Center for Molecular Target Discovery & Development

Research Output 1980 2020

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2019
1 Citation (Scopus)

A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery

McMillan, E. A., Kwon, G., Clemenceau, J. R., Fisher, K. W., Vaden, R. M., Shaikh, A. F., Neilsen, B. K., Kelly, D., Potts, M. B., Sung, Y. J., Mendiratta, S., Hight, S. K., Lee, Y., MacMillan, J. B., Lewis, R. E., Kim, H. S. & White, M. A., Oct 17 2019, In : Cell Chemical Biology. 26, 10, p. 1380-1392.e6

Research output: Contribution to journalArticle

Biological Products
Ontology
Genes
Genome
Pharmacologic Actions

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Zheng, X. F., Acharya, S. S., Choe, K. N., Nikhil, K., Adelmant, G., Satapathy, S. R., Sharma, S., Viccaro, K., Rana, S., Natarajan, A., Sicinski, P., Marto, J. A., Shah, K. & Chowdhury, D., Dec 1 2019, In : Nature communications. 10, 1, 4252.

Research output: Contribution to journalArticle

Open Access
mitosis
phosphatases
Mitosis
DNA Repair
Chromatin
1 Citation (Scopus)

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Linsdley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., Mar 20 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1294-1299 6 p.

Research output: Contribution to journalArticle

Acute Pain
Opioid Receptors
Morphine
Analgesics
G Protein-Coupled Inwardly-Rectifying Potassium Channels

A patent review of bisphosphonates in treating bone disease

Holstein, S. A., May 4 2019, In : Expert Opinion on Therapeutic Patents. 29, 5, p. 315-325 11 p.

Research output: Contribution to journalArticle

Bone Diseases
Diphosphonates
Protein Prenylation
Farnesyltranstransferase
Bone and Bones
3 Citations (Scopus)

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Xing, X., Kane, D. P., Bulock, C. R., Moore, E. A., Sharma, S., Chabes, A. & Shcherbakova, P. V., Dec 1 2019, In : Nature communications. 10, 1, 374.

Research output: Contribution to journalArticle

Exonucleases
DNA-Directed DNA Polymerase
enzymes
Substitution reactions
deoxyribonucleic acid

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors

Al-Mugotir, M., Kolar, C., Vance, K., Kelly, D. L., Natarajan, A. & Borgstahl, G. E. O., Mar 15 2019, In : Analytical Biochemistry. 569, p. 46-52 7 p.

Research output: Contribution to journalArticle

Assays
Proteins
Fluorescence
Replication Protein A
Protein Transport

Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells

Sliker, B. H., Goetz, B. T., Peters, H. L., Poelaert, B. J., Borgstahl, G. E. O. & Solheim, J. C., Jun 3 2019, In : Cancer Biology and Therapy. 20, 6, p. 931-940 10 p.

Research output: Contribution to journalArticle

beta 2-Microglobulin
Amyloid beta-Protein Precursor
Pancreatic Neoplasms
Cell Movement
Cell Line
1 Citation (Scopus)

BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis

Huang, K., O’Neill, K. L., Li, J., Zhou, W., Han, N., Pang, X., Wu, W., Struble, L., Borgstahl, G., Liu, Z., Zhang, L. & Luo, X., Nov 1 2019, In : Cell Research. 29, 11, p. 942-952 11 p.

Research output: Contribution to journalArticle

Apoptosis
Proteins
Membranes
Mitochondrial Membranes
Mitochondria

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Nowialis, P., Lopusna, K., Opavska, J., Haney, S. L., Abraham, A., Sheng, P., Riva, A., Natarajan, A., Guryanova, O., Simpson, M., Hlady, R., Xie, M. & Opavsky, R., Dec 1 2019, In : Nature communications. 10, 1, 4374.

Research output: Contribution to journalArticle

Open Access
accessories
Methyltransferases
Accessories
Embryonic Development
mice

CDK5 inhibitor downregulates Mcl-1 and sensitizes pancreatic cancer cell lines to navitoclax

Kour, S., Rana, S., Contreras, J. I., King, H. M., Robb, C. M., Sonawane, Y. A., Bendjennat, M., Crawford, A. J., Barger, C. J., Kizhake, S., Luo, X., Hollingsworth, M. A. & Natarajan, A., Oct 2019, In : Molecular pharmacology. 96, 4, p. 419-429 11 p.

