. 1037-1047 11 p.

Research output: Contribution to journalArticle

Pharmacology
Apoptosis
Proteins
Cell Line
Neoplasms

BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis

Huang, K., O’Neill, K. L., Li, J., Zhou, W., Han, N., Pang, X., Wu, W., Struble, L., Borgstahl, G., Liu, Z., Zhang, L. & Luo, X., Nov 1 2019, In : Cell Research. 29, 11, p. 942-952 11 p.

Research output: Contribution to journalArticle

Apoptosis
Proteins
Membranes
Mitochondrial Membranes
Mitochondria
1 Citation (Scopus)

BORIS Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through GALNT14

Hillman, J. C., Pugacheva, E. M., Barger, C. J., Sribenja, S., Rosario, S., Albahrani, M., Truskinovsky, A. M., Stablewski, A., Liu, S., Loukinov, D. I., Zentner, G. E., Lobanenkov, V. V., Karpf, A. R. & Higgins, M. J., Oct 1 2019, In : Molecular cancer research : MCR. 17, 10, p. 2051-2062 12 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Cell Movement
Carcinoma
Fallopian Tubes
Neoplasms

Breast Cancer Collaborative Registry informs understanding of factors predicting sleep quality

Berger, A. M., Kupzyk, K. A., Djalilova, D. M. & Cowan, K. H., Apr 1 2019, In : Supportive Care in Cancer. 27, 4, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

Registries
Sleep
Breast Neoplasms
Nonparametric Statistics
Health Status
1 Citation (Scopus)

Cancer-Associated Fibroblasts Enhance Survival and Progression of the Aggressive Pancreatic Tumor Via FGF-2 and CXCL8

Awaji, M., Futakuchi, M., Heavican, T., Iqbal, J. & Singh, R. K., Apr 1 2019, In : Cancer Microenvironment. 12, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Survival
Neoplasms
Coculture Techniques
Conditioned Culture Medium
4 Citations (Scopus)

Cancer-associated fibroblasts’ functional heterogeneity in pancreatic ductal adenocarcinoma

Awaji, M. & Singh, R. K., Mar 2019, In : Cancers. 11, 3, 290.

Research output: Contribution to journalReview article

Open Access
Adenocarcinoma
Extracellular Matrix
Inflammation
Neoplasms
Myofibroblasts
7 Citations (Scopus)

Cancer-associated mucins: role in immune modulation and metastasis

Bhatia, R., Gautam, S. K., Cannon, A., Thompson, C., Hall, B. R., Aithal, A., Banerjee, K., Jain, M., Solheim, J. C., Kumar, S. & Batra, S. K., Jun 15 2019, In : Cancer and Metastasis Reviews. 38, 1-2, p. 223-236 14 p.

Research output: Contribution to journalReview article

Mucins
Neoplasm Metastasis
Neoplasms
Dendritic Cells
Glycosylation

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Nowialis, P., Lopusna, K., Opavska, J., Haney, S. L., Abraham, A., Sheng, P., Riva, A., Natarajan, A., Guryanova, O., Simpson, M., Hlady, R., Xie, M. & Opavsky, R., Dec 1 2019, In : Nature communications. 10, 1, 4374.

Research output: Contribution to journalArticle

Open Access
accessories
Methyltransferases
Accessories
Embryonic Development
mice

Caveat medicus: Clinician experiences in publishing reports of serious oncology-associated adverse drug reactions

Bennett, C. L., Schooley, B., Taylor, M. A., Witherspoon, B. J., Godwin, A., Vemula, J., Ausdenmoore, H. C., Sartor, O., Tony Yang, Y., Armitage, J. O., Hrushesky, W. J., Restaino, J., Thomsen, H. S., Yarnold, P. R., Young, T., Knopf, K. B. & Chen, B., Jan 1 2019, In : PloS one. 14, 7, e0219521.

Research output: Contribution to journalArticle

Open Access
Oncology
Drug-Related Side Effects and Adverse Reactions
Pharmacovigilance
drugs
Motivation

CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax

Kour, S., Rana, S., Contreras, J. I., King, H. M., Robb, C. M., Sonawane, Y. A., Bendjennat, M., Crawford, A. J., Barger, C. J., Kizhake, S., Luo, X., Hollingsworth, M. A. & Natarajan, A., Oct 1 2019, In : Molecular pharmacology. 96, 4, p. 419-429 11 p.

