Research Output 1979 2019

2019

Adaptation of an R5 simian-human immunodeficiency virus encoding an HIV clade a envelope with or without ablation of adaptive host immunity: Differential selection of viral mutants

Zhou, M., Humbert, M., Mukhtar, M. M., Scinto, H. B., Vyas, H. K., Lakhashe, S. K., Byrareddy, S. N., Maurer, G., Thorat, S., Owuor, J., Lai, Z., Chen, Y., Griffiths, A., Chenine, A. L., Gumber, S., Villinger, F., Montefiori, D. & Ruprecht, R. M., May 1 2019, In : Journal of virology. 93, 9, e02267-18.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Human immunodeficiency virus
Adaptive Immunity
immunity
HIV

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

He, C., Lv, X., Huang, C., Angeletti, P. C., Hua, G., Dong, J., Zhou, J., Wang, Z., Ma, B., Chen, X., Lambert, P. F., Rueda, B. R., Davis, J. S. & Wang, C., Mar 5 2019, In : Cell Reports. 26, 10, p. 2636-2650.e5

Research output: Contribution to journalArticle

Open Access
Uterine Cervical Neoplasms
Carcinogenesis
Animals
Animal Models
Infection

Anti-Claudin-1 Conjugated to a Near-Infrared Fluorophore Targets Colon Cancer in PDOX Mouse Models

Hollandsworth, H. M., Lwin, T. M., Amirfakhri, S., Filemoni, F., Batra, S. K., Hoffman, R. M., Dhawan, P. & Bouvet, M., Oct 1 2019, In : Journal of Surgical Research. 242, p. 145-150 6 p.

Research output: Contribution to journalArticle

Claudin-1
Colonic Neoplasms
Optical Imaging
Antibodies
Coloring Agents

Aperiodic order coming of age: From inorganic materials to dynamic protein superstructures

Borgstahl, G. E., Goldman, A. I. & Thiel, P. A., Jan 1 2019, In : Acta Crystallographica Section A: Foundations and Advances. 75, p. 212-213 2 p.

Research output: Contribution to journalEditorial

Open Access
Quasicrystals
inorganic materials
proteins
Proteins

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors

Al-Mugotir, M., Kolar, C., Vance, K., Kelly, D. L., Natarajan, A. & Borgstahl, G. E., Mar 15 2019, In : Analytical Biochemistry. 569, p. 46-52 7 p.

Research output: Contribution to journalArticle

Assays
Proteins
Fluorescence
Replication Protein A
Protein Transport

Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells

Sliker, B. H., Goetz, B. T., Peters, H. L., Poelaert, B. J., Borgstahl, G. E. & Solheim, J. C., Jan 1 2019, In : Cancer Biology and Therapy.

Research output: Contribution to journalArticle

beta 2-Microglobulin
Amyloid beta-Protein Precursor
Pancreatic Neoplasms
Cell Movement
Cell Line

Biphasic changes in airway epithelial cell EGF receptor binding and phosphorylation induced by components of hogbarn dust

Dodmane, P. R., Schulte, N. A., Heires, A. J., Band, H., Romberger, D. & Toews, M. L., Jan 1 2019, In : Experimental Lung Research.

Research output: Contribution to journalArticle

Phosphorylation
Dust
Epidermal Growth Factor Receptor
Epithelial Cells
Confocal microscopy
1 Citation (Scopus)

Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

Bergdolt, L. & Dunaevsky-Hutt, A., Jan 1 2019, (Accepted/In press) In : Progress in Neurobiology.

Research output: Contribution to journalArticle

Brain Diseases
Mothers
Brain
Schizophrenia
Nervous System Diseases

Cancer-associated fibroblasts’ functional heterogeneity in pancreatic ductal adenocarcinoma

Awaji, M. & Singh, R. K., Mar 1 2019, In : Cancers. 11, 3, 290.

