Center for Molecular Target Discovery & Development

Research Output 1980 2020

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Review article
2020

Summary of the Third Annual Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Al-Kadhimi, Z., Costa, L. J., Hahn, T., Hari, P., Hillengass, J., Jacob, A., Munshi, N. C., Oliva, S., Pasquini, M. C., Shi, Q., Stadtmauer, E. A., Waldvogel, S. L. & McCarthy, P. L., Jan 2020, In : Biology of Blood and Marrow Transplantation. 26, 1, p. e7-e15

Research output: Contribution to journalReview article

Residual Neoplasm
Bone Marrow
Clinical Trials
Transplants
Education
2019

A review of the molecular design and biological activities of RXR agonists

de Almeida, N. R. & Conda-Sheridan, M., Jul 2019, In : Medicinal Research Reviews. 39, 4, p. 1372-1397 26 p.

Research output: Contribution to journalReview article

Retinoid X Receptors
Cytoplasmic and Nuclear Receptors
Molecular Structure
Parkinson Disease
Alzheimer Disease
1 Citation (Scopus)

Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases

Sharma, S. & Hopkins, C. R., Sep 12 2019, In : Journal of Medicinal Chemistry. 62, 17, p. 7589-7602 14 p.

Research output: Contribution to journalReview article

Transient Receptor Potential Channels
Chronic Renal Insufficiency
Cations
Kidney
Brain

The evolving role of maintenance therapy following autologous stem cell transplantation in multiple myeloma

Merz, A. M. A., Merz, M., Hillengass, J., Holstein, S. A. & McCarthy, P., Oct 3 2019, In : Expert review of anticancer therapy. 19, 10, p. 889-898 10 p.

Research output: Contribution to journalReview article

Stem Cell Transplantation
Multiple Myeloma
Maintenance
Autologous Transplantation
Cytogenetics
2018
9 Citations (Scopus)

Mechanisms of erythrocyte development and regeneration: Implications for regenerative medicine and beyond

Bresnick, E. H., Hewitt, K. J., Mehta, C., Keles, S., Paulson, R. F. & Johnson, K. D., Jan 2018, In : Development (Cambridge). 145, 1, dev151423.

Research output: Contribution to journalReview article

Regenerative Medicine
Regeneration
Erythrocytes
Hematopoietic Stem Cells
Oxygen
2015
86 Citations (Scopus)

American Society of Blood and Marrow Transplantation, European Society of Blood and Marrow Transplantation, Blood and Marrow Transplant Clinical Trials Network, and International Myeloma Working Group Consensus Conference on Salvage Hematopoietic Cell Transplantation in Patients with Relapsed Multiple Myeloma

Giralt, S., Garderet, L., Durie, B., Cook, G., Gahrton, G., Bruno, B., Hari, P., Lokhorst, H., McCarthy, P., Krishnan, A., Sonneveld, P., Goldschmidt, H., Jagannath, S., Barlogie, B., Mateos, M., Gimsing, P., Sezer, O., Mikhael, J., Lu, J., Dimopoulos, M. & 45 others, Mazumder, A., Palumbo, A., Abonour, R., Anderson, K., Attal, M., Blade, J., Bird, J., Cavo, M., Comenzo, R., de la Rubia, J., Einsele, H., Garcia-Sanz, R., Hillengass, J., Holstein, S., Johnsen, H. E., Joshua, D., Koehne, G., Kumar, S., Kyle, R., Leleu, X., Lonial, S., Ludwig, H., Nahi, H., Nooka, A., Orlowski, R., Rajkumar, V., Reiman, A., Richardson, P., Riva, E., San Miguel, J., Turreson, I., Usmani, S., Vesole, D., Bensinger, W., Qazilbash, M., Efebera, Y., Mohty, M., Gasparreto, C., Gajewski, J., LeMaistre, C. F., Bredeson, C., Moreau, P., Pasquini, M., Kroeger, N. & Stadtmauer, E., Dec 2015, In : Biology of Blood and Marrow Transplantation. 21, 12, p. 2039-2051 13 p.

Research output: Contribution to journalReview article

Cell Transplantation
Multiple Myeloma
Transplantation
Bone Marrow
Clinical Trials
15 Citations (Scopus)

Management of relapsed multiple myeloma after autologous stem cell transplant

Holstein, S. A., Richardson, P. G., Laubach, J. P. & McCarthy, P. L., May 1 2015, In : Biology of Blood and Marrow Transplantation. 21, 5, p. 793-798 6 p.