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Down-Regulation
Cell Line
Apoptosis
Clustered Regularly Interspaced Short Palindromic Repeats

Clinical impact of Internet-based tools to guide therapeutic decisions for mantle cell lymphoma

Gopalsamy, S. N., Rosenthal, K. M., Ayers, A. A., Goy, A., Leonard, J. P., Vose, J. M., Obholz, K. L., Armitage, J. O. & Flowers, C. R., Jul 29 2019, In : Leukemia and Lymphoma. 60, 9, p. 2255-2263 9 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Internet
Therapeutics
Expert Testimony
Standard of Care
28 Citations (Scopus)

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., Tomar, G., Papke, B., Hobbs, G. A., Yan, L., Hayes, T. K., Diehl, J. N., Goode, G. D., Chaika, N. V., Wang, Y., Zhang, G. F. & 11 others, Witkiewicz, A. K., Knudsen, E. S., Petricoin, E. F., Singh, P. K., Macdonald, J. M., Tran, N. L., Lyssiotis, C. A., Ying, H., Kimmelman, A. C., Cox, A. D. & Der, C. J., Apr 1 2019, In : Nature Medicine. 25, 4, p. 628-640 13 p.

Research output: Contribution to journalArticle

Autophagy
Chloroquine
Pancreatic Neoplasms
Fluxes
Adenocarcinoma

Combination therapies and drug delivery platforms in combating pancreatic cancer

Lei, F., Xi, X., Batra, S. K. & Bronich, T. K., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 682-694 13 p.

Research output: Contribution to journalReview article

Open Access
Combination Drug Therapy
Pancreatic Neoplasms
Adenocarcinoma
Therapeutics
Neoplasms
1 Citation (Scopus)

Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.

Kozmin, S. G., Rogozin, I. B., Moore, E. A., Abney, M., Schaaper, R. M. & Pavlov, Y. I., Sep 11 2019, In : Science Advances. 5, 9, eaaw3915.

Research output: Contribution to journalReview article

Open Access
staphylococcus
deoxyribonucleic acid
yeast
nucleotides
synthesis

Common genetic variants contribute to incomplete penetrance: evidence from cancer-free BRCA1 mutation carriers

Downs, B., Sherman, S., Cui, J., Kim, Y. C., Snyder, C., Christensen, M., Luo, J., Lynch, H. & Wang, S. M., Jan 2019, In : European Journal of Cancer. 107, p. 68-78 11 p.

Research output: Contribution to journalArticle

Penetrance
Mutation
Neoplasms
Breast
Breast Neoplasms
Open Access
Blood Vessels
Prostatic Neoplasms
Perfusion
Neoplasms
Bombesin Receptors

Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad

Grigorenko, B. L., Novichkova, D. A., Lushchekina, S. V., Zueva, I. V., Schopfer, L. M., Nemukhin, A. V., Varfolomeev, S. D., Lockridge, O. & Masson, P., Jun 1 2019, In : Chemico-Biological Interactions. 306, p. 138-146 9 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Organophosphates
Enzymes
Electrophoresis
Cell culture

Correction to: Analgesic effects of the GIRK activator, VU0466551, Alone and in combination with morphine in acute and persistent pain models (ACS Chemical Neuroscience (2019) 10:3 (1294-1299) DOI: 10.1021/acschemneuro.8b00370)

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Lindsley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., May 15 2019, In : ACS Chemical Neuroscience. 10, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Chemical Models
Acute Pain
Neurosciences
Morphine
Names
1 Citation (Scopus)

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI

Hu, W. F., Krieger, K. L., Lagundžin, D., Li, X., Cheung, R. S., Taniguchi, T., Johnson, K. R., Bessho, T., Monteiro, A. N. A. & Woods, N. T., Dec 1 2019, In : Cell Death Discovery. 5, 1, 105.

Research output: Contribution to journalArticle

Open Access
Phosphoric Monoester Hydrolases
DNA Repair
Breast Neoplasms
Survival
DNA Damage

CXCR2: A novel mediator of mammary tumor bone metastasis

Sharma, B., Nannuru, K. C., Saxena, S., Varney, M. L. & Singh, R. K., Mar 2019, In : International journal of molecular sciences. 20, 5, 1237.