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Down-Regulation
Cell Line
Apoptosis
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI

Hu, W. F., Krieger, K. L., Lagundžin, D., Li, X., Cheung, R. S., Taniguchi, T., Johnson, K. R., Bessho, T., Monteiro, A. N. A. & Woods, N. T., Dec 1 2019, In : Cell Death Discovery. 5, 1, 105.

Research output: Contribution to journalArticle

Open Access
Phosphoric Monoester Hydrolases
DNA Repair
Breast Neoplasms
Survival
DNA Damage
5 Citations (Scopus)

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu 4 )

Bollinger, S. R., Engers, D. W., Panarese, J. D., West, M., Engers, J. L., Loch, M. T., Rodriguez, A. L., Blobaum, A. L., Jones, C. K., Thompson Gray, A., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 342-358 17 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Structure-Activity Relationship
Catalepsy
Haloperidol
Parkinson Disease

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

Sharma, S., Kozek, K. A., Abney, K. K., Kumar, S., Gautam, N., Alnouti, Y., David Weaver, C. & Hopkins, C. R., Mar 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 6, p. 791-796 6 p.

Research output: Contribution to journalArticle

G Protein-Coupled Inwardly-Rectifying Potassium Channels
Acetamides
Inwardly Rectifying Potassium Channel
Potassium Channels
GTP-Binding Proteins

Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel

Aretz, C. D., Morwitzer, M. J., Sanford, A. G., Hogan, A. M., Portillo, M. V., Kharade, S. V., Kramer, M., McCarthey, J. B., Trigueros, R. R., Piermarini, P. M., Denton, J. S. & Hopkins, C. R., Jun 14 2019, In : ACS infectious diseases. 5, 6, p. 917-931 15 p.

Research output: Contribution to journalArticle

Aedes
Culicidae
Malpighian Tubules
Dengue
Ion Channels
Loop of Henle
Pharmaceutical Chemistry
Potassium Channels
Diuretics
Potassium
5 Citations (Scopus)

Discovery of VU2957 (Valiglurax): An mGlu 4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease

Panarese, J. D., Engers, D. W., Wu, Y. J., Bronson, J. J., Macor, J. E., Chun, A., Rodriguez, A. L., Felts, A. S., Engers, J. L., Loch, M. T., Emmitte, K. A., Castelhano, A. L., Kates, M. J., Nader, M. A., Jones, C. K., Blobaum, A. L., Conn, P. J., Niswender, C. M., Hopkins, C. R. & Lindsley, C. W., Mar 14 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 255-260 6 p.

Research output: Contribution to journalArticle

Pulse amplitude modulation
Toxicology
Modulators
Parkinson Disease
Pharmacology

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis

Milani, M., Beckett, A. J., Al-Zebeeby, A., Luo, X., Prior, I. A., Cohen, G. M. & Varadarajan, S., Dec 1 2019, In : Cell Death Discovery. 5, 1, 117.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Dynamics
Apoptosis
Cytochromes c
Proteins
Mitochondrial Membranes

Functional impacts of the brca1-mtorc2 interaction in breast cancer

Krieger, K. L., Hu, W. F., Ripperger, T. & Woods, N. T., Dec 1 2019, In : International journal of molecular sciences. 20, 23, 5876.

Research output: Contribution to journalArticle

Open Access
breast
DNA
cancer
Breast Neoplasms
Cells
1 Citation (Scopus)

Genistein treatment duration effects biomarkers of cell motility in human prostate

Zhang, H., Gordon, R., Li, W., Yang, X., Pattanayak, A., Fowler, G., Zhang, L., Catalona, W. J., Ding, Y., Xu, L., Huang, X., Jovanovic, B., Kelly, D. L., Jiang, H. & Bergan, R., Mar 2019, In : PloS one. 14, 3, e0214078.

Research output: Contribution to journalArticle

Open Access
Genistein
genistein
Biomarkers
cell movement
Cell Movement

Identification of an Anti-MRSA Cyclic Lipodepsipeptide, WBP-29479A1, by Genome Mining of Lysobacter antibioticus

Sang, M., Wang, H., Shen, Y., Rodrigues De Almeida, N., Conda-Sheridan, M., Li, S., Li, Y. & Du, L., Aug 16 2019, In : Organic Letters. 21, 16, p. 6432-6436 5 p.