Research output: Contribution to journalReview article

Open Access
Adenocarcinoma
Extracellular Matrix
Inflammation
Neoplasms
Myofibroblasts
1 Citation (Scopus)

Cancer-associated mucins: role in immune modulation and metastasis

Bhatia, R., Gautam, S. K., Cannon, A., Thompson, C., Hall, B. R., Aithal, A., Banerjee, K., Jain, M., Solheim, J. C., Kumar, S. & Batra, S. K., Jan 1 2019, (Accepted/In press) In : Cancer and Metastasis Reviews.

Research output: Contribution to journalArticle

Mucins
Neoplasm Metastasis
Neoplasms
Dendritic Cells
Glycosylation
Ghrelin
Ethanol
Alcohols
Insulin
Nonesterified Fatty Acids

CXCR2: A Novel Mediator of Mammary Tumor Bone Metastasis

Sharma, B., Nannuru, K. C., Saxena, S., Varney, M. L. & Singh, R. K., Mar 12 2019, In : International journal of molecular sciences. 20, 5

Research output: Contribution to journalArticle

Open Access
CXC Chemokines
Chemokine Receptors
metastasis
bones
Tumors

CXCR4-targeted liposomal mediated co-delivery of pirfenidone and AMD3100 for the treatment of TGFΒ-induced HSC-T6 cells activation

Ullah, A., Wang, K., Wu, P., Oupicky, D. & Sun, M., Jan 1 2019, In : International Journal of Nanomedicine. 14, p. 2927-2944 18 p.

Research output: Contribution to journalArticle

Open Access
Liposomes
Chemical activation
Liver
Liver Cirrhosis
Cell death

Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity

Yin, L., Zeng, Y., Xiao, Y., Chen, Y., Shen, H. & Dong, J., Jun 1 2019, In : Cell Death and Disease. 10, 6, 385.

Research output: Contribution to journalArticle

Open Access
CDC2 Protein Kinase
Serine
Protein Isoforms
Phosphorylation
Mitosis

Deep Learning/Artificial Intelligence and Blood-Based DNA Epigenomic Prediction of Cerebral Palsy

Bahado-Singh, R. O., Vishweswaraiah, S., Aydas, B., Mishra, N. K., Guda, C. & Radhakrishna, U., Apr 27 2019, In : International journal of molecular sciences. 20, 9

Research output: Contribution to journalArticle

Open Access
Blood substitutes
Blood Substitutes
artificial intelligence
methylation
Methylation

Direct and selective lineage conversion of human fibroblasts to dopaminergic precursors

He, M., Zhang, H., Li, Y., Tian, C., Tang, B., Huang, Y. & Zheng, J. C., Apr 23 2019, In : Neuroscience Letters. 699, p. 16-23 8 p.

Research output: Contribution to journalArticle

Fibroblasts
Parkinson Disease
Transcription Factors
Transplantation
Dopaminergic Neurons

Divergent HIV-1-directed immune responses generated by systemic and mucosal immunization with replicating single-cycle adenoviruses in rhesus macaques

Matchett, W. E., Anguiano-Zarate, S. S., Nehete, P. N., Shelton, K., Nehete, B. P., Yang, G., Dorta-Estremera, S., Barnette, P., Xiao, P., Byrareddy, S. N., Villinger, F., Hessell, A. J., Haigwood, N. L., Sastry, K. J. & Barry, M. A., May 1 2019, In : Journal of virology. 93, 10, e02016-18.

Research output: Contribution to journalArticle

Adenoviridae
Human immunodeficiency virus 1
Macaca mulatta
HIV-1
Immunization
1 Citation (Scopus)

Dual delivery nanoscale device for miR-345 and gemcitabine co-delivery to treat pancreatic cancer

Uz, M., Kalaga, M., Pothuraju, R., Ju, J., Junker, W. M., Batra, S. K., Mallapragada, S. & Rachagani, S., Jan 28 2019, In : Journal of Controlled Release. 294, p. 237-246 10 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Equipment and Supplies
Heterografts
Neoplasms

Effect of nanoformulated copper/zinc superoxide dismutase on chronic ethanol-induced alterations in liver and adipose tissue

Natarajan, G., Perriotte-Olson, C., Casey, C. A., Donohue, T., Talmon, G. A., Harris, E. N., Kabanov, A. V. & Viswanathan, S., Sep 1 2019, In : Alcohol. 79, p. 71-79 9 p.