Research output: Contribution to journalArticle

Open Access
CXC Chemokines
Chemokine Receptors
metastasis
bones
Tumors

Cyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression

Stauffer, S., Zeng, Y., Santos, M., Zhou, J., Chen, Y. & Dong, J., Oct 28 2019, In : Journal of cell science. 132, 20

Research output: Contribution to journalArticle

Open Access
CDC2 Protein Kinase
AMP-Activated Protein Kinases
Chromosomes
Phosphorylation
Mitosis

Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity

Yin, L., Zeng, Y., Xiao, Y., Chen, Y., Shen, H. & Dong, J., Jun 1 2019, In : Cell Death and Disease. 10, 6, 385.

Research output: Contribution to journalArticle

Open Access
CDC2 Protein Kinase
Serine
Protein Isoforms
Phosphorylation
Mitosis

Delineating the role of FANCA in glucose-stimulated insulin secretion in β cells through its protein interactome

Lagundžin, D., Hu, W. F., Law, H. C. H., Krieger, K. L., Qiao, F., Clement, E. J., Drincic, A. T., Nedić, O., Naldrett, M. J., Alvarez, S. & Woods, N. T., Jan 1 2019, In : PloS one. 14, 8, e0220568.

Research output: Contribution to journalArticle

Open Access
insulin secretion
Insulin
Glucose
glucose
Fanconi Anemia
2 Citations (Scopus)

Design of Hedgehog pathway inhibitors for cancer treatment

Bariwal, J., Kumar, V., Dong, Y. & Mahato, R. I., May 2019, In : Medicinal Research Reviews. 39, 3, p. 1137-1204 68 p.

Research output: Contribution to journalReview article

Nanomedicine
Structure-Activity Relationship
Biological Products
Embryonic Development
Neoplasms
4 Citations (Scopus)

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu 4 )

Bollinger, S. R., Engers, D. W., Panarese, J. D., West, M., Engers, J. L., Loch, M. T., Rodriguez, A. L., Blobaum, A. L., Jones, C. K., Thompson Gray, A., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 342-358 17 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Structure-Activity Relationship
Catalepsy
Haloperidol
Parkinson Disease

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

Sharma, S., Kozek, K. A., Abney, K. K., Kumar, S., Gautam, N., Alnouti, Y., David Weaver, C. & Hopkins, C. R., Mar 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 6, p. 791-796 6 p.

Research output: Contribution to journalArticle

G Protein-Coupled Inwardly-Rectifying Potassium Channels
Acetamides
Inwardly Rectifying Potassium Channel
Potassium Channels
GTP-Binding Proteins

Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel

Aretz, C. D., Morwitzer, M. J., Sanford, A. G., Hogan, A. M., Portillo, M. V., Kharade, S. V., Kramer, M., McCarthey, J. B., Trigueros, R. R., Piermarini, P. M., Denton, J. S. & Hopkins, C. R., Jun 14 2019, In : ACS infectious diseases. 5, 6, p. 917-931 15 p.

Research output: Contribution to journalArticle

Aedes
Culicidae
Malpighian Tubules
Dengue
Ion Channels
Loop of Henle
Pharmaceutical Chemistry
Potassium Channels
Diuretics
Potassium
5 Citations (Scopus)

Discovery of VU2957 (Valiglurax): An mGlu 4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease

Panarese, J. D., Engers, D. W., Wu, Y. J., Bronson, J. J., Macor, J. E., Chun, A., Rodriguez, A. L., Felts, A. S., Engers, J. L., Loch, M. T., Emmitte, K. A., Castelhano, A. L., Kates, M. J., Nader, M. A., Jones, C. K., Blobaum, A. L., Conn, P. J., Niswender, C. M., Hopkins, C. R. & Lindsley, C. W., Mar 14 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 255-260 6 p.

Research output: Contribution to journalArticle

Pulse amplitude modulation
Toxicology
Modulators
Parkinson Disease
Pharmacology

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis

Milani, M., Beckett, A. J., Al-Zebeeby, A., Luo, X., Prior, I. A., Cohen, G. M. & Varadarajan, S., Dec 1 2019, In : Cell Death Discovery. 5, 1, 117.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Dynamics
Apoptosis
Cytochromes c
Proteins
Mitochondrial Membranes
3 Citations (Scopus)

Dual delivery nanoscale device for miR-345 and gemcitabine co-delivery to treat pancreatic cancer

Uz, M., Kalaga, M., Pothuraju, R., Ju, J., Junker, W. M., Batra, S. K., Mallapragada, S. & Rachagani, S., Jan 28 2019, In : Journal of Controlled Release. 294, p. 237-246 10 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Equipment and Supplies
Heterografts
Neoplasms