Research output: Contribution to journalArticle

Lysobacter
Vitamin K 2
Hydroxy Acids
genome
fatty acids
Open Access
Staphylococcus epidermidis
Cerebrospinal Fluid
Catheters
Biomarkers
Inflammation
4 Citations (Scopus)

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Haney, S. L., Varney, M. L., Chhonker, Y. S., Shin, S., Mehla, K., Crawford, A. J., Smith, H. J., Smith, L. M., Murry, D. J., Hollingsworth, M. A. & Holstein, S. A., Jun 27 2019, In : Oncogene. 38, 26, p. 5308-5320 13 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Adenocarcinoma
Mucins
Unfolded Protein Response
Terpenes

Modeling the Effects of Multiple Myeloma on Kidney Function

Walk, J. C., Ayati, B. P. & Holstein, S. A., Dec 1 2019, In : Scientific reports. 9, 1, 1726.

Research output: Contribution to journalArticle

Open Access
Multiple Myeloma
Kidney
Fibrosis
Population
Proximal Kidney Tubule
1 Citation (Scopus)
Short-Term Memory
Neoplasms
Cues
Task Performance and Analysis
Neuroimaging

Novel benzimidazole phosphonates as potential inhibitors of protein prenylation

Bhuiyan, N. H., Varney, M. L., Wiemer, D. F. & Holstein, S. A., Dec 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 24, 126757.

Research output: Contribution to journalArticle

Protein Prenylation
Organophosphonates
Diphosphonates
Geranyltranstransferase
Biosynthesis
4 Citations (Scopus)

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. K. & Wen, H., Mar 19 2019, In : Immunity. 50, 3, p. 576-590.e6

Research output: Contribution to journalArticle

Receptor-Interacting Protein Serine-Threonine Kinases
Innate Immunity
Protein Interaction Domains and Motifs
Inflammation
Acetylglucosamine

Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer

Leiphrakpam, P. D., Lazenby, A. J., Chowdhury, S., Smith, L. M., Mathiesen, M., Brattain, M. G., Wang, J., Black, J. D. & Are, C., Jan 1 2019, (Accepted/In press) In : Journal of Surgical Oncology. 121, 3, p. 547-560 14 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Therapeutics
Somatomedin Receptors
sodium-hydrogen exchanger regulatory factor
Cell Survival
3 Citations (Scopus)

Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging

Graham, L. C., Naldrett, M. J., Kohama, S. G., Smith, C., Lamont, D. J., McColl, B. W., Gillingwater, T. H., Skehel, P., Urbanski, H. F. & Wishart, T. M., Apr 23 2019, In : Cell Reports. 27, 4, p. 1018-1026.e4

Research output: Contribution to journalArticle

Open Access
Synapses
Primates
Brain
Aging of materials
Proteome
4 Citations (Scopus)

Selective degradation of CDK6 by a palbociclib based PROTAC

Rana, S., Bendjennat, M., Kour, S., King, H. M., Kizhake, S., Zahid, M. & Natarajan, A., Jun 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 11, p. 1375-1379 5 p.

Research output: Contribution to journalArticle

Phosphotransferases
Degradation
Adenosine Triphosphate
Binding Sites
Cyclin-Dependent Kinases

Selective inhibition of histone deacetylases 1/2/6 in combination with gemcitabine: A promising combination for pancreatic cancer therapy

Laschanzky, R. S., Humphrey, L. E., Ma, J., Smith, L. M., Enke, T. J., Shukla, S. K., Dasgupta, A., Singh, P. K., Howell, G. M., Brattain, M. G., Ly, Q. P., Black, A. R. & Black, J. D., Sep 2019, In : Cancers. 11, 9, 1327.

Research output: Contribution to journalArticle

Open Access
gemcitabine
Histone Deacetylases
Pancreatic Neoplasms
Adenocarcinoma
Histone Deacetylase Inhibitors

Self-Assembled Nanostructures of Peptide Amphiphiles: Charge Regulation by Size Regulation

Zaldivar, G., Vemulapalli, S., Udumula, V., Conda-Sheridan, M. & Tagliazucchi, M., Jun 24 2019, In : Journal of Physical Chemistry C. 123, 28, p. 17606-17615 10 p.