Research output: Contribution to journalReview article

Stem Cell Transplantation
Multiple Myeloma
Stem Cells
Transplants
Recurrence
2014
4 Citations (Scopus)

Epigenetic and genetic mechanisms in red cell biology

Hewitt, K. J., Sanalkumar, R., Johnson, K. D., Keles, S. & Bresnick, E. H., May 2014, In : Current Opinion in Hematology. 21, 3, p. 155-164 10 p.

Research output: Contribution to journalReview article

Epigenomics
Chromatin
Cell Biology
Erythropoiesis
Transcriptome
4 Citations (Scopus)

Multiple myeloma

Holstein, S. A., Liu, H. & McCarthy, P. L., Dec 1 2014, In : Hematology/Oncology Clinics of North America. 28, 6, p. 1113-1129 17 p.

Research output: Contribution to journalReview article

Multiple Myeloma
Stem Cells
Transplants
Gene Expression Profiling
Cytogenetics
2013
11 Citations (Scopus)

Cellular reprogramming to reset epigenetic signatures

Hewitt, K. J. & Garlick, J. A., Jul 1 2013, In : Molecular Aspects of Medicine. 34, 4, p. 841-848 8 p.

Research output: Contribution to journalReview article

Stem cells
Epigenomics
DNA Methylation
Induced Pluripotent Stem Cells
Genes
105 Citations (Scopus)

DNA damage tolerance: A double-edged sword guarding the genome

Ghosal, G. & Chen, J., Jun 1 2013, In : Translational Cancer Research. 2, 3, p. 107-129 23 p.

Research output: Contribution to journalReview article

DNA Damage
Genome
Genomic Instability
DNA Repair
Cell Cycle Checkpoints
2012
24 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on begacestat (GSI-953)

Hopkins, C. R., Jan 18 2012, In : ACS Chemical Neuroscience. 3, 1, p. 3-4 2 p.

Research output: Contribution to journalReview article

Neurosciences
Thiophenes
Amyloid Precursor Protein Secretases
Clinical Trials, Phase I
Molecules
4 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on BMS-708163

Hopkins, C. R., Mar 21 2012, In : ACS Chemical Neuroscience. 3, 3, p. 149-150 2 p.

Research output: Contribution to journalReview article

Amyloid Precursor Protein Secretases
Phase II Clinical Trials
Sulfonamides
Neurosciences
Alzheimer Disease
2 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on potiga (Ezogabine)

Hopkins, C. R., Aug 15 2012, In : ACS Chemical Neuroscience. 3, 8, 1 p.

Research output: Contribution to journalReview article

Neurosciences
Molecules
United States Food and Drug Administration
Seizures
Pharmaceutical Preparations
9 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on suvorexant

Hopkins, C. R., Sep 19 2012, In : ACS Chemical Neuroscience. 3, 9, p. 647-648 2 p.

Research output: Contribution to journalReview article

Phase III Clinical Trials
Neurosciences
Sleep
Placebos
Molecules
162 Citations (Scopus)

Allosteric modulation of seven transmembrane spanning receptors: Theory, practice, and opportunities for central nervous system drug discovery

Melancon, B. J., Hopkins, C. R., Wood, M. R., Emmitte, K. A., Niswender, C. M., Christopoulos, A., Conn, P. J. & Lindsley, C. W., Feb 23 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1445-1464 20 p.

Research output: Contribution to journalReview article

Allosteric Regulation
Central Nervous System Agents
Metabotropic Glutamate Receptors
Muscarinic Receptors
Drug Discovery
24 Citations (Scopus)

BRCT domains: A little more than kin, and less than kind

Gerloff, D. L., Woods, N. T., Farago, A. A. & Monteiro, A. N. A., Aug 14 2012, In : FEBS Letters. 586, 17, p. 2711-2716 6 p.

Research output: Contribution to journalReview article

DNA Damage
Biological Phenomena
Protein Array Analysis
Nucleotide Motifs
Human Genome
24 Citations (Scopus)

Is there a future for prenyltransferase inhibitors in cancer therapy?

Holstein, S. A. & Hohl, R. J., Dec 2012, In : Current Opinion in Pharmacology. 12, 6, p. 704-709 6 p.

Research output: Contribution to journalReview article

Dimethylallyltranstransferase
Clinical Trials
Farnesyltranstransferase
Prenylation
Post Translational Protein Processing
26 Citations (Scopus)
Patents
Parkinson Disease
Therapeutics
Pain
Glutamate Receptors
9 Citations (Scopus)

Therapeutic additions and possible deletions in oncology in 2011

Holstein, S. A. & Hohl, R. J., Jan 1 2012, In : Clinical Pharmacology and Therapeutics. 91, 1, p. 15-17 3 p.