Research output: Contribution to journalArticle

Liver
Superoxide Dismutase
Adipose Tissue
Zinc
Copper

Engineering hydrogel based cancer microenvironments for in vitro breast cancer cell culture and therapeutics screening

Shi, W., Kuss, M. A., Mohapatra, B., Mirza, S., Band, H., Band, V. & Duan, B., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tumor Microenvironment
Hydrogel
Cell culture
Collagen
Hydrogels

Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition

Abdalla, M. Y., Ahmad, I. M., Rachagani, S., Banerjee, K., Thompson, C. M., Maurer, H. C., Olive, K. P., Bailey, K. L., Britigan, B. E. & Kumar, S., Jan 1 2019, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

gemcitabine
Heme Oxygenase-1
Pancreatic Neoplasms
Cells
Adenocarcinoma

Epigenetic activation of POTE genes in ovarian cancer

Sharma, A., Albahrani, M., Zhang, W., Kufel, C. N., James, S. R., Odunsi, K., Klinkebiel, D. L. & Karpf, A. R., Jan 1 2019, In : Epigenetics.

Research output: Contribution to journalArticle

decitabine
Epigenomics
Ovarian Neoplasms
Transcriptional Activation
Epigenetic Repression

Epigenetically dysregulated genes and pathways implicated in the pathogenesis of non-syndromic high myopia

Vishweswaraiah, S., Swierkowska, J., Ratnamala, U., Mishra, N. K., Guda, C., Chettiar, S. S., Johar, K. R., Mrugacz, M., Karolak, J. A., Gajecka, M. & Radhakrishna, U., Dec 1 2019, In : Scientific Reports. 9, 1, 4145.

Research output: Contribution to journalArticle

Open Access
Myopia
Genes
Methylation
Area Under Curve
Vision Disorders

ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

Neilsen, B. K., Frodyma, D. E., McCall, J. L., Fisher, K. W. & Lewis, R. E., Jan 1 2019, In : PLoS One. 14, 1, e0209224.

Research output: Contribution to journalArticle

colorectal neoplasms
Colonic Neoplasms
Cell proliferation
Cells
cell proliferation

Erratum: O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 (Immunity (2019) 50(3) (576–590.e6), (S1074761319300305) (10.1016/j.immuni.2019.01.007))

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. & Wen, H., Jan 1 2019, In : Immunity.

Research output: Contribution to journalComment/debate

Receptor-Interacting Protein Serine-Threonine Kinases
Immunity
Sepsis
Inflammation
O-GlcNAc transferase

Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism

Thomes, P. G., Rasineni, K., Yang, L., Donohue, T., Kubik, J. L., McNiven, M. A. & Casey, C. A., Apr 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 316, 4, p. G509-G518

Research output: Contribution to journalArticle

Fatty Liver
Autophagy
Ethanol
Lipids
Liver

Evaluating the metabolic alterations in pancreatic cancer

Dasgupta, A., Shukla, S. K., Gunda, V., King, R. J. & Singh, P., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 221-228 8 p. (Methods in Molecular Biology; vol. 1882).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pancreatic Neoplasms
Neoplasms
Metabolic Networks and Pathways
Glutamine
Oxygen Consumption

Factors Predictive of Reoperation After Pancreaticoduodenectomy for Pancreatic Cancer

Hall, B. R., Sleightholm, R., Smith, L. M., Sayles, H. & Are, C., Jan 1 2019, In : Indian Journal of Surgical Oncology.