Research output: Contribution to journalArticle

Amphiphiles
Peptides
peptides
Nanostructures
lysine
2 Citations (Scopus)

SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p

Wu, W., He, K., Guo, Q., Chen, J., Zhang, M., Huang, K., Yang, D., Wu, L., Deng, Y., Luo, X., Yu, H., Ding, Q. & Xiang, G., May 2019, In : Journal of cellular and molecular medicine. 23, 5, p. 3118-3129 12 p.

Research output: Contribution to journalArticle

Open Access
MicroRNAs
Colorectal Neoplasms
Proteins
Energy Metabolism
Apoptosis
3 Citations (Scopus)

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

Parkash, V., Kulkarni, Y., ter Beek, J., Shcherbakova, P. V., Kamerlin, S. C. L. & Johansson, E., Dec 1 2019, In : Nature communications. 10, 1, 373.

Research output: Contribution to journalArticle

Exonucleases
DNA-Directed DNA Polymerase
Substitution reactions
deoxyribonucleic acid
cancer

Supercell refinement: A cautionary tale

Lovelace, J., Petrícek, V., Murshudov, G. & Borgstahl, G. E. O., Sep 1 2019, In : Acta Crystallographica Section D: Structural Biology. 75, p. 852-860 9 p.

Research output: Contribution to journalArticle

Open Access
Profilins
Actins
Proteins

Understanding interactions of Citropin 1.1 analogues with model membranes and their influence on biological activity

Rodrigues de Almeida, N., Catazaro, J., Krishnaiah, M., Singh Chhonker, Y., Murry, D. J., Powers, R. & Conda-Sheridan, M., Sep 2019, In : Peptides. 119, 170119.

Research output: Contribution to journalArticle

Bioactivity
Membranes
Peptides
Pathogens
Antimicrobial Cationic Peptides

VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir3 channels and reduces stress-induced hyperthermia in mice

Vo, B. N., Abney, K. K., Anderson, A., Marron Fernandez de Velasco, E., Benneyworth, M. A., Daniels, J. S., Morrison, R. D., Hopkins, C. R., Weaver, C. D. & Wickman, K., Jul 2019, In : British Journal of Pharmacology. 176, 13, p. 2238-2249 12 p.

Research output: Contribution to journalArticle

Induced Hyperthermia
Nervous System Diseases
GTP-Binding Proteins
Inwardly Rectifying Potassium Channel
Electrophysiology

ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors

Bhuiyan, N. H., Varney, M. L., Bhattacharya, D. S., Payne, W. M., Mohs, A. M., Holstein, S. A. & Wiemer, D. F., Oct 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 19, 126633.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Terpenes
Diphosphonates
Plasma Cells
Protein Prenylation
2017
7 Citations (Scopus)

GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia

Hewitt, K. J., Katsumura, K. R., Matson, D. R., Devadas, P., Tanimura, N., Hebert, A. S., Coon, J. J., Kim, J. S., Dewey, C. N., Keles, S., Hao, S., Paulson, R. F. & Bresnick, E. H., Aug 7 2017, In : Developmental cell. 42, 3, p. 213-225.e4

Research output: Contribution to journalArticle

GATA Transcription Factors
Anemia
Regeneration
Cell Survival
Blood
2016
2 Citations (Scopus)

A hierarchical framework for state-space matrix inference and clustering

Zuo, C., Chen, K., Hewitt, K. J., Bresnick, E. H. & Keleş, S., Sep 2016, In : Annals of Applied Statistics. 10, 3, p. 1348-1372 25 p.

Research output: Contribution to journalArticle

State Space
Clustering
Transcription factors
Transcription Factor
Genes
2 Citations (Scopus)

Anaplastic Multiple Myeloma: An Aggressive Variant With a Poor Response to Novel Therapies

Ammannagari, N., Celotto, K., Neppalli, V., Lee, K. & Holstein, S. A., Sep 1 2016, In : Clinical Lymphoma, Myeloma and Leukemia. 16, 9, p. e129-e131

Research output: Contribution to journalArticle

Proteasome Inhibitors
Multiple Myeloma
Therapeutics
9 Citations (Scopus)

A new motif for inhibitors of geranylgeranyl diphosphate synthase

Foust, B. J., Allen, C., Holstein, S. A. & Wiemer, D. F., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 16, p. 3734-3741 8 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Carbon
Terpenes
Protein Prenylation
Organophosphonates
50 Citations (Scopus)

Identification of evening complex associated proteins in arabidopsis by affinity purification and mass spectrometry

Huang, H., Alvarez, S., Bindbeutel, R., Shen, Z., Naldrett, M. J., Evans, B. S., Briggs, S. P., Hicks, L. M., Kay, S. A. & Nusinow, D. A., Jan 2016, In : Molecular and Cellular Proteomics. 15, 1, p. 201-217 17 p.