Research output: Contribution to journalReview article

United States Food and Drug Administration
Therapeutic Uses
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Non-Hodgkin's Lymphoma
2011
31 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on ELND006: Another γ-secretase inhibitor fails in the clinic

Hopkins, C. R., Jun 15 2011, In : ACS Chemical Neuroscience. 2, 6, p. 279-280 2 p.

Research output: Contribution to journalReview article

Amyloid Precursor Protein Secretases
Neurosciences
N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide
Alzheimer Disease
Clinical Trials
2 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on STX209 (Arbaclofen)

Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, 1 p.

Research output: Contribution to journalReview article

GABA-B Receptor Agonists
Butyric Acid
Neurosciences
Molecules
Industry
2 Citations (Scopus)

ACS chemical neuroscience molecule spotlight on telcagepant (MK-0974)

Hopkins, C. R., Jul 20 2011, In : ACS Chemical Neuroscience. 2, 7, p. 334-335 2 p.

Research output: Contribution to journalReview article

Neurosciences
Molecules
Calcitonin Gene-Related Peptide Receptors
Phase III Clinical Trials
Migraine Disorders
30 Citations (Scopus)

Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics

Robichaud, A. J., Engers, D. W., Lindsley, C. W. & Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, p. 433-449 17 p.

Research output: Contribution to journalReview article

Neurology
Central Nervous System
Ligands
Pharmacokinetics
Solubility
2010
12 Citations (Scopus)

Applications of nanotechnology to imaging and therapy of brain tumors

Mohs, A. M. & Provenzale, J. M., Aug 1 2010, In : Neuroimaging Clinics of North America. 20, 3, p. 283-292 10 p.

Research output: Contribution to journalReview article

Nanotechnology
Brain Neoplasms
Nanoparticles
Nanomedicine
Technology
46 Citations (Scopus)

The antipsychotic potential of muscarinic allosteric modulation

Bridges, T. M., LeBois, E. P., Hopkins, C. R., Wood, M. R., Jones, C. K., Conn, P. J. & Lindsley, C. W., May 1 2010, In : Drug News and Perspectives. 23, 4, p. 229-240 12 p.

Research output: Contribution to journalReview article

xanomeline
Cholinergic Agents
Antipsychotic Agents
Muscarinic Receptors
Ligands
2009
51 Citations (Scopus)

MGluR4-positive allosteric modulation as potential treatment for Parkinson's disease

Hopkins, C. R., Lindsley, C. W. & Niswender, C. M., Jun 1 2009, In : Future Medicinal Chemistry. 1, 3, p. 501-513 13 p.

Research output: Contribution to journalReview article

Parkinson Disease
Therapeutics
Nerve Degeneration
Metabotropic Glutamate Receptors
Dopaminergic Neurons
35 Citations (Scopus)

Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease

Lindsley, C. W., Niswender, C. M., Engers, D. W. & Hopkins, C. R., Dec 1 2009, In : Current Topics in Medicinal Chemistry. 9, 10, p. 949-963 15 p.

Research output: Contribution to journalReview article

Parkinson Disease
Explosions
Basal Ganglia
metabotropic glutamate receptor 4
2008
876 Citations (Scopus)

Bioconjugated quantum dots for in vivo molecular and cellular imaging

Smith, A. M., Duan, H., Mohs, A. M. & Nie, S., Aug 17 2008, In : Advanced Drug Delivery Reviews. 60, 11, p. 1226-1240 15 p.

Research output: Contribution to journalReview article

Quantum Dots
Molecular Imaging
Nanoparticles
Photobleaching
Light
27 Citations (Scopus)

Epidermal growth factor receptor-directed therapy in esophageal cancer

Pande, A. U., Iyer, R. V., Rani, A., Maddipatla, S., Yang, G. Y., Nwogu, C. E., Black, J. D., Levea, C. M. & Javle, M. M., Jun 1 2008, In : ONCOLOGY. 73, 5-6, p. 281-289 9 p.

Research output: Contribution to journalReview article

Esophageal Neoplasms
Epidermal Growth Factor Receptor
oxaliplatin
Radiotherapy
Adenocarcinoma

Molecule of the month

Hopkins, C. R., Dec 1 2008, In : Current Topics in Medicinal Chemistry. 8, 18, p. 1710-1711 2 p.

Research output: Contribution to journalReview article

2007
41 Citations (Scopus)

Gadolinium(III)-based blood-pool contrast agents for magnetic resonance imaging: Status and clinical potential

Mohs, A. M. & Lu, Z. R., Mar 1 2007, In : Expert Opinion on Drug Delivery. 4, 2, p. 149-164 16 p.