Research output: Contribution to journalArticle

Pancreaticoduodenectomy
Operating Rooms
Pancreatic Neoplasms
Reoperation
Pylorus

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Seshacharyulu, P., Rachagani, S., Muniyan, S., Siddiqui, J. A., Cruz, E., Sharma, S., Krishnan, R., Killips, B. J., Sheinin, Y., Lele, S. M., Smith, L. M., Talmon, G. A., Palanimuthu Ponnusamy, M., Datta, K. & Batra, S. K., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Geranyltranstransferase
Monomeric GTP-Binding Proteins
Prostatic Neoplasms
Mevalonic Acid
zoledronic acid

Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis

Fonseca, T. L., Fernandes, G. W., Bocco, B. M. L. C., Keshavarzian, A., Jakate, S., Donohue, T., Gereben, B. & Bianco, A. C., Jan 1 2019, In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Iodide Peroxidase
Fatty Liver
Liver
Animals
Genes
Open Access
temozolomide
Pituitary Neoplasms
Radiation
Adrenocorticotropic Hormone
Pituitary ACTH Hypersecretion

Hospital Regional Network Formation and ‘Brand Sharing’: Appearances May Be Deceiving

Reames, B. N., Anaya, D. A. & Are, C., Jan 1 2019, (Accepted/In press) In : Annals of Surgical Oncology.

Research output: Contribution to journalArticle

Comorbidity
HIV
Viruses
Liver
Hepatitis B virus
1 Citation (Scopus)

IL1RL1 is dynamically expressed on Cbfb-MYH11 + leukemia stem cells and promotes cell survival

Wang, Y., Richter, L., Becker, M., Amador, C. & Hyde, R. K., Dec 1 2019, In : Scientific Reports. 9, 1, 1729.

Research output: Contribution to journalArticle

Open Access
Cell Survival
Leukemia
Stem Cells
Myeloid Cells
Acute Myeloid Leukemia

Immunometabolic Alterations by HPV Infection: New Dimensions to Head and Neck Cancer Disparity

Chaudhary, S., Ganguly, K., Muniyan, S., Pothuraju, R., Sayed, Z., Jones, D. T., Batra, S. K. & Macha, M. A., Mar 1 2019, In : Journal of the National Cancer Institute. 111, 3, p. 233-244 12 p.

Research output: Contribution to journalArticle

Open Access
Papillomavirus Infections
Head and Neck Neoplasms
African Americans
Population
Neoplasms

Induced neural progenitor cells abundantly secrete extracellular vesicles and promote the proliferation of neural progenitors via extracellular signal–regulated kinase pathways

Ma, Y., Wang, K., Pan, J., Fan, Z., Tian, C., Deng, X., Ma, K., Xia, X., Huang, Y. & Zheng, J. C., Apr 1 2019, In : Neurobiology of Disease. 124, p. 322-334 13 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Phosphotransferases
Stem Cells
Extracellular Signal-Regulated MAP Kinases
Therapeutic Uses
1 Citation (Scopus)

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Haney, S. L., Varney, M. L., Chhonker, Y. S., Shin, S., Mehla, K., Crawford, A. J., Smith, H. J., Smith, L. M., Murry, D. J., Hollingsworth, M. A. & Holstein, S. A., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Adenocarcinoma
Mucins
Unfolded Protein Response
Terpenes

In Situ AFM Analysis Investigating Disassembly of DNA Nanoparticles and Nanofilms

Zou, Y., Wan, L., Blacklock, J., Xie, L., Carroll, S., Oupicky, D. & Mao, G., Jan 1 2019, In : Methods in molecular biology (Clifton, N.J.). 1943, p. 199-209 11 p.

Research output: Contribution to journalArticle

Nanoparticles
DNA
Genes
Safety
polycations

Intrahepatic Cholangiocarcinoma: Rising Burden and Glaring Disparities

Yanala, U., Malhotra, G., Are, C. & Padussis, J., Jan 1 2019, In : Annals of Surgical Oncology.

Research output: Contribution to journalEditorial

Open Access
Cholangiocarcinoma
2 Citations (Scopus)

Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer

Carmicheal, J., Hayashi, C., Huang, X., Liu, L., Lu, Y., Krasnoslobodtsev, A. V., Lushnikov, A., Kshirsagar, P. G., Patel, A., Jain, M., Lyubchenko, Y. L., Lu, Y., Batra, S. K. & Kaur, S., Feb 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 16, p. 88-96 9 p.