Research output: Contribution to journalArticle

Open Access
Arabidopsis Proteins
Phytochrome B
Purification
Mass spectrometry
Clocks
28 Citations (Scopus)

PCH1 integrates circadian and light-signaling pathways to control photoperiod-responsive growth in Arabidopsis

Huang, H., Yoo, C. Y., Bindbeutel, R., Goldsworthy, J., Tielking, A., Alvarez, S., Naldrett, M. J., Evans, B. S., Chen, M. & Nusinow, D. A., Feb 3 2016, In : eLife. 5, FEBRUARY2016, e13292.

Research output: Contribution to journalArticle

Open Access
Phytochrome B
Photoperiod
Arabidopsis
Light
Growth
3 Citations (Scopus)

Stereocontrolled regeneration of olefins from epoxides

Wills, V. S., Zhou, X., Allen, C., Holstein, S. A. & Wiemer, D. F., Mar 23 2016, In : Tetrahedron Letters. 57, 12, p. 1335-1337 3 p.

Research output: Contribution to journalArticle

Epoxy Compounds
Alkenes
Regeneration
trifluoroacetic anhydride
Alcohols
2015
18 Citations (Scopus)

Cis-regulatory mechanisms governing stem and progenitor cell transitions

Johnson, K. D., Kong, G., Gao, X., Chang, Y. I., Hewitt, K. J., Sanalkumar, R., Prathibha, R., Ranheim, E. A., Dewey, C. N., Zhang, J. & Bresnick, E. H., Sep 2015, In : Science Advances. 1, 8, e1500503.

Research output: Contribution to journalArticle

Proto-Oncogenes
Acute Myeloid Leukemia
Stem Cells
Embryonic Structures
Encyclopedias
20 Citations (Scopus)

Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome

Hewitt, K. J., Kim, D. H., Devadas, P., Prathibha, R., Zuo, C., Sanalkumar, R., Johnson, K. D., Kang, Y. A., Kim, J. S., Dewey, C. N., Keles, S. & Bresnick, E. H., Jan 1 2015, In : Molecular Cell. 59, 1, p. 62-74 13 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem Cells
Genome
Stem Cell Factor
Gold
13 Citations (Scopus)

Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells

Dykstra, K. M., Allen, C., Born, E. J., Tong, H. & Holstein, S. A., Jan 1 2015, In : Oncotarget. 6, 39, p. 41535-41549 15 p.

Research output: Contribution to journalArticle

Biosynthetic Pathways
Terpenes
Autophagy
Multiple Myeloma
Transferases
3 Citations (Scopus)

Multiplexing strategy for simultaneous detection of redox-, phospho- and total proteome-understanding TOR regulating pathways in Chlamydomonas reinhardtii

Rodrigues, S. P., Alvarez, S., Werth, E. G., Slade, W. O., Gau, B., Cahoon, E. B. & Hicks, L. M., Sep 7 2015, In : Analytical Methods. 7, 17, p. 7336-7344 9 p.

Research output: Contribution to journalArticle

Sirolimus
Proteome
Multiplexing
Pulse time modulation
Cell signaling
6 Citations (Scopus)

N-oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation

Zhou, X., Born, E. J., Allen, C., Holstein, S. A. & Wiemer, D. F., Jun 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 11, p. 2331-2334 4 p., 22604.

Research output: Contribution to journalArticle

Prenylation
Oxides
Derivatives
Acids
Pyridines
5 Citations (Scopus)

Phase I and pharmacokinetic study of the novel anthracycline derivative 5-imino-13-deoxydoxorubicin (GPX-150) in patients with advanced solid tumors

Holstein, S. A., Bigelow, J. C., Olson, R. D., Vestal, R. E., Walsh, G. M. & Hohl, R. J., Jun 22 2015, In : Investigational New Drugs. 33, 3, p. 594-602 9 p.

Research output: Contribution to journalArticle

Anthracyclines
Pharmacokinetics
Neoplasms
Maximum Tolerated Dose
Neutropenia