Research output: Contribution to journalReview article

Gadolinium
Contrast Media
Magnetic Resonance Imaging
Vascular Endothelium
Cardiovascular System
2006
48 Citations (Scopus)

Polydisulfide Gd(III) chelates as biodegradable macromolecular magnetic resonance imaging contrast agents

Lu, Z. R., Mohs, A. M., Zong, Y. & Feng, Y., Dec 1 2006, In : International journal of nanomedicine. 1, 1, p. 31-40 10 p.

Research output: Contribution to journalReview article

Gadolinium
Magnetic resonance
Contrast Media
Magnetic Resonance Imaging
Imaging techniques
2004
121 Citations (Scopus)

Isoprenoids: Remarkable diversity of form and function

Holstein, S. A. & Hohl, R. J., Apr 1 2004, In : Lipids. 39, 4, p. 293-309 17 p.

Research output: Contribution to journalReview article

isoprenoids
Terpenes
pyrophosphates
anti-ulcer activity
Hydroxymethylglutaryl CoA Reductases
2003
10 Citations (Scopus)

ErbB family targeting

Black, J. D., Brattain, M. G., Krishnamurthi, S. A., Dawson, D. M. & Willson, J. K. V., Dec 1 2003, In : Current Opinion in Investigational Drugs. 4, 12, p. 1451-1454 4 p.

Research output: Contribution to journalReview article

Neoplasms
Epidermal Growth Factor Receptor
Phosphotransferases
Clinical Trials
Antibodies
50 Citations (Scopus)

Functions of eukaryotic DNA polymerases.

Shcherbakova, P. V., Bebenek, K. & Kunkel, T. A., Feb 26 2003, In : Science of aging knowledge environment : SAGE KE. 2003, 8, p. RE3

Research output: Contribution to journalReview article

DNA-Directed DNA Polymerase
DNA
DNA Damage
Cell Cycle Checkpoints
DNA Repair
2001
805 Citations (Scopus)

Sp1 and Krüppel-like factor family of transcription factors in cell growth regulation and cancer

Black, A. R., Black, J. D. & Azizkhan-Clifford, J., Jul 19 2001, In : Journal of Cellular Physiology. 188, 2, p. 143-160 18 p.

Research output: Contribution to journalReview article

Cell growth
Tumors
Transcription Factors
Transcription
Growth
2000
153 Citations (Scopus)

Protein kinase C-mediated regulation of the cell cycle.

Black, J. D., Apr 1 2000, In : Frontiers in bioscience : a journal and virtual library. 5, p. D406-423

Research output: Contribution to journalReview article

Protein Kinase C
Cell Cycle
Cells
Cell growth
Lamin Type B
1999
2096 Citations (Scopus)

Biochemical pathways of caspase activation during apoptosis

Budihardjo, I., Oliver, H., Lutter, M., Luo, X. & Wang, X., Dec 1 1999, In : Annual Review of Cell and Developmental Biology. 15, p. 269-290 22 p.

Research output: Contribution to journalReview article

Caspases
Apoptosis
Death Domain Receptors
Mitochondria
Caspase 9
101 Citations (Scopus)

Regulation of E2F: A family of transcription factors involved in proliferation control

Black, A. R. & Azizkhan-Clifford, J., Sep 17 1999, In : Gene. 237, 2, p. 281-302 22 p.

Research output: Contribution to journalReview article

Transcription Factors
Cell Proliferation
Cell Cycle
E2F Transcription Factors
Retinoblastoma
1991
33 Citations (Scopus)

The biology and physiology of the heat shock and glucose-regulated stress protein systems.

Black, A. R. & Subjeck, J. R., 1991, In : Methods and achievements in experimental pathology. 15, p. 126-166 41 p.

Research output: Contribution to journalReview article

Ubiquitins
Body Temperature Regulation
Heat-Shock Proteins
Shock
Hot Temperature
1989
9 Citations (Scopus)

Multifunctional glycoprotein receptors for insulin and the insulin-like growth factors.

Czech, M. P., Lewis, R. E. & Corvera, S., 1989, In : Ciba Foundation symposium. 145, p. 27-41; discussion 42-44

Research output: Contribution to journalReview article

IGF Type 2 Receptor
Insulin-Like Growth Factor II
Insulin Receptor
Somatomedins
Glycoproteins
1988
132 Citations (Scopus)

Insulin receptor signaling. Activation of multiple serine kinases

Czech, M. P., Klarlund, J. K., Yagaloff, K. A., Bradford, A. P. & Lewis, R. E., Jan 1 1988, In : Journal of Biological Chemistry. 263, 23, p. 11017-11020 4 p.

Research output: Contribution to journalReview article

Biological Models
Enzyme Activation
Protein-Serine-Threonine Kinases
Insulin Receptor
Protein Kinases