Research output: Contribution to journalArticle

Exosomes
Raman Spectrum Analysis
Pancreatic Neoplasms
Early Detection of Cancer
Raman spectroscopy

LIMD1 phosphorylation in mitosis is required for mitotic progression and its tumor-suppressing activity

Zhou, J., Zhang, L., Zhou, W., Chen, Y., Cheng, Y. & Dong, J., Jan 1 2019, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

Phosphorylation
Mitosis
Tumors
bis(2,3,3,3-tetrachloropropyl) ether
Lung Neoplasms

Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases

Mishra, S., Verma, S. S., Rai, V., Awasthee, N., Chava, S., Hui, K. M., Kumar, A. P., Challagundla, K. B., Sethi, G. & Gupta, S. C., Jan 1 2019, In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalReview article

Long Noncoding RNA
Phytochemicals
Chronic Disease
Neoplasms
Berberine

Managing Squamous Cell Esophageal Cancer

Batra, R., Malhotra, G. K., Singh, S. & Are, C., Jan 1 2019, In : Surgical Clinics of North America.

Research output: Contribution to journalReview article

Squamous Cell Neoplasms
Esophageal Neoplasms

Meningeal lymphatics in aging and Alzheimer's disease

Jaffe, R. J., Dave, R. S. & Byrareddy, S. N., Mar 1 2019, In : Journal of Threatened Taxa. 7, S2.

Research output: Contribution to journalEditorial

Alzheimer disease

MnTE-2-PyP attenuates TGF-β-induced epithelial-mesenchymal transition of colorectal cancer cells by inhibiting the Smad2/3 signaling pathway

Yang, Y., Zhang, P., Yan, R., Wang, Q., Fang, E., Wu, H., Li, S., Tan, H., Zhou, X., Ma, X., Tang, Y., Huang, Y., Deng, R., Liu, Y., Tong, S., Wang, Z., Deegan, R. E. & Tong, Q., Jan 1 2019, In : Oxidative Medicine and Cellular Longevity. 2019, 8639791.

Research output: Contribution to journalArticle

Open Access
Epithelial-Mesenchymal Transition
Transforming Growth Factors
Colorectal Neoplasms
Cells
Smad2 Protein

Molecular and physiological evaluation of pancreatic cancer-induced cachexia

Shukla, S. K., Dasgupta, A., Mulder, S. E. & Singh, P., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 321-333 13 p. (Methods in Molecular Biology; vol. 1882).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cachexia
Pancreatic Neoplasms
Muscles
Fats
Rotarod Performance Test

Mutant p53 R175H promotes cancer initiation in the pancreas by stabilizing HSP70

Polireddy, K., Singh, K., Pruski, M., Jones, N. C., Manisundaram, N. V., Ponnela, P., Ouellette, M. M., Van Buren, G., Younes, M., Bynon, J. S., Dar, W. A. & Bailey, J. M., Jul 1 2019, In : Cancer Letters. 453, p. 122-130 9 p.

Research output: Contribution to journalArticle

Pancreas
Pancreatic Neoplasms
Neoplasms
Mutation
Immunoprecipitation

Novel therapies hijack the blood-brain barrier to eradicate glioblastoma cancer stem cells

Vengoji, R., Palanimuthu Ponnusamy, M., Rachagani, S., Mahapatra, S., Batra, S. K., Shonka, N. A. & Macha, M. A., Mar 12 2019, In : Carcinogenesis. 40, 1, p. 2-14 13 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Glioblastoma
Blood-Brain Barrier
temozolomide
Radiotherapy
1 Citation (Scopus)

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. & Wen, H., Mar 19 2019, In : Immunity. 50, 3, p. 576-590.e6

Research output: Contribution to journalArticle

Receptor-Interacting Protein Serine-Threonine Kinases
Innate Immunity
Protein Interaction Domains and Motifs
Inflammation
Acetylglucosamine

Optimizing intracellular signaling domains for CAR NK cells in HIV immunotherapy: a comprehensive review

Zenere, G., Olwenyi, O. A., Byrareddy, S. N. & Braun, S. E., Jan 1 2019, In : Drug Discovery Today.

Research output: Contribution to journalReview article

Antigen Receptors
Natural Killer Cells
Immunotherapy
HIV
HIV